Tofacitinib_SNU-1 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Tofacitinib perturbation in SNU-1 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Tofacitinib_SNU-1 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
PCBP2 poly(rC) binding protein 2 0.0317418
RBPJ recombination signal binding protein for immunoglobulin kappa J region 0.0296248
CITED2 Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 2 0.0240378
PPP3CA protein phosphatase 3, catalytic subunit, alpha isozyme 0.0232209
SOX6 SRY (sex determining region Y)-box 6 0.0218784
KMT2E lysine (K)-specific methyltransferase 2E 0.0211436
EPS8 epidermal growth factor receptor pathway substrate 8 0.0210164
ENO2 enolase 2 (gamma, neuronal) 0.0204749
EVI5 ecotropic viral integration site 5 0.0192025
TOP2A topoisomerase (DNA) II alpha 170kDa 0.0190974
PHLDA1 pleckstrin homology-like domain, family A, member 1 0.0182275
SMC3 structural maintenance of chromosomes 3 0.0175371
MORF4L2 mortality factor 4 like 2 0.017037
P4HA1 prolyl 4-hydroxylase, alpha polypeptide I 0.0170006
KTN1 kinectin 1 (kinesin receptor) 0.0167101
GBE1 glucan (1,4-alpha-), branching enzyme 1 0.0166627
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 0.0164021
CENPF centromere protein F, 350/400kDa 0.0162453
GOLGA4 golgin A4 0.0161734
MBNL1 muscleblind-like splicing regulator 1 0.0161116
SYNE2 spectrin repeat containing, nuclear envelope 2 0.0152288
RIOK3 RIO kinase 3 0.0149908
BACH2 BTB and CNC homology 1, basic leucine zipper transcription factor 2 0.0146358
TENT4A terminal nucleotidyltransferase 4A 0.0143711
SRP54 signal recognition particle 54kDa 0.0142568
WSB1 WD repeat and SOCS box containing 1 0.0140866
GLS2 glutaminase 2 (liver, mitochondrial) 0.0139755
KDM2A lysine (K)-specific demethylase 2A 0.0139023
ERBIN erbb2 interacting protein 0.013868
CAMK1D calcium/calmodulin-dependent protein kinase ID 0.0136855
XPO1 exportin 1 0.013527
BIRC6 baculoviral IAP repeat containing 6 0.0133413
UBA6 ubiquitin-like modifier activating enzyme 6 0.0132168
ANKRD36B ankyrin repeat domain 36B 0.0131141
FAM13A family with sequence similarity 13, member A 0.0130732
KIF5C kinesin family member 5C 0.0127139
PCM1 pericentriolar material 1 0.0123447
SMC4 structural maintenance of chromosomes 4 0.0123174
NAV2 neuron navigator 2 0.0123124
GFPT1 glutamine--fructose-6-phosphate transaminase 1 0.0122465
NUP58 nucleoporin 58 0.0120561
TXNIP thioredoxin interacting protein 0.0119542
HILPDA hypoxia inducible lipid droplet-associated 0.0116975
KDM6A lysine (K)-specific demethylase 6A 0.0116868
FN1 fibronectin 1 0.0115285
PIK3C3 phosphatidylinositol 3-kinase, catalytic subunit type 3 0.0114395
PFKFB4 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 4 0.0113394
INSIG2 insulin induced gene 2 0.0111662
CEP192 centrosomal protein 192kDa 0.0111231
ZFP36L1 ZFP36 ring finger protein-like 1 0.0111171
SREK1 splicing regulatory glutamine/lysine-rich protein 1 0.011105
SIK3 SIK family kinase 3 0.0110024
RAB18 RAB18, member RAS oncogene family 0.0109154
RCOR1 REST corepressor 1 0.0108943
HIVEP2 human immunodeficiency virus type I enhancer binding protein 2 0.0108696
NDRG1 N-myc downstream regulated 1 0.0107144
RAB6A RAB6A, member RAS oncogene family 0.0106767
NAA35 N(alpha)-acetyltransferase 35, NatC auxiliary subunit 0.0106319
PDS5B PDS5 cohesin associated factor B 0.0106071
ANKRD36C ankyrin repeat domain 36C 0.0106006
PHLPP1 PH domain and leucine rich repeat protein phosphatase 1 0.0105729
ARSJ arylsulfatase family, member J 0.0105145
ATAD2 ATPase family, AAA domain containing 2 0.0104479
ARID4B AT rich interactive domain 4B (RBP1-like) 0.0103927
PCGF5 polycomb group ring finger 5 0.0103913
SUCO SUN domain containing ossification factor 0.0103647
CRY1 cryptochrome circadian clock 1 0.0101584
PPME1 protein phosphatase methylesterase 1 0.0100683
TPD52 tumor protein D52 0.00996304
ITSN2 intersectin 2 0.00994229
HMGCS1 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble) 0.00987554
TMF1 TATA element modulatory factor 1 0.00987417
PIAS2 protein inhibitor of activated STAT, 2 0.009871
SRRM1 serine/arginine repetitive matrix 1 0.00968421
FNIP1 folliculin interacting protein 1 0.00960736
SPAG9 sperm associated antigen 9 0.00947838
SBNO1 strawberry notch homolog 1 (Drosophila) 0.00941906
KDM4C lysine (K)-specific demethylase 4C 0.00936063
LNPK lunapark, ER junction formation factor 0.00932616
POLR2B polymerase (RNA) II (DNA directed) polypeptide B, 140kDa 0.00923463
MACROD2 MACRO domain containing 2 0.00917107
PBX3 pre-B-cell leukemia homeobox 3 0.00916739
ECT2 epithelial cell transforming 2 0.00914597
KPNA4 karyopherin alpha 4 (importin alpha 3) 0.00913142
BNIP3L BCL2/adenovirus E1B 19kDa interacting protein 3-like 0.00912787
SFSWAP splicing factor, suppressor of white-apricot family 0.00909242
AKAP12 A kinase (PRKA) anchor protein 12 0.00905424
P4HB prolyl 4-hydroxylase, beta polypeptide 0.00902501
ANKRD36 ankyrin repeat domain 36 0.00902331
ELOVL5 ELOVL fatty acid elongase 5 0.00900131
ADAMTS6 ADAM metallopeptidase with thrombospondin type 1 motif, 6 0.00898081
ESYT2 extended synaptotagmin-like protein 2 0.00897053
CAMK2D calcium/calmodulin-dependent protein kinase II delta 0.00895702
LRCH1 leucine-rich repeats and calponin homology (CH) domain containing 1 0.00893051
TANC2 tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 2 0.00890627
HDGF hepatoma-derived growth factor 0.00887541
VEZT vezatin, adherens junctions transmembrane protein 0.00884915
HNRNPA1 heterogeneous nuclear ribonucleoprotein A1 0.00883519
ZCCHC7 zinc finger, CCHC domain containing 7 0.00882849
RIC1 RAB6A GEF complex partner 1 0.00882437

decreased expression

Symbol Name Standardized Value
PTMA prothymosin, alpha -0.174664
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.162657
AHNAK AHNAK nucleoprotein -0.138257
VCL vinculin -0.111504
TPT1 tumor protein, translationally-controlled 1 -0.109563
PDE4D phosphodiesterase 4D, cAMP-specific -0.105566
TMSB4X thymosin beta 4, X-linked -0.0950386
RPS6 ribosomal protein S6 -0.09278
PKM pyruvate kinase, muscle -0.0824611
SCD stearoyl-CoA desaturase (delta-9-desaturase) -0.0791062
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.07075
ACTG1 actin gamma 1 -0.0672705
BMP10 bone morphogenetic protein 10 -0.0648438
RPL35A ribosomal protein L35a -0.0639421
S100A6 S100 calcium binding protein A6 -0.0545646
RPS8 ribosomal protein S8 -0.0537272
RPL12 ribosomal protein L12 -0.0529914
FLNB filamin B, beta -0.0528718
B3GALT1 UDP-Gal:betaGlcNAc beta 1,3-galactosyltransferase, polypeptide 1 -0.0523948
EGFR epidermal growth factor receptor -0.0511563
RPL26 ribosomal protein L26 -0.050813
STAT1 signal transducer and activator of transcription 1, 91kDa -0.0491402
RPLP1 ribosomal protein, large, P1 -0.0490319
RPL34 ribosomal protein L34 -0.048819
GLI2 GLI family zinc finger 2 -0.0481081
RPS19 ribosomal protein S19 -0.0473008
LOC112694756 uncharaterized LOC112694756 -0.045297
MINDY2 MINDY lysine 48 deubiquitinase 2 -0.0437303
PYGB phosphorylase, glycogen; brain -0.0436605
RPL19 ribosomal protein L19 -0.0435239
RPL23 ribosomal protein L23 -0.0430178
RPL11 ribosomal protein L11 -0.0407905
TNFRSF11B tumor necrosis factor receptor superfamily, member 11b -0.0376748
S100A4 S100 calcium binding protein A4 -0.0367489
ADAM10 ADAM metallopeptidase domain 10 -0.0361281
RPLP2 ribosomal protein, large, P2 -0.0356316
RPL31 ribosomal protein L31 -0.0355429
RPS27A ribosomal protein S27a -0.0354099
NFAT5 nuclear factor of activated T-cells 5, tonicity-responsive -0.0353337
TM4SF1 transmembrane 4 L six family member 1 -0.0350982
RPS23 ribosomal protein S23 -0.0349768
RPL4 ribosomal protein L4 -0.0348799
RPS13 ribosomal protein S13 -0.0346173
RPL36 ribosomal protein L36 -0.033938
RPLP0 ribosomal protein, large, P0 -0.0336792
RPL9 ribosomal protein L9 -0.0326441
NFE2L2 nuclear factor, erythroid 2-like 2 -0.032593
SQSTM1 sequestosome 1 -0.0306441
RPL13A ribosomal protein L13a -0.0304567
RPS24 ribosomal protein S24 -0.0302756
RPL37A ribosomal protein L37a -0.0291089
MYO5C myosin VC -0.0289811
NPAS2 neuronal PAS domain protein 2 -0.028773
RPL32 ribosomal protein L32 -0.0286992
ZEB1 zinc finger E-box binding homeobox 1 -0.0282889
RACK1 receptor for activated C kinase 1 -0.0282174
CCND1 cyclin D1 -0.0281172
SERPINB1 serpin peptidase inhibitor, clade B (ovalbumin), member 1 -0.0279844
ZMYND8 zinc finger, MYND-type containing 8 -0.0275015
DOCK3 dedicator of cytokinesis 3 -0.0273024
LDHA lactate dehydrogenase A -0.0270712
RPS21 ribosomal protein S21 -0.0263962
RPS3 ribosomal protein S3 -0.0262076
ENOX1 ecto-NOX disulfide-thiol exchanger 1 -0.0261759
ZBTB20 zinc finger and BTB domain containing 20 -0.0253526
PARP14 poly (ADP-ribose) polymerase family, member 14 -0.025153
RPL17-C18ORF32 RPL17-C18orf32 readthrough -0.0250791
EEF2 eukaryotic translation elongation factor 2 -0.0250192
DUSP4 dual specificity phosphatase 4 -0.0244521
NCEH1 neutral cholesterol ester hydrolase 1 -0.0242766
RPS16 ribosomal protein S16 -0.0242182
RPS11 ribosomal protein S11 -0.0240857
NBEA neurobeachin -0.0240759
RPS2 ribosomal protein S2 -0.0239793
IMMP2L IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) -0.0233957
HDLBP high density lipoprotein binding protein -0.023392
SMYD3 SET and MYND domain containing 3 -0.0232115
RIGI RNA sensor RIG-I -0.0230768
RPS25 ribosomal protein S25 -0.023026
RPL30 ribosomal protein L30 -0.0227115
OSMR oncostatin M receptor -0.0226861
ALDH1A2 aldehyde dehydrogenase 1 family, member A2 -0.0226504
EIF1 eukaryotic translation initiation factor 1 -0.0224473
CALM2 calmodulin 2 (phosphorylase kinase, delta) -0.0224374
TAS2R14 taste receptor, type 2, member 14 -0.022394
HSPA8 heat shock 70kDa protein 8 -0.0220327
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group) -0.0215759
RPL8 ribosomal protein L8 -0.0215548
HNRNPK heterogeneous nuclear ribonucleoprotein K -0.0215329
GCNT1 glucosaminyl (N-acetyl) transferase 1, core 2 -0.0214095
MICAL2 microtubule associated monooxygenase, calponin and LIM domain containing 2 -0.0213731
TMSB10 thymosin beta 10 -0.0210725
TJP1 tight junction protein 1 -0.0208314
RHOA ras homolog family member A -0.0208115
ANK2 ankyrin 2, neuronal -0.0208046
FOXP1 forkhead box P1 -0.0207959
SP100 SP100 nuclear antigen -0.0207954
KLF3 Kruppel-like factor 3 (basic) -0.0205126
MYL12B myosin, light chain 12B, regulatory -0.0205032
RPS4X ribosomal protein S4, X-linked -0.020248