Tolcapone_LS 180 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Tolcapone perturbation in LS 180 cell line (Tahoe Therapeutics)
Similar Terms
Downloads & Tools

Genes

200 genes differentially expressed following the Tolcapone_LS 180 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
FAT1 FAT atypical cadherin 1 0.145151
MUC17 mucin 17, cell surface associated 0.129393
LMO7 LIM domain 7 0.0892114
KRT18 keratin 18, type I 0.0757111
MYO1E myosin IE 0.0646064
SPTBN1 spectrin, beta, non-erythrocytic 1 0.0577741
PSD3 pleckstrin and Sec7 domain containing 3 0.054413
DSPP dentin sialophosphoprotein 0.0524721
MED13 mediator complex subunit 13 0.0505689
GRIN2B glutamate receptor, ionotropic, N-methyl D-aspartate 2B 0.0469511
NFAT5 nuclear factor of activated T-cells 5, tonicity-responsive 0.0469379
EPS8 epidermal growth factor receptor pathway substrate 8 0.0451871
FOXO1 forkhead box O1 0.0450082
SOX9 SRY (sex determining region Y)-box 9 0.0443228
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group) 0.0428657
MYO5B myosin VB 0.0417384
LAMA4 laminin, alpha 4 0.0384859
PDLIM5 PDZ and LIM domain 5 0.0382975
PPP3CA protein phosphatase 3, catalytic subunit, alpha isozyme 0.0380312
ITGA6 integrin, alpha 6 0.0374817
GAREM1 GRB2 associated regulator of MAPK1 subtype 1 0.037269
ATP2B1 ATPase, Ca++ transporting, plasma membrane 1 0.0370016
RNF145 ring finger protein 145 0.0369175
LGR4 leucine-rich repeat containing G protein-coupled receptor 4 0.0363816
MYH9 myosin, heavy chain 9, non-muscle 0.0356683
PELI1 pellino E3 ubiquitin protein ligase 1 0.0350491
SLC2A1 solute carrier family 2 (facilitated glucose transporter), member 1 0.0349484
AKAP13 A kinase (PRKA) anchor protein 13 0.034507
EXT1 exostosin glycosyltransferase 1 0.0337687
TCF7L2 transcription factor 7-like 2 (T-cell specific, HMG-box) 0.0320097
SMAD2 SMAD family member 2 0.0314158
PPP2R2A protein phosphatase 2, regulatory subunit B, alpha 0.0310593
MPRIP myosin phosphatase Rho interacting protein 0.0308498
MACF1 microtubule-actin crosslinking factor 1 0.0303773
ALCAM activated leukocyte cell adhesion molecule 0.0295683
RPL19 ribosomal protein L19 0.0284465
MED13L mediator complex subunit 13-like 0.0284465
NAB1 NGFI-A binding protein 1 (EGR1 binding protein 1) 0.0281093
SVIL supervillin 0.0279752
ACTN4 actinin, alpha 4 0.0279035
BAIAP2L1 BAI1-associated protein 2-like 1 0.0278724
TBC1D8 TBC1 domain family, member 8 (with GRAM domain) 0.0275705
CTBP2 C-terminal binding protein 2 0.0274079
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.0272782
LRCH1 leucine-rich repeats and calponin homology (CH) domain containing 1 0.0272446
PSME4 proteasome (prosome, macropain) activator subunit 4 0.027214
RCOR1 REST corepressor 1 0.0269802
TPM3 tropomyosin 3 0.0264464
LPP LIM domain containing preferred translocation partner in lipoma 0.0262673
CEMIP cell migration inducing protein, hyaluronan binding 0.0261195
B4GALNT3 beta-1,4-N-acetyl-galactosaminyl transferase 3 0.0256494
PTBP3 polypyrimidine tract binding protein 3 0.0249442
MCL1 myeloid cell leukemia 1 0.0247119
WAC WW domain containing adaptor with coiled-coil 0.0245081
MUC13 mucin 13, cell surface associated 0.0242115
UBE2H ubiquitin-conjugating enzyme E2H 0.0234099
YWHAZ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta 0.0232159
CNOT1 CCR4-NOT transcription complex, subunit 1 0.0230326
TEAD1 TEA domain family member 1 (SV40 transcriptional enhancer factor) 0.022977
DIP2B DIP2 disco-interacting protein 2 homolog B (Drosophila) 0.0227435
RNF217 ring finger protein 217 0.0226073
KMT2E lysine (K)-specific methyltransferase 2E 0.0223572
LOC102724023 ES1 protein homolog, mitochondrial 0.0220264
LURAP1L leucine rich adaptor protein 1-like 0.0218967
CTNND1 catenin (cadherin-associated protein), delta 1 0.0218534
MSI2 musashi RNA-binding protein 2 0.0218438
ARHGAP26 Rho GTPase activating protein 26 0.0217708
CSNK1A1 casein kinase 1, alpha 1 0.0216164
FHIP1A FHF complex subunit HOOK interacting protein 1A 0.0215307
PLEC plectin 0.0212394
ITGA2 integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) 0.021211
ANKRD17 ankyrin repeat domain 17 0.0211573
TFG TRK-fused gene 0.0210625
SERINC5 serine incorporator 5 0.020923
CD46 CD46 molecule, complement regulatory protein 0.0208907
MICAL2 microtubule associated monooxygenase, calponin and LIM domain containing 2 0.0208816
PTPRK protein tyrosine phosphatase, receptor type, K 0.0208484
USP6NL USP6 N-terminal like 0.0205121
SLK STE20-like kinase 0.0204227
RREB1 ras responsive element binding protein 1 0.0203185
ERRFI1 ERBB receptor feedback inhibitor 1 0.0200211
PITPNC1 phosphatidylinositol transfer protein, cytoplasmic 1 0.0199852
DYRK1A dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1A 0.0199587
STT3B STT3B, subunit of the oligosaccharyltransferase complex (catalytic) 0.0199414
COPA coatomer protein complex, subunit alpha 0.0198599
USP9X ubiquitin specific peptidase 9, X-linked 0.0197636
RAB3GAP1 RAB3 GTPase activating protein subunit 1 (catalytic) 0.0194037
SPTAN1 spectrin, alpha, non-erythrocytic 1 0.0193855
ZSWIM6 zinc finger, SWIM-type containing 6 0.0193755
LRRC1 leucine rich repeat containing 1 0.019238
GULP1 GULP, engulfment adaptor PTB domain containing 1 0.0191445
ADAM19 ADAM metallopeptidase domain 19 0.0188949
PUM2 pumilio RNA-binding family member 2 0.0188888
TRIO trio Rho guanine nucleotide exchange factor 0.0187646
TXNIP thioredoxin interacting protein 0.0185806
KRT8 keratin 8, type II 0.018513
SFPQ splicing factor proline/glutamine-rich 0.0184781
ABHD2 abhydrolase domain containing 2 0.0184771
SAMD5 sterile alpha motif domain containing 5 0.0184425
CLCN3 chloride channel, voltage-sensitive 3 0.0182338

decreased expression

Symbol Name Standardized Value
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.278954
RPS6 ribosomal protein S6 -0.175449
TPT1 tumor protein, translationally-controlled 1 -0.135977
RPL35A ribosomal protein L35a -0.117377
PTMA prothymosin, alpha -0.116544
TMSB10 thymosin beta 10 -0.11356
RPLP1 ribosomal protein, large, P1 -0.105297
RPS8 ribosomal protein S8 -0.0889998
FTL ferritin, light polypeptide -0.0846169
RPL34 ribosomal protein L34 -0.0806536
RPLP2 ribosomal protein, large, P2 -0.0788226
RPS29 ribosomal protein S29 -0.0773677
RPL37A ribosomal protein L37a -0.0730366
RPS19 ribosomal protein S19 -0.0682274
RPS13 ribosomal protein S13 -0.0667278
RPL12 ribosomal protein L12 -0.0660556
RPS27A ribosomal protein S27a -0.06423
RPS23 ribosomal protein S23 -0.0630621
MT2A metallothionein 2A -0.0610211
RPS24 ribosomal protein S24 -0.0580625
RPL36 ribosomal protein L36 -0.0564328
ACTG1 actin gamma 1 -0.0554276
RPL23 ribosomal protein L23 -0.0542958
RPL9 ribosomal protein L9 -0.0541443
RPL31 ribosomal protein L31 -0.0532355
RPL38 ribosomal protein L38 -0.0530936
RPL7A ribosomal protein L7a -0.0525128
RPS25 ribosomal protein S25 -0.0519911
EIF1 eukaryotic translation initiation factor 1 -0.0486264
RPL13A ribosomal protein L13a -0.0469459
RPS3 ribosomal protein S3 -0.0467482
TNS4 tensin 4 -0.0461843
PKM pyruvate kinase, muscle -0.0459719
RPS11 ribosomal protein S11 -0.0454341
AGR2 anterior gradient 2 -0.0452964
RPL26 ribosomal protein L26 -0.0440969
S100A10 S100 calcium binding protein A10 -0.0438748
RPL5 ribosomal protein L5 -0.0433328
PABPC1 poly(A) binding protein, cytoplasmic 1 -0.0426879
MUC6 mucin 6, oligomeric mucus/gel-forming -0.0424587
RPL32 ribosomal protein L32 -0.0416335
RPS21 ribosomal protein S21 -0.041593
RPL28 ribosomal protein L28 -0.0395693
RPL11 ribosomal protein L11 -0.039246
VDAC1 voltage-dependent anion channel 1 -0.0383236
GPRC5A G protein-coupled receptor, class C, group 5, member A -0.0366882
RPS20 ribosomal protein S20 -0.0358087
RPL8 ribosomal protein L8 -0.0352821
IER3 immediate early response 3 -0.0352815
RPL37 ribosomal protein L37 -0.0350026
HMGB1 high mobility group box 1 -0.034818
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 -0.0345293
RPS27 ribosomal protein S27 -0.034346
HSPD1 heat shock 60kDa protein 1 (chaperonin) -0.0334247
ANXA2 annexin A2 -0.0326961
RPL36A ribosomal protein L36a -0.0325837
RPS14 ribosomal protein S14 -0.0324076
EGR1 early growth response 1 -0.0323431
RPS16 ribosomal protein S16 -0.0318965
TPM4 tropomyosin 4 -0.0317478
KPNB1 karyopherin (importin) beta 1 -0.0316684
RPLP0 ribosomal protein, large, P0 -0.0315645
PNISR PNN-interacting serine/arginine-rich protein -0.0314611
GOLGA4 golgin A4 -0.0311607
RPS15 ribosomal protein S15 -0.0306608
RPL27A ribosomal protein L27a -0.0306194
SLC25A3 solute carrier family 25 (mitochondrial carrier; phosphate carrier), member 3 -0.0294777
S100P S100 calcium binding protein P -0.0293453
UQCRB ubiquinol-cytochrome c reductase binding protein -0.0292734
RPL17-C18ORF32 RPL17-C18orf32 readthrough -0.0291266
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.0289774
HNRNPH1 heterogeneous nuclear ribonucleoprotein H1 (H) -0.0287828
RPL15 ribosomal protein L15 -0.0274864
ATP5F1B ATP synthase F1 subunit beta -0.0272154
YWHAB tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta -0.0267752
RPS17 ribosomal protein S17 -0.0266476
RPL30 ribosomal protein L30 -0.026537
RPL27 ribosomal protein L27 -0.0263262
RAN RAN, member RAS oncogene family -0.0261649
PSMA7 proteasome (prosome, macropain) subunit, alpha type, 7 -0.025781
S100A6 S100 calcium binding protein A6 -0.0256037
KTN1 kinectin 1 (kinesin receptor) -0.0250949
DEK DEK proto-oncogene -0.0249995
S100A9 S100 calcium binding protein A9 -0.024963
MUC5AC mucin 5AC, oligomeric mucus/gel-forming -0.0245102
GNAS GNAS complex locus -0.0243269
RPS10 ribosomal protein S10 -0.0238378
H2AZ1 H2A.Z variant histone 1 -0.0237158
MT1X metallothionein 1X -0.0235326
GSTP1 glutathione S-transferase pi 1 -0.0235187
RNF43 ring finger protein 43 -0.0234557
SELENOK selenoprotein K -0.0233481
GPHN gephyrin -0.0231096
EIF5B eukaryotic translation initiation factor 5B -0.0230436
VIM vimentin -0.0229791
SLC25A5 solute carrier family 25 (mitochondrial carrier; adenine nucleotide translocator), member 5 -0.0225627
SCD stearoyl-CoA desaturase (delta-9-desaturase) -0.022257
COX5A cytochrome c oxidase subunit Va -0.0221415
TBCA tubulin folding cofactor A -0.0221331
GCC2 GRIP and coiled-coil domain containing 2 -0.0220069