| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | Tofacitinib perturbation in SW 1088 cell line (Tahoe Therapeutics) |
| Similar Terms | |
| Downloads & Tools |
200 genes differentially expressed following the Tofacitinib_SW 1088 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| IGFBP3 | insulin-like growth factor binding protein 3 | 0.105827 |
| NRXN3 | neurexin 3 | 0.090846 |
| EGFR | epidermal growth factor receptor | 0.0635571 |
| CDH13 | cadherin 13 | 0.0626237 |
| TRIO | trio Rho guanine nucleotide exchange factor | 0.0557295 |
| VCL | vinculin | 0.0528734 |
| RABGEF1 | RAB guanine nucleotide exchange factor (GEF) 1 | 0.040871 |
| ASPH | aspartate beta-hydroxylase | 0.0366362 |
| PTPN12 | protein tyrosine phosphatase, non-receptor type 12 | 0.0364728 |
| ZBTB20 | zinc finger and BTB domain containing 20 | 0.0354118 |
| BACE2 | beta-site APP-cleaving enzyme 2 | 0.0348431 |
| SEC24A | SEC24 family member A | 0.0340721 |
| TTC3 | tetratricopeptide repeat domain 3 | 0.0324602 |
| DCBLD2 | discoidin, CUB and LCCL domain containing 2 | 0.0317317 |
| SDK1 | sidekick cell adhesion molecule 1 | 0.0305673 |
| GBE1 | glucan (1,4-alpha-), branching enzyme 1 | 0.0302303 |
| NAV1 | neuron navigator 1 | 0.0302124 |
| ITGAV | integrin, alpha V | 0.0297608 |
| HDAC9 | histone deacetylase 9 | 0.028984 |
| CALD1 | caldesmon 1 | 0.0285821 |
| F3 | coagulation factor III (thromboplastin, tissue factor) | 0.0281771 |
| ITFG1 | integrin alpha FG-GAP repeat containing 1 | 0.027884 |
| SEMA5A | sema domain, seven thrombospondin repeats (type 1 and type 1-like), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 5A | 0.027645 |
| DPYSL2 | dihydropyrimidinase-like 2 | 0.0274982 |
| HNRNPC | heterogeneous nuclear ribonucleoprotein C (C1/C2) | 0.0267392 |
| INTS6 | integrator complex subunit 6 | 0.0259581 |
| MYOF | myoferlin | 0.0259431 |
| ANLN | anillin, actin binding protein | 0.0258276 |
| HIP1 | huntingtin interacting protein 1 | 0.0255012 |
| INSIG2 | insulin induced gene 2 | 0.0252335 |
| RAB31 | RAB31, member RAS oncogene family | 0.0246578 |
| DMTF1 | cyclin D binding myb-like transcription factor 1 | 0.0244636 |
| FNIP1 | folliculin interacting protein 1 | 0.02436 |
| SAMD4A | sterile alpha motif domain containing 4A | 0.0242307 |
| DSTN | destrin (actin depolymerizing factor) | 0.0240323 |
| COG5 | component of oligomeric golgi complex 5 | 0.0239958 |
| HERC4 | HECT and RLD domain containing E3 ubiquitin protein ligase 4 | 0.0238809 |
| AKAP9 | A kinase (PRKA) anchor protein 9 | 0.0237823 |
| SLC25A51 | solute carrier family 25, member 51 | 0.0237714 |
| RAP1A | RAP1A, member of RAS oncogene family | 0.0236278 |
| VEGFC | vascular endothelial growth factor C | 0.0235296 |
| ABL2 | ABL proto-oncogene 2, non-receptor tyrosine kinase | 0.0234793 |
| AKAP12 | A kinase (PRKA) anchor protein 12 | 0.0233012 |
| SMURF1 | SMAD specific E3 ubiquitin protein ligase 1 | 0.0232714 |
| NCOR1 | nuclear receptor corepressor 1 | 0.0230749 |
| GLIS3 | GLIS family zinc finger 3 | 0.0230442 |
| ARHGAP24 | Rho GTPase activating protein 24 | 0.0229397 |
| PRELID2 | PRELI domain containing 2 | 0.0228039 |
| PDLIM5 | PDZ and LIM domain 5 | 0.0226281 |
| MYH9 | myosin, heavy chain 9, non-muscle | 0.0225241 |
| CELF1 | CUGBP, Elav-like family member 1 | 0.0225141 |
| YEATS2 | YEATS domain containing 2 | 0.0221065 |
| VPS13B | vacuolar protein sorting 13 homolog B (yeast) | 0.0219453 |
| CORO1C | coronin, actin binding protein, 1C | 0.0218954 |
| HNRNPR | heterogeneous nuclear ribonucleoprotein R | 0.0218792 |
| SLC4A7 | solute carrier family 4, sodium bicarbonate cotransporter, member 7 | 0.0217569 |
| SIPA1L1 | signal-induced proliferation-associated 1 like 1 | 0.0213936 |
| FAM107B | family with sequence similarity 107, member B | 0.0213616 |
| HNRNPA2B1 | heterogeneous nuclear ribonucleoprotein A2/B1 | 0.0213374 |
| RNF145 | ring finger protein 145 | 0.0212594 |
| MACF1 | microtubule-actin crosslinking factor 1 | 0.0212164 |
| SOX5 | SRY (sex determining region Y)-box 5 | 0.0211734 |
| NBEAL1 | neurobeachin-like 1 | 0.0210973 |
| ACER3 | alkaline ceramidase 3 | 0.020863 |
| WRN | Werner syndrome, RecQ helicase-like | 0.0208493 |
| WWTR1 | WW domain containing transcription regulator 1 | 0.0206957 |
| RPS6KA3 | ribosomal protein S6 kinase, 90kDa, polypeptide 3 | 0.0206564 |
| RASAL2 | RAS protein activator like 2 | 0.0204513 |
| SH3KBP1 | SH3-domain kinase binding protein 1 | 0.0203985 |
| SND1 | staphylococcal nuclease and tudor domain containing 1 | 0.0203828 |
| LPP | LIM domain containing preferred translocation partner in lipoma | 0.0202271 |
| RND3 | Rho family GTPase 3 | 0.020185 |
| NUDCD3 | NudC domain containing 3 | 0.0201045 |
| ATP13A3 | ATPase type 13A3 | 0.0200204 |
| KRIT1 | KRIT1, ankyrin repeat containing | 0.0198691 |
| RAD51B | RAD51 paralog B | 0.0198084 |
| XPO1 | exportin 1 | 0.019713 |
| UBE2E1 | ubiquitin-conjugating enzyme E2E 1 | 0.019557 |
| AGO3 | argonaute RISC catalytic component 3 | 0.0195486 |
| MSI2 | musashi RNA-binding protein 2 | 0.0195347 |
| SUCO | SUN domain containing ossification factor | 0.0194497 |
| GPATCH2L | G patch domain containing 2-like | 0.0194164 |
| CACUL1 | CDK2-associated, cullin domain 1 | 0.0192898 |
| ALK | anaplastic lymphoma receptor tyrosine kinase | 0.0189655 |
| SPATS2L | spermatogenesis associated, serine-rich 2-like | 0.0189373 |
| AUH | AU RNA binding protein/enoyl-CoA hydratase | 0.0189267 |
| ETNK1 | ethanolamine kinase 1 | 0.0189076 |
| ERO1A | endoplasmic reticulum oxidoreductase 1 alpha | 0.0187837 |
| DYNC1LI2 | dynein, cytoplasmic 1, light intermediate chain 2 | 0.0186386 |
| DST | dystonin | 0.0184212 |
| EPC2 | enhancer of polycomb homolog 2 (Drosophila) | 0.0183957 |
| MPRIP | myosin phosphatase Rho interacting protein | 0.0183851 |
| HNRNPD | heterogeneous nuclear ribonucleoprotein D (AU-rich element RNA binding protein 1, 37kDa) | 0.0183534 |
| FMNL2 | formin-like 2 | 0.0181816 |
| MBTD1 | mbt domain containing 1 | 0.0180064 |
| ECPAS | Ecm29 proteasome adaptor and scaffold | 0.0179044 |
| EFNA5 | ephrin-A5 | 0.0176033 |
| RALGAPB | Ral GTPase activating protein, beta subunit (non-catalytic) | 0.017456 |
| ZNF644 | zinc finger protein 644 | 0.0174461 |
| WSB1 | WD repeat and SOCS box containing 1 | 0.0172094 |
| Symbol | Name | Standardized Value |
|---|---|---|
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | -0.252709 |
| MT2A | metallothionein 2A | -0.128646 |
| TMSB10 | thymosin beta 10 | -0.115836 |
| B2M | beta-2-microglobulin | -0.0938767 |
| SDC4 | syndecan 4 | -0.0869009 |
| HLA-B | major histocompatibility complex, class I, B | -0.0795508 |
| COL1A2 | collagen, type I, alpha 2 | -0.0757868 |
| UBC | ubiquitin C | -0.0688026 |
| CCNI | cyclin I | -0.0670671 |
| COL1A1 | collagen, type I, alpha 1 | -0.0668957 |
| SPARC | secreted protein, acidic, cysteine-rich (osteonectin) | -0.0641843 |
| ENO1 | enolase 1, (alpha) | -0.0634866 |
| PTMA | prothymosin, alpha | -0.0610861 |
| TGFBI | transforming growth factor, beta-induced, 68kDa | -0.0566508 |
| FN1 | fibronectin 1 | -0.0538885 |
| TXNIP | thioredoxin interacting protein | -0.0503785 |
| ARID4B | AT rich interactive domain 4B (RBP1-like) | -0.049627 |
| COL6A1 | collagen, type VI, alpha 1 | -0.0486554 |
| CALU | calumenin | -0.0479979 |
| TPT1 | tumor protein, translationally-controlled 1 | -0.0464303 |
| CYP1B1 | cytochrome P450, family 1, subfamily B, polypeptide 1 | -0.046344 |
| EEF2 | eukaryotic translation elongation factor 2 | -0.0451369 |
| NAMPT | nicotinamide phosphoribosyltransferase | -0.0441869 |
| LDHA | lactate dehydrogenase A | -0.044103 |
| ITGA5 | integrin, alpha 5 (fibronectin receptor, alpha polypeptide) | -0.0437581 |
| LGALS1 | lectin, galactoside-binding, soluble, 1 | -0.0435648 |
| ACTG1 | actin gamma 1 | -0.0430472 |
| LOX | lysyl oxidase | -0.0427133 |
| CALR | calreticulin | -0.0407458 |
| ZC3HAV1 | zinc finger CCCH-type, antiviral 1 | -0.0379767 |
| VIM | vimentin | -0.03783 |
| SEC31A | SEC31 homolog A (S. cerevisiae) | -0.0377574 |
| H3-3B | H3.3 histone B | -0.0368681 |
| PABPC1 | poly(A) binding protein, cytoplasmic 1 | -0.0367098 |
| SLC2A3 | solute carrier family 2 (facilitated glucose transporter), member 3 | -0.0362785 |
| NDRG1 | N-myc downstream regulated 1 | -0.0361383 |
| GRB10 | growth factor receptor-bound protein 10 | -0.0359808 |
| BASP1 | brain abundant, membrane attached signal protein 1 | -0.0354611 |
| KMT2E | lysine (K)-specific methyltransferase 2E | -0.0352647 |
| AHNAK | AHNAK nucleoprotein | -0.0352606 |
| COL5A2 | collagen, type V, alpha 2 | -0.0348342 |
| JUN | jun proto-oncogene | -0.0343643 |
| ITGA3 | integrin, alpha 3 (antigen CD49C, alpha 3 subunit of VLA-3 receptor) | -0.0341512 |
| RIGI | RNA sensor RIG-I | -0.0334323 |
| WTAP | Wilms tumor 1 associated protein | -0.0329968 |
| YWHAZ | tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta | -0.0329029 |
| POTEF | POTE ankyrin domain family, member F | -0.0327855 |
| RPL32 | ribosomal protein L32 | -0.03268 |
| RPS11 | ribosomal protein S11 | -0.0317487 |
| BSG | basigin (Ok blood group) | -0.0315246 |
| RPLP1 | ribosomal protein, large, P1 | -0.0313467 |
| S100A9 | S100 calcium binding protein A9 | -0.0311931 |
| P4HB | prolyl 4-hydroxylase, beta polypeptide | -0.0309137 |
| GANAB | glucosidase, alpha; neutral AB | -0.0304355 |
| FTL | ferritin, light polypeptide | -0.0302656 |
| DSCAM | Down syndrome cell adhesion molecule | -0.0302417 |
| IL6 | interleukin 6 | -0.0302345 |
| SMAD3 | SMAD family member 3 | -0.0301803 |
| SPAG9 | sperm associated antigen 9 | -0.0296841 |
| RPL28 | ribosomal protein L28 | -0.029203 |
| DKK3 | dickkopf WNT signaling pathway inhibitor 3 | -0.0279463 |
| SRPK2 | SRSF protein kinase 2 | -0.0273172 |
| EFHD2 | EF-hand domain family, member D2 | -0.0272878 |
| ECE1 | endothelin converting enzyme 1 | -0.0268774 |
| EIF4A1 | eukaryotic translation initiation factor 4A1 | -0.0267474 |
| FLNB | filamin B, beta | -0.0265829 |
| GNAS | GNAS complex locus | -0.0259216 |
| POLR2A | polymerase (RNA) II (DNA directed) polypeptide A, 220kDa | -0.0257239 |
| ELF2 | E74-like factor 2 (ets domain transcription factor) | -0.025709 |
| FBN1 | fibrillin 1 | -0.025637 |
| RPL34 | ribosomal protein L34 | -0.0252867 |
| SERPINE2 | serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2 | -0.0249598 |
| ANXA5 | annexin A5 | -0.0247681 |
| ARRDC3 | arrestin domain containing 3 | -0.0246108 |
| STAT3 | signal transducer and activator of transcription 3 (acute-phase response factor) | -0.0245996 |
| FEZ2 | fasciculation and elongation protein zeta 2 (zygin II) | -0.0245416 |
| RPL23 | ribosomal protein L23 | -0.0245033 |
| RPLP2 | ribosomal protein, large, P2 | -0.0244915 |
| RPS25 | ribosomal protein S25 | -0.0244829 |
| HSP90AB1 | heat shock protein 90kDa alpha (cytosolic), class B member 1 | -0.0244677 |
| UGP2 | UDP-glucose pyrophosphorylase 2 | -0.0244391 |
| NUCKS1 | nuclear casein kinase and cyclin-dependent kinase substrate 1 | -0.024429 |
| AKT3 | v-akt murine thymoma viral oncogene homolog 3 | -0.0243031 |
| GFPT2 | glutamine-fructose-6-phosphate transaminase 2 | -0.0242322 |
| NACA | nascent polypeptide-associated complex alpha subunit | -0.0241611 |
| CSDE1 | cold shock domain containing E1, RNA-binding | -0.0239567 |
| COL4A2 | collagen, type IV, alpha 2 | -0.0239359 |
| DPYD | dihydropyrimidine dehydrogenase | -0.0236627 |
| DNAJC1 | DnaJ (Hsp40) homolog, subfamily C, member 1 | -0.0236483 |
| RERE | arginine-glutamic acid dipeptide (RE) repeats | -0.0235171 |
| GSK3B | glycogen synthase kinase 3 beta | -0.0232913 |
| PAFAH1B1 | platelet-activating factor acetylhydrolase 1b, regulatory subunit 1 (45kDa) | -0.0232485 |
| FLNA | filamin A, alpha | -0.0231316 |
| ARL8B | ADP-ribosylation factor-like 8B | -0.0230002 |
| SLC38A1 | solute carrier family 38, member 1 | -0.0227477 |
| CAMSAP2 | calmodulin regulated spectrin-associated protein family, member 2 | -0.0226565 |
| GNAQ | guanine nucleotide binding protein (G protein), q polypeptide | -0.0225154 |
| NDUFA4 | NDUFA4, mitochondrial complex associated | -0.022383 |
| MARCHF6 | membrane associated ring-CH-type finger 6 | -0.0223114 |
| SERPINE1 | serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 | -0.022309 |
