Tolcapone_HS-578T Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Tolcapone perturbation in HS-578T cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Tolcapone_HS-578T drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
COL6A3 collagen, type VI, alpha 3 0.237477
VEGFA vascular endothelial growth factor A 0.0956845
MYH9 myosin, heavy chain 9, non-muscle 0.0908918
TRIO trio Rho guanine nucleotide exchange factor 0.0845523
SPOCK1 sparc/osteonectin, cwcv and kazal-like domains proteoglycan (testican) 1 0.0792234
DST dystonin 0.0687108
NDRG1 N-myc downstream regulated 1 0.0579116
ADAMTS6 ADAM metallopeptidase with thrombospondin type 1 motif, 6 0.0571581
PABPC1 poly(A) binding protein, cytoplasmic 1 0.0559935
KCNMA1 potassium channel, calcium activated large conductance subfamily M alpha, member 1 0.0538053
DOCK5 dedicator of cytokinesis 5 0.0532511
UBR5 ubiquitin protein ligase E3 component n-recognin 5 0.0523482
TIMP3 TIMP metallopeptidase inhibitor 3 0.0509037
NAV2 neuron navigator 2 0.0501281
GBE1 glucan (1,4-alpha-), branching enzyme 1 0.0476834
CALD1 caldesmon 1 0.0441974
FN1 fibronectin 1 0.0417993
HDAC9 histone deacetylase 9 0.0413243
HIPK2 homeodomain interacting protein kinase 2 0.0403286
MBNL1 muscleblind-like splicing regulator 1 0.039178
HMGA2 high mobility group AT-hook 2 0.0355656
SPAG9 sperm associated antigen 9 0.0345306
ASAP1 ArfGAP with SH3 domain, ankyrin repeat and PH domain 1 0.0344723
CDH13 cadherin 13 0.0344208
MAP1B microtubule-associated protein 1B 0.0341847
LAMC1 laminin, gamma 1 (formerly LAMB2) 0.0340283
IGF2BP2 insulin-like growth factor 2 mRNA binding protein 2 0.0333788
PPP1R15A protein phosphatase 1, regulatory subunit 15A 0.0330822
STC2 stanniocalcin 2 0.0329854
MACF1 microtubule-actin crosslinking factor 1 0.0328892
VEGFC vascular endothelial growth factor C 0.0327751
CD109 CD109 molecule 0.0321102
VCAN versican 0.0315815
EGFR epidermal growth factor receptor 0.0315603
EIF4G1 eukaryotic translation initiation factor 4 gamma, 1 0.0312914
SETD5 SET domain containing 5 0.0309136
FLNA filamin A, alpha 0.0300896
RBMS3 RNA binding motif, single stranded interacting protein 3 0.0299328
QKI QKI, KH domain containing, RNA binding 0.0295836
BIRC6 baculoviral IAP repeat containing 6 0.0295738
PLEC plectin 0.02867
FAM13A family with sequence similarity 13, member A 0.0283696
FMNL2 formin-like 2 0.0280323
NKAIN3 Na+/K+ transporting ATPase interacting 3 0.0278936
LOXL2 lysyl oxidase-like 2 0.0276352
CENPF centromere protein F, 350/400kDa 0.0273966
MAP4K4 mitogen-activated protein kinase kinase kinase kinase 4 0.0270549
AXL AXL receptor tyrosine kinase 0.0265394
IGFBP3 insulin-like growth factor binding protein 3 0.0265033
TAOK1 TAO kinase 1 0.0264544
RBFOX2 RNA binding protein, fox-1 homolog (C. elegans) 2 0.0263561
TOP2A topoisomerase (DNA) II alpha 170kDa 0.0260695
FLNB filamin B, beta 0.0260606
ERBIN erbb2 interacting protein 0.0253119
SPTBN1 spectrin, beta, non-erythrocytic 1 0.0249914
LMO7 LIM domain 7 0.024908
SAMD4A sterile alpha motif domain containing 4A 0.0248338
ITGA5 integrin, alpha 5 (fibronectin receptor, alpha polypeptide) 0.0248131
HIVEP2 human immunodeficiency virus type I enhancer binding protein 2 0.0246852
MYOF myoferlin 0.0243617
ADAM9 ADAM metallopeptidase domain 9 0.0241763
ATXN1 ataxin 1 0.0240428
TSC22D2 TSC22 domain family, member 2 0.0239215
LHFPL2 lipoma HMGIC fusion partner-like 2 0.0238704
KIF13A kinesin family member 13A 0.0237213
BRD4 bromodomain containing 4 0.0236232
ERO1A endoplasmic reticulum oxidoreductase 1 alpha 0.0234598
ZFAND3 zinc finger, AN1-type domain 3 0.0234396
MMAB methylmalonic aciduria (cobalamin deficiency) cblB type 0.0234189
KPNA4 karyopherin alpha 4 (importin alpha 3) 0.0232129
RAPGEF2 Rap guanine nucleotide exchange factor (GEF) 2 0.0231173
SMC4 structural maintenance of chromosomes 4 0.0230229
PIEZO2 piezo-type mechanosensitive ion channel component 2 0.0228942
SLC2A1 solute carrier family 2 (facilitated glucose transporter), member 1 0.0228157
KCNQ5 potassium channel, voltage gated KQT-like subfamily Q, member 5 0.0222202
CSPP1 centrosome and spindle pole associated protein 1 0.0221697
PTK2 protein tyrosine kinase 2 0.0218618
HSPA1A heat shock 70kDa protein 1A 0.021774
HSPA9 heat shock 70kDa protein 9 (mortalin) 0.0217645
ANLN anillin, actin binding protein 0.0217296
PCM1 pericentriolar material 1 0.0216744
LPP LIM domain containing preferred translocation partner in lipoma 0.0216633
CDH2 cadherin 2, type 1, N-cadherin (neuronal) 0.0214611
CRIM1 cysteine rich transmembrane BMP regulator 1 (chordin-like) 0.0213767
PICALM phosphatidylinositol binding clathrin assembly protein 0.0212813
MRTFA myocardin related transcription factor A 0.0212238
MLLT10 myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 10 0.0212046
GRB10 growth factor receptor-bound protein 10 0.0211827
SLC38A2 solute carrier family 38, member 2 0.0211705
PTPN14 protein tyrosine phosphatase, non-receptor type 14 0.021101
NAV3 neuron navigator 3 0.0210675
FOSL1 FOS-like antigen 1 0.0210283
WAC WW domain containing adaptor with coiled-coil 0.0209478
HYOU1 hypoxia up-regulated 1 0.0208822
TMF1 TATA element modulatory factor 1 0.0207986
ARHGAP35 Rho GTPase activating protein 35 0.0207957
UBA6 ubiquitin-like modifier activating enzyme 6 0.0206419
EPS8 epidermal growth factor receptor pathway substrate 8 0.0205518
AGAP1 ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 0.0204514
COPA coatomer protein complex, subunit alpha 0.0203235

decreased expression

Symbol Name Standardized Value
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.291134
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.244058
CXCL8 chemokine (C-X-C motif) ligand 8 -0.195506
COL1A1 collagen, type I, alpha 1 -0.178299
MT2A metallothionein 2A -0.16903
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.100405
STC1 stanniocalcin 1 -0.0942452
IER3 immediate early response 3 -0.0879864
TMSB10 thymosin beta 10 -0.0869585
NAMPT nicotinamide phosphoribosyltransferase -0.0817485
CD44 CD44 molecule (Indian blood group) -0.0801073
COL1A2 collagen, type I, alpha 2 -0.0788391
TM4SF1 transmembrane 4 L six family member 1 -0.0784235
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 -0.0775893
RPS8 ribosomal protein S8 -0.066967
RPL35A ribosomal protein L35a -0.0639859
FTH1 ferritin, heavy polypeptide 1 -0.0632298
TPT1 tumor protein, translationally-controlled 1 -0.0592286
TMEM158 transmembrane protein 158 (gene/pseudogene) -0.0571168
IL6 interleukin 6 -0.0559838
HLA-B major histocompatibility complex, class I, B -0.0551929
LGALS1 lectin, galactoside-binding, soluble, 1 -0.0517519
ENO1 enolase 1, (alpha) -0.0504717
PTGS2 prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase) -0.049793
COL3A1 collagen, type III, alpha 1 -0.045835
VIM vimentin -0.04559
OSMR oncostatin M receptor -0.043787
ACTG1 actin gamma 1 -0.0432377
RPL26 ribosomal protein L26 -0.0416441
SERPINE2 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2 -0.0413221
RPL34 ribosomal protein L34 -0.0412848
SLC39A14 solute carrier family 39 (zinc transporter), member 14 -0.0388859
TIMP1 TIMP metallopeptidase inhibitor 1 -0.0380977
RPL12 ribosomal protein L12 -0.037546
S100A9 S100 calcium binding protein A9 -0.0370435
CANX calnexin -0.0368027
LOC112694756 uncharaterized LOC112694756 -0.0362799
FTL ferritin, light polypeptide -0.0359876
CLIC4 chloride intracellular channel 4 -0.0354929
RPL11 ribosomal protein L11 -0.035336
CALR calreticulin -0.0349551
RACK1 receptor for activated C kinase 1 -0.0347916
ZBTB20 zinc finger and BTB domain containing 20 -0.034049
STAT1 signal transducer and activator of transcription 1, 91kDa -0.033839
RPL30 ribosomal protein L30 -0.0335176
RPS3 ribosomal protein S3 -0.0334998
SRGN serglycin -0.0334144
F3 coagulation factor III (thromboplastin, tissue factor) -0.0330705
RPS24 ribosomal protein S24 -0.0329545
RPS6 ribosomal protein S6 -0.0327355
SLC5A3 solute carrier family 5 (sodium/myo-inositol cotransporter), member 3 -0.0324873
RPLP0 ribosomal protein, large, P0 -0.0324003
EIF1 eukaryotic translation initiation factor 1 -0.0323732
RPL23 ribosomal protein L23 -0.031885
GNAS GNAS complex locus -0.0315769
RPL8 ribosomal protein L8 -0.0315244
ERRFI1 ERBB receptor feedback inhibitor 1 -0.0305237
RPS25 ribosomal protein S25 -0.0291944
INHBA inhibin, beta A -0.0291652
PAPPA pregnancy-associated plasma protein A, pappalysin 1 -0.0287409
AHNAK AHNAK nucleoprotein -0.0282534
PTMA prothymosin, alpha -0.0277108
RPS13 ribosomal protein S13 -0.0274782
LDHA lactate dehydrogenase A -0.0273629
S100A6 S100 calcium binding protein A6 -0.0271724
RPL28 ribosomal protein L28 -0.0267864
RPS5 ribosomal protein S5 -0.0267805
RPS16 ribosomal protein S16 -0.0267493
RPL7 ribosomal protein L7 -0.0264717
RIGI RNA sensor RIG-I -0.0264244
IFI6 interferon, alpha-inducible protein 6 -0.026044
ISG15 ISG15 ubiquitin-like modifier -0.0256858
RPLP1 ribosomal protein, large, P1 -0.0254758
RPS19 ribosomal protein S19 -0.0254205
ST3GAL1 ST3 beta-galactoside alpha-2,3-sialyltransferase 1 -0.0250937
RPS27A ribosomal protein S27a -0.024963
FKBP10 FK506 binding protein 10, 65 kDa -0.0249477
CAVIN1 caveolae associated protein 1 -0.0243163
ICAM1 intercellular adhesion molecule 1 -0.0242622
IGFBP7 insulin-like growth factor binding protein 7 -0.0241903
RPL13A ribosomal protein L13a -0.0239594
HAS2 hyaluronan synthase 2 -0.0238853
RPS21 ribosomal protein S21 -0.0238249
RPL37A ribosomal protein L37a -0.0236931
RPL5 ribosomal protein L5 -0.0235958
RPS12 ribosomal protein S12 -0.0235664
P4HA2 prolyl 4-hydroxylase, alpha polypeptide II -0.0234793
RPL37 ribosomal protein L37 -0.0230805
ASPH aspartate beta-hydroxylase -0.0230206
RPS11 ribosomal protein S11 -0.0228619
UBC ubiquitin C -0.0227991
MMP3 matrix metallopeptidase 3 -0.0227273
RPL27 ribosomal protein L27 -0.0226731
RPL19 ribosomal protein L19 -0.0222674
CALM1 calmodulin 1 (phosphorylase kinase, delta) -0.0222537
SLC25A37 solute carrier family 25 (mitochondrial iron transporter), member 37 -0.0221445
RPL31 ribosomal protein L31 -0.0217474
IL6ST interleukin 6 signal transducer -0.02138
TMSB4X thymosin beta 4, X-linked -0.021297
RPL9 ribosomal protein L9 -0.021131