| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | Tolcapone perturbation in Hs 766T cell line (Tahoe Therapeutics) |
| Similar Terms | |
| Downloads & Tools |
200 genes differentially expressed following the Tolcapone_Hs 766T drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| LMO7 | LIM domain 7 | 0.191752 |
| MYOF | myoferlin | 0.134024 |
| CD55 | CD55 molecule, decay accelerating factor for complement (Cromer blood group) | 0.11794 |
| TRIO | trio Rho guanine nucleotide exchange factor | 0.0923567 |
| MYH9 | myosin, heavy chain 9, non-muscle | 0.0922689 |
| MBNL1 | muscleblind-like splicing regulator 1 | 0.0905867 |
| PLEC | plectin | 0.0871156 |
| FLNB | filamin B, beta | 0.0757878 |
| MBNL2 | muscleblind-like splicing regulator 2 | 0.0746782 |
| PDE4D | phosphodiesterase 4D, cAMP-specific | 0.0727295 |
| ITGA2 | integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) | 0.0656681 |
| MACF1 | microtubule-actin crosslinking factor 1 | 0.0630144 |
| MEF2A | myocyte enhancer factor 2A | 0.06225 |
| FNDC3B | fibronectin type III domain containing 3B | 0.0604329 |
| MSN | moesin | 0.057272 |
| PALM2AKAP2 | PALM2 and AKAP2 fusion | 0.0570655 |
| SULF1 | sulfatase 1 | 0.0566254 |
| FOXP1 | forkhead box P1 | 0.0539351 |
| PHLDB2 | pleckstrin homology-like domain, family B, member 2 | 0.0535154 |
| CLU | clusterin | 0.0526883 |
| DPYD | dihydropyrimidine dehydrogenase | 0.0525597 |
| CD44 | CD44 molecule (Indian blood group) | 0.0519189 |
| HSP90AB1 | heat shock protein 90kDa alpha (cytosolic), class B member 1 | 0.0516676 |
| ARHGAP21 | Rho GTPase activating protein 21 | 0.050102 |
| HIVEP2 | human immunodeficiency virus type I enhancer binding protein 2 | 0.0495949 |
| AHNAK | AHNAK nucleoprotein | 0.0483876 |
| IL1RAPL1 | interleukin 1 receptor accessory protein-like 1 | 0.0482745 |
| PTK2 | protein tyrosine kinase 2 | 0.0482249 |
| NFATC2 | nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 2 | 0.0479668 |
| KRT17 | keratin 17, type I | 0.0469313 |
| GPRC5A | G protein-coupled receptor, class C, group 5, member A | 0.0465134 |
| DST | dystonin | 0.045916 |
| DOCK5 | dedicator of cytokinesis 5 | 0.0458186 |
| APLP2 | amyloid beta (A4) precursor-like protein 2 | 0.0435517 |
| TSC22D1 | TSC22 domain family, member 1 | 0.0433861 |
| PALLD | palladin, cytoskeletal associated protein | 0.0431999 |
| RAI14 | retinoic acid induced 14 | 0.0425576 |
| NEK7 | NIMA-related kinase 7 | 0.0424967 |
| TGM2 | transglutaminase 2 | 0.0416724 |
| PPP1R15A | protein phosphatase 1, regulatory subunit 15A | 0.0411967 |
| SEPTIN9 | septin 9 | 0.0409257 |
| SMAD3 | SMAD family member 3 | 0.0392384 |
| KLF5 | Kruppel-like factor 5 (intestinal) | 0.0392107 |
| ASPH | aspartate beta-hydroxylase | 0.0391437 |
| RNF217 | ring finger protein 217 | 0.0379959 |
| JMJD1C | jumonji domain containing 1C | 0.0377053 |
| MECOM | MDS1 and EVI1 complex locus | 0.0374786 |
| AOPEP | aminopeptidase O (putative) | 0.0372106 |
| BARX2 | BARX homeobox 2 | 0.0371056 |
| STC1 | stanniocalcin 1 | 0.0369556 |
| PRELID2 | PRELI domain containing 2 | 0.0368843 |
| MTSS1 | metastasis suppressor 1 | 0.0367536 |
| DOK5 | docking protein 5 | 0.036619 |
| ARRDC3 | arrestin domain containing 3 | 0.0349114 |
| ZEB1 | zinc finger E-box binding homeobox 1 | 0.0348741 |
| FN1 | fibronectin 1 | 0.0346486 |
| CRIM1 | cysteine rich transmembrane BMP regulator 1 (chordin-like) | 0.0340562 |
| TPM3 | tropomyosin 3 | 0.0339066 |
| AKAP13 | A kinase (PRKA) anchor protein 13 | 0.0329406 |
| FOXO1 | forkhead box O1 | 0.0329037 |
| MYO10 | myosin X | 0.0328305 |
| EXT1 | exostosin glycosyltransferase 1 | 0.032015 |
| PSD3 | pleckstrin and Sec7 domain containing 3 | 0.0319024 |
| LNPEP | leucyl/cystinyl aminopeptidase | 0.0318858 |
| ANO6 | anoctamin 6 | 0.0310625 |
| NRG1 | neuregulin 1 | 0.0309802 |
| PICALM | phosphatidylinositol binding clathrin assembly protein | 0.0309724 |
| SMG1 | SMG1 phosphatidylinositol 3-kinase-related kinase | 0.0308014 |
| ST3GAL6 | ST3 beta-galactoside alpha-2,3-sialyltransferase 6 | 0.0305807 |
| ZSWIM6 | zinc finger, SWIM-type containing 6 | 0.0304656 |
| GRB10 | growth factor receptor-bound protein 10 | 0.0304457 |
| NR3C1 | nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor) | 0.0303216 |
| PTPN13 | protein tyrosine phosphatase, non-receptor type 13 (APO-1/CD95 (Fas)-associated phosphatase) | 0.0300155 |
| CDKN2A | cyclin-dependent kinase inhibitor 2A | 0.0299217 |
| ASAP2 | ArfGAP with SH3 domain, ankyrin repeat and PH domain 2 | 0.0298277 |
| CUL4B | cullin 4B | 0.0296897 |
| PDLIM5 | PDZ and LIM domain 5 | 0.0296754 |
| ZC3H11A | zinc finger CCCH-type containing 11A | 0.029431 |
| RASAL2 | RAS protein activator like 2 | 0.0290764 |
| RICTOR | RPTOR independent companion of MTOR, complex 2 | 0.0290751 |
| DHFR | dihydrofolate reductase | 0.0289634 |
| SAMD9 | sterile alpha motif domain containing 9 | 0.0288198 |
| SLC5A3 | solute carrier family 5 (sodium/myo-inositol cotransporter), member 3 | 0.0288044 |
| ETS1 | v-ets avian erythroblastosis virus E26 oncogene homolog 1 | 0.0284414 |
| RIN2 | Ras and Rab interactor 2 | 0.028368 |
| CEP250 | centrosomal protein 250kDa | 0.0282442 |
| CTNNA1 | catenin (cadherin-associated protein), alpha 1, 102kDa | 0.0276901 |
| FLNA | filamin A, alpha | 0.0275713 |
| HSPH1 | heat shock 105kDa/110kDa protein 1 | 0.0271554 |
| HNRNPU | heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) | 0.027132 |
| TLN1 | talin 1 | 0.0270402 |
| EFNA5 | ephrin-A5 | 0.0270108 |
| HSPA8 | heat shock 70kDa protein 8 | 0.0264826 |
| BHLHE40 | basic helix-loop-helix family, member e40 | 0.0264063 |
| EIF4G2 | eukaryotic translation initiation factor 4 gamma, 2 | 0.0262935 |
| DOCK9 | dedicator of cytokinesis 9 | 0.0257346 |
| SEMA3C | sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C | 0.0256672 |
| PTPN14 | protein tyrosine phosphatase, non-receptor type 14 | 0.025318 |
| AMOTL1 | angiomotin like 1 | 0.0251136 |
| SPTAN1 | spectrin, alpha, non-erythrocytic 1 | 0.0250613 |
| Symbol | Name | Standardized Value |
|---|---|---|
| TIMP3 | TIMP metallopeptidase inhibitor 3 | -0.21963 |
| PTMA | prothymosin, alpha | -0.134386 |
| HLA-B | major histocompatibility complex, class I, B | -0.113753 |
| TPT1 | tumor protein, translationally-controlled 1 | -0.109319 |
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | -0.106117 |
| B2M | beta-2-microglobulin | -0.103031 |
| IGF2 | insulin-like growth factor 2 | -0.0904587 |
| RPL35A | ribosomal protein L35a | -0.06953 |
| HM13 | histocompatibility (minor) 13 | -0.0652581 |
| RPS24 | ribosomal protein S24 | -0.063575 |
| S100A10 | S100 calcium binding protein A10 | -0.0551544 |
| HSP90B1 | heat shock protein 90kDa beta (Grp94), member 1 | -0.0517078 |
| RPL37A | ribosomal protein L37a | -0.0511573 |
| EGR1 | early growth response 1 | -0.0510549 |
| RPLP2 | ribosomal protein, large, P2 | -0.0506934 |
| RPL31 | ribosomal protein L31 | -0.0490647 |
| MT2A | metallothionein 2A | -0.0471354 |
| RPS21 | ribosomal protein S21 | -0.0466271 |
| POTEF | POTE ankyrin domain family, member F | -0.046465 |
| FTL | ferritin, light polypeptide | -0.0457865 |
| RPS8 | ribosomal protein S8 | -0.0456194 |
| YWHAB | tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta | -0.0454436 |
| RPS13 | ribosomal protein S13 | -0.045266 |
| TMSB10 | thymosin beta 10 | -0.044712 |
| GNAS | GNAS complex locus | -0.0444229 |
| IFI6 | interferon, alpha-inducible protein 6 | -0.0430784 |
| RPL34 | ribosomal protein L34 | -0.0430523 |
| SERPINE1 | serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 | -0.042959 |
| RPL36A | ribosomal protein L36a | -0.0401444 |
| RPS27A | ribosomal protein S27a | -0.0398125 |
| CAVIN1 | caveolae associated protein 1 | -0.0392565 |
| HSPA5 | heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) | -0.0389437 |
| RPS25 | ribosomal protein S25 | -0.0381885 |
| ACTG1 | actin gamma 1 | -0.0380608 |
| VDAC1 | voltage-dependent anion channel 1 | -0.0356903 |
| RPLP1 | ribosomal protein, large, P1 | -0.0354896 |
| TPM4 | tropomyosin 4 | -0.0351906 |
| ZRANB2 | zinc finger, RAN-binding domain containing 2 | -0.0345562 |
| MDK | midkine (neurite growth-promoting factor 2) | -0.0341805 |
| ZMYND8 | zinc finger, MYND-type containing 8 | -0.0337262 |
| IER3 | immediate early response 3 | -0.0335781 |
| PODXL | podocalyxin-like | -0.0329466 |
| PTP4A2 | protein tyrosine phosphatase type IVA, member 2 | -0.0325847 |
| SPINK5 | serine peptidase inhibitor, Kazal type 5 | -0.0322825 |
| RPL9 | ribosomal protein L9 | -0.032002 |
| ABI3BP | ABI family, member 3 (NESH) binding protein | -0.0316533 |
| RPL11 | ribosomal protein L11 | -0.0312223 |
| S100A6 | S100 calcium binding protein A6 | -0.0307866 |
| RPL7A | ribosomal protein L7a | -0.0306991 |
| IFITM3 | interferon induced transmembrane protein 3 | -0.030197 |
| ALCAM | activated leukocyte cell adhesion molecule | -0.0301947 |
| SH3BGRL3 | SH3 domain binding glutamate-rich protein like 3 | -0.0298299 |
| RPL26 | ribosomal protein L26 | -0.0296652 |
| RABGEF1 | RAB guanine nucleotide exchange factor (GEF) 1 | -0.0290199 |
| RPS23 | ribosomal protein S23 | -0.0289786 |
| WSB1 | WD repeat and SOCS box containing 1 | -0.0287727 |
| RPL38 | ribosomal protein L38 | -0.0281304 |
| PSMA7 | proteasome (prosome, macropain) subunit, alpha type, 7 | -0.0276797 |
| EIF1 | eukaryotic translation initiation factor 1 | -0.0276028 |
| TMEM165 | transmembrane protein 165 | -0.0275524 |
| SLC25A5 | solute carrier family 25 (mitochondrial carrier; adenine nucleotide translocator), member 5 | -0.0271825 |
| MYL12B | myosin, light chain 12B, regulatory | -0.0270351 |
| CST3 | cystatin C | -0.0266623 |
| RPS6 | ribosomal protein S6 | -0.0265813 |
| CSTB | cystatin B (stefin B) | -0.0264629 |
| FSCN1 | fascin actin-bundling protein 1 | -0.0263345 |
| ZNFX1 | zinc finger, NFX1-type containing 1 | -0.0262316 |
| SEC31A | SEC31 homolog A (S. cerevisiae) | -0.026222 |
| NDRG1 | N-myc downstream regulated 1 | -0.0261071 |
| IFI27 | interferon, alpha-inducible protein 27 | -0.0258711 |
| VIM | vimentin | -0.0257827 |
| RBM25 | RNA binding motif protein 25 | -0.0257514 |
| NT5C2 | 5'-nucleotidase, cytosolic II | -0.0257381 |
| CAP1 | CAP, adenylate cyclase-associated protein 1 (yeast) | -0.0256642 |
| TM4SF1 | transmembrane 4 L six family member 1 | -0.0255905 |
| PLTP | phospholipid transfer protein | -0.0255764 |
| S100A11 | S100 calcium binding protein A11 | -0.0254212 |
| ZFP36L1 | ZFP36 ring finger protein-like 1 | -0.0252549 |
| RPS15 | ribosomal protein S15 | -0.0251255 |
| CHCHD2 | coiled-coil-helix-coiled-coil-helix domain containing 2 | -0.025099 |
| HLA-A | major histocompatibility complex, class I, A | -0.0250659 |
| SLC25A37 | solute carrier family 25 (mitochondrial iron transporter), member 37 | -0.0248403 |
| LAMC2 | laminin, gamma 2 | -0.0246968 |
| CAPZA1 | capping protein (actin filament) muscle Z-line, alpha 1 | -0.0246038 |
| RPS29 | ribosomal protein S29 | -0.0245189 |
| POMP | proteasome maturation protein | -0.0245168 |
| SP100 | SP100 nuclear antigen | -0.0243066 |
| ISG15 | ISG15 ubiquitin-like modifier | -0.0241672 |
| LITAF | lipopolysaccharide-induced TNF factor | -0.0235588 |
| RALY | RALY heterogeneous nuclear ribonucleoprotein | -0.0234594 |
| HELZ2 | helicase with zinc finger 2, transcriptional coactivator | -0.0233167 |
| LMNA | lamin A/C | -0.0232388 |
| NECTIN4 | nectin cell adhesion molecule 4 | -0.0231801 |
| RPL37 | ribosomal protein L37 | -0.0228318 |
| UQCRB | ubiquinol-cytochrome c reductase binding protein | -0.0227114 |
| HNRNPH1 | heterogeneous nuclear ribonucleoprotein H1 (H) | -0.0226947 |
| S100A2 | S100 calcium binding protein A2 | -0.0226134 |
| GUK1 | guanylate kinase 1 | -0.0223505 |
| CTSD | cathepsin D | -0.0223004 |
| ANKHD1 | ankyrin repeat and KH domain containing 1 | -0.0222838 |
