Tolcapone_CHP-212 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Tolcapone perturbation in CHP-212 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Tolcapone_CHP-212 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
VCL vinculin 0.160825
FMN1 formin 1 0.121794
ZSWIM6 zinc finger, SWIM-type containing 6 0.080886
NALF1 NALCN channel auxiliary factor 1 0.0705537
VMP1 vacuole membrane protein 1 0.0645935
THSD4 thrombospondin, type I, domain containing 4 0.0586826
TLE4 transducin-like enhancer of split 4 0.0512883
DST dystonin 0.05085
INTS6 integrator complex subunit 6 0.0443568
PDLIM5 PDZ and LIM domain 5 0.0426455
MACF1 microtubule-actin crosslinking factor 1 0.0422269
GBE1 glucan (1,4-alpha-), branching enzyme 1 0.0407225
EXT1 exostosin glycosyltransferase 1 0.0396912
PPFIBP1 PTPRF interacting protein, binding protein 1 (liprin beta 1) 0.0393296
LPP LIM domain containing preferred translocation partner in lipoma 0.0377031
UBR5 ubiquitin protein ligase E3 component n-recognin 5 0.037228
TIMP3 TIMP metallopeptidase inhibitor 3 0.0369685
SEPTIN9 septin 9 0.0368997
NPAS2 neuronal PAS domain protein 2 0.0365882
STK38L serine/threonine kinase 38 like 0.0364366
CDH10 cadherin 10, type 2 (T2-cadherin) 0.0358643
RAD51B RAD51 paralog B 0.0356034
ATXN1 ataxin 1 0.0347369
MYCN v-myc avian myelocytomatosis viral oncogene neuroblastoma derived homolog 0.0338637
MYH9 myosin, heavy chain 9, non-muscle 0.0332704
TPM1 tropomyosin 1 (alpha) 0.0329687
TIMP2 TIMP metallopeptidase inhibitor 2 0.0319782
NFAT5 nuclear factor of activated T-cells 5, tonicity-responsive 0.031906
FAM107B family with sequence similarity 107, member B 0.031823
SLIT2 slit homolog 2 (Drosophila) 0.0308431
FERMT2 fermitin family member 2 0.0306479
DNMBP dynamin binding protein 0.0306249
PRKCA protein kinase C, alpha 0.0305339
TCF12 transcription factor 12 0.0304591
MCL1 myeloid cell leukemia 1 0.0287059
HIVEP2 human immunodeficiency virus type I enhancer binding protein 2 0.0284449
HOMER1 homer scaffolding protein 1 0.0282576
MYO1E myosin IE 0.0282296
LSAMP limbic system-associated membrane protein 0.0280496
ZNF148 zinc finger protein 148 0.0278897
VEGFA vascular endothelial growth factor A 0.0274155
MSI2 musashi RNA-binding protein 2 0.0273804
KDM4C lysine (K)-specific demethylase 4C 0.0271063
SETBP1 SET binding protein 1 0.0268171
EXOC4 exocyst complex component 4 0.0268141
DGKH diacylglycerol kinase, eta 0.0267908
DPH6 diphthamine biosynthesis 6 0.0266658
FAM13A family with sequence similarity 13, member A 0.0266401
AGAP1 ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 0.0263333
ZNF638 zinc finger protein 638 0.0262307
PCBP2 poly(rC) binding protein 2 0.0251846
TEAD1 TEA domain family member 1 (SV40 transcriptional enhancer factor) 0.0250638
FNDC3A fibronectin type III domain containing 3A 0.0250214
ANTXR1 anthrax toxin receptor 1 0.0249514
SLITRK6 SLIT and NTRK-like family, member 6 0.0248829
ABL2 ABL proto-oncogene 2, non-receptor tyrosine kinase 0.0246409
EGFR epidermal growth factor receptor 0.0244412
ADAMTS1 ADAM metallopeptidase with thrombospondin type 1 motif, 1 0.0241809
AHR aryl hydrocarbon receptor 0.0239033
ZMIZ1 zinc finger, MIZ-type containing 1 0.0234511
NR4A3 nuclear receptor subfamily 4, group A, member 3 0.0228791
CREBBP CREB binding protein 0.0225564
MMAB methylmalonic aciduria (cobalamin deficiency) cblB type 0.0223901
CTNND1 catenin (cadherin-associated protein), delta 1 0.0219949
LIMA1 LIM domain and actin binding 1 0.0218481
PITPNC1 phosphatidylinositol transfer protein, cytoplasmic 1 0.021522
ACTN1 actinin, alpha 1 0.0213094
PSD3 pleckstrin and Sec7 domain containing 3 0.0212688
PTPRE protein tyrosine phosphatase, receptor type, E 0.0212595
SCFD1 sec1 family domain containing 1 0.0209742
CDH13 cadherin 13 0.0204473
RNF150 ring finger protein 150 0.0200525
LUC7L3 LUC7-like 3 (S. cerevisiae) 0.0198669
HNRNPC heterogeneous nuclear ribonucleoprotein C (C1/C2) 0.0194449
ZCCHC7 zinc finger, CCHC domain containing 7 0.019191
RABGEF1 RAB guanine nucleotide exchange factor (GEF) 1 0.019149
IMMP2L IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) 0.019129
WDR1 WD repeat domain 1 0.0189007
NCOR2 nuclear receptor corepressor 2 0.0188262
AP1G1 adaptor-related protein complex 1, gamma 1 subunit 0.0187988
PALLD palladin, cytoskeletal associated protein 0.018797
MAML2 mastermind-like 2 (Drosophila) 0.0187095
IGF2BP3 insulin-like growth factor 2 mRNA binding protein 3 0.0185794
BICD1 bicaudal D homolog 1 (Drosophila) 0.0185192
TENM4 teneurin transmembrane protein 4 0.0183831
PHLDA1 pleckstrin homology-like domain, family A, member 1 0.0183608
AMOTL1 angiomotin like 1 0.0183155
DIP2C DIP2 disco-interacting protein 2 homolog C (Drosophila) 0.0182925
KCNMA1 potassium channel, calcium activated large conductance subfamily M alpha, member 1 0.0181996
B3GALT1 UDP-Gal:betaGlcNAc beta 1,3-galactosyltransferase, polypeptide 1 0.0181802
GLCCI1 glucocorticoid induced 1 0.0181096
MYCBP2 MYC binding protein 2, E3 ubiquitin protein ligase 0.0178253
MED13 mediator complex subunit 13 0.0177395
CHD9 chromodomain helicase DNA binding protein 9 0.0176458
ITGA2 integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) 0.0175575
PLCB1 phospholipase C, beta 1 (phosphoinositide-specific) 0.0174942
JMJD1C jumonji domain containing 1C 0.0174867
RPTOR regulatory associated protein of MTOR, complex 1 0.0174462
BBX bobby sox homolog (Drosophila) 0.0173961
PDE4D phosphodiesterase 4D, cAMP-specific 0.0173426

decreased expression

Symbol Name Standardized Value
DDX1 DEAD (Asp-Glu-Ala-Asp) box helicase 1 -0.246724
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.165269
IGF2 insulin-like growth factor 2 -0.158149
PTMA prothymosin, alpha -0.128636
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.10559
VIM vimentin -0.104376
RPS6 ribosomal protein S6 -0.0784403
RPL23 ribosomal protein L23 -0.0735961
RPL19 ribosomal protein L19 -0.0671688
RPL35A ribosomal protein L35a -0.0557694
B2M beta-2-microglobulin -0.0528035
COL1A1 collagen, type I, alpha 1 -0.0514028
RPLP1 ribosomal protein, large, P1 -0.0513673
TMSB10 thymosin beta 10 -0.0502635
EIF1 eukaryotic translation initiation factor 1 -0.049292
COL3A1 collagen, type III, alpha 1 -0.0484311
RBMS3 RNA binding motif, single stranded interacting protein 3 -0.0463964
RPS24 ribosomal protein S24 -0.0453413
TPT1 tumor protein, translationally-controlled 1 -0.0453102
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.0439436
MAP1B microtubule-associated protein 1B -0.0411312
NCAM2 neural cell adhesion molecule 2 -0.040926
KPNB1 karyopherin (importin) beta 1 -0.038347
NPEPPS aminopeptidase puromycin sensitive -0.0369894
RPL34 ribosomal protein L34 -0.0368856
NAMPT nicotinamide phosphoribosyltransferase -0.0364112
GULP1 GULP, engulfment adaptor PTB domain containing 1 -0.0357163
H3-3B H3.3 histone B -0.0354893
GARS1 glycyl-tRNA synthetase 1 -0.0346468
IER3 immediate early response 3 -0.0330245
RPL32 ribosomal protein L32 -0.0327568
RPL12 ribosomal protein L12 -0.0319669
RSL1D1 ribosomal L1 domain containing 1 -0.0319461
RPLP0 ribosomal protein, large, P0 -0.0316496
NUCKS1 nuclear casein kinase and cyclin-dependent kinase substrate 1 -0.0311903
RPL36 ribosomal protein L36 -0.0309894
RPS19 ribosomal protein S19 -0.0305468
AKT3 v-akt murine thymoma viral oncogene homolog 3 -0.0301313
ACTG1 actin gamma 1 -0.0299137
RPL37 ribosomal protein L37 -0.0296854
RPL38 ribosomal protein L38 -0.0296252
S100A6 S100 calcium binding protein A6 -0.0296147
CANX calnexin -0.0296057
HNRNPU heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) -0.0289321
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 -0.0287855
FTL ferritin, light polypeptide -0.0282538
ANXA2 annexin A2 -0.0281643
CCND1 cyclin D1 -0.0276409
RPS27A ribosomal protein S27a -0.0271109
TAF1D TATA box binding protein (TBP)-associated factor, RNA polymerase I, D, 41kDa -0.0267815
HMGB2 high mobility group box 2 -0.0263201
RHOBTB3 Rho-related BTB domain containing 3 -0.0263121
RPS21 ribosomal protein S21 -0.0254531
SCN9A sodium channel, voltage gated, type IX alpha subunit -0.0254079
NME2 NME/NM23 nucleoside diphosphate kinase 2 -0.0253874
CSDE1 cold shock domain containing E1, RNA-binding -0.0253792
TOP2A topoisomerase (DNA) II alpha 170kDa -0.0253599
RPS3 ribosomal protein S3 -0.0251868
RPS5 ribosomal protein S5 -0.0247689
TNRC6B trinucleotide repeat containing 6B -0.0246316
WDR45B WD repeat domain 45B -0.0246233
CRH corticotropin releasing hormone -0.0244885
RAD21 RAD21 homolog (S. pombe) -0.0240066
ENO1 enolase 1, (alpha) -0.0239808
SMARCE1 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily e, member 1 -0.0238887
RPS23 ribosomal protein S23 -0.0237905
S100A9 S100 calcium binding protein A9 -0.0235108
RPL11 ribosomal protein L11 -0.0233246
HAND2 heart and neural crest derivatives expressed 2 -0.0231339
AHNAK AHNAK nucleoprotein -0.0228346
H1-0 H1.0 linker histone -0.0222093
RACK1 receptor for activated C kinase 1 -0.022204
NEK7 NIMA-related kinase 7 -0.0221725
SMG7 SMG7 nonsense mediated mRNA decay factor -0.0217827
RPL35 ribosomal protein L35 -0.0217761
RPS27 ribosomal protein S27 -0.021764
MAP3K2 mitogen-activated protein kinase kinase kinase 2 -0.0216413
RPS29 ribosomal protein S29 -0.021539
TOMM20 translocase of outer mitochondrial membrane 20 homolog (yeast) -0.0214982
MBD5 methyl-CpG binding domain protein 5 -0.0213992
TENT5A terminal nucleotidyltransferase 5A -0.021324
SMARCC1 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily c, member 1 -0.0212059
NOP58 NOP58 ribonucleoprotein -0.021105
DLC1 DLC1 Rho GTPase activating protein -0.0209549
KDM3A lysine (K)-specific demethylase 3A -0.0205493
CD36 CD36 molecule (thrombospondin receptor) -0.020483
P4HA2 prolyl 4-hydroxylase, alpha polypeptide II -0.0204055
RPL31 ribosomal protein L31 -0.0203827
MAP4 microtubule-associated protein 4 -0.0202014
EIF3A eukaryotic translation initiation factor 3, subunit A -0.0198361
TBX2 T-box 2 -0.0198142
RPL26 ribosomal protein L26 -0.0197753
RPS15 ribosomal protein S15 -0.0197701
SCG2 secretogranin II -0.019695
YME1L1 YME1-like 1 ATPase -0.019677
PTK2 protein tyrosine kinase 2 -0.0195567
OGA O-GlcNAcase -0.0195244
GPC5 glypican 5 -0.0195237
IGFBP4 insulin-like growth factor binding protein 4 -0.0194888
RPS4X ribosomal protein S4, X-linked -0.0194644