| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | Tolcapone perturbation in KATO III cell line (Tahoe Therapeutics) |
| Similar Terms | |
| Downloads & Tools |
200 genes differentially expressed following the Tolcapone_KATO III drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| LMO7 | LIM domain 7 | 0.136598 |
| MYH9 | myosin, heavy chain 9, non-muscle | 0.127909 |
| MUC17 | mucin 17, cell surface associated | 0.105626 |
| PPP1R15A | protein phosphatase 1, regulatory subunit 15A | 0.100649 |
| APLP2 | amyloid beta (A4) precursor-like protein 2 | 0.0956732 |
| CTNNB1 | catenin (cadherin-associated protein), beta 1, 88kDa | 0.0827702 |
| TMC5 | transmembrane channel-like 5 | 0.081533 |
| HSP90AB1 | heat shock protein 90kDa alpha (cytosolic), class B member 1 | 0.0796537 |
| ANXA1 | annexin A1 | 0.0783611 |
| FAT1 | FAT atypical cadherin 1 | 0.0774266 |
| RPL19 | ribosomal protein L19 | 0.0773831 |
| SPTBN1 | spectrin, beta, non-erythrocytic 1 | 0.0752292 |
| HNRNPA2B1 | heterogeneous nuclear ribonucleoprotein A2/B1 | 0.0743493 |
| MBNL2 | muscleblind-like splicing regulator 2 | 0.0729317 |
| MAML2 | mastermind-like 2 (Drosophila) | 0.0681774 |
| FGFR2 | fibroblast growth factor receptor 2 | 0.0634923 |
| PLEC | plectin | 0.0610012 |
| EZR | ezrin | 0.06064 |
| VEGFA | vascular endothelial growth factor A | 0.0596242 |
| DSPP | dentin sialophosphoprotein | 0.0581013 |
| EEPD1 | endonuclease/exonuclease/phosphatase family domain containing 1 | 0.0580883 |
| KRT18 | keratin 18, type I | 0.0564274 |
| AGAP1 | ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 | 0.0563383 |
| CALR | calreticulin | 0.0541958 |
| ASPH | aspartate beta-hydroxylase | 0.0514126 |
| RNF213 | ring finger protein 213 | 0.0505549 |
| HYOU1 | hypoxia up-regulated 1 | 0.0487962 |
| SEPTIN9 | septin 9 | 0.0485296 |
| SYNE2 | spectrin repeat containing, nuclear envelope 2 | 0.0479304 |
| HSP90AA1 | heat shock protein 90kDa alpha (cytosolic), class A member 1 | 0.0475594 |
| NFE2L1 | nuclear factor, erythroid 2-like 1 | 0.047346 |
| SPTAN1 | spectrin, alpha, non-erythrocytic 1 | 0.0471868 |
| ZSWIM6 | zinc finger, SWIM-type containing 6 | 0.0455906 |
| HNRNPA1 | heterogeneous nuclear ribonucleoprotein A1 | 0.0452272 |
| SLC2A1 | solute carrier family 2 (facilitated glucose transporter), member 1 | 0.0451093 |
| PCSK5 | proprotein convertase subtilisin/kexin type 5 | 0.0412188 |
| HSPA8 | heat shock 70kDa protein 8 | 0.0408477 |
| EFNA5 | ephrin-A5 | 0.0406187 |
| EHBP1 | EH domain binding protein 1 | 0.0394538 |
| NDRG1 | N-myc downstream regulated 1 | 0.0392376 |
| SLC38A2 | solute carrier family 38, member 2 | 0.0389795 |
| FLNB | filamin B, beta | 0.038583 |
| MBNL1 | muscleblind-like splicing regulator 1 | 0.0381509 |
| DOCK5 | dedicator of cytokinesis 5 | 0.0371025 |
| KLHL29 | kelch-like family member 29 | 0.036242 |
| ITGA6 | integrin, alpha 6 | 0.0361262 |
| ATXN1 | ataxin 1 | 0.0355883 |
| HNRNPU | heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) | 0.0352512 |
| BAIAP2L1 | BAI1-associated protein 2-like 1 | 0.0351133 |
| TMSB4X | thymosin beta 4, X-linked | 0.0345427 |
| ENO1 | enolase 1, (alpha) | 0.034172 |
| GCLC | glutamate-cysteine ligase, catalytic subunit | 0.0338502 |
| FTL | ferritin, light polypeptide | 0.0329481 |
| PTPRK | protein tyrosine phosphatase, receptor type, K | 0.0328654 |
| ERRFI1 | ERBB receptor feedback inhibitor 1 | 0.0326058 |
| TMTC2 | transmembrane and tetratricopeptide repeat containing 2 | 0.0322664 |
| AKAP13 | A kinase (PRKA) anchor protein 13 | 0.0319654 |
| RPS12 | ribosomal protein S12 | 0.0316532 |
| BACE2 | beta-site APP-cleaving enzyme 2 | 0.0314799 |
| SET | SET nuclear proto-oncogene | 0.031447 |
| POF1B | premature ovarian failure, 1B | 0.030961 |
| EEF1G | eukaryotic translation elongation factor 1 gamma | 0.030388 |
| TNIK | TRAF2 and NCK interacting kinase | 0.0302109 |
| GULP1 | GULP, engulfment adaptor PTB domain containing 1 | 0.0297391 |
| ANKRD11 | ankyrin repeat domain 11 | 0.0294851 |
| GOLGB1 | golgin B1 | 0.0291967 |
| TPM3 | tropomyosin 3 | 0.0283711 |
| HNRNPUL2 | heterogeneous nuclear ribonucleoprotein U-like 2 | 0.0280924 |
| NUPR1 | nuclear protein, transcriptional regulator, 1 | 0.0280091 |
| MACF1 | microtubule-actin crosslinking factor 1 | 0.0277575 |
| EIF4G1 | eukaryotic translation initiation factor 4 gamma, 1 | 0.0277131 |
| FRMD5 | FERM domain containing 5 | 0.0274639 |
| INTS6 | integrator complex subunit 6 | 0.0274485 |
| P4HB | prolyl 4-hydroxylase, beta polypeptide | 0.0272073 |
| PCBP2 | poly(rC) binding protein 2 | 0.0271097 |
| GDA | guanine deaminase | 0.026726 |
| PKM | pyruvate kinase, muscle | 0.0266728 |
| PTPRN2 | protein tyrosine phosphatase, receptor type, N polypeptide 2 | 0.0264688 |
| CMIP | c-Maf inducing protein | 0.0255948 |
| MYH14 | myosin, heavy chain 14, non-muscle | 0.0255461 |
| EFNB2 | ephrin-B2 | 0.0253325 |
| TMF1 | TATA element modulatory factor 1 | 0.0250848 |
| CRIM1 | cysteine rich transmembrane BMP regulator 1 (chordin-like) | 0.0250581 |
| ARHGEF12 | Rho guanine nucleotide exchange factor (GEF) 12 | 0.0247783 |
| ASAP2 | ArfGAP with SH3 domain, ankyrin repeat and PH domain 2 | 0.0246959 |
| UBASH3B | ubiquitin associated and SH3 domain containing B | 0.0246616 |
| IMMP2L | IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) | 0.0246342 |
| HKDC1 | hexokinase domain containing 1 | 0.0245122 |
| DNAJA1 | DnaJ (Hsp40) homolog, subfamily A, member 1 | 0.0243211 |
| EIF4B | eukaryotic translation initiation factor 4B | 0.0241927 |
| GRB10 | growth factor receptor-bound protein 10 | 0.0240948 |
| LCN2 | lipocalin 2 | 0.0239777 |
| FNDC3B | fibronectin type III domain containing 3B | 0.0239076 |
| SMAD3 | SMAD family member 3 | 0.0238225 |
| SLK | STE20-like kinase | 0.0235896 |
| HUWE1 | HECT, UBA and WWE domain containing 1, E3 ubiquitin protein ligase | 0.0234811 |
| PFKP | phosphofructokinase, platelet | 0.0231809 |
| EGLN3 | egl-9 family hypoxia-inducible factor 3 | 0.0230856 |
| TXNIP | thioredoxin interacting protein | 0.0230598 |
| RPS7 | ribosomal protein S7 | 0.023049 |
| Symbol | Name | Standardized Value |
|---|---|---|
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | -0.154108 |
| NPSR1 | neuropeptide S receptor 1 | -0.0841451 |
| POTEF | POTE ankyrin domain family, member F | -0.0741854 |
| CEACAM5 | carcinoembryonic antigen-related cell adhesion molecule 5 | -0.0707604 |
| CEACAM6 | carcinoembryonic antigen-related cell adhesion molecule 6 (non-specific cross reacting antigen) | -0.0676949 |
| AGR2 | anterior gradient 2 | -0.0655019 |
| TPT1 | tumor protein, translationally-controlled 1 | -0.064979 |
| S100A6 | S100 calcium binding protein A6 | -0.064956 |
| HSPA5 | heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) | -0.0640371 |
| TMSB10 | thymosin beta 10 | -0.0578831 |
| RPS21 | ribosomal protein S21 | -0.0517073 |
| ACTG1 | actin gamma 1 | -0.0486936 |
| HSD17B12 | hydroxysteroid (17-beta) dehydrogenase 12 | -0.0449404 |
| H1-0 | H1.0 linker histone | -0.0449187 |
| RPL35A | ribosomal protein L35a | -0.041531 |
| WDR45B | WD repeat domain 45B | -0.0414395 |
| PRSS3 | protease, serine, 3 | -0.0408464 |
| S100A10 | S100 calcium binding protein A10 | -0.0403966 |
| PPDPF | pancreatic progenitor cell differentiation and proliferation factor | -0.0361462 |
| RPS24 | ribosomal protein S24 | -0.0355802 |
| TMEM123 | transmembrane protein 123 | -0.0351892 |
| S100A9 | S100 calcium binding protein A9 | -0.03463 |
| PTMA | prothymosin, alpha | -0.0342729 |
| ASNS | asparagine synthetase (glutamine-hydrolyzing) | -0.0330567 |
| INSIG1 | insulin induced gene 1 | -0.0329609 |
| RAB1A | RAB1A, member RAS oncogene family | -0.0316869 |
| GNAS | GNAS complex locus | -0.0314364 |
| DLG1 | discs, large homolog 1 (Drosophila) | -0.0299818 |
| RBM39 | RNA binding motif protein 39 | -0.0299527 |
| GARS1 | glycyl-tRNA synthetase 1 | -0.0296882 |
| ACSS2 | acyl-CoA synthetase short-chain family member 2 | -0.0296509 |
| DEK | DEK proto-oncogene | -0.0285124 |
| GMDS | GDP-mannose 4,6-dehydratase | -0.0284777 |
| NUCKS1 | nuclear casein kinase and cyclin-dependent kinase substrate 1 | -0.0280633 |
| PPIB | peptidylprolyl isomerase B (cyclophilin B) | -0.0277032 |
| MYL12B | myosin, light chain 12B, regulatory | -0.027567 |
| SCD | stearoyl-CoA desaturase (delta-9-desaturase) | -0.027302 |
| TM4SF1 | transmembrane 4 L six family member 1 | -0.0260745 |
| ARL6IP1 | ADP-ribosylation factor-like 6 interacting protein 1 | -0.0253314 |
| RAB2A | RAB2A, member RAS oncogene family | -0.0252765 |
| PPARG | peroxisome proliferator-activated receptor gamma | -0.0251711 |
| H3-3B | H3.3 histone B | -0.024875 |
| ACACA | acetyl-CoA carboxylase alpha | -0.0246889 |
| RPL34 | ribosomal protein L34 | -0.0240231 |
| RPL38 | ribosomal protein L38 | -0.0238182 |
| B2M | beta-2-microglobulin | -0.023712 |
| SMC4 | structural maintenance of chromosomes 4 | -0.0237111 |
| CHCHD2 | coiled-coil-helix-coiled-coil-helix domain containing 2 | -0.0235719 |
| CEP95 | centrosomal protein 95kDa | -0.0232735 |
| YWHAB | tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta | -0.0231242 |
| ST14 | suppression of tumorigenicity 14 (colon carcinoma) | -0.0229788 |
| PFN1 | profilin 1 | -0.0228653 |
| RPLP0 | ribosomal protein, large, P0 | -0.022728 |
| TAX1BP1 | Tax1 (human T-cell leukemia virus type I) binding protein 1 | -0.0224631 |
| COG5 | component of oligomeric golgi complex 5 | -0.0222581 |
| MDK | midkine (neurite growth-promoting factor 2) | -0.0221567 |
| SLC25A5 | solute carrier family 25 (mitochondrial carrier; adenine nucleotide translocator), member 5 | -0.0220908 |
| GSTP1 | glutathione S-transferase pi 1 | -0.0220449 |
| CD2AP | CD2-associated protein | -0.0219736 |
| ZFAND3 | zinc finger, AN1-type domain 3 | -0.0218949 |
| KLK10 | kallikrein-related peptidase 10 | -0.0218003 |
| TMPRSS4 | transmembrane protease, serine 4 | -0.021797 |
| GPX2 | glutathione peroxidase 2 | -0.0217928 |
| EPCAM | epithelial cell adhesion molecule | -0.0217918 |
| LY6E | lymphocyte antigen 6 complex, locus E | -0.0214638 |
| SLC7A11 | solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11 | -0.0212687 |
| FDFT1 | farnesyl-diphosphate farnesyltransferase 1 | -0.0212659 |
| HLA-B | major histocompatibility complex, class I, B | -0.0209983 |
| MON2 | MON2 homolog (S. cerevisiae) | -0.0209835 |
| CLINT1 | clathrin interactor 1 | -0.0209451 |
| NECTIN2 | nectin cell adhesion molecule 2 | -0.0209429 |
| ACBD3 | acyl-CoA binding domain containing 3 | -0.0209386 |
| THOC2 | THO complex 2 | -0.020625 |
| HMGB1 | high mobility group box 1 | -0.0206129 |
| SAMD12 | sterile alpha motif domain containing 12 | -0.0202965 |
| IARS1 | isoleucyl-tRNA synthetase 1 | -0.0201674 |
| KPNB1 | karyopherin (importin) beta 1 | -0.0200087 |
| RPS5 | ribosomal protein S5 | -0.0198234 |
| MUC1 | mucin 1, cell surface associated | -0.019521 |
| NPC1 | Niemann-Pick disease, type C1 | -0.0194131 |
| KRT17 | keratin 17, type I | -0.0192206 |
| ANLN | anillin, actin binding protein | -0.0191355 |
| CLDN4 | claudin 4 | -0.0189743 |
| HMGCS1 | 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble) | -0.0189316 |
| RPL32 | ribosomal protein L32 | -0.0188365 |
| ANKHD1 | ankyrin repeat and KH domain containing 1 | -0.0187148 |
| RPLP1 | ribosomal protein, large, P1 | -0.0185976 |
| ITFG1 | integrin alpha FG-GAP repeat containing 1 | -0.0185388 |
| ZFP36L2 | ZFP36 ring finger protein-like 2 | -0.0182209 |
| AP3B1 | adaptor-related protein complex 3, beta 1 subunit | -0.017979 |
| RBM25 | RNA binding motif protein 25 | -0.0179468 |
| NF1 | neurofibromin 1 | -0.0176655 |
| EGR1 | early growth response 1 | -0.0176534 |
| SLC6A14 | solute carrier family 6 (amino acid transporter), member 14 | -0.0170122 |
| CCNI | cyclin I | -0.0168968 |
| TFF2 | trefoil factor 2 | -0.0167777 |
| LMAN1 | lectin, mannose-binding, 1 | -0.0167179 |
| RNF168 | ring finger protein 168, E3 ubiquitin protein ligase | -0.0167131 |
| ACTR2 | ARP2 actin-related protein 2 homolog (yeast) | -0.0166925 |
| PDCD10 | programmed cell death 10 | -0.0166859 |
