| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | Tolcapone perturbation in A-172 cell line (Tahoe Therapeutics) |
| Similar Terms | |
| Downloads & Tools |
200 genes differentially expressed following the Tolcapone_A-172 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| AKAP12 | A kinase (PRKA) anchor protein 12 | 0.1023 |
| PODXL | podocalyxin-like | 0.0880199 |
| TRIO | trio Rho guanine nucleotide exchange factor | 0.0793671 |
| LOXL2 | lysyl oxidase-like 2 | 0.0762901 |
| MYH9 | myosin, heavy chain 9, non-muscle | 0.0735361 |
| FLNA | filamin A, alpha | 0.0705676 |
| SPTBN1 | spectrin, beta, non-erythrocytic 1 | 0.0683819 |
| DST | dystonin | 0.0671757 |
| CDH13 | cadherin 13 | 0.0568792 |
| CENPF | centromere protein F, 350/400kDa | 0.0523761 |
| HNRNPA2B1 | heterogeneous nuclear ribonucleoprotein A2/B1 | 0.0522581 |
| PALM2AKAP2 | PALM2 and AKAP2 fusion | 0.0489569 |
| SPTAN1 | spectrin, alpha, non-erythrocytic 1 | 0.046803 |
| HSP90AB1 | heat shock protein 90kDa alpha (cytosolic), class B member 1 | 0.0465118 |
| PLEC | plectin | 0.0447265 |
| MACF1 | microtubule-actin crosslinking factor 1 | 0.0434883 |
| ABL2 | ABL proto-oncogene 2, non-receptor tyrosine kinase | 0.043277 |
| DCBLD2 | discoidin, CUB and LCCL domain containing 2 | 0.0429515 |
| LAMC1 | laminin, gamma 1 (formerly LAMB2) | 0.0425923 |
| MAP4K4 | mitogen-activated protein kinase kinase kinase kinase 4 | 0.0392564 |
| APP | amyloid beta (A4) precursor protein | 0.0368083 |
| AHNAK2 | AHNAK nucleoprotein 2 | 0.0365409 |
| FNDC3B | fibronectin type III domain containing 3B | 0.0360563 |
| ABCA1 | ATP-binding cassette, sub-family A (ABC1), member 1 | 0.0351055 |
| HDAC9 | histone deacetylase 9 | 0.0347185 |
| CRIM1 | cysteine rich transmembrane BMP regulator 1 (chordin-like) | 0.0345296 |
| KCNMA1 | potassium channel, calcium activated large conductance subfamily M alpha, member 1 | 0.0334489 |
| PBX3 | pre-B-cell leukemia homeobox 3 | 0.0333068 |
| HSP90AA1 | heat shock protein 90kDa alpha (cytosolic), class A member 1 | 0.0331947 |
| ASPH | aspartate beta-hydroxylase | 0.0319283 |
| IGFN1 | immunoglobulin-like and fibronectin type III domain containing 1 | 0.0301225 |
| GLIS3 | GLIS family zinc finger 3 | 0.0292265 |
| NAV2 | neuron navigator 2 | 0.0291595 |
| TFPI | tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor) | 0.0286509 |
| LHFPL2 | lipoma HMGIC fusion partner-like 2 | 0.0282914 |
| COL5A1 | collagen, type V, alpha 1 | 0.0277109 |
| MBNL1 | muscleblind-like splicing regulator 1 | 0.0275118 |
| VCL | vinculin | 0.0273799 |
| ANKRD11 | ankyrin repeat domain 11 | 0.0272864 |
| SOX9 | SRY (sex determining region Y)-box 9 | 0.0264057 |
| EGFR | epidermal growth factor receptor | 0.0262258 |
| HIVEP2 | human immunodeficiency virus type I enhancer binding protein 2 | 0.0260311 |
| ZSWIM6 | zinc finger, SWIM-type containing 6 | 0.0249674 |
| ZMIZ1 | zinc finger, MIZ-type containing 1 | 0.0247936 |
| MPRIP | myosin phosphatase Rho interacting protein | 0.0247834 |
| ANO6 | anoctamin 6 | 0.0244846 |
| L1CAM | L1 cell adhesion molecule | 0.0244053 |
| COL4A2 | collagen, type IV, alpha 2 | 0.0243937 |
| ITGA3 | integrin, alpha 3 (antigen CD49C, alpha 3 subunit of VLA-3 receptor) | 0.0240417 |
| TMSB4X | thymosin beta 4, X-linked | 0.0238426 |
| NAV1 | neuron navigator 1 | 0.0236498 |
| PIEZO1 | piezo-type mechanosensitive ion channel component 1 | 0.0233553 |
| DSPP | dentin sialophosphoprotein | 0.0226105 |
| IGF2BP2 | insulin-like growth factor 2 mRNA binding protein 2 | 0.0225465 |
| TPM3 | tropomyosin 3 | 0.0224914 |
| ACTN4 | actinin, alpha 4 | 0.0223178 |
| MSN | moesin | 0.0221735 |
| PPP1R15A | protein phosphatase 1, regulatory subunit 15A | 0.0220133 |
| NEK7 | NIMA-related kinase 7 | 0.021367 |
| DIP2C | DIP2 disco-interacting protein 2 homolog C (Drosophila) | 0.0209521 |
| FNIP1 | folliculin interacting protein 1 | 0.0209509 |
| SEPTIN9 | septin 9 | 0.0208723 |
| NFE2L1 | nuclear factor, erythroid 2-like 1 | 0.0207282 |
| MCL1 | myeloid cell leukemia 1 | 0.0207073 |
| AGAP1 | ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 | 0.0205632 |
| MB21D2 | Mab-21 domain containing 2 | 0.0203595 |
| GOLGB1 | golgin B1 | 0.020264 |
| LDHA | lactate dehydrogenase A | 0.020225 |
| INTS6 | integrator complex subunit 6 | 0.0201659 |
| RASSF8 | Ras association (RalGDS/AF-6) domain family (N-terminal) member 8 | 0.0199928 |
| TOP2A | topoisomerase (DNA) II alpha 170kDa | 0.0199304 |
| FSTL1 | follistatin-like 1 | 0.0198356 |
| PDLIM5 | PDZ and LIM domain 5 | 0.0194841 |
| DOCK5 | dedicator of cytokinesis 5 | 0.0192045 |
| FNIP2 | folliculin interacting protein 2 | 0.0191957 |
| FLNB | filamin B, beta | 0.0188554 |
| HUWE1 | HECT, UBA and WWE domain containing 1, E3 ubiquitin protein ligase | 0.018772 |
| RNF213 | ring finger protein 213 | 0.0186851 |
| ADAM19 | ADAM metallopeptidase domain 19 | 0.0185536 |
| IQGAP3 | IQ motif containing GTPase activating protein 3 | 0.0183568 |
| STAT1 | signal transducer and activator of transcription 1, 91kDa | 0.0181463 |
| RNF144A | ring finger protein 144A | 0.0181034 |
| ZC3H11A | zinc finger CCCH-type containing 11A | 0.0175174 |
| PPP6R3 | protein phosphatase 6, regulatory subunit 3 | 0.0174467 |
| AHNAK | AHNAK nucleoprotein | 0.0171898 |
| SQSTM1 | sequestosome 1 | 0.0171278 |
| CEP250 | centrosomal protein 250kDa | 0.0170565 |
| ZEB1 | zinc finger E-box binding homeobox 1 | 0.0169304 |
| LHFPL6 | LHFPL tetraspan subfamily member 6 | 0.0167558 |
| NUMA1 | nuclear mitotic apparatus protein 1 | 0.0167554 |
| ITGA2 | integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) | 0.0167149 |
| SDK1 | sidekick cell adhesion molecule 1 | 0.0167055 |
| CYTH3 | cytohesin 3 | 0.0167 |
| NCOR2 | nuclear receptor corepressor 2 | 0.0166399 |
| EZR | ezrin | 0.0165584 |
| DYNC1H1 | dynein, cytoplasmic 1, heavy chain 1 | 0.0165138 |
| DYRK1A | dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1A | 0.0164969 |
| SMC4 | structural maintenance of chromosomes 4 | 0.0164607 |
| PLXNA2 | plexin A2 | 0.0163961 |
| GBE1 | glucan (1,4-alpha-), branching enzyme 1 | 0.0163618 |
| Symbol | Name | Standardized Value |
|---|---|---|
| IGFBP3 | insulin-like growth factor binding protein 3 | -0.276369 |
| SPARC | secreted protein, acidic, cysteine-rich (osteonectin) | -0.197846 |
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | -0.177934 |
| VIM | vimentin | -0.1274 |
| TMSB10 | thymosin beta 10 | -0.124693 |
| MT2A | metallothionein 2A | -0.0811872 |
| HLA-B | major histocompatibility complex, class I, B | -0.0766103 |
| SERPINE1 | serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 | -0.0726572 |
| SUCNR1 | succinate receptor 1 | -0.063675 |
| CD99 | CD99 molecule | -0.0618179 |
| PLAT | plasminogen activator, tissue | -0.0607315 |
| DLG1 | discs, large homolog 1 (Drosophila) | -0.0599932 |
| S100A10 | S100 calcium binding protein A10 | -0.0578949 |
| S100A6 | S100 calcium binding protein A6 | -0.0562791 |
| ADAMTS6 | ADAM metallopeptidase with thrombospondin type 1 motif, 6 | -0.0532684 |
| PTMA | prothymosin, alpha | -0.0522198 |
| B2M | beta-2-microglobulin | -0.0515181 |
| COL1A2 | collagen, type I, alpha 2 | -0.0507944 |
| MX2 | MX dynamin-like GTPase 2 | -0.0480965 |
| IFITM1 | interferon induced transmembrane protein 1 | -0.0420484 |
| SLC38A1 | solute carrier family 38, member 1 | -0.038605 |
| DIRAS3 | DIRAS family, GTP-binding RAS-like 3 | -0.0375361 |
| FN1 | fibronectin 1 | -0.0368456 |
| ABI3BP | ABI family, member 3 (NESH) binding protein | -0.0368034 |
| HSP90B1 | heat shock protein 90kDa beta (Grp94), member 1 | -0.0366486 |
| SERPINE2 | serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2 | -0.0355772 |
| P4HA1 | prolyl 4-hydroxylase, alpha polypeptide I | -0.0345804 |
| FTL | ferritin, light polypeptide | -0.0335914 |
| RPS6 | ribosomal protein S6 | -0.0332851 |
| ZBTB20 | zinc finger and BTB domain containing 20 | -0.032078 |
| TPT1 | tumor protein, translationally-controlled 1 | -0.0318162 |
| DKK1 | dickkopf WNT signaling pathway inhibitor 1 | -0.0317249 |
| HSPB1 | heat shock 27kDa protein 1 | -0.0317146 |
| MT1X | metallothionein 1X | -0.0312582 |
| IFITM3 | interferon induced transmembrane protein 3 | -0.0312308 |
| LMNA | lamin A/C | -0.0309379 |
| RSAD2 | radical S-adenosyl methionine domain containing 2 | -0.0308214 |
| MARCKS | myristoylated alanine-rich protein kinase C substrate | -0.0308056 |
| EIF1 | eukaryotic translation initiation factor 1 | -0.0304468 |
| PDIA3 | protein disulfide isomerase family A, member 3 | -0.0304391 |
| MYADM | myeloid-associated differentiation marker | -0.0303084 |
| P4HB | prolyl 4-hydroxylase, beta polypeptide | -0.0296605 |
| GNB4 | guanine nucleotide binding protein (G protein), beta polypeptide 4 | -0.0291714 |
| LY6E | lymphocyte antigen 6 complex, locus E | -0.027894 |
| LOX | lysyl oxidase | -0.0256771 |
| TPM4 | tropomyosin 4 | -0.0237692 |
| UBC | ubiquitin C | -0.0235126 |
| RPL28 | ribosomal protein L28 | -0.0227287 |
| ACTG1 | actin gamma 1 | -0.0225669 |
| RPS19 | ribosomal protein S19 | -0.0225024 |
| S100A4 | S100 calcium binding protein A4 | -0.0220611 |
| FTH1 | ferritin, heavy polypeptide 1 | -0.0220537 |
| RPL34 | ribosomal protein L34 | -0.0216905 |
| POTEF | POTE ankyrin domain family, member F | -0.021249 |
| RPL35A | ribosomal protein L35a | -0.0209634 |
| GNAS | GNAS complex locus | -0.0209351 |
| KRT81 | keratin 81, type II | -0.0208264 |
| CALR | calreticulin | -0.0201574 |
| RPS13 | ribosomal protein S13 | -0.0201418 |
| RPS15 | ribosomal protein S15 | -0.0201415 |
| CKAP4 | cytoskeleton-associated protein 4 | -0.0198496 |
| ARL4C | ADP-ribosylation factor-like 4C | -0.0196076 |
| LMAN1 | lectin, mannose-binding, 1 | -0.019596 |
| TPM1 | tropomyosin 1 (alpha) | -0.019444 |
| ACBD3 | acyl-CoA binding domain containing 3 | -0.0194243 |
| WSB1 | WD repeat and SOCS box containing 1 | -0.0193999 |
| PPIB | peptidylprolyl isomerase B (cyclophilin B) | -0.0191452 |
| CSTB | cystatin B (stefin B) | -0.0188256 |
| H3-3B | H3.3 histone B | -0.0187652 |
| VDAC1 | voltage-dependent anion channel 1 | -0.0185092 |
| CUX1 | cut-like homeobox 1 | -0.0184719 |
| PFN1 | profilin 1 | -0.0183127 |
| RNF168 | ring finger protein 168, E3 ubiquitin protein ligase | -0.0182896 |
| ZMYND8 | zinc finger, MYND-type containing 8 | -0.0178742 |
| HLA-C | major histocompatibility complex, class I, C | -0.0177744 |
| ISG15 | ISG15 ubiquitin-like modifier | -0.017726 |
| RTN4 | reticulon 4 | -0.0176102 |
| SRPK2 | SRSF protein kinase 2 | -0.0174642 |
| CHCHD2 | coiled-coil-helix-coiled-coil-helix domain containing 2 | -0.0172677 |
| ASTN2 | astrotactin 2 | -0.0169859 |
| IFI27 | interferon, alpha-inducible protein 27 | -0.0169637 |
| SH3BP5 | SH3-domain binding protein 5 (BTK-associated) | -0.0169282 |
| DYNLT1 | dynein, light chain, Tctex-type 1 | -0.0168229 |
| COL1A1 | collagen, type I, alpha 1 | -0.0167407 |
| RPLP2 | ribosomal protein, large, P2 | -0.0164652 |
| SCAF11 | SR-related CTD-associated factor 11 | -0.0164515 |
| P4HA2 | prolyl 4-hydroxylase, alpha polypeptide II | -0.0164483 |
| SCD | stearoyl-CoA desaturase (delta-9-desaturase) | -0.0164385 |
| CD81 | CD81 molecule | -0.0164121 |
| INSIG1 | insulin induced gene 1 | -0.0162818 |
| KPNB1 | karyopherin (importin) beta 1 | -0.0162493 |
| RAB1A | RAB1A, member RAS oncogene family | -0.0160259 |
| WARS1 | tryptophanyl-tRNA synthetase 1 | -0.0158945 |
| PABPC1 | poly(A) binding protein, cytoplasmic 1 | -0.0157596 |
| TTC3 | tetratricopeptide repeat domain 3 | -0.0157526 |
| UAP1 | UDP-N-acetylglucosamine pyrophosphorylase 1 | -0.015704 |
| TXNIP | thioredoxin interacting protein | -0.0154175 |
| TAPBP | TAP binding protein (tapasin) | -0.0153397 |
| ANXA2 | annexin A2 | -0.0153263 |
| RPS8 | ribosomal protein S8 | -0.0153095 |
