| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | Tofacitinib perturbation in SNU-423 cell line (Tahoe Therapeutics) |
| Similar Terms | |
| Downloads & Tools |
200 genes differentially expressed following the Tofacitinib_SNU-423 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| FRMD4A | FERM domain containing 4A | 0.099491 |
| IQCJ-SCHIP1 | IQCJ-SCHIP1 readthrough | 0.0913388 |
| KCNMA1 | potassium channel, calcium activated large conductance subfamily M alpha, member 1 | 0.0913043 |
| HMGA2 | high mobility group AT-hook 2 | 0.0671811 |
| HDAC9 | histone deacetylase 9 | 0.0584708 |
| VCL | vinculin | 0.0577265 |
| INTS6 | integrator complex subunit 6 | 0.0566924 |
| ZSWIM6 | zinc finger, SWIM-type containing 6 | 0.0541003 |
| MYOF | myoferlin | 0.0479135 |
| TRIO | trio Rho guanine nucleotide exchange factor | 0.0442231 |
| ANKS1B | ankyrin repeat and sterile alpha motif domain containing 1B | 0.0402528 |
| ATXN1 | ataxin 1 | 0.0393804 |
| BICC1 | BicC family RNA binding protein 1 | 0.0377066 |
| LDHA | lactate dehydrogenase A | 0.0363834 |
| NHS | Nance-Horan syndrome (congenital cataracts and dental anomalies) | 0.0359526 |
| CADM1 | cell adhesion molecule 1 | 0.0347916 |
| TMEM132D | transmembrane protein 132D | 0.0346312 |
| GLIS3 | GLIS family zinc finger 3 | 0.0343511 |
| NEDD4L | neural precursor cell expressed, developmentally down-regulated 4-like, E3 ubiquitin protein ligase | 0.033766 |
| FNIP1 | folliculin interacting protein 1 | 0.0327087 |
| CDH13 | cadherin 13 | 0.0326075 |
| SDK1 | sidekick cell adhesion molecule 1 | 0.0303357 |
| NFAT5 | nuclear factor of activated T-cells 5, tonicity-responsive | 0.02993 |
| DUSP10 | dual specificity phosphatase 10 | 0.0294374 |
| FRMPD4 | FERM and PDZ domain containing 4 | 0.0293092 |
| PDLIM5 | PDZ and LIM domain 5 | 0.0280505 |
| PSD3 | pleckstrin and Sec7 domain containing 3 | 0.027654 |
| ZHX2 | zinc fingers and homeoboxes 2 | 0.0260587 |
| TBC1D8 | TBC1 domain family, member 8 (with GRAM domain) | 0.0257911 |
| IMMP2L | IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) | 0.0253627 |
| SLC35F3 | solute carrier family 35, member F3 | 0.025269 |
| DCBLD2 | discoidin, CUB and LCCL domain containing 2 | 0.0239911 |
| ZFAND3 | zinc finger, AN1-type domain 3 | 0.0239337 |
| ERBIN | erbb2 interacting protein | 0.0235744 |
| SQSTM1 | sequestosome 1 | 0.0232443 |
| PHLDA1 | pleckstrin homology-like domain, family A, member 1 | 0.0226878 |
| CPEB4 | cytoplasmic polyadenylation element binding protein 4 | 0.0224372 |
| SPOCK1 | sparc/osteonectin, cwcv and kazal-like domains proteoglycan (testican) 1 | 0.0221125 |
| AKT3 | v-akt murine thymoma viral oncogene homolog 3 | 0.0218301 |
| LAMC1 | laminin, gamma 1 (formerly LAMB2) | 0.0216248 |
| GRB10 | growth factor receptor-bound protein 10 | 0.0215976 |
| PRELID2 | PRELI domain containing 2 | 0.0210243 |
| SMYD3 | SET and MYND domain containing 3 | 0.0207146 |
| COL7A1 | collagen, type VII, alpha 1 | 0.0199213 |
| SOX9 | SRY (sex determining region Y)-box 9 | 0.0198293 |
| JAG1 | jagged 1 | 0.0198017 |
| TRIM55 | tripartite motif containing 55 | 0.0190909 |
| AFF3 | AF4/FMR2 family, member 3 | 0.0190702 |
| RBMS3 | RNA binding motif, single stranded interacting protein 3 | 0.0190306 |
| FHIT | fragile histidine triad | 0.0190129 |
| PLPP4 | phospholipid phosphatase 4 | 0.0182638 |
| UBAP2 | ubiquitin associated protein 2 | 0.0177385 |
| PRKCA | protein kinase C, alpha | 0.0177374 |
| HSP90AA1 | heat shock protein 90kDa alpha (cytosolic), class A member 1 | 0.0177151 |
| MED13 | mediator complex subunit 13 | 0.0174149 |
| MAPK8 | mitogen-activated protein kinase 8 | 0.0172115 |
| EXOC4 | exocyst complex component 4 | 0.0171545 |
| WWOX | WW domain containing oxidoreductase | 0.0168808 |
| FBXL7 | F-box and leucine-rich repeat protein 7 | 0.0166223 |
| CTNNA1 | catenin (cadherin-associated protein), alpha 1, 102kDa | 0.0166194 |
| TIMP2 | TIMP metallopeptidase inhibitor 2 | 0.0166073 |
| SVIL | supervillin | 0.0166036 |
| EXT1 | exostosin glycosyltransferase 1 | 0.0165584 |
| ANKRD1 | ankyrin repeat domain 1 (cardiac muscle) | 0.0165578 |
| ABTB2 | ankyrin repeat and BTB (POZ) domain containing 2 | 0.016551 |
| SMAD2 | SMAD family member 2 | 0.0162861 |
| IARS1 | isoleucyl-tRNA synthetase 1 | 0.0161758 |
| IRS2 | insulin receptor substrate 2 | 0.0160737 |
| ARHGAP24 | Rho GTPase activating protein 24 | 0.0158494 |
| SUPT3H | suppressor of Ty 3 homolog (S. cerevisiae) | 0.0157926 |
| USP9X | ubiquitin specific peptidase 9, X-linked | 0.015777 |
| CREBRF | CREB3 regulatory factor | 0.0156635 |
| FER | fer (fps/fes related) tyrosine kinase | 0.0156116 |
| TLE4 | transducin-like enhancer of split 4 | 0.0155096 |
| DTNA | dystrobrevin, alpha | 0.0152763 |
| TPM1 | tropomyosin 1 (alpha) | 0.0152219 |
| AUTS2 | autism susceptibility candidate 2 | 0.0149016 |
| DLG1 | discs, large homolog 1 (Drosophila) | 0.0147839 |
| DDIT3 | DNA-damage-inducible transcript 3 | 0.0147363 |
| SLC38A2 | solute carrier family 38, member 2 | 0.0147013 |
| WDR27 | WD repeat domain 27 | 0.0146163 |
| PTPRK | protein tyrosine phosphatase, receptor type, K | 0.0142165 |
| WASF1 | WAS protein family, member 1 | 0.0141861 |
| MICAL2 | microtubule associated monooxygenase, calponin and LIM domain containing 2 | 0.014183 |
| UST | uronyl-2-sulfotransferase | 0.0141606 |
| GPR39 | G protein-coupled receptor 39 | 0.0139254 |
| KPNA4 | karyopherin alpha 4 (importin alpha 3) | 0.0138993 |
| EGFR | epidermal growth factor receptor | 0.0137658 |
| RPS4X | ribosomal protein S4, X-linked | 0.0135743 |
| PALLD | palladin, cytoskeletal associated protein | 0.0135414 |
| FRMD6 | FERM domain containing 6 | 0.0134841 |
| KLHL4 | kelch-like family member 4 | 0.0134329 |
| STARD13 | StAR-related lipid transfer (START) domain containing 13 | 0.0133915 |
| ARHGAP22 | Rho GTPase activating protein 22 | 0.0133801 |
| COG6 | component of oligomeric golgi complex 6 | 0.0133744 |
| ADGRB3 | adhesion G protein-coupled receptor B3 | 0.0131842 |
| SLC4A7 | solute carrier family 4, sodium bicarbonate cotransporter, member 7 | 0.0129153 |
| MBD5 | methyl-CpG binding domain protein 5 | 0.0127379 |
| TENM2 | teneurin transmembrane protein 2 | 0.0126303 |
| TMEM178B | transmembrane protein 178B | 0.0125572 |
| Symbol | Name | Standardized Value |
|---|---|---|
| NAMPT | nicotinamide phosphoribosyltransferase | -0.202966 |
| VIM | vimentin | -0.162679 |
| HLA-B | major histocompatibility complex, class I, B | -0.146275 |
| IFIT3 | interferon-induced protein with tetratricopeptide repeats 3 | -0.110024 |
| ELL2 | elongation factor, RNA polymerase II, 2 | -0.10771 |
| STAT1 | signal transducer and activator of transcription 1, 91kDa | -0.100908 |
| MT2A | metallothionein 2A | -0.097581 |
| FN1 | fibronectin 1 | -0.0865789 |
| UGCG | UDP-glucose ceramide glucosyltransferase | -0.0830133 |
| B2M | beta-2-microglobulin | -0.0810118 |
| IGFBP3 | insulin-like growth factor binding protein 3 | -0.0783155 |
| HIF1A | hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) | -0.0709032 |
| IFI16 | interferon, gamma-inducible protein 16 | -0.0677999 |
| PARP14 | poly (ADP-ribose) polymerase family, member 14 | -0.0672911 |
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | -0.0667578 |
| TMSB4X | thymosin beta 4, X-linked | -0.0665235 |
| HLA-E | major histocompatibility complex, class I, E | -0.0645924 |
| ZMYND8 | zinc finger, MYND-type containing 8 | -0.0627267 |
| PLOD2 | procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 | -0.0621159 |
| MYH9 | myosin, heavy chain 9, non-muscle | -0.06162 |
| SERPINE1 | serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 | -0.0615916 |
| BASP1 | brain abundant, membrane attached signal protein 1 | -0.0605028 |
| NDRG1 | N-myc downstream regulated 1 | -0.0602937 |
| STC1 | stanniocalcin 1 | -0.0591074 |
| AKAP12 | A kinase (PRKA) anchor protein 12 | -0.0589554 |
| EIF2AK2 | eukaryotic translation initiation factor 2-alpha kinase 2 | -0.0588293 |
| IFI6 | interferon, alpha-inducible protein 6 | -0.0562649 |
| MARCKS | myristoylated alanine-rich protein kinase C substrate | -0.0561994 |
| CDCP1 | CUB domain containing protein 1 | -0.0535212 |
| RIGI | RNA sensor RIG-I | -0.0525965 |
| FNDC3B | fibronectin type III domain containing 3B | -0.0512773 |
| BTG1 | B-cell translocation gene 1, anti-proliferative | -0.0510397 |
| RPS6 | ribosomal protein S6 | -0.050804 |
| HSP90B1 | heat shock protein 90kDa beta (Grp94), member 1 | -0.0500063 |
| PTMA | prothymosin, alpha | -0.048618 |
| GRIN2A | glutamate receptor, ionotropic, N-methyl D-aspartate 2A | -0.0482516 |
| MKI67 | marker of proliferation Ki-67 | -0.0476218 |
| ERRFI1 | ERBB receptor feedback inhibitor 1 | -0.0474902 |
| BNIP3 | BCL2/adenovirus E1B 19kDa interacting protein 3 | -0.0467089 |
| ADM | adrenomedullin | -0.0466649 |
| TPT1 | tumor protein, translationally-controlled 1 | -0.0462799 |
| P4HA1 | prolyl 4-hydroxylase, alpha polypeptide I | -0.0462677 |
| ZNF292 | zinc finger protein 292 | -0.0458502 |
| ITGB1 | integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) | -0.0446647 |
| MXI1 | MAX interactor 1, dimerization protein | -0.0441601 |
| ICAM1 | intercellular adhesion molecule 1 | -0.0430352 |
| IFITM3 | interferon induced transmembrane protein 3 | -0.0429934 |
| SP100 | SP100 nuclear antigen | -0.0422337 |
| SOD2 | superoxide dismutase 2, mitochondrial | -0.0416881 |
| CD44 | CD44 molecule (Indian blood group) | -0.0415715 |
| PGK1 | phosphoglycerate kinase 1 | -0.0414017 |
| PLSCR1 | phospholipid scramblase 1 | -0.0406617 |
| IFIT2 | interferon-induced protein with tetratricopeptide repeats 2 | -0.0404078 |
| STAT3 | signal transducer and activator of transcription 3 (acute-phase response factor) | -0.0395425 |
| EIF1 | eukaryotic translation initiation factor 1 | -0.0394394 |
| IFITM1 | interferon induced transmembrane protein 1 | -0.0392944 |
| RNF213 | ring finger protein 213 | -0.0383547 |
| RPS8 | ribosomal protein S8 | -0.0382334 |
| MX1 | MX dynamin-like GTPase 1 | -0.0381087 |
| SLC38A1 | solute carrier family 38, member 1 | -0.0375943 |
| IER3 | immediate early response 3 | -0.0373891 |
| HLA-A | major histocompatibility complex, class I, A | -0.0372469 |
| TOP2A | topoisomerase (DNA) II alpha 170kDa | -0.0369964 |
| CENPF | centromere protein F, 350/400kDa | -0.0365579 |
| ZNFX1 | zinc finger, NFX1-type containing 1 | -0.0356406 |
| APP | amyloid beta (A4) precursor protein | -0.0354267 |
| SPARC | secreted protein, acidic, cysteine-rich (osteonectin) | -0.0353229 |
| ZC3HAV1 | zinc finger CCCH-type, antiviral 1 | -0.03522 |
| IFIH1 | interferon induced with helicase C domain 1 | -0.0350635 |
| ERO1A | endoplasmic reticulum oxidoreductase 1 alpha | -0.0349753 |
| NAV2 | neuron navigator 2 | -0.0348803 |
| ANLN | anillin, actin binding protein | -0.0345497 |
| ARRDC3 | arrestin domain containing 3 | -0.0344916 |
| SDC4 | syndecan 4 | -0.0344639 |
| TPM4 | tropomyosin 4 | -0.034413 |
| RTN4 | reticulon 4 | -0.0336082 |
| ENO1 | enolase 1, (alpha) | -0.0328922 |
| LRRFIP1 | leucine rich repeat (in FLII) interacting protein 1 | -0.032827 |
| ARL6IP1 | ADP-ribosylation factor-like 6 interacting protein 1 | -0.0327633 |
| RPL36A | ribosomal protein L36a | -0.0325641 |
| PAPPA | pregnancy-associated plasma protein A, pappalysin 1 | -0.032554 |
| CTSB | cathepsin B | -0.032259 |
| OSMR | oncostatin M receptor | -0.0319636 |
| FTH1 | ferritin, heavy polypeptide 1 | -0.0312207 |
| RND3 | Rho family GTPase 3 | -0.0309163 |
| PMP22 | peripheral myelin protein 22 | -0.0308886 |
| RNF24 | ring finger protein 24 | -0.0302013 |
| ESYT2 | extended synaptotagmin-like protein 2 | -0.0300318 |
| UBA6 | ubiquitin-like modifier activating enzyme 6 | -0.0297878 |
| MAP3K5 | mitogen-activated protein kinase kinase kinase 5 | -0.0297636 |
| NPEPPS | aminopeptidase puromycin sensitive | -0.02955 |
| RBPJ | recombination signal binding protein for immunoglobulin kappa J region | -0.0295458 |
| EGR1 | early growth response 1 | -0.0292976 |
| SYAP1 | synapse associated protein 1 | -0.0291738 |
| YWHAZ | tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta | -0.0291638 |
| C3 | complement component 3 | -0.0291308 |
| PHLDB2 | pleckstrin homology-like domain, family B, member 2 | -0.0291051 |
| CALM2 | calmodulin 2 (phosphorylase kinase, delta) | -0.0289921 |
| COL1A2 | collagen, type I, alpha 2 | -0.0287241 |
| RRBP1 | ribosome binding protein 1 | -0.0284116 |
