| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | Tolcapone perturbation in HepG2/C3A cell line (Tahoe Therapeutics) |
| Similar Terms | |
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200 genes differentially expressed following the Tolcapone_HepG2/C3A drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| HSP90AB1 | heat shock protein 90kDa alpha (cytosolic), class B member 1 | 0.0880834 |
| SVIL | supervillin | 0.0705151 |
| FAM107B | family with sequence similarity 107, member B | 0.0599468 |
| ANKRD1 | ankyrin repeat domain 1 (cardiac muscle) | 0.0581696 |
| PSME4 | proteasome (prosome, macropain) activator subunit 4 | 0.0502551 |
| HIVEP2 | human immunodeficiency virus type I enhancer binding protein 2 | 0.0489259 |
| PAWR | PRKC, apoptosis, WT1, regulator | 0.0471725 |
| PCBP2 | poly(rC) binding protein 2 | 0.0458814 |
| MYH9 | myosin, heavy chain 9, non-muscle | 0.0446096 |
| EEF2 | eukaryotic translation elongation factor 2 | 0.0444535 |
| DIAPH1 | diaphanous-related formin 1 | 0.0436307 |
| VEGFA | vascular endothelial growth factor A | 0.0429016 |
| ABTB2 | ankyrin repeat and BTB (POZ) domain containing 2 | 0.0421198 |
| FAT1 | FAT atypical cadherin 1 | 0.0404243 |
| CCNY | cyclin Y | 0.0401723 |
| HSP90AA1 | heat shock protein 90kDa alpha (cytosolic), class A member 1 | 0.0400865 |
| PABPC1 | poly(A) binding protein, cytoplasmic 1 | 0.0396179 |
| CRY1 | cryptochrome circadian clock 1 | 0.0375762 |
| GRB10 | growth factor receptor-bound protein 10 | 0.0372735 |
| TNS1 | tensin 1 | 0.0370758 |
| SPAG9 | sperm associated antigen 9 | 0.0361942 |
| ITGAV | integrin, alpha V | 0.0353813 |
| ZEB1 | zinc finger E-box binding homeobox 1 | 0.0341914 |
| MKLN1 | muskelin 1, intracellular mediator containing kelch motifs | 0.0335896 |
| TF | transferrin | 0.0334263 |
| FERMT2 | fermitin family member 2 | 0.0326885 |
| SOD2 | superoxide dismutase 2, mitochondrial | 0.0322823 |
| EPS8 | epidermal growth factor receptor pathway substrate 8 | 0.0307833 |
| TRIO | trio Rho guanine nucleotide exchange factor | 0.0305178 |
| HNRNPA1 | heterogeneous nuclear ribonucleoprotein A1 | 0.0304583 |
| AKAP13 | A kinase (PRKA) anchor protein 13 | 0.0301375 |
| IGF2BP2 | insulin-like growth factor 2 mRNA binding protein 2 | 0.0301125 |
| WAC | WW domain containing adaptor with coiled-coil | 0.0297506 |
| MYO1B | myosin IB | 0.0296238 |
| FHIP1A | FHF complex subunit HOOK interacting protein 1A | 0.0296181 |
| MACF1 | microtubule-actin crosslinking factor 1 | 0.0295492 |
| STRN3 | striatin, calmodulin binding protein 3 | 0.0290385 |
| KYNU | kynureninase | 0.0290003 |
| QKI | QKI, KH domain containing, RNA binding | 0.0289521 |
| KMT2C | lysine (K)-specific methyltransferase 2C | 0.0286191 |
| ITCH | itchy E3 ubiquitin protein ligase | 0.0281947 |
| ARHGAP9 | Rho GTPase activating protein 9 | 0.0278353 |
| ERRFI1 | ERBB receptor feedback inhibitor 1 | 0.0277131 |
| AHR | aryl hydrocarbon receptor | 0.0273031 |
| AFDN | afadin, adherens junction formation factor | 0.0264962 |
| ZNF644 | zinc finger protein 644 | 0.026321 |
| HNRNPR | heterogeneous nuclear ribonucleoprotein R | 0.0262455 |
| RASA2 | RAS p21 protein activator 2 | 0.0261291 |
| ATP2B1 | ATPase, Ca++ transporting, plasma membrane 1 | 0.0260689 |
| USP47 | ubiquitin specific peptidase 47 | 0.0260177 |
| CORO1C | coronin, actin binding protein, 1C | 0.0259713 |
| YTHDC1 | YTH domain containing 1 | 0.0259591 |
| ZFAND3 | zinc finger, AN1-type domain 3 | 0.0259236 |
| FOXP1 | forkhead box P1 | 0.0255845 |
| SMURF2 | SMAD specific E3 ubiquitin protein ligase 2 | 0.025579 |
| LCOR | ligand dependent nuclear receptor corepressor | 0.0254075 |
| BCL2L1 | BCL2-like 1 | 0.0252591 |
| CEMIP2 | cell migration inducing hyaluronidase 2 | 0.0252325 |
| EGLN1 | egl-9 family hypoxia-inducible factor 1 | 0.0251721 |
| EEF1A1 | eukaryotic translation elongation factor 1 alpha 1 | 0.0251154 |
| KDM6A | lysine (K)-specific demethylase 6A | 0.0251123 |
| SORL1 | sortilin-related receptor, L(DLR class) A repeats containing | 0.0250883 |
| TPM1 | tropomyosin 1 (alpha) | 0.0250627 |
| TNFAIP3 | tumor necrosis factor, alpha-induced protein 3 | 0.0249388 |
| OPTN | optineurin | 0.0245811 |
| UBR4 | ubiquitin protein ligase E3 component n-recognin 4 | 0.0245787 |
| TXNRD1 | thioredoxin reductase 1 | 0.0245646 |
| RB1CC1 | RB1-inducible coiled-coil 1 | 0.0243807 |
| MYO6 | myosin VI | 0.02433 |
| HSPH1 | heat shock 105kDa/110kDa protein 1 | 0.0238862 |
| SNX9 | sorting nexin 9 | 0.0238321 |
| CSGALNACT2 | chondroitin sulfate N-acetylgalactosaminyltransferase 2 | 0.0237349 |
| EPC2 | enhancer of polycomb homolog 2 (Drosophila) | 0.023489 |
| TNFRSF21 | tumor necrosis factor receptor superfamily, member 21 | 0.0233941 |
| NFAT5 | nuclear factor of activated T-cells 5, tonicity-responsive | 0.0233197 |
| HSPA1B | heat shock 70kDa protein 1B | 0.0232958 |
| NUP58 | nucleoporin 58 | 0.0232363 |
| ACSL3 | acyl-CoA synthetase long-chain family member 3 | 0.0232184 |
| FNDC3B | fibronectin type III domain containing 3B | 0.0231938 |
| MAP2K1 | mitogen-activated protein kinase kinase 1 | 0.0231496 |
| SEC31A | SEC31 homolog A (S. cerevisiae) | 0.0230007 |
| GAREM1 | GRB2 associated regulator of MAPK1 subtype 1 | 0.0229615 |
| RTN4 | reticulon 4 | 0.0229606 |
| DYRK1A | dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1A | 0.0228617 |
| RANBP9 | RAN binding protein 9 | 0.0227424 |
| CRIM1 | cysteine rich transmembrane BMP regulator 1 (chordin-like) | 0.0226782 |
| GOLGA4 | golgin A4 | 0.0225624 |
| ANKRD11 | ankyrin repeat domain 11 | 0.0224197 |
| HSPA1A | heat shock 70kDa protein 1A | 0.0223083 |
| TOP1 | topoisomerase (DNA) I | 0.0222109 |
| C3 | complement component 3 | 0.022149 |
| ABCA5 | ATP-binding cassette, sub-family A (ABC1), member 5 | 0.0219442 |
| YME1L1 | YME1-like 1 ATPase | 0.0219022 |
| CUL3 | cullin 3 | 0.0218246 |
| SFPQ | splicing factor proline/glutamine-rich | 0.0217809 |
| DTNA | dystrobrevin, alpha | 0.0217759 |
| CTNNAL1 | catenin (cadherin-associated protein), alpha-like 1 | 0.0216904 |
| DDIT4 | DNA-damage-inducible transcript 4 | 0.0213532 |
| KMT2E | lysine (K)-specific methyltransferase 2E | 0.0211956 |
| PSMD14 | proteasome (prosome, macropain) 26S subunit, non-ATPase, 14 | 0.0211558 |
| Symbol | Name | Standardized Value |
|---|---|---|
| MT2A | metallothionein 2A | -0.15255 |
| SERPINA3 | serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 3 | -0.149617 |
| GPC6 | glypican 6 | -0.142263 |
| SERPINA1 | serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 1 | -0.137166 |
| MAML2 | mastermind-like 2 (Drosophila) | -0.12829 |
| TIMP1 | TIMP metallopeptidase inhibitor 1 | -0.113577 |
| TMSB10 | thymosin beta 10 | -0.108748 |
| ENO1 | enolase 1, (alpha) | -0.105464 |
| EHBP1 | EH domain binding protein 1 | -0.103578 |
| TPT1 | tumor protein, translationally-controlled 1 | -0.102026 |
| APOA2 | apolipoprotein A-II | -0.100472 |
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | -0.0980864 |
| LRMDA | leucine rich melanocyte differentiation associated | -0.0826385 |
| RPS19 | ribosomal protein S19 | -0.0817708 |
| NPAS2 | neuronal PAS domain protein 2 | -0.0798211 |
| TM4SF1 | transmembrane 4 L six family member 1 | -0.0781675 |
| PLCB1 | phospholipase C, beta 1 (phosphoinositide-specific) | -0.0772654 |
| RPL23 | ribosomal protein L23 | -0.0757423 |
| GMDS | GDP-mannose 4,6-dehydratase | -0.074817 |
| SLC38A2 | solute carrier family 38, member 2 | -0.0730045 |
| RPS6 | ribosomal protein S6 | -0.0704209 |
| FRMD5 | FERM domain containing 5 | -0.0701986 |
| CP | ceruloplasmin (ferroxidase) | -0.0671141 |
| RPLP1 | ribosomal protein, large, P1 | -0.0636963 |
| RPS24 | ribosomal protein S24 | -0.062085 |
| PEG3 | paternally expressed 3 | -0.0590588 |
| RPL37A | ribosomal protein L37a | -0.0558083 |
| H1-0 | H1.0 linker histone | -0.0555799 |
| AHNAK | AHNAK nucleoprotein | -0.0541954 |
| FTL | ferritin, light polypeptide | -0.0539501 |
| GPC3 | glypican 3 | -0.0516944 |
| ROCK2 | Rho-associated, coiled-coil containing protein kinase 2 | -0.0512713 |
| RPL35A | ribosomal protein L35a | -0.0498484 |
| ATP10A | ATPase, class V, type 10A | -0.0496449 |
| MAGI2 | membrane associated guanylate kinase, WW and PDZ domain containing 2 | -0.0492279 |
| RPS12 | ribosomal protein S12 | -0.0481272 |
| RPS27A | ribosomal protein S27a | -0.0475974 |
| ITGA1 | integrin, alpha 1 | -0.0456572 |
| RPL11 | ribosomal protein L11 | -0.0455931 |
| RPS21 | ribosomal protein S21 | -0.044458 |
| ZMYND8 | zinc finger, MYND-type containing 8 | -0.0442791 |
| ZBTB20 | zinc finger and BTB domain containing 20 | -0.0440631 |
| TMEM123 | transmembrane protein 123 | -0.043638 |
| RPL31 | ribosomal protein L31 | -0.042929 |
| RPLP2 | ribosomal protein, large, P2 | -0.0428931 |
| AKAP12 | A kinase (PRKA) anchor protein 12 | -0.0426701 |
| APOB | apolipoprotein B | -0.0425405 |
| RPL34 | ribosomal protein L34 | -0.0422263 |
| RNASET2 | ribonuclease T2 | -0.0411789 |
| ACSL4 | acyl-CoA synthetase long-chain family member 4 | -0.0409138 |
| GNAS | GNAS complex locus | -0.0407101 |
| PTTG1IP | pituitary tumor-transforming 1 interacting protein | -0.0404788 |
| ASPH | aspartate beta-hydroxylase | -0.0401571 |
| OSMR | oncostatin M receptor | -0.0401341 |
| ISG15 | ISG15 ubiquitin-like modifier | -0.0389484 |
| IFITM1 | interferon induced transmembrane protein 1 | -0.0378941 |
| HSPA5 | heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) | -0.0374 |
| B2M | beta-2-microglobulin | -0.0369437 |
| ITPR2 | inositol 1,4,5-trisphosphate receptor, type 2 | -0.0363868 |
| S100A9 | S100 calcium binding protein A9 | -0.035922 |
| SLC16A3 | solute carrier family 16 (monocarboxylate transporter), member 3 | -0.0358634 |
| TFPI | tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor) | -0.0354553 |
| SOX5 | SRY (sex determining region Y)-box 5 | -0.0348031 |
| EML4 | echinoderm microtubule associated protein like 4 | -0.0338256 |
| RPS5 | ribosomal protein S5 | -0.0338014 |
| RPS29 | ribosomal protein S29 | -0.0336886 |
| RPS8 | ribosomal protein S8 | -0.0334131 |
| MARCKS | myristoylated alanine-rich protein kinase C substrate | -0.0330306 |
| RERE | arginine-glutamic acid dipeptide (RE) repeats | -0.0329815 |
| RIGI | RNA sensor RIG-I | -0.0329666 |
| LOC112694756 | uncharaterized LOC112694756 | -0.0329602 |
| RPL9 | ribosomal protein L9 | -0.0326919 |
| SDC4 | syndecan 4 | -0.0321059 |
| DOCK4 | dedicator of cytokinesis 4 | -0.031915 |
| RPL38 | ribosomal protein L38 | -0.0318212 |
| RPL12 | ribosomal protein L12 | -0.0318004 |
| APOE | apolipoprotein E | -0.030665 |
| PGK1 | phosphoglycerate kinase 1 | -0.0305715 |
| PEG10 | paternally expressed 10 | -0.0304403 |
| SOX4 | SRY (sex determining region Y)-box 4 | -0.0301743 |
| RPL36 | ribosomal protein L36 | -0.0296114 |
| AMBP | alpha-1-microglobulin/bikunin precursor | -0.0295822 |
| WSB1 | WD repeat and SOCS box containing 1 | -0.0293689 |
| P4HA1 | prolyl 4-hydroxylase, alpha polypeptide I | -0.0292181 |
| RPL19 | ribosomal protein L19 | -0.0288469 |
| GBE1 | glucan (1,4-alpha-), branching enzyme 1 | -0.0288462 |
| RPL28 | ribosomal protein L28 | -0.0284002 |
| RPL26 | ribosomal protein L26 | -0.0281627 |
| MAPK14 | mitogen-activated protein kinase 14 | -0.0279926 |
| TRIM26 | tripartite motif containing 26 | -0.0273091 |
| PTCHD4 | patched domain containing 4 | -0.027094 |
| APOA1 | apolipoprotein A-I | -0.0269773 |
| PARP14 | poly (ADP-ribose) polymerase family, member 14 | -0.026507 |
| HDAC4 | histone deacetylase 4 | -0.0263814 |
| RPS14 | ribosomal protein S14 | -0.0260569 |
| KIZ | kizuna centrosomal protein | -0.0260489 |
| RPS3 | ribosomal protein S3 | -0.0256127 |
| ERGIC1 | endoplasmic reticulum-golgi intermediate compartment (ERGIC) 1 | -0.0254455 |
| RNF213 | ring finger protein 213 | -0.0253633 |
| ELL2 | elongation factor, RNA polymerase II, 2 | -0.0252006 |
