| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | Tolcapone perturbation in A-427 cell line (Tahoe Therapeutics) |
| Similar Terms | |
| Downloads & Tools |
200 genes differentially expressed following the Tolcapone_A-427 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| AREG | amphiregulin | 0.0945607 |
| CELF2 | CUGBP, Elav-like family member 2 | 0.0933653 |
| HSP90AB1 | heat shock protein 90kDa alpha (cytosolic), class B member 1 | 0.0933612 |
| SEMA3C | sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C | 0.0892933 |
| PDE4D | phosphodiesterase 4D, cAMP-specific | 0.0863209 |
| ZSWIM6 | zinc finger, SWIM-type containing 6 | 0.0787193 |
| RPL19 | ribosomal protein L19 | 0.0744153 |
| TENM3 | teneurin transmembrane protein 3 | 0.0720287 |
| HIVEP2 | human immunodeficiency virus type I enhancer binding protein 2 | 0.0666214 |
| PPP6R3 | protein phosphatase 6, regulatory subunit 3 | 0.0653594 |
| NFAT5 | nuclear factor of activated T-cells 5, tonicity-responsive | 0.0648999 |
| SLC38A2 | solute carrier family 38, member 2 | 0.0635753 |
| HDAC9 | histone deacetylase 9 | 0.0606874 |
| TEAD1 | TEA domain family member 1 (SV40 transcriptional enhancer factor) | 0.0606475 |
| PDGFC | platelet derived growth factor C | 0.0604663 |
| UAP1 | UDP-N-acetylglucosamine pyrophosphorylase 1 | 0.0595287 |
| PCBP2 | poly(rC) binding protein 2 | 0.0588078 |
| HERC4 | HECT and RLD domain containing E3 ubiquitin protein ligase 4 | 0.0570636 |
| HMGA2 | high mobility group AT-hook 2 | 0.056857 |
| GSK3B | glycogen synthase kinase 3 beta | 0.0530084 |
| MED13L | mediator complex subunit 13-like | 0.0522134 |
| INTS6 | integrator complex subunit 6 | 0.0496942 |
| HNRNPA2B1 | heterogeneous nuclear ribonucleoprotein A2/B1 | 0.0452699 |
| SPAG9 | sperm associated antigen 9 | 0.0444894 |
| ITGB1 | integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) | 0.0437617 |
| SLC2A3 | solute carrier family 2 (facilitated glucose transporter), member 3 | 0.0434271 |
| SEMA3A | sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3A | 0.0432617 |
| PHC3 | polyhomeotic homolog 3 (Drosophila) | 0.0427712 |
| ERBB4 | erb-b2 receptor tyrosine kinase 4 | 0.0424553 |
| TPI1 | triosephosphate isomerase 1 | 0.0411283 |
| SETD5 | SET domain containing 5 | 0.0407201 |
| HNRNPA1 | heterogeneous nuclear ribonucleoprotein A1 | 0.0403986 |
| DST | dystonin | 0.0401218 |
| ZFAND3 | zinc finger, AN1-type domain 3 | 0.0399673 |
| SNCA | synuclein, alpha (non A4 component of amyloid precursor) | 0.0391667 |
| USP34 | ubiquitin specific peptidase 34 | 0.0390515 |
| CCNL1 | cyclin L1 | 0.0390105 |
| ETNK1 | ethanolamine kinase 1 | 0.0386725 |
| EPHA6 | EPH receptor A6 | 0.0386047 |
| IMMP2L | IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) | 0.0367205 |
| MPG | N-methylpurine-DNA glycosylase | 0.0366961 |
| ADGRG6 | adhesion G protein-coupled receptor G6 | 0.0365287 |
| RERE | arginine-glutamic acid dipeptide (RE) repeats | 0.0363736 |
| RAPGEF6 | Rap guanine nucleotide exchange factor (GEF) 6 | 0.0363271 |
| USP9X | ubiquitin specific peptidase 9, X-linked | 0.0362704 |
| SFPQ | splicing factor proline/glutamine-rich | 0.0361288 |
| SERTAD2 | SERTA domain containing 2 | 0.0357083 |
| ERBIN | erbb2 interacting protein | 0.0357051 |
| CMIP | c-Maf inducing protein | 0.0353842 |
| MARCHF4 | membrane associated ring-CH-type finger 4 | 0.0353804 |
| RPL3 | ribosomal protein L3 | 0.0352213 |
| HUWE1 | HECT, UBA and WWE domain containing 1, E3 ubiquitin protein ligase | 0.0347669 |
| ANKS1B | ankyrin repeat and sterile alpha motif domain containing 1B | 0.0341662 |
| DENND5A | DENN/MADD domain containing 5A | 0.0341211 |
| EFNA5 | ephrin-A5 | 0.0337887 |
| VMP1 | vacuole membrane protein 1 | 0.0337579 |
| MSRB3 | methionine sulfoxide reductase B3 | 0.0336836 |
| MMP12 | matrix metallopeptidase 12 | 0.0327737 |
| ARID1B | AT rich interactive domain 1B (SWI1-like) | 0.0327607 |
| ANKRD17 | ankyrin repeat domain 17 | 0.0325884 |
| KDM5A | lysine (K)-specific demethylase 5A | 0.0319477 |
| CRIM1 | cysteine rich transmembrane BMP regulator 1 (chordin-like) | 0.0319097 |
| WNK1 | WNK lysine deficient protein kinase 1 | 0.0315973 |
| OXR1 | oxidation resistance 1 | 0.0313882 |
| NEK7 | NIMA-related kinase 7 | 0.0311628 |
| BIRC6 | baculoviral IAP repeat containing 6 | 0.0310086 |
| RPS12 | ribosomal protein S12 | 0.0305984 |
| EIF4G1 | eukaryotic translation initiation factor 4 gamma, 1 | 0.0301379 |
| LRBA | LPS-responsive vesicle trafficking, beach and anchor containing | 0.0298878 |
| ZBTB20 | zinc finger and BTB domain containing 20 | 0.0295822 |
| PUM1 | pumilio RNA-binding family member 1 | 0.02934 |
| MEMO1 | mediator of cell motility 1 | 0.0293179 |
| TPM3 | tropomyosin 3 | 0.0292926 |
| TRIO | trio Rho guanine nucleotide exchange factor | 0.0292784 |
| BIRC3 | baculoviral IAP repeat containing 3 | 0.029079 |
| EXOC6B | exocyst complex component 6B | 0.029064 |
| PUM2 | pumilio RNA-binding family member 2 | 0.0289825 |
| CARD16 | caspase recruitment domain family, member 16 | 0.0288821 |
| UBR4 | ubiquitin protein ligase E3 component n-recognin 4 | 0.0287719 |
| MYPN | myopalladin | 0.0285559 |
| RCOR1 | REST corepressor 1 | 0.0283824 |
| TBL1XR1 | transducin (beta)-like 1 X-linked receptor 1 | 0.0283361 |
| VPS8 | vacuolar protein sorting 8 homolog (S. cerevisiae) | 0.0282583 |
| CSNK1A1 | casein kinase 1, alpha 1 | 0.0281746 |
| TMCC1 | transmembrane and coiled-coil domain family 1 | 0.0279973 |
| MBNL1 | muscleblind-like splicing regulator 1 | 0.0278383 |
| YAP1 | Yes-associated protein 1 | 0.0277355 |
| RAP1B | RAP1B, member of RAS oncogene family | 0.0274982 |
| TNRC6C | trinucleotide repeat containing 6C | 0.0274058 |
| AXIN2 | axin 2 | 0.0273319 |
| KDM6A | lysine (K)-specific demethylase 6A | 0.0271003 |
| PICALM | phosphatidylinositol binding clathrin assembly protein | 0.0269732 |
| RALGAPB | Ral GTPase activating protein, beta subunit (non-catalytic) | 0.0267789 |
| TSC22D2 | TSC22 domain family, member 2 | 0.0267192 |
| PSME4 | proteasome (prosome, macropain) activator subunit 4 | 0.026597 |
| DSCAM | Down syndrome cell adhesion molecule | 0.0264842 |
| MYH9 | myosin, heavy chain 9, non-muscle | 0.0262035 |
| AEBP2 | AE binding protein 2 | 0.0257842 |
| NFIB | nuclear factor I/B | 0.025776 |
| EGLN1 | egl-9 family hypoxia-inducible factor 1 | 0.0256567 |
| Symbol | Name | Standardized Value |
|---|---|---|
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | -0.272401 |
| HSP90B1 | heat shock protein 90kDa beta (Grp94), member 1 | -0.131177 |
| ACTG1 | actin gamma 1 | -0.115915 |
| VIM | vimentin | -0.109194 |
| KPNB1 | karyopherin (importin) beta 1 | -0.0872733 |
| CUBN | cubilin (intrinsic factor-cobalamin receptor) | -0.0775075 |
| ALDH1A1 | aldehyde dehydrogenase 1 family, member A1 | -0.0651691 |
| MKI67 | marker of proliferation Ki-67 | -0.0633552 |
| IFIH1 | interferon induced with helicase C domain 1 | -0.0621683 |
| TPT1 | tumor protein, translationally-controlled 1 | -0.0609748 |
| PTMA | prothymosin, alpha | -0.0576892 |
| HSPA5 | heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) | -0.0566206 |
| RPL35A | ribosomal protein L35a | -0.0535971 |
| SERPINB2 | serpin peptidase inhibitor, clade B (ovalbumin), member 2 | -0.0443541 |
| CCND1 | cyclin D1 | -0.0442606 |
| TMEM123 | transmembrane protein 123 | -0.0440373 |
| SLC38A1 | solute carrier family 38, member 1 | -0.043797 |
| RPS6 | ribosomal protein S6 | -0.0432941 |
| S100A10 | S100 calcium binding protein A10 | -0.0423928 |
| VDAC1 | voltage-dependent anion channel 1 | -0.0409928 |
| HSPD1 | heat shock 60kDa protein 1 (chaperonin) | -0.0406111 |
| TPM4 | tropomyosin 4 | -0.0390203 |
| HSP90AA1 | heat shock protein 90kDa alpha (cytosolic), class A member 1 | -0.038425 |
| RPL38 | ribosomal protein L38 | -0.0383089 |
| CANX | calnexin | -0.0373365 |
| AHNAK | AHNAK nucleoprotein | -0.0367713 |
| RSL1D1 | ribosomal L1 domain containing 1 | -0.0349044 |
| NHSL1 | NHS-like 1 | -0.0341225 |
| PDIA3 | protein disulfide isomerase family A, member 3 | -0.0341172 |
| TMEM41B | transmembrane protein 41B | -0.0338178 |
| MYL12A | myosin, light chain 12A, regulatory, non-sarcomeric | -0.0337189 |
| CAVIN1 | caveolae associated protein 1 | -0.0331307 |
| PITPNC1 | phosphatidylinositol transfer protein, cytoplasmic 1 | -0.0330681 |
| S100A6 | S100 calcium binding protein A6 | -0.0320437 |
| LRRTM4 | leucine rich repeat transmembrane neuronal 4 | -0.032031 |
| ASPH | aspartate beta-hydroxylase | -0.0320251 |
| TM4SF1 | transmembrane 4 L six family member 1 | -0.0314645 |
| ANXA1 | annexin A1 | -0.031398 |
| WDR45B | WD repeat domain 45B | -0.0306874 |
| RPL34 | ribosomal protein L34 | -0.0305089 |
| BRI3BP | BRI3 binding protein | -0.0302278 |
| TUBB | tubulin, beta class I | -0.0300759 |
| HSPB1 | heat shock 27kDa protein 1 | -0.0298809 |
| DEK | DEK proto-oncogene | -0.0296503 |
| AKAP12 | A kinase (PRKA) anchor protein 12 | -0.0294661 |
| RPS27A | ribosomal protein S27a | -0.0291848 |
| GNAS | GNAS complex locus | -0.0286796 |
| ACTR2 | ARP2 actin-related protein 2 homolog (yeast) | -0.0277724 |
| HMGB1 | high mobility group box 1 | -0.0272616 |
| ERO1A | endoplasmic reticulum oxidoreductase 1 alpha | -0.0271928 |
| GCG | glucagon | -0.026996 |
| FAM110C | family with sequence similarity 110, member C | -0.0265102 |
| UBTF | upstream binding transcription factor, RNA polymerase I | -0.026366 |
| CALM2 | calmodulin 2 (phosphorylase kinase, delta) | -0.0262881 |
| SCD | stearoyl-CoA desaturase (delta-9-desaturase) | -0.0261204 |
| RPS13 | ribosomal protein S13 | -0.025672 |
| SMURF2 | SMAD specific E3 ubiquitin protein ligase 2 | -0.0253237 |
| MYL12B | myosin, light chain 12B, regulatory | -0.0250925 |
| RAB1A | RAB1A, member RAS oncogene family | -0.0250842 |
| MTAP | methylthioadenosine phosphorylase | -0.0244487 |
| TANC2 | tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 2 | -0.0243627 |
| TRMT112 | tRNA methyltransferase 11-2 homolog (S. cerevisiae) | -0.0243338 |
| ARL6IP1 | ADP-ribosylation factor-like 6 interacting protein 1 | -0.0241514 |
| ZFR | zinc finger RNA binding protein | -0.0239353 |
| RPS15 | ribosomal protein S15 | -0.0233632 |
| FUS | FUS RNA binding protein | -0.0233248 |
| GFPT1 | glutamine--fructose-6-phosphate transaminase 1 | -0.0231295 |
| KRR1 | KRR1, small subunit (SSU) processome component, homolog (yeast) | -0.0227201 |
| PA2G4 | proliferation-associated 2G4, 38kDa | -0.0226655 |
| EPCAM | epithelial cell adhesion molecule | -0.022658 |
| CENPF | centromere protein F, 350/400kDa | -0.0226308 |
| WSB1 | WD repeat and SOCS box containing 1 | -0.0224546 |
| KIF18B | kinesin family member 18B | -0.0224182 |
| ROCK2 | Rho-associated, coiled-coil containing protein kinase 2 | -0.0222841 |
| TOP2A | topoisomerase (DNA) II alpha 170kDa | -0.0215351 |
| SRGAP1 | SLIT-ROBO Rho GTPase activating protein 1 | -0.0214401 |
| MATR3 | matrin 3 | -0.0213291 |
| CHCHD2 | coiled-coil-helix-coiled-coil-helix domain containing 2 | -0.0207923 |
| YWHAB | tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta | -0.0205069 |
| H1-0 | H1.0 linker histone | -0.0204585 |
| PRR11 | proline rich 11 | -0.0198862 |
| PRDX1 | peroxiredoxin 1 | -0.0197894 |
| SRP72 | signal recognition particle 72kDa | -0.0197725 |
| ITGA2 | integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) | -0.0196528 |
| RPL37 | ribosomal protein L37 | -0.0193885 |
| ARPC5 | actin related protein 2/3 complex, subunit 5, 16kDa | -0.0187607 |
| RACK1 | receptor for activated C kinase 1 | -0.0187429 |
| NAV3 | neuron navigator 3 | -0.018648 |
| RPS29 | ribosomal protein S29 | -0.0183368 |
| NAP1L1 | nucleosome assembly protein 1-like 1 | -0.0181607 |
| UBB | ubiquitin B | -0.0180764 |
| SMC4 | structural maintenance of chromosomes 4 | -0.0179952 |
| LMAN1 | lectin, mannose-binding, 1 | -0.0179839 |
| RPLP0 | ribosomal protein, large, P0 | -0.0178895 |
| RPL6 | ribosomal protein L6 | -0.0176934 |
| RPS21 | ribosomal protein S21 | -0.017542 |
| RPS24 | ribosomal protein S24 | -0.0174898 |
| ARPC2 | actin related protein 2/3 complex, subunit 2, 34kDa | -0.0174507 |
| PPM1G | protein phosphatase, Mg2+/Mn2+ dependent, 1G | -0.0171332 |
| CAP1 | CAP, adenylate cyclase-associated protein 1 (yeast) | -0.0171164 |
