| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | Tolcapone perturbation in MIA PaCa-2 cell line (Tahoe Therapeutics) |
| Similar Terms | |
| Downloads & Tools |
200 genes differentially expressed following the Tolcapone_MIA PaCa-2 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| DST | dystonin | 0.0645264 |
| MACF1 | microtubule-actin crosslinking factor 1 | 0.0607071 |
| WWTR1 | WW domain containing transcription regulator 1 | 0.0605978 |
| BCAR3 | breast cancer anti-estrogen resistance 3 | 0.0553446 |
| PSD3 | pleckstrin and Sec7 domain containing 3 | 0.0549092 |
| CAPRIN2 | caprin family member 2 | 0.0537587 |
| RPL19 | ribosomal protein L19 | 0.0448827 |
| ZBTB38 | zinc finger and BTB domain containing 38 | 0.0369362 |
| FMNL2 | formin-like 2 | 0.0366618 |
| VCL | vinculin | 0.0348553 |
| ZSWIM6 | zinc finger, SWIM-type containing 6 | 0.0334683 |
| NPAS2 | neuronal PAS domain protein 2 | 0.0327866 |
| ITGB1 | integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) | 0.0318251 |
| TM4SF1 | transmembrane 4 L six family member 1 | 0.0314885 |
| LOXL2 | lysyl oxidase-like 2 | 0.0299508 |
| SPAG9 | sperm associated antigen 9 | 0.0289057 |
| MYH9 | myosin, heavy chain 9, non-muscle | 0.0288353 |
| CMIP | c-Maf inducing protein | 0.0287157 |
| SCD | stearoyl-CoA desaturase (delta-9-desaturase) | 0.0281032 |
| NCEH1 | neutral cholesterol ester hydrolase 1 | 0.0275862 |
| SMAD3 | SMAD family member 3 | 0.0260234 |
| APLP2 | amyloid beta (A4) precursor-like protein 2 | 0.0251801 |
| ERRFI1 | ERBB receptor feedback inhibitor 1 | 0.0250988 |
| DSCAM | Down syndrome cell adhesion molecule | 0.0244906 |
| BIRC3 | baculoviral IAP repeat containing 3 | 0.0231859 |
| RCOR1 | REST corepressor 1 | 0.0231611 |
| TFPI | tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor) | 0.0228494 |
| INTS6 | integrator complex subunit 6 | 0.02268 |
| CFLAR | CASP8 and FADD-like apoptosis regulator | 0.0216909 |
| HNRNPA2B1 | heterogeneous nuclear ribonucleoprotein A2/B1 | 0.0206255 |
| HOMER1 | homer scaffolding protein 1 | 0.0203208 |
| SDCCAG8 | serologically defined colon cancer antigen 8 | 0.0200152 |
| PRELID2 | PRELI domain containing 2 | 0.0199514 |
| SPTAN1 | spectrin, alpha, non-erythrocytic 1 | 0.0198298 |
| IGF2BP3 | insulin-like growth factor 2 mRNA binding protein 3 | 0.0197711 |
| DYNC1H1 | dynein, cytoplasmic 1, heavy chain 1 | 0.0194772 |
| BNIP3L | BCL2/adenovirus E1B 19kDa interacting protein 3-like | 0.01872 |
| ARHGAP5 | Rho GTPase activating protein 5 | 0.0187167 |
| SLC4A7 | solute carrier family 4, sodium bicarbonate cotransporter, member 7 | 0.0182638 |
| NEK10 | NIMA-related kinase 10 | 0.0177107 |
| TRIP12 | thyroid hormone receptor interactor 12 | 0.0176652 |
| EIF4G3 | eukaryotic translation initiation factor 4 gamma, 3 | 0.0173554 |
| HSP90AB1 | heat shock protein 90kDa alpha (cytosolic), class B member 1 | 0.0173282 |
| USP12 | ubiquitin specific peptidase 12 | 0.0173145 |
| ERC1 | ELKS/RAB6-interacting/CAST family member 1 | 0.0171969 |
| SVIL | supervillin | 0.0170595 |
| RUNX1 | runt-related transcription factor 1 | 0.0169357 |
| HSPA5 | heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) | 0.0167262 |
| RAD51B | RAD51 paralog B | 0.0165901 |
| TXNRD1 | thioredoxin reductase 1 | 0.0162811 |
| RAPH1 | Ras association (RalGDS/AF-6) and pleckstrin homology domains 1 | 0.0161787 |
| SLC20A1 | solute carrier family 20 (phosphate transporter), member 1 | 0.0161045 |
| AREG | amphiregulin | 0.0160957 |
| MYOF | myoferlin | 0.0159515 |
| TRIO | trio Rho guanine nucleotide exchange factor | 0.0159065 |
| RFFL | ring finger and FYVE-like domain containing E3 ubiquitin protein ligase | 0.0150409 |
| SYNE2 | spectrin repeat containing, nuclear envelope 2 | 0.0150128 |
| MBD5 | methyl-CpG binding domain protein 5 | 0.0149251 |
| MCL1 | myeloid cell leukemia 1 | 0.0149039 |
| CAPN2 | calpain 2, (m/II) large subunit | 0.0142677 |
| RERE | arginine-glutamic acid dipeptide (RE) repeats | 0.0141229 |
| ZEB1 | zinc finger E-box binding homeobox 1 | 0.0140688 |
| KDM4C | lysine (K)-specific demethylase 4C | 0.0140557 |
| SOX9 | SRY (sex determining region Y)-box 9 | 0.0138896 |
| MB21D2 | Mab-21 domain containing 2 | 0.0138752 |
| IGF2BP2 | insulin-like growth factor 2 mRNA binding protein 2 | 0.0138343 |
| UAP1 | UDP-N-acetylglucosamine pyrophosphorylase 1 | 0.0138157 |
| ADARB1 | adenosine deaminase, RNA-specific, B1 | 0.0138024 |
| JMJD1C | jumonji domain containing 1C | 0.0134346 |
| HIVEP3 | human immunodeficiency virus type I enhancer binding protein 3 | 0.0134133 |
| CTNNA1 | catenin (cadherin-associated protein), alpha 1, 102kDa | 0.0133339 |
| RPS12 | ribosomal protein S12 | 0.0131959 |
| FNIP1 | folliculin interacting protein 1 | 0.0131829 |
| EMP1 | epithelial membrane protein 1 | 0.013181 |
| AGAP1 | ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 | 0.0131775 |
| ASAP1 | ArfGAP with SH3 domain, ankyrin repeat and PH domain 1 | 0.0130476 |
| PDLIM5 | PDZ and LIM domain 5 | 0.0126398 |
| WDR27 | WD repeat domain 27 | 0.012576 |
| PLEC | plectin | 0.0124103 |
| GLS2 | glutaminase 2 (liver, mitochondrial) | 0.0123764 |
| KDM4B | lysine (K)-specific demethylase 4B | 0.0123537 |
| CSNK1A1 | casein kinase 1, alpha 1 | 0.0123412 |
| SFPQ | splicing factor proline/glutamine-rich | 0.0122863 |
| CEP250 | centrosomal protein 250kDa | 0.0121883 |
| PIEZO1 | piezo-type mechanosensitive ion channel component 1 | 0.0121847 |
| PYGB | phosphorylase, glycogen; brain | 0.0119413 |
| SND1 | staphylococcal nuclease and tudor domain containing 1 | 0.0118913 |
| TOP1 | topoisomerase (DNA) I | 0.0117855 |
| DNAJB6 | DnaJ (Hsp40) homolog, subfamily B, member 6 | 0.0117171 |
| HIVEP2 | human immunodeficiency virus type I enhancer binding protein 2 | 0.0117046 |
| DIAPH1 | diaphanous-related formin 1 | 0.0115987 |
| SPTBN1 | spectrin, beta, non-erythrocytic 1 | 0.011502 |
| CAMTA1 | calmodulin binding transcription activator 1 | 0.0114361 |
| HERC4 | HECT and RLD domain containing E3 ubiquitin protein ligase 4 | 0.0114039 |
| USP9X | ubiquitin specific peptidase 9, X-linked | 0.0113462 |
| HDLBP | high density lipoprotein binding protein | 0.0112615 |
| NFAT5 | nuclear factor of activated T-cells 5, tonicity-responsive | 0.0111948 |
| HSPA8 | heat shock 70kDa protein 8 | 0.0111615 |
| EZR | ezrin | 0.0111593 |
| SMURF2 | SMAD specific E3 ubiquitin protein ligase 2 | 0.0111324 |
| Symbol | Name | Standardized Value |
|---|---|---|
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | -0.200687 |
| POTEF | POTE ankyrin domain family, member F | -0.0806045 |
| PTMA | prothymosin, alpha | -0.0622006 |
| HLA-B | major histocompatibility complex, class I, B | -0.0571353 |
| IL1RAPL1 | interleukin 1 receptor accessory protein-like 1 | -0.047417 |
| TMSB10 | thymosin beta 10 | -0.0409233 |
| SEMA3A | sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3A | -0.0371044 |
| RPS6 | ribosomal protein S6 | -0.036708 |
| DLG1 | discs, large homolog 1 (Drosophila) | -0.0349448 |
| FTH1 | ferritin, heavy polypeptide 1 | -0.0331928 |
| RPL35A | ribosomal protein L35a | -0.0316084 |
| SERPINE1 | serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 | -0.0302987 |
| ZMYND8 | zinc finger, MYND-type containing 8 | -0.0301731 |
| ACTG1 | actin gamma 1 | -0.0269887 |
| NUCKS1 | nuclear casein kinase and cyclin-dependent kinase substrate 1 | -0.0258199 |
| WSB1 | WD repeat and SOCS box containing 1 | -0.0246322 |
| FTL | ferritin, light polypeptide | -0.0230339 |
| KPNB1 | karyopherin (importin) beta 1 | -0.0221937 |
| GPRC5A | G protein-coupled receptor, class C, group 5, member A | -0.0213881 |
| VDAC1 | voltage-dependent anion channel 1 | -0.0210341 |
| KHDRBS1 | KH domain containing, RNA binding, signal transduction associated 1 | -0.020972 |
| CD44 | CD44 molecule (Indian blood group) | -0.0209631 |
| SEMA3C | sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C | -0.0208245 |
| TP63 | tumor protein p63 | -0.0206296 |
| EGR1 | early growth response 1 | -0.0201772 |
| PABPC1 | poly(A) binding protein, cytoplasmic 1 | -0.0201727 |
| NPEPPS | aminopeptidase puromycin sensitive | -0.0192725 |
| VIM | vimentin | -0.0184187 |
| PTPRF | protein tyrosine phosphatase, receptor type, F | -0.0178679 |
| SERPINA3 | serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 3 | -0.0178325 |
| TNS3 | tensin 3 | -0.0178053 |
| TAPBP | TAP binding protein (tapasin) | -0.0174819 |
| RPS19 | ribosomal protein S19 | -0.0173255 |
| RPS13 | ribosomal protein S13 | -0.0170744 |
| RIGI | RNA sensor RIG-I | -0.0167926 |
| B2M | beta-2-microglobulin | -0.0162896 |
| GNAS | GNAS complex locus | -0.0160935 |
| RBM25 | RNA binding motif protein 25 | -0.0158153 |
| PRKRIP1 | PRKR interacting protein 1 (IL11 inducible) | -0.0153966 |
| ZNF148 | zinc finger protein 148 | -0.0151789 |
| MT1E | metallothionein 1E | -0.014957 |
| EEF2 | eukaryotic translation elongation factor 2 | -0.0148522 |
| TOMM20 | translocase of outer mitochondrial membrane 20 homolog (yeast) | -0.014836 |
| ADAM10 | ADAM metallopeptidase domain 10 | -0.0147845 |
| THOC2 | THO complex 2 | -0.0147349 |
| P4HA1 | prolyl 4-hydroxylase, alpha polypeptide I | -0.0147096 |
| S100A9 | S100 calcium binding protein A9 | -0.0147022 |
| LDHA | lactate dehydrogenase A | -0.0145765 |
| ZFP36L1 | ZFP36 ring finger protein-like 1 | -0.0145485 |
| WASF2 | WAS protein family, member 2 | -0.0144653 |
| RASSF8 | Ras association (RalGDS/AF-6) domain family (N-terminal) member 8 | -0.0142947 |
| TMSB4X | thymosin beta 4, X-linked | -0.0140951 |
| PTK2 | protein tyrosine kinase 2 | -0.0140381 |
| PFN1 | profilin 1 | -0.0140341 |
| MATR3 | matrin 3 | -0.0139266 |
| CANX | calnexin | -0.0139188 |
| EIF3M | eukaryotic translation initiation factor 3, subunit M | -0.0138279 |
| MAP3K2 | mitogen-activated protein kinase kinase kinase 2 | -0.013795 |
| EFNA5 | ephrin-A5 | -0.0137224 |
| IFIH1 | interferon induced with helicase C domain 1 | -0.0136777 |
| RPL28 | ribosomal protein L28 | -0.0135274 |
| TANC2 | tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 2 | -0.0132762 |
| ERO1A | endoplasmic reticulum oxidoreductase 1 alpha | -0.0132621 |
| CADM2 | cell adhesion molecule 2 | -0.0132618 |
| MYADM | myeloid-associated differentiation marker | -0.0131917 |
| FAF1 | Fas (TNFRSF6) associated factor 1 | -0.0128508 |
| IFITM1 | interferon induced transmembrane protein 1 | -0.0128271 |
| CENPF | centromere protein F, 350/400kDa | -0.0127661 |
| SEPTIN7 | septin 7 | -0.0127097 |
| PKM | pyruvate kinase, muscle | -0.0127095 |
| RPS21 | ribosomal protein S21 | -0.012695 |
| LOC112694756 | uncharaterized LOC112694756 | -0.0125855 |
| RLF | rearranged L-myc fusion | -0.0125635 |
| EIF2AK2 | eukaryotic translation initiation factor 2-alpha kinase 2 | -0.012518 |
| SRGAP1 | SLIT-ROBO Rho GTPase activating protein 1 | -0.0124327 |
| RBMX | RNA binding motif protein, X-linked | -0.0123345 |
| EPHA4 | EPH receptor A4 | -0.0122938 |
| NIPSNAP2 | nipsnap homolog 2 | -0.0122487 |
| MAP1LC3B | microtubule-associated protein 1 light chain 3 beta | -0.0122244 |
| DPH6 | diphthamine biosynthesis 6 | -0.0120927 |
| TTC28 | tetratricopeptide repeat domain 28 | -0.0120778 |
| TNFRSF6B | tumor necrosis factor receptor superfamily, member 6b, decoy | -0.0120511 |
| TMEM123 | transmembrane protein 123 | -0.0119639 |
| ENO1 | enolase 1, (alpha) | -0.0119492 |
| RPL8 | ribosomal protein L8 | -0.0119076 |
| TFDP2 | transcription factor Dp-2 (E2F dimerization partner 2) | -0.0118556 |
| RBPJ | recombination signal binding protein for immunoglobulin kappa J region | -0.0116852 |
| SLC25A6 | solute carrier family 25 (mitochondrial carrier; adenine nucleotide translocator), member 6 | -0.0116574 |
| HLA-A | major histocompatibility complex, class I, A | -0.0116403 |
| ZC3HAV1 | zinc finger CCCH-type, antiviral 1 | -0.0115394 |
| HSPB1 | heat shock 27kDa protein 1 | -0.0113852 |
| NOP58 | NOP58 ribonucleoprotein | -0.0112401 |
| LY6E | lymphocyte antigen 6 complex, locus E | -0.0111476 |
| ANKIB1 | ankyrin repeat and IBR domain containing 1 | -0.0111026 |
| SEC24A | SEC24 family member A | -0.0110486 |
| ALDH7A1 | aldehyde dehydrogenase 7 family, member A1 | -0.0109989 |
| CNOT2 | CCR4-NOT transcription complex, subunit 2 | -0.010907 |
| TCERG1 | transcription elongation regulator 1 | -0.0108977 |
| TOP2A | topoisomerase (DNA) II alpha 170kDa | -0.0108972 |
| ASTN2 | astrotactin 2 | -0.0108968 |
