Tofacitinib_NCI-H661 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Tofacitinib perturbation in NCI-H661 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Tofacitinib_NCI-H661 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
IMMP2L IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) 0.102835
HDAC9 histone deacetylase 9 0.0972417
NTM neurotrimin 0.0681698
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 0.0667499
SAMD4A sterile alpha motif domain containing 4A 0.0641899
ZEB2 zinc finger E-box binding homeobox 2 0.0570019
CDH10 cadherin 10, type 2 (T2-cadherin) 0.0533821
HNRNPC heterogeneous nuclear ribonucleoprotein C (C1/C2) 0.0528503
RERE arginine-glutamic acid dipeptide (RE) repeats 0.0526723
ANKRD33B ankyrin repeat domain 33B 0.0507783
TENM3 teneurin transmembrane protein 3 0.0496002
FNDC3B fibronectin type III domain containing 3B 0.0482498
SRP54 signal recognition particle 54kDa 0.0481282
RALGAPA1 Ral GTPase activating protein, alpha subunit 1 (catalytic) 0.0478686
SEMA3A sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3A 0.0474947
PLPP1 phospholipid phosphatase 1 0.0473975
IGF2BP3 insulin-like growth factor 2 mRNA binding protein 3 0.0451163
MAML2 mastermind-like 2 (Drosophila) 0.0451014
LRRC4C leucine rich repeat containing 4C 0.0410919
ZNF292 zinc finger protein 292 0.0373789
NEBL nebulette 0.0362386
PGAP1 post-GPI attachment to proteins 1 0.034642
UBR5 ubiquitin protein ligase E3 component n-recognin 5 0.033591
BTAF1 BTAF1 RNA polymerase II, B-TFIID transcription factor-associated, 170kDa 0.0329259
PRKAG2 protein kinase, AMP-activated, gamma 2 non-catalytic subunit 0.0329023
TRIO trio Rho guanine nucleotide exchange factor 0.0321613
PHF3 PHD finger protein 3 0.0313469
MEIS2 Meis homeobox 2 0.0312269
UACA uveal autoantigen with coiled-coil domains and ankyrin repeats 0.0311206
RBM39 RNA binding motif protein 39 0.0310313
SPIRE1 spire-type actin nucleation factor 1 0.0307284
USP25 ubiquitin specific peptidase 25 0.0292748
ANKRD12 ankyrin repeat domain 12 0.0292279
TSC22D2 TSC22 domain family, member 2 0.0285983
VAPA VAMP (vesicle-associated membrane protein)-associated protein A, 33kDa 0.0284204
MEF2A myocyte enhancer factor 2A 0.0281193
ZCCHC7 zinc finger, CCHC domain containing 7 0.0276629
UTRN utrophin 0.0265378
TRPS1 trichorhinophalangeal syndrome I 0.0264499
MED13L mediator complex subunit 13-like 0.0264214
FOXG1 forkhead box G1 0.0263673
GPHN gephyrin 0.0260358
OGT O-linked N-acetylglucosamine (GlcNAc) transferase 0.0259567
SCFD1 sec1 family domain containing 1 0.0257873
BRWD1 bromodomain and WD repeat domain containing 1 0.0251576
PARD3B par-3 family cell polarity regulator beta 0.0251572
CPLANE1 ciliogenesis and planar polarity effector complex subunit 1 0.0249837
CEP350 centrosomal protein 350kDa 0.0248093
BMPR1A bone morphogenetic protein receptor, type IA 0.0247855
AKT3 v-akt murine thymoma viral oncogene homolog 3 0.0246295
GALNTL6 polypeptide N-acetylgalactosaminyltransferase-like 6 0.0242759
TAS2R14 taste receptor, type 2, member 14 0.0241097
DST dystonin 0.0240238
TOX thymocyte selection-associated high mobility group box 0.0239114
GOLGA4 golgin A4 0.0237899
MEF2C myocyte enhancer factor 2C 0.0236939
STRN3 striatin, calmodulin binding protein 3 0.0236869
FLNB filamin B, beta 0.0235866
ARIH1 ariadne RBR E3 ubiquitin protein ligase 1 0.0234937
JMJD1C jumonji domain containing 1C 0.0234363
DYRK1A dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1A 0.0232216
SLC5A3 solute carrier family 5 (sodium/myo-inositol cotransporter), member 3 0.0232196
ROBO1 roundabout, axon guidance receptor, homolog 1 (Drosophila) 0.0228316
CDC14A cell division cycle 14A 0.0226628
PIAS2 protein inhibitor of activated STAT, 2 0.0226596
PLEKHG1 pleckstrin homology domain containing, family G (with RhoGef domain) member 1 0.0226125
CHD7 chromodomain helicase DNA binding protein 7 0.0224916
SIK3 SIK family kinase 3 0.0222813
SHROOM3 shroom family member 3 0.0221173
RCOR1 REST corepressor 1 0.0220738
ACAP2 ArfGAP with coiled-coil, ankyrin repeat and PH domains 2 0.02205
PDE3A phosphodiesterase 3A, cGMP-inhibited 0.0218235
ARID1B AT rich interactive domain 1B (SWI1-like) 0.0216144
KDM3A lysine (K)-specific demethylase 3A 0.0213789
PRKD1 protein kinase D1 0.0211357
BAZ1A bromodomain adjacent to zinc finger domain, 1A 0.0210704
SUCO SUN domain containing ossification factor 0.0209535
NF1 neurofibromin 1 0.020925
ARB2A ARB2 cotranscriptional regulator A 0.020848
ORC4 origin recognition complex, subunit 4 0.0208455
INTS6 integrator complex subunit 6 0.0206568
FOXP2 forkhead box P2 0.0206253
KMT2C lysine (K)-specific methyltransferase 2C 0.0205402
MBD5 methyl-CpG binding domain protein 5 0.0201129
ATXN2 ataxin 2 0.0199144
SMAD4 SMAD family member 4 0.0198806
DIDO1 death inducer-obliterator 1 0.0197749
TNRC6A trinucleotide repeat containing 6A 0.019771
HECTD4 HECT domain containing E3 ubiquitin protein ligase 4 0.0196526
HEATR5A HEAT repeat containing 5A 0.0196336
PRR16 proline rich 16 0.0195535
FARS2 phenylalanyl-tRNA synthetase 2, mitochondrial 0.0193916
RNF216 ring finger protein 216 0.0193389
PTK2 protein tyrosine kinase 2 0.019313
KDM6A lysine (K)-specific demethylase 6A 0.0192941
EZH2 enhancer of zeste 2 polycomb repressive complex 2 subunit 0.0192887
PICALM phosphatidylinositol binding clathrin assembly protein 0.0191146
TBC1D12 TBC1 domain family, member 12 0.0190879
PPP6R3 protein phosphatase 6, regulatory subunit 3 0.0188956
UBE2H ubiquitin-conjugating enzyme E2H 0.0188728

decreased expression

Symbol Name Standardized Value
VIM vimentin -0.2643
TMSB10 thymosin beta 10 -0.164404
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.107403
RPS6 ribosomal protein S6 -0.0927766
RPS16 ribosomal protein S16 -0.0807849
PCDH9 protocadherin 9 -0.0714316
ACTG1 actin gamma 1 -0.0704779
MDK midkine (neurite growth-promoting factor 2) -0.0690498
PTMA prothymosin, alpha -0.0670071
PABPC1 poly(A) binding protein, cytoplasmic 1 -0.064952
NUCKS1 nuclear casein kinase and cyclin-dependent kinase substrate 1 -0.0645742
RPL35A ribosomal protein L35a -0.0579682
CDH6 cadherin 6, type 2, K-cadherin (fetal kidney) -0.0579165
MKI67 marker of proliferation Ki-67 -0.0568049
TPT1 tumor protein, translationally-controlled 1 -0.0529911
RPS8 ribosomal protein S8 -0.0520517
PEG10 paternally expressed 10 -0.051747
TOP2A topoisomerase (DNA) II alpha 170kDa -0.0510639
TMSB4X thymosin beta 4, X-linked -0.0503216
RPL19 ribosomal protein L19 -0.0478322
RPL12 ribosomal protein L12 -0.0463315
CENPF centromere protein F, 350/400kDa -0.0462212
COL1A2 collagen, type I, alpha 2 -0.045087
CTNNA3 catenin (cadherin-associated protein), alpha 3 -0.0445737
ITGAV integrin, alpha V -0.0435873
RPS19 ribosomal protein S19 -0.0431303
GPC3 glypican 3 -0.0421655
ASH1L ash1 (absent, small, or homeotic)-like (Drosophila) -0.0417633
RPL11 ribosomal protein L11 -0.0415496
HMGB1 high mobility group box 1 -0.0406613
POTEF POTE ankyrin domain family, member F -0.0401384
HSPB1 heat shock 27kDa protein 1 -0.0398713
PSMA7 proteasome (prosome, macropain) subunit, alpha type, 7 -0.0397714
EMP1 epithelial membrane protein 1 -0.0395012
SERF2 small EDRK-rich factor 2 -0.0393534
MYL12B myosin, light chain 12B, regulatory -0.0373558
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.0364742
CBX3 chromobox homolog 3 -0.0363425
CENPE centromere protein E, 312kDa -0.0358928
NAP1L1 nucleosome assembly protein 1-like 1 -0.0352996
RPLP1 ribosomal protein, large, P1 -0.0350473
S100A9 S100 calcium binding protein A9 -0.034799
NACA nascent polypeptide-associated complex alpha subunit -0.0347531
BMPR2 bone morphogenetic protein receptor, type II (serine/threonine kinase) -0.0344511
APOE apolipoprotein E -0.0340105
PFN1 profilin 1 -0.0340033
PPDPF pancreatic progenitor cell differentiation and proliferation factor -0.0336541
RPL30 ribosomal protein L30 -0.0334431
RPS21 ribosomal protein S21 -0.0330903
WSB1 WD repeat and SOCS box containing 1 -0.0321481
RPL5 ribosomal protein L5 -0.0321217
COL11A1 collagen, type XI, alpha 1 -0.0318787
RPLP0 ribosomal protein, large, P0 -0.0318522
EIF1 eukaryotic translation initiation factor 1 -0.0317373
RPS24 ribosomal protein S24 -0.0315061
DACH1 dachshund family transcription factor 1 -0.031406
RPL31 ribosomal protein L31 -0.0306754
RPLP2 ribosomal protein, large, P2 -0.0305773
ENO1 enolase 1, (alpha) -0.0304121
FTL ferritin, light polypeptide -0.0297538
CELF1 CUGBP, Elav-like family member 1 -0.029659
MRPS30 mitochondrial ribosomal protein S30 -0.0294336
FBL fibrillarin -0.0293986
KCTD16 potassium channel tetramerization domain containing 16 -0.0293372
PA2G4 proliferation-associated 2G4, 38kDa -0.0292782
EEF2 eukaryotic translation elongation factor 2 -0.0288677
ASPM asp (abnormal spindle) homolog, microcephaly associated (Drosophila) -0.0288525
HSPD1 heat shock 60kDa protein 1 (chaperonin) -0.0287671
RPL23 ribosomal protein L23 -0.0287014
SPAG9 sperm associated antigen 9 -0.0286768
RPL7 ribosomal protein L7 -0.028407
ATP5F1B ATP synthase F1 subunit beta -0.0280466
KPNB1 karyopherin (importin) beta 1 -0.0279217
YES1 YES proto-oncogene 1, Src family tyrosine kinase -0.0277812
S100A10 S100 calcium binding protein A10 -0.0276683
NIPBL Nipped-B homolog (Drosophila) -0.0269098
COL3A1 collagen, type III, alpha 1 -0.0267581
SPTSSA serine palmitoyltransferase, small subunit A -0.0267542
RPL34 ribosomal protein L34 -0.0266368
SAMD4B sterile alpha motif domain containing 4B -0.0264018
STMN1 stathmin 1 -0.0256105
PTGES3 prostaglandin E synthase 3 (cytosolic) -0.0254092
RTN4 reticulon 4 -0.0253762
ERBB4 erb-b2 receptor tyrosine kinase 4 -0.0253269
DEK DEK proto-oncogene -0.0253265
MARCKS myristoylated alanine-rich protein kinase C substrate -0.0251424
PCLO piccolo presynaptic cytomatrix protein -0.025009
ADGRL2 adhesion G protein-coupled receptor L2 -0.0249792
RPS5 ribosomal protein S5 -0.0248304
ARHGAP15 Rho GTPase activating protein 15 -0.0248077
ARL6IP5 ADP-ribosylation factor-like 6 interacting protein 5 -0.0246702
RPL36A ribosomal protein L36a -0.0246383
GNAS GNAS complex locus -0.0245608
RPL38 ribosomal protein L38 -0.0242809
GNB1 guanine nucleotide binding protein (G protein), beta polypeptide 1 -0.024223
KHDRBS1 KH domain containing, RNA binding, signal transduction associated 1 -0.0242113
FST follistatin -0.0241989
RPS14 ribosomal protein S14 -0.0241091
RPS27A ribosomal protein S27a -0.0240236
MAP3K2 mitogen-activated protein kinase kinase kinase 2 -0.0236865