| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | Tofacitinib perturbation in SW 1271 cell line (Tahoe Therapeutics) |
| Similar Terms | |
| Downloads & Tools |
200 genes differentially expressed following the Tofacitinib_SW 1271 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| ZSWIM6 | zinc finger, SWIM-type containing 6 | 0.0424935 |
| HMGA2 | high mobility group AT-hook 2 | 0.0381109 |
| INTS6 | integrator complex subunit 6 | 0.0380332 |
| SVIL | supervillin | 0.0326147 |
| SLC4A7 | solute carrier family 4, sodium bicarbonate cotransporter, member 7 | 0.0267741 |
| MBNL1 | muscleblind-like splicing regulator 1 | 0.0263122 |
| KCNMA1 | potassium channel, calcium activated large conductance subfamily M alpha, member 1 | 0.0261338 |
| HSP90AA1 | heat shock protein 90kDa alpha (cytosolic), class A member 1 | 0.0257902 |
| PBX3 | pre-B-cell leukemia homeobox 3 | 0.0251929 |
| BICD1 | bicaudal D homolog 1 (Drosophila) | 0.024322 |
| JARID2 | jumonji, AT rich interactive domain 2 | 0.0241427 |
| VCL | vinculin | 0.0239478 |
| WWOX | WW domain containing oxidoreductase | 0.0239282 |
| SLC38A2 | solute carrier family 38, member 2 | 0.0235762 |
| MACF1 | microtubule-actin crosslinking factor 1 | 0.022815 |
| CD55 | CD55 molecule, decay accelerating factor for complement (Cromer blood group) | 0.0221951 |
| DTNA | dystrobrevin, alpha | 0.0215282 |
| SMURF2 | SMAD specific E3 ubiquitin protein ligase 2 | 0.0212367 |
| PPFIBP1 | PTPRF interacting protein, binding protein 1 (liprin beta 1) | 0.0212232 |
| ABTB2 | ankyrin repeat and BTB (POZ) domain containing 2 | 0.0208558 |
| TTC19 | tetratricopeptide repeat domain 19 | 0.0191904 |
| DNAJC1 | DnaJ (Hsp40) homolog, subfamily C, member 1 | 0.0187842 |
| PALM2AKAP2 | PALM2 and AKAP2 fusion | 0.0171886 |
| SUPT3H | suppressor of Ty 3 homolog (S. cerevisiae) | 0.0171337 |
| HIPK2 | homeodomain interacting protein kinase 2 | 0.016761 |
| ALS2 | amyotrophic lateral sclerosis 2 (juvenile) | 0.0166825 |
| KLF6 | Kruppel-like factor 6 | 0.0166401 |
| CD44 | CD44 molecule (Indian blood group) | 0.016575 |
| CCDC88A | coiled-coil domain containing 88A | 0.0164121 |
| EXOC4 | exocyst complex component 4 | 0.0161927 |
| DST | dystonin | 0.0161469 |
| SMURF1 | SMAD specific E3 ubiquitin protein ligase 1 | 0.0159404 |
| MSN | moesin | 0.0158365 |
| DCBLD2 | discoidin, CUB and LCCL domain containing 2 | 0.0155474 |
| RNF217 | ring finger protein 217 | 0.0154941 |
| FMNL2 | formin-like 2 | 0.0154471 |
| COMMD10 | COMM domain containing 10 | 0.0154321 |
| OGDH | oxoglutarate (alpha-ketoglutarate) dehydrogenase (lipoamide) | 0.015393 |
| SIK2 | salt-inducible kinase 2 | 0.0152813 |
| GPR39 | G protein-coupled receptor 39 | 0.0152773 |
| CARMIL1 | capping protein regulator and myosin 1 linker 1 | 0.0151969 |
| TNRC6B | trinucleotide repeat containing 6B | 0.0149248 |
| KATNAL1 | katanin p60 subunit A-like 1 | 0.0147696 |
| JAK1 | Janus kinase 1 | 0.0145658 |
| NR4A3 | nuclear receptor subfamily 4, group A, member 3 | 0.0145143 |
| CHD7 | chromodomain helicase DNA binding protein 7 | 0.0142684 |
| FNDC3A | fibronectin type III domain containing 3A | 0.0142658 |
| RHOBTB3 | Rho-related BTB domain containing 3 | 0.0142213 |
| NSMCE2 | non-SMC element 2, MMS21 homolog (S. cerevisiae) | 0.01419 |
| SMAD3 | SMAD family member 3 | 0.0141078 |
| FN1 | fibronectin 1 | 0.0140139 |
| CRIM1 | cysteine rich transmembrane BMP regulator 1 (chordin-like) | 0.0139752 |
| TBC1D8 | TBC1 domain family, member 8 (with GRAM domain) | 0.0138095 |
| SERPINE1 | serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 | 0.0138052 |
| ATP1B3 | ATPase, Na+/K+ transporting, beta 3 polypeptide | 0.013557 |
| ELOF1 | elongation factor 1 homolog (S. cerevisiae) | 0.0135406 |
| ZFP36L1 | ZFP36 ring finger protein-like 1 | 0.0133586 |
| CALM1 | calmodulin 1 (phosphorylase kinase, delta) | 0.0133179 |
| MARCHF4 | membrane associated ring-CH-type finger 4 | 0.0133148 |
| FAM168A | family with sequence similarity 168, member A | 0.0132873 |
| EPC2 | enhancer of polycomb homolog 2 (Drosophila) | 0.0132451 |
| FNDC3B | fibronectin type III domain containing 3B | 0.0132204 |
| SUMF1 | sulfatase modifying factor 1 | 0.0131567 |
| STAG2 | stromal antigen 2 | 0.0130586 |
| RBM6 | RNA binding motif protein 6 | 0.0129768 |
| POTEF | POTE ankyrin domain family, member F | 0.0129626 |
| TRMT11 | tRNA methyltransferase 11 homolog (S. cerevisiae) | 0.0128306 |
| RALA | v-ral simian leukemia viral oncogene homolog A (ras related) | 0.0128284 |
| CDK6 | cyclin-dependent kinase 6 | 0.012774 |
| CCDC91 | coiled-coil domain containing 91 | 0.0127409 |
| FTO | fat mass and obesity associated | 0.0127156 |
| TLE4 | transducin-like enhancer of split 4 | 0.012691 |
| BZW1 | basic leucine zipper and W2 domains 1 | 0.0126545 |
| PODXL | podocalyxin-like | 0.012472 |
| OLA1 | Obg-like ATPase 1 | 0.0123891 |
| CDK13 | cyclin-dependent kinase 13 | 0.0123578 |
| CLIP4 | CAP-GLY domain containing linker protein family, member 4 | 0.0123572 |
| CPEB2 | cytoplasmic polyadenylation element binding protein 2 | 0.0123283 |
| SATB2 | SATB homeobox 2 | 0.0123117 |
| FAM3C | family with sequence similarity 3, member C | 0.0121619 |
| MT2A | metallothionein 2A | 0.0120269 |
| DOCK5 | dedicator of cytokinesis 5 | 0.0119719 |
| ST3GAL6 | ST3 beta-galactoside alpha-2,3-sialyltransferase 6 | 0.0118683 |
| TTC14 | tetratricopeptide repeat domain 14 | 0.0118556 |
| IFIT2 | interferon-induced protein with tetratricopeptide repeats 2 | 0.0118018 |
| HIVEP2 | human immunodeficiency virus type I enhancer binding protein 2 | 0.0117541 |
| PURA | purine-rich element binding protein A | 0.0115666 |
| LARP1B | La ribonucleoprotein domain family, member 1B | 0.011535 |
| MED4 | mediator complex subunit 4 | 0.011473 |
| LOC102724023 | ES1 protein homolog, mitochondrial | 0.0113989 |
| KLF12 | Kruppel-like factor 12 | 0.0113988 |
| ROBO2 | roundabout, axon guidance receptor, homolog 2 (Drosophila) | 0.0113885 |
| TEAD1 | TEA domain family member 1 (SV40 transcriptional enhancer factor) | 0.0113658 |
| ATF4 | activating transcription factor 4 | 0.0113119 |
| SCAMP1 | secretory carrier membrane protein 1 | 0.0112683 |
| SASH1 | SAM and SH3 domain containing 1 | 0.0111646 |
| BBS9 | Bardet-Biedl syndrome 9 | 0.0111635 |
| HBEGF | heparin-binding EGF-like growth factor | 0.0111594 |
| CACNA2D1 | calcium channel, voltage-dependent, alpha 2/delta subunit 1 | 0.0111398 |
| STXBP5 | syntaxin binding protein 5 (tomosyn) | 0.0111051 |
| Symbol | Name | Standardized Value |
|---|---|---|
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | -0.0873819 |
| DSCAM | Down syndrome cell adhesion molecule | -0.0660509 |
| ZNF292 | zinc finger protein 292 | -0.0533222 |
| OSMR | oncostatin M receptor | -0.0491432 |
| GOLGA4 | golgin A4 | -0.0444594 |
| EEF2 | eukaryotic translation elongation factor 2 | -0.0427267 |
| TAF1D | TATA box binding protein (TBP)-associated factor, RNA polymerase I, D, 41kDa | -0.0409188 |
| PTMA | prothymosin, alpha | -0.0406236 |
| NAMPT | nicotinamide phosphoribosyltransferase | -0.0392918 |
| YBX3 | Y box binding protein 3 | -0.0392727 |
| UBC | ubiquitin C | -0.0382428 |
| LDHA | lactate dehydrogenase A | -0.0377515 |
| HOOK2 | hook microtubule-tethering protein 2 | -0.033508 |
| PHLDB2 | pleckstrin homology-like domain, family B, member 2 | -0.0312497 |
| RPS27A | ribosomal protein S27a | -0.0312279 |
| NAP1L1 | nucleosome assembly protein 1-like 1 | -0.0311362 |
| DERA | deoxyribose-phosphate aldolase (putative) | -0.0307802 |
| PRRC2B | proline-rich coiled-coil 2B | -0.0307455 |
| ANKRD28 | ankyrin repeat domain 28 | -0.0292225 |
| SEMA4B | sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4B | -0.0289887 |
| VIM | vimentin | -0.0287818 |
| POLR2A | polymerase (RNA) II (DNA directed) polypeptide A, 220kDa | -0.0287101 |
| DENND4A | DENN/MADD domain containing 4A | -0.028698 |
| RBM39 | RNA binding motif protein 39 | -0.0286792 |
| RPL4 | ribosomal protein L4 | -0.0284657 |
| DYNC2H1 | dynein, cytoplasmic 2, heavy chain 1 | -0.0273682 |
| TPM4 | tropomyosin 4 | -0.0272797 |
| CANX | calnexin | -0.0263002 |
| ABL2 | ABL proto-oncogene 2, non-receptor tyrosine kinase | -0.0262904 |
| PLOD2 | procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 | -0.0261344 |
| SREK1 | splicing regulatory glutamine/lysine-rich protein 1 | -0.0260574 |
| TANC2 | tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 2 | -0.0254247 |
| SMYD3 | SET and MYND domain containing 3 | -0.0252779 |
| EIF1 | eukaryotic translation initiation factor 1 | -0.0252159 |
| AHNAK | AHNAK nucleoprotein | -0.0249782 |
| MATR3 | matrin 3 | -0.0247906 |
| RAB1A | RAB1A, member RAS oncogene family | -0.0243635 |
| GNAS | GNAS complex locus | -0.023415 |
| NUFIP2 | nuclear fragile X mental retardation protein interacting protein 2 | -0.0234059 |
| IGFBP3 | insulin-like growth factor binding protein 3 | -0.023361 |
| BIRC6 | baculoviral IAP repeat containing 6 | -0.0232731 |
| RPS13 | ribosomal protein S13 | -0.023215 |
| UBR4 | ubiquitin protein ligase E3 component n-recognin 4 | -0.0227414 |
| RPL19 | ribosomal protein L19 | -0.0225867 |
| ATG7 | autophagy related 7 | -0.0222556 |
| NUP58 | nucleoporin 58 | -0.0218781 |
| CBFA2T2 | core-binding factor, runt domain, alpha subunit 2; translocated to, 2 | -0.0217458 |
| RBM25 | RNA binding motif protein 25 | -0.0216261 |
| MNAT1 | MNAT CDK-activating kinase assembly factor 1 | -0.0214892 |
| TGFBR2 | transforming growth factor, beta receptor II (70/80kDa) | -0.0213334 |
| HNRNPA2B1 | heterogeneous nuclear ribonucleoprotein A2/B1 | -0.0212469 |
| RPL23 | ribosomal protein L23 | -0.0212445 |
| RPL26 | ribosomal protein L26 | -0.0211663 |
| NPM1 | nucleophosmin (nucleolar phosphoprotein B23, numatrin) | -0.0211443 |
| TMSB10 | thymosin beta 10 | -0.0209979 |
| PNISR | PNN-interacting serine/arginine-rich protein | -0.0208901 |
| EIF3A | eukaryotic translation initiation factor 3, subunit A | -0.0207826 |
| VPS13A | vacuolar protein sorting 13 homolog A (S. cerevisiae) | -0.0207155 |
| H3-3B | H3.3 histone B | -0.0207148 |
| TAF1 | TAF1 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 250kDa | -0.0206513 |
| ZC3HAV1 | zinc finger CCCH-type, antiviral 1 | -0.0206231 |
| IL1RAP | interleukin 1 receptor accessory protein | -0.0206099 |
| PCBP2 | poly(rC) binding protein 2 | -0.020572 |
| WDR45B | WD repeat domain 45B | -0.0205478 |
| EFNA5 | ephrin-A5 | -0.0205403 |
| RPL37 | ribosomal protein L37 | -0.0203509 |
| SLC2A3 | solute carrier family 2 (facilitated glucose transporter), member 3 | -0.020228 |
| ENO1 | enolase 1, (alpha) | -0.0202185 |
| DDX46 | DEAD (Asp-Glu-Ala-Asp) box polypeptide 46 | -0.0200829 |
| CEP290 | centrosomal protein 290kDa | -0.0200658 |
| SCD | stearoyl-CoA desaturase (delta-9-desaturase) | -0.0200318 |
| CFDP1 | craniofacial development protein 1 | -0.0197672 |
| WNK1 | WNK lysine deficient protein kinase 1 | -0.0197224 |
| TAF15 | TAF15 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 68kDa | -0.0197072 |
| HILPDA | hypoxia inducible lipid droplet-associated | -0.019615 |
| CDCP1 | CUB domain containing protein 1 | -0.0194957 |
| BIRC3 | baculoviral IAP repeat containing 3 | -0.0194616 |
| DYNC1H1 | dynein, cytoplasmic 1, heavy chain 1 | -0.0194197 |
| ABL1 | ABL proto-oncogene 1, non-receptor tyrosine kinase | -0.0194188 |
| AARS1 | alanyl-tRNA synthetase 1 | -0.0193406 |
| TPT1 | tumor protein, translationally-controlled 1 | -0.018894 |
| PRPF8 | pre-mRNA processing factor 8 | -0.0188873 |
| XRN2 | 5'-3' exoribonuclease 2 | -0.0185066 |
| USP22 | ubiquitin specific peptidase 22 | -0.0184501 |
| ATP11B | ATPase, class VI, type 11B | -0.0182239 |
| EIF4A1 | eukaryotic translation initiation factor 4A1 | -0.0180758 |
| ADNP | activity-dependent neuroprotector homeobox | -0.0179593 |
| ERRFI1 | ERBB receptor feedback inhibitor 1 | -0.0179509 |
| YBX1 | Y box binding protein 1 | -0.0179264 |
| PRKD1 | protein kinase D1 | -0.0178911 |
| ACER3 | alkaline ceramidase 3 | -0.0177572 |
| EIF2S2 | eukaryotic translation initiation factor 2, subunit 2 beta, 38kDa | -0.017748 |
| P4HA1 | prolyl 4-hydroxylase, alpha polypeptide I | -0.0177415 |
| TBC1D5 | TBC1 domain family, member 5 | -0.0177362 |
| AVL9 | AVL9 homolog (S. cerevisiase) | -0.0176415 |
| ZNF148 | zinc finger protein 148 | -0.0176408 |
| HSP90B1 | heat shock protein 90kDa beta (Grp94), member 1 | -0.0175873 |
| RNF216 | ring finger protein 216 | -0.0174543 |
| PDCD6IP | programmed cell death 6 interacting protein | -0.0173611 |
| GBE1 | glucan (1,4-alpha-), branching enzyme 1 | -0.0172885 |
