Tolcapone_COLO 205 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Tolcapone perturbation in COLO 205 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Tolcapone_COLO 205 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
LMO7 LIM domain 7 0.175883
MACC1 metastasis associated in colon cancer 1 0.0943146
SYNE2 spectrin repeat containing, nuclear envelope 2 0.0894476
SPTBN1 spectrin, beta, non-erythrocytic 1 0.0664654
FOS FBJ murine osteosarcoma viral oncogene homolog 0.0645378
SPATA13 spermatogenesis associated 13 0.0507443
EXT1 exostosin glycosyltransferase 1 0.0496024
TMC5 transmembrane channel-like 5 0.0493014
DSCAM Down syndrome cell adhesion molecule 0.0491255
AKAP13 A kinase (PRKA) anchor protein 13 0.0461495
TRIO trio Rho guanine nucleotide exchange factor 0.0455188
EPS8 epidermal growth factor receptor pathway substrate 8 0.0428678
ARHGEF38 Rho guanine nucleotide exchange factor (GEF) 38 0.0420804
EZR ezrin 0.0404064
SMAD3 SMAD family member 3 0.0400459
ZBTB20 zinc finger and BTB domain containing 20 0.0393574
FNDC3B fibronectin type III domain containing 3B 0.0389341
ERBIN erbb2 interacting protein 0.0389217
CYP3A5 cytochrome P450, family 3, subfamily A, polypeptide 5 0.0381592
IGFBP3 insulin-like growth factor binding protein 3 0.0380456
MYH9 myosin, heavy chain 9, non-muscle 0.0380119
PHF3 PHD finger protein 3 0.0379873
KIF16B kinesin family member 16B 0.0375043
EPSTI1 epithelial stromal interaction 1 (breast) 0.0373214
PLSCR1 phospholipid scramblase 1 0.0368241
ARIH1 ariadne RBR E3 ubiquitin protein ligase 1 0.0362511
RAD51B RAD51 paralog B 0.0362096
PPP1R15A protein phosphatase 1, regulatory subunit 15A 0.0361835
TRIM2 tripartite motif containing 2 0.0348697
MSI2 musashi RNA-binding protein 2 0.0348579
ZNF292 zinc finger protein 292 0.0342873
MYO1E myosin IE 0.0339298
MBNL2 muscleblind-like splicing regulator 2 0.0338342
STS steroid sulfatase (microsomal), isozyme S 0.0314387
SPAG9 sperm associated antigen 9 0.031285
DNAJC15 DnaJ (Hsp40) homolog, subfamily C, member 15 0.030543
BAIAP2L1 BAI1-associated protein 2-like 1 0.0304352
ATP11A ATPase, class VI, type 11A 0.030296
GMDS GDP-mannose 4,6-dehydratase 0.0300692
HIVEP2 human immunodeficiency virus type I enhancer binding protein 2 0.0295003
OCLN occludin 0.0294697
DUSP10 dual specificity phosphatase 10 0.0289942
GRK3 G protein-coupled receptor kinase 3 0.0280697
STAT1 signal transducer and activator of transcription 1, 91kDa 0.0274326
ETV6 ets variant 6 0.027351
AFF1 AF4/FMR2 family, member 1 0.0272538
EGLN3 egl-9 family hypoxia-inducible factor 3 0.0266557
IGF1R insulin-like growth factor 1 receptor 0.0263195
MX1 MX dynamin-like GTPase 1 0.0262941
MGAT5 mannosyl (alpha-1,6-)-glycoprotein beta-1,6-N-acetyl-glucosaminyltransferase 0.0258561
JUN jun proto-oncogene 0.0249475
MCU mitochondrial calcium uniporter 0.0249388
PADI1 peptidyl arginine deiminase, type I 0.024586
MAML2 mastermind-like 2 (Drosophila) 0.0245428
FNIP1 folliculin interacting protein 1 0.0241529
FZR1 fizzy/cell division cycle 20 related 1 (Drosophila) 0.0241019
HNRNPU heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) 0.0240874
CDHR2 cadherin-related family member 2 0.0240826
RBM47 RNA binding motif protein 47 0.0239631
ITGA6 integrin, alpha 6 0.0238573
USP54 ubiquitin specific peptidase 54 0.0238483
SAMD4A sterile alpha motif domain containing 4A 0.0236484
TOX3 TOX high mobility group box family member 3 0.0229815
VMP1 vacuole membrane protein 1 0.0227321
ARHGAP26 Rho GTPase activating protein 26 0.0223265
ATXN1 ataxin 1 0.0219847
ZHX2 zinc fingers and homeoboxes 2 0.0218053
SLC22A23 solute carrier family 22, member 23 0.0215519
GOLGB1 golgin B1 0.0212944
FNIP2 folliculin interacting protein 2 0.0212447
PRKCA protein kinase C, alpha 0.0211263
GK glycerol kinase 0.0210548
CRIM1 cysteine rich transmembrane BMP regulator 1 (chordin-like) 0.0210447
FAT1 FAT atypical cadherin 1 0.0209686
LRBA LPS-responsive vesicle trafficking, beach and anchor containing 0.0209309
ZSWIM6 zinc finger, SWIM-type containing 6 0.0209008
DHFR dihydrofolate reductase 0.0207357
DSPP dentin sialophosphoprotein 0.0206129
RHPN2 rhophilin, Rho GTPase binding protein 2 0.0205038
HUWE1 HECT, UBA and WWE domain containing 1, E3 ubiquitin protein ligase 0.0201382
FOSB FBJ murine osteosarcoma viral oncogene homolog B 0.0201365
SLK STE20-like kinase 0.0201073
TUT7 terminal uridylyl transferase 7 0.0199791
ADIPOR2 adiponectin receptor 2 0.019688
PDLIM5 PDZ and LIM domain 5 0.0194775
BCLAF1 BCL2-associated transcription factor 1 0.019477
SCARB1 scavenger receptor class B, member 1 0.019362
HNRNPC heterogeneous nuclear ribonucleoprotein C (C1/C2) 0.0192773
RAB7A RAB7A, member RAS oncogene family 0.0190545
EHBP1 EH domain binding protein 1 0.0189962
SLC2A1 solute carrier family 2 (facilitated glucose transporter), member 1 0.0189085
CSTPP1 centriolar satellite-associated tubulin polyglutamylase complex regulator 1 0.0188648
ELOF1 elongation factor 1 homolog (S. cerevisiae) 0.0188306
ATP2B4 ATPase, Ca++ transporting, plasma membrane 4 0.0186243
MYO5B myosin VB 0.0184945
MLPH melanophilin 0.0184451
GAREM1 GRB2 associated regulator of MAPK1 subtype 1 0.0180566
FNBP4 formin binding protein 4 0.0180162
IGF2BP2 insulin-like growth factor 2 mRNA binding protein 2 0.0178051
EPHB2 EPH receptor B2 0.0177811

decreased expression

Symbol Name Standardized Value
B2M beta-2-microglobulin -0.239488
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.22961
TPT1 tumor protein, translationally-controlled 1 -0.199608
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.151428
HLA-B major histocompatibility complex, class I, B -0.116581
PTMA prothymosin, alpha -0.101543
LCN2 lipocalin 2 -0.0958944
IFI6 interferon, alpha-inducible protein 6 -0.0946626
RPS6 ribosomal protein S6 -0.0912042
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.0862665
RPL35A ribosomal protein L35a -0.0852823
FTL ferritin, light polypeptide -0.0816114
RPL23 ribosomal protein L23 -0.0750239
TMSB10 thymosin beta 10 -0.0718331
RPLP1 ribosomal protein, large, P1 -0.0702996
MT2A metallothionein 2A -0.0661814
C6ORF132 chromosome 6 open reading frame 132 -0.0655454
PABPC1 poly(A) binding protein, cytoplasmic 1 -0.0644371
RPL34 ribosomal protein L34 -0.0623168
IFI27 interferon, alpha-inducible protein 27 -0.0611866
ACTG1 actin gamma 1 -0.0584091
EIF1 eukaryotic translation initiation factor 1 -0.0530724
RPS19 ribosomal protein S19 -0.0530187
RPS8 ribosomal protein S8 -0.0490463
RPL12 ribosomal protein L12 -0.0480996
PDIA3 protein disulfide isomerase family A, member 3 -0.0480767
RPL31 ribosomal protein L31 -0.0475378
HLA-C major histocompatibility complex, class I, C -0.0462838
TXNIP thioredoxin interacting protein -0.0457765
PKM pyruvate kinase, muscle -0.0454799
S100A10 S100 calcium binding protein A10 -0.0447437
PERP PERP, TP53 apoptosis effector -0.0435379
RUNX1 runt-related transcription factor 1 -0.0431329
RPS24 ribosomal protein S24 -0.0427971
RPLP2 ribosomal protein, large, P2 -0.0411932
POTEF POTE ankyrin domain family, member F -0.0404132
RHOBTB3 Rho-related BTB domain containing 3 -0.0401077
CST3 cystatin C -0.0385584
ELF3 E74-like factor 3 (ets domain transcription factor, epithelial-specific ) -0.0380118
SLC38A1 solute carrier family 38, member 1 -0.03795
RPL37A ribosomal protein L37a -0.0376688
RPLP0 ribosomal protein, large, P0 -0.0371718
RPL11 ribosomal protein L11 -0.0364797
GPRC5A G protein-coupled receptor, class C, group 5, member A -0.0360444
RPL28 ribosomal protein L28 -0.0352123
GNAS GNAS complex locus -0.0348328
GFPT1 glutamine--fructose-6-phosphate transaminase 1 -0.0348311
YWHAB tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta -0.0348256
RNF43 ring finger protein 43 -0.0343133
WSB1 WD repeat and SOCS box containing 1 -0.0339951
LOC112694756 uncharaterized LOC112694756 -0.0339747
ERO1A endoplasmic reticulum oxidoreductase 1 alpha -0.0337561
RPS3 ribosomal protein S3 -0.033275
HMGB1 high mobility group box 1 -0.0331061
TOP2A topoisomerase (DNA) II alpha 170kDa -0.032957
S100A9 S100 calcium binding protein A9 -0.0328588
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 -0.0325021
LDHA lactate dehydrogenase A -0.0321235
RPS21 ribosomal protein S21 -0.0319603
S100A6 S100 calcium binding protein A6 -0.031832
RPS27 ribosomal protein S27 -0.0316511
RPS13 ribosomal protein S13 -0.0315735
RPS23 ribosomal protein S23 -0.0315665
RPL19 ribosomal protein L19 -0.0315639
RACK1 receptor for activated C kinase 1 -0.0312357
H3-3B H3.3 histone B -0.0308137
RPL26 ribosomal protein L26 -0.030725
RPS14 ribosomal protein S14 -0.0305477
DSTN destrin (actin depolymerizing factor) -0.0303694
WDR45B WD repeat domain 45B -0.0298913
KPNB1 karyopherin (importin) beta 1 -0.0295178
RPS25 ribosomal protein S25 -0.029397
RPL36 ribosomal protein L36 -0.0292682
NRIP1 nuclear receptor interacting protein 1 -0.0290775
UQCRB ubiquinol-cytochrome c reductase binding protein -0.0287092
RPL32 ribosomal protein L32 -0.0285401
RPL38 ribosomal protein L38 -0.0283736
RPL7A ribosomal protein L7a -0.0282493
RPS29 ribosomal protein S29 -0.0281537
VIM vimentin -0.0281338
RPL37 ribosomal protein L37 -0.0279615
DIAPH3 diaphanous-related formin 3 -0.0277949
XAF1 XIAP associated factor 1 -0.0276146
RPL30 ribosomal protein L30 -0.0275075
MKI67 marker of proliferation Ki-67 -0.0272543
IFITM3 interferon induced transmembrane protein 3 -0.0271569
NDRG1 N-myc downstream regulated 1 -0.0267125
RPL9 ribosomal protein L9 -0.0262592
PRRC2C proline-rich coiled-coil 2C -0.0262359
IER3 immediate early response 3 -0.0257873
BPTF bromodomain PHD finger transcription factor -0.025769
CSTB cystatin B (stefin B) -0.0255159
ENO1 enolase 1, (alpha) -0.0251154
RPL27A ribosomal protein L27a -0.0249149
LY6E lymphocyte antigen 6 complex, locus E -0.0248022
RPS11 ribosomal protein S11 -0.0244311
NUCKS1 nuclear casein kinase and cyclin-dependent kinase substrate 1 -0.0243622
CALR calreticulin -0.0243112
RPS4X ribosomal protein S4, X-linked -0.0242615
RPL36A ribosomal protein L36a -0.0241634