| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | Tofacitinib perturbation in SW 900 cell line (Tahoe Therapeutics) |
| Similar Terms | |
| Downloads & Tools |
200 genes differentially expressed following the Tofacitinib_SW 900 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| VCL | vinculin | 0.0627654 |
| KCNMA1 | potassium channel, calcium activated large conductance subfamily M alpha, member 1 | 0.051896 |
| ASPH | aspartate beta-hydroxylase | 0.0419054 |
| GRB10 | growth factor receptor-bound protein 10 | 0.0343272 |
| PLIN2 | perilipin 2 | 0.0334412 |
| ENO2 | enolase 2 (gamma, neuronal) | 0.0330503 |
| INTS6 | integrator complex subunit 6 | 0.0300136 |
| TBC1D8 | TBC1 domain family, member 8 (with GRAM domain) | 0.0280279 |
| NRG1 | neuregulin 1 | 0.0261825 |
| ZC3HAV1 | zinc finger CCCH-type, antiviral 1 | 0.0235131 |
| ZSWIM6 | zinc finger, SWIM-type containing 6 | 0.0230778 |
| GPATCH2L | G patch domain containing 2-like | 0.0229466 |
| ERRFI1 | ERBB receptor feedback inhibitor 1 | 0.0220705 |
| CADM1 | cell adhesion molecule 1 | 0.0215602 |
| NPAS2 | neuronal PAS domain protein 2 | 0.0208619 |
| PDLIM5 | PDZ and LIM domain 5 | 0.0201941 |
| PHLDA1 | pleckstrin homology-like domain, family A, member 1 | 0.0199159 |
| TRIO | trio Rho guanine nucleotide exchange factor | 0.0198667 |
| AKAP12 | A kinase (PRKA) anchor protein 12 | 0.0193948 |
| PRKCA | protein kinase C, alpha | 0.0192039 |
| CLIP2 | CAP-GLY domain containing linker protein 2 | 0.0191457 |
| MBNL1 | muscleblind-like splicing regulator 1 | 0.0184355 |
| PRELID2 | PRELI domain containing 2 | 0.0179036 |
| MRPS6 | mitochondrial ribosomal protein S6 | 0.0174744 |
| LTBP1 | latent transforming growth factor beta binding protein 1 | 0.0172123 |
| GPC6 | glypican 6 | 0.0170347 |
| RAB10 | RAB10, member RAS oncogene family | 0.0164025 |
| RASAL2 | RAS protein activator like 2 | 0.0162237 |
| MYOF | myoferlin | 0.0158999 |
| SCFD1 | sec1 family domain containing 1 | 0.0156111 |
| ATP2B1 | ATPase, Ca++ transporting, plasma membrane 1 | 0.0155051 |
| TUFT1 | tuftelin 1 | 0.0155011 |
| KCNQ5 | potassium channel, voltage gated KQT-like subfamily Q, member 5 | 0.0151931 |
| VIM | vimentin | 0.0151597 |
| HERC4 | HECT and RLD domain containing E3 ubiquitin protein ligase 4 | 0.0149938 |
| NXN | nucleoredoxin | 0.0149269 |
| CD109 | CD109 molecule | 0.0148191 |
| TPI1 | triosephosphate isomerase 1 | 0.014763 |
| ZBTB20 | zinc finger and BTB domain containing 20 | 0.014393 |
| PALLD | palladin, cytoskeletal associated protein | 0.0141972 |
| SOX9 | SRY (sex determining region Y)-box 9 | 0.0138112 |
| NR3C1 | nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor) | 0.01378 |
| HMGA1 | high mobility group AT-hook 1 | 0.0137779 |
| WDFY2 | WD repeat and FYVE domain containing 2 | 0.0137682 |
| ZCCHC7 | zinc finger, CCHC domain containing 7 | 0.0135441 |
| ARIH1 | ariadne RBR E3 ubiquitin protein ligase 1 | 0.0134295 |
| NHS | Nance-Horan syndrome (congenital cataracts and dental anomalies) | 0.0133439 |
| POTEF | POTE ankyrin domain family, member F | 0.0132917 |
| SVIL | supervillin | 0.0132386 |
| SEMA4A | sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4A | 0.0127866 |
| FOSB | FBJ murine osteosarcoma viral oncogene homolog B | 0.0126555 |
| YWHAZ | tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta | 0.0124944 |
| FNIP1 | folliculin interacting protein 1 | 0.012493 |
| FHIT | fragile histidine triad | 0.0124061 |
| DLG1 | discs, large homolog 1 (Drosophila) | 0.0124008 |
| SPIRE1 | spire-type actin nucleation factor 1 | 0.0122632 |
| TAS2R14 | taste receptor, type 2, member 14 | 0.0122615 |
| ABLIM1 | actin binding LIM protein 1 | 0.0122591 |
| DSTN | destrin (actin depolymerizing factor) | 0.0122263 |
| CPEB2 | cytoplasmic polyadenylation element binding protein 2 | 0.0121822 |
| NR4A2 | nuclear receptor subfamily 4, group A, member 2 | 0.0120351 |
| RAI14 | retinoic acid induced 14 | 0.011975 |
| MYO10 | myosin X | 0.0119612 |
| NALF1 | NALCN channel auxiliary factor 1 | 0.0118118 |
| RCOR1 | REST corepressor 1 | 0.0117995 |
| MBD5 | methyl-CpG binding domain protein 5 | 0.0117546 |
| SLC35F3 | solute carrier family 35, member F3 | 0.0116851 |
| TTC3 | tetratricopeptide repeat domain 3 | 0.0116518 |
| AKAP9 | A kinase (PRKA) anchor protein 9 | 0.0115483 |
| MAML2 | mastermind-like 2 (Drosophila) | 0.0115053 |
| MYO1E | myosin IE | 0.0114762 |
| GLIS3 | GLIS family zinc finger 3 | 0.0112913 |
| RABGEF1 | RAB guanine nucleotide exchange factor (GEF) 1 | 0.0111289 |
| UACA | uveal autoantigen with coiled-coil domains and ankyrin repeats | 0.0110984 |
| HIVEP2 | human immunodeficiency virus type I enhancer binding protein 2 | 0.0109471 |
| UBASH3B | ubiquitin associated and SH3 domain containing B | 0.0107815 |
| FERMT2 | fermitin family member 2 | 0.0107702 |
| MGAT5 | mannosyl (alpha-1,6-)-glycoprotein beta-1,6-N-acetyl-glucosaminyltransferase | 0.0106452 |
| KIF16B | kinesin family member 16B | 0.0106151 |
| RAD51B | RAD51 paralog B | 0.0102889 |
| TFPI | tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor) | 0.0101956 |
| ATF4 | activating transcription factor 4 | 0.0101776 |
| ATF6 | activating transcription factor 6 | 0.0100135 |
| ATXN1 | ataxin 1 | 0.00998294 |
| MAP4K3 | mitogen-activated protein kinase kinase kinase kinase 3 | 0.00992518 |
| SFRP1 | secreted frizzled-related protein 1 | 0.00984733 |
| HSP90AA1 | heat shock protein 90kDa alpha (cytosolic), class A member 1 | 0.00983869 |
| N4BP2L2 | NEDD4 binding protein 2-like 2 | 0.00977762 |
| UBAP2 | ubiquitin associated protein 2 | 0.00976778 |
| AGPAT4 | 1-acylglycerol-3-phosphate O-acyltransferase 4 | 0.0097604 |
| RABGAP1L | RAB GTPase activating protein 1-like | 0.00975542 |
| UTRN | utrophin | 0.00967911 |
| VCAN | versican | 0.00966237 |
| TTC19 | tetratricopeptide repeat domain 19 | 0.0096487 |
| LDHA | lactate dehydrogenase A | 0.00963057 |
| BZW1 | basic leucine zipper and W2 domains 1 | 0.00962361 |
| UPP1 | uridine phosphorylase 1 | 0.00952711 |
| SLC38A2 | solute carrier family 38, member 2 | 0.00952234 |
| IRS2 | insulin receptor substrate 2 | 0.00945196 |
| ADIPOR2 | adiponectin receptor 2 | 0.00939369 |
| Symbol | Name | Standardized Value |
|---|---|---|
| PTGS2 | prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase) | -0.09565 |
| NAMPT | nicotinamide phosphoribosyltransferase | -0.092681 |
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | -0.0904836 |
| HSP90B1 | heat shock protein 90kDa beta (Grp94), member 1 | -0.0726054 |
| CYP1B1 | cytochrome P450, family 1, subfamily B, polypeptide 1 | -0.0697821 |
| UBC | ubiquitin C | -0.0595133 |
| CXCL8 | chemokine (C-X-C motif) ligand 8 | -0.0527923 |
| HLA-B | major histocompatibility complex, class I, B | -0.0435158 |
| HSPA5 | heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) | -0.0410874 |
| RPS27A | ribosomal protein S27a | -0.0406225 |
| MT2A | metallothionein 2A | -0.0396819 |
| POLR2A | polymerase (RNA) II (DNA directed) polypeptide A, 220kDa | -0.0362392 |
| HIF1A | hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) | -0.0352739 |
| OSMR | oncostatin M receptor | -0.0348324 |
| PRRC2C | proline-rich coiled-coil 2C | -0.0336629 |
| PTMA | prothymosin, alpha | -0.0299475 |
| IFI16 | interferon, gamma-inducible protein 16 | -0.0282301 |
| FTH1 | ferritin, heavy polypeptide 1 | -0.0281021 |
| SMAD3 | SMAD family member 3 | -0.0276386 |
| CANX | calnexin | -0.0273376 |
| GPCPD1 | glycerophosphocholine phosphodiesterase GDE1 homolog (S. cerevisiae) | -0.0263881 |
| ITGA1 | integrin, alpha 1 | -0.026168 |
| ITGA2 | integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) | -0.0261352 |
| OGA | O-GlcNAcase | -0.0255335 |
| SQSTM1 | sequestosome 1 | -0.025086 |
| APP | amyloid beta (A4) precursor protein | -0.0237571 |
| TXNIP | thioredoxin interacting protein | -0.0229414 |
| MAP3K5 | mitogen-activated protein kinase kinase kinase 5 | -0.0223026 |
| MCTP2 | multiple C2 domains, transmembrane 2 | -0.0219382 |
| SMOX | spermine oxidase | -0.0219212 |
| NPM1 | nucleophosmin (nucleolar phosphoprotein B23, numatrin) | -0.0216707 |
| ZMYND8 | zinc finger, MYND-type containing 8 | -0.0215043 |
| TPT1 | tumor protein, translationally-controlled 1 | -0.0209561 |
| ARL6IP1 | ADP-ribosylation factor-like 6 interacting protein 1 | -0.0206149 |
| PELO | pelota homolog (Drosophila) | -0.0201841 |
| SLC25A37 | solute carrier family 25 (mitochondrial iron transporter), member 37 | -0.0199259 |
| STAT1 | signal transducer and activator of transcription 1, 91kDa | -0.019701 |
| NPC1 | Niemann-Pick disease, type C1 | -0.0196806 |
| PLOD2 | procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 | -0.0193652 |
| IFI6 | interferon, alpha-inducible protein 6 | -0.0192574 |
| TMEM165 | transmembrane protein 165 | -0.0189404 |
| GBE1 | glucan (1,4-alpha-), branching enzyme 1 | -0.0186556 |
| RRBP1 | ribosome binding protein 1 | -0.0185753 |
| EEF2 | eukaryotic translation elongation factor 2 | -0.0183301 |
| TXNRD1 | thioredoxin reductase 1 | -0.0183195 |
| CALU | calumenin | -0.0182887 |
| WDR45B | WD repeat domain 45B | -0.0181565 |
| IER3 | immediate early response 3 | -0.0180746 |
| KDM3A | lysine (K)-specific demethylase 3A | -0.0176442 |
| S100A6 | S100 calcium binding protein A6 | -0.0174955 |
| CTNNB1 | catenin (cadherin-associated protein), beta 1, 88kDa | -0.0173427 |
| RPL26 | ribosomal protein L26 | -0.0172566 |
| SOX4 | SRY (sex determining region Y)-box 4 | -0.0172252 |
| BASP1 | brain abundant, membrane attached signal protein 1 | -0.0171702 |
| DDX5 | DEAD (Asp-Glu-Ala-Asp) box helicase 5 | -0.0170283 |
| EIF3A | eukaryotic translation initiation factor 3, subunit A | -0.0168851 |
| EIF2AK2 | eukaryotic translation initiation factor 2-alpha kinase 2 | -0.0168385 |
| ATP2B4 | ATPase, Ca++ transporting, plasma membrane 4 | -0.016711 |
| RBPJ | recombination signal binding protein for immunoglobulin kappa J region | -0.0166542 |
| HNRNPU | heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) | -0.0165925 |
| ARHGAP35 | Rho GTPase activating protein 35 | -0.0163249 |
| ANKRD28 | ankyrin repeat domain 28 | -0.0162803 |
| RNF213 | ring finger protein 213 | -0.0161987 |
| ACSL4 | acyl-CoA synthetase long-chain family member 4 | -0.0161843 |
| PARP14 | poly (ADP-ribose) polymerase family, member 14 | -0.0159041 |
| TFPI2 | tissue factor pathway inhibitor 2 | -0.0157157 |
| MYH9 | myosin, heavy chain 9, non-muscle | -0.0154544 |
| UBE2K | ubiquitin-conjugating enzyme E2K | -0.0154254 |
| EREG | epiregulin | -0.0154202 |
| NRIP1 | nuclear receptor interacting protein 1 | -0.0153286 |
| SDC4 | syndecan 4 | -0.0153273 |
| FNBP1 | formin binding protein 1 | -0.015233 |
| PLEKHB2 | pleckstrin homology domain containing, family B (evectins) member 2 | -0.0151526 |
| IFI27 | interferon, alpha-inducible protein 27 | -0.0150845 |
| NEK7 | NIMA-related kinase 7 | -0.0148873 |
| ELL2 | elongation factor, RNA polymerase II, 2 | -0.0148856 |
| ABL2 | ABL proto-oncogene 2, non-receptor tyrosine kinase | -0.0147234 |
| IFI44L | interferon-induced protein 44-like | -0.0142184 |
| ZNF292 | zinc finger protein 292 | -0.0141527 |
| MAP3K2 | mitogen-activated protein kinase kinase kinase 2 | -0.0139979 |
| CAB39 | calcium binding protein 39 | -0.0139518 |
| YME1L1 | YME1-like 1 ATPase | -0.0139316 |
| ADAR | adenosine deaminase, RNA-specific | -0.0136395 |
| TGFBR2 | transforming growth factor, beta receptor II (70/80kDa) | -0.0134693 |
| UGCG | UDP-glucose ceramide glucosyltransferase | -0.0133968 |
| ACTR2 | ARP2 actin-related protein 2 homolog (yeast) | -0.0133821 |
| TNFRSF10B | tumor necrosis factor receptor superfamily, member 10b | -0.0133791 |
| SLC25A36 | solute carrier family 25 (pyrimidine nucleotide carrier), member 36 | -0.0133297 |
| RICTOR | RPTOR independent companion of MTOR, complex 2 | -0.0132653 |
| AHNAK | AHNAK nucleoprotein | -0.0132236 |
| ARHGEF12 | Rho guanine nucleotide exchange factor (GEF) 12 | -0.0132109 |
| EIF4A1 | eukaryotic translation initiation factor 4A1 | -0.0131525 |
| VEZT | vezatin, adherens junctions transmembrane protein | -0.0128774 |
| CFB | complement factor B | -0.0128272 |
| AHR | aryl hydrocarbon receptor | -0.0127766 |
| YTHDC1 | YTH domain containing 1 | -0.0127364 |
| NPEPPS | aminopeptidase puromycin sensitive | -0.0127308 |
| SUPT5H | suppressor of Ty 5 homolog (S. cerevisiae) | -0.0125944 |
| FBXO32 | F-box protein 32 | -0.0125785 |
| DENND5B | DENN/MADD domain containing 5B | -0.012547 |
