| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | Tolcapone perturbation in NCI-H1573 cell line (Tahoe Therapeutics) |
| Similar Terms | |
| Downloads & Tools |
200 genes differentially expressed following the Tolcapone_NCI-H1573 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| EGFR | epidermal growth factor receptor | 0.213059 |
| ERO1A | endoplasmic reticulum oxidoreductase 1 alpha | 0.187715 |
| CES1 | carboxylesterase 1 | 0.122496 |
| SEMA3C | sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C | 0.114941 |
| SPAG9 | sperm associated antigen 9 | 0.102643 |
| SLTM | SAFB-like, transcription modulator | 0.100409 |
| NAMPT | nicotinamide phosphoribosyltransferase | 0.0927761 |
| PDE4D | phosphodiesterase 4D, cAMP-specific | 0.0875737 |
| ERRFI1 | ERBB receptor feedback inhibitor 1 | 0.0866108 |
| ELL2 | elongation factor, RNA polymerase II, 2 | 0.0824395 |
| FTH1 | ferritin, heavy polypeptide 1 | 0.076959 |
| DSCAM | Down syndrome cell adhesion molecule | 0.075312 |
| GRAMD1B | GRAM domain containing 1B | 0.0742385 |
| MYH9 | myosin, heavy chain 9, non-muscle | 0.0713681 |
| MCL1 | myeloid cell leukemia 1 | 0.0709939 |
| TXNRD1 | thioredoxin reductase 1 | 0.0706762 |
| MYOF | myoferlin | 0.0681967 |
| ARIH1 | ariadne RBR E3 ubiquitin protein ligase 1 | 0.0679887 |
| FAM13A | family with sequence similarity 13, member A | 0.0667901 |
| LMO7 | LIM domain 7 | 0.066029 |
| RUNX1 | runt-related transcription factor 1 | 0.0648364 |
| HIVEP2 | human immunodeficiency virus type I enhancer binding protein 2 | 0.0644101 |
| RBPJ | recombination signal binding protein for immunoglobulin kappa J region | 0.0600475 |
| TOP1 | topoisomerase (DNA) I | 0.0599576 |
| DOCK5 | dedicator of cytokinesis 5 | 0.0595082 |
| FHIP1A | FHF complex subunit HOOK interacting protein 1A | 0.05812 |
| ARRDC3 | arrestin domain containing 3 | 0.0568922 |
| PM20D1 | peptidase M20 domain containing 1 | 0.0563275 |
| KMT2E | lysine (K)-specific methyltransferase 2E | 0.0555417 |
| PLEC | plectin | 0.0549789 |
| HNRNPU | heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) | 0.054064 |
| AGO2 | argonaute RISC catalytic component 2 | 0.0534759 |
| ASPH | aspartate beta-hydroxylase | 0.0531436 |
| NFKB1 | nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 | 0.0529113 |
| THSD4 | thrombospondin, type I, domain containing 4 | 0.0517436 |
| RNF145 | ring finger protein 145 | 0.051489 |
| PPP6R3 | protein phosphatase 6, regulatory subunit 3 | 0.0507807 |
| JMJD1C | jumonji domain containing 1C | 0.0505814 |
| MCTP1 | multiple C2 domains, transmembrane 1 | 0.0504179 |
| CAPZA2 | capping protein (actin filament) muscle Z-line, alpha 2 | 0.0502221 |
| INTS6 | integrator complex subunit 6 | 0.0492725 |
| UVRAG | UV radiation resistance associated | 0.049177 |
| SOD2 | superoxide dismutase 2, mitochondrial | 0.0488805 |
| LOC112694756 | uncharaterized LOC112694756 | 0.0483804 |
| SHANK2 | SH3 and multiple ankyrin repeat domains 2 | 0.0480916 |
| HELZ | helicase with zinc finger | 0.0476137 |
| ZC3H11A | zinc finger CCCH-type containing 11A | 0.0470425 |
| RICTOR | RPTOR independent companion of MTOR, complex 2 | 0.0466854 |
| SMAD3 | SMAD family member 3 | 0.0457675 |
| PDLIM5 | PDZ and LIM domain 5 | 0.0457246 |
| PTPRJ | protein tyrosine phosphatase, receptor type, J | 0.0454788 |
| HYOU1 | hypoxia up-regulated 1 | 0.045396 |
| HOMER1 | homer scaffolding protein 1 | 0.0447042 |
| PYGL | phosphorylase, glycogen, liver | 0.0445258 |
| USP9X | ubiquitin specific peptidase 9, X-linked | 0.0441682 |
| BCAR3 | breast cancer anti-estrogen resistance 3 | 0.0436423 |
| NEDD4L | neural precursor cell expressed, developmentally down-regulated 4-like, E3 ubiquitin protein ligase | 0.0432746 |
| GSK3B | glycogen synthase kinase 3 beta | 0.0429421 |
| NR3C1 | nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor) | 0.0427417 |
| GCLC | glutamate-cysteine ligase, catalytic subunit | 0.0415245 |
| TSC22D2 | TSC22 domain family, member 2 | 0.0413801 |
| FZR1 | fizzy/cell division cycle 20 related 1 (Drosophila) | 0.0411348 |
| TBC1D22A | TBC1 domain family, member 22A | 0.0406835 |
| NPTN | neuroplastin | 0.0386111 |
| CTNNA1 | catenin (cadherin-associated protein), alpha 1, 102kDa | 0.0371865 |
| ATP13A3 | ATPase type 13A3 | 0.0371085 |
| DYNC1H1 | dynein, cytoplasmic 1, heavy chain 1 | 0.0368544 |
| ATP2B1 | ATPase, Ca++ transporting, plasma membrane 1 | 0.0366867 |
| HSPA8 | heat shock 70kDa protein 8 | 0.0365883 |
| HOOK2 | hook microtubule-tethering protein 2 | 0.0365624 |
| PCBP2 | poly(rC) binding protein 2 | 0.0364451 |
| EFNA5 | ephrin-A5 | 0.036384 |
| DTNA | dystrobrevin, alpha | 0.0362547 |
| UBC | ubiquitin C | 0.0361456 |
| DSPP | dentin sialophosphoprotein | 0.0354871 |
| TPD52 | tumor protein D52 | 0.0354533 |
| ANKRD37 | ankyrin repeat domain 37 | 0.0352585 |
| PHLDA1 | pleckstrin homology-like domain, family A, member 1 | 0.0352262 |
| PAPOLA | poly(A) polymerase alpha | 0.0350034 |
| ABTB2 | ankyrin repeat and BTB (POZ) domain containing 2 | 0.034306 |
| SIK3 | SIK family kinase 3 | 0.034097 |
| DYRK1A | dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1A | 0.0340072 |
| EGLN3 | egl-9 family hypoxia-inducible factor 3 | 0.0337927 |
| ANO6 | anoctamin 6 | 0.0336416 |
| VOPP1 | vesicular, overexpressed in cancer, prosurvival protein 1 | 0.0335754 |
| MYO1E | myosin IE | 0.0334922 |
| UBA6 | ubiquitin-like modifier activating enzyme 6 | 0.0331156 |
| ECT2 | epithelial cell transforming 2 | 0.0330726 |
| HUWE1 | HECT, UBA and WWE domain containing 1, E3 ubiquitin protein ligase | 0.0330275 |
| ROBO1 | roundabout, axon guidance receptor, homolog 1 (Drosophila) | 0.0330067 |
| PUM2 | pumilio RNA-binding family member 2 | 0.0329091 |
| PTPRM | protein tyrosine phosphatase, receptor type, M | 0.0319156 |
| MACF1 | microtubule-actin crosslinking factor 1 | 0.0318412 |
| KCMF1 | potassium channel modulatory factor 1 | 0.0313847 |
| PITPNC1 | phosphatidylinositol transfer protein, cytoplasmic 1 | 0.0311973 |
| EPAS1 | endothelial PAS domain protein 1 | 0.0311913 |
| CNOT1 | CCR4-NOT transcription complex, subunit 1 | 0.0311381 |
| NSUN6 | NOP2/Sun domain family, member 6 | 0.0307277 |
| YWHAZ | tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta | 0.0307103 |
| TNFAIP8 | tumor necrosis factor, alpha-induced protein 8 | 0.0306885 |
| Symbol | Name | Standardized Value |
|---|---|---|
| MT2A | metallothionein 2A | -0.157249 |
| TMSB10 | thymosin beta 10 | -0.110401 |
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | -0.102929 |
| TPT1 | tumor protein, translationally-controlled 1 | -0.0998386 |
| ACTG1 | actin gamma 1 | -0.0696862 |
| EGR1 | early growth response 1 | -0.069426 |
| RPL35A | ribosomal protein L35a | -0.0631085 |
| CEACAM5 | carcinoembryonic antigen-related cell adhesion molecule 5 | -0.0577977 |
| MYL12A | myosin, light chain 12A, regulatory, non-sarcomeric | -0.0504899 |
| RPL37A | ribosomal protein L37a | -0.0454572 |
| RPS24 | ribosomal protein S24 | -0.0444352 |
| SLC38A1 | solute carrier family 38, member 1 | -0.041073 |
| HLA-B | major histocompatibility complex, class I, B | -0.0405552 |
| SEC61G | Sec61 gamma subunit | -0.0390701 |
| ZMYND8 | zinc finger, MYND-type containing 8 | -0.0381355 |
| LAMC2 | laminin, gamma 2 | -0.0350306 |
| RPL31 | ribosomal protein L31 | -0.0346194 |
| BLZF1 | basic leucine zipper nuclear factor 1 | -0.0337667 |
| RBM25 | RNA binding motif protein 25 | -0.0335588 |
| IER3 | immediate early response 3 | -0.0325689 |
| ANKRD12 | ankyrin repeat domain 12 | -0.0320873 |
| RPS3 | ribosomal protein S3 | -0.0317258 |
| RPL9 | ribosomal protein L9 | -0.0315546 |
| MT1X | metallothionein 1X | -0.0314956 |
| FTL | ferritin, light polypeptide | -0.0307239 |
| ZBTB20 | zinc finger and BTB domain containing 20 | -0.0292947 |
| B2M | beta-2-microglobulin | -0.0287052 |
| HM13 | histocompatibility (minor) 13 | -0.0283146 |
| CALM1 | calmodulin 1 (phosphorylase kinase, delta) | -0.027904 |
| RPS29 | ribosomal protein S29 | -0.0274702 |
| RPS27A | ribosomal protein S27a | -0.0273587 |
| YWHAB | tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta | -0.0270771 |
| RPL34 | ribosomal protein L34 | -0.0267492 |
| MKNK2 | MAP kinase interacting serine/threonine kinase 2 | -0.0264098 |
| IFI6 | interferon, alpha-inducible protein 6 | -0.0263784 |
| LANCL2 | LanC lantibiotic synthetase component C-like 2 (bacterial) | -0.0258692 |
| CST3 | cystatin C | -0.0256979 |
| ID1 | inhibitor of DNA binding 1, dominant negative helix-loop-helix protein | -0.0245553 |
| EIF1 | eukaryotic translation initiation factor 1 | -0.0240815 |
| POTEF | POTE ankyrin domain family, member F | -0.0239353 |
| STAT1 | signal transducer and activator of transcription 1, 91kDa | -0.0238864 |
| S100A11 | S100 calcium binding protein A11 | -0.0236788 |
| RPS8 | ribosomal protein S8 | -0.0235401 |
| RPLP1 | ribosomal protein, large, P1 | -0.02353 |
| RPLP2 | ribosomal protein, large, P2 | -0.0234929 |
| S100A6 | S100 calcium binding protein A6 | -0.0234845 |
| MYL12B | myosin, light chain 12B, regulatory | -0.0234699 |
| RPS6 | ribosomal protein S6 | -0.023256 |
| AREG | amphiregulin | -0.023227 |
| RTN4 | reticulon 4 | -0.0232075 |
| ARPC2 | actin related protein 2/3 complex, subunit 2, 34kDa | -0.0230874 |
| S100A9 | S100 calcium binding protein A9 | -0.0229269 |
| VIM | vimentin | -0.0228366 |
| RABGEF1 | RAB guanine nucleotide exchange factor (GEF) 1 | -0.0227682 |
| PSMA7 | proteasome (prosome, macropain) subunit, alpha type, 7 | -0.022657 |
| WSB1 | WD repeat and SOCS box containing 1 | -0.0221755 |
| H3-3B | H3.3 histone B | -0.0220868 |
| EIF2AK2 | eukaryotic translation initiation factor 2-alpha kinase 2 | -0.0214584 |
| GFPT1 | glutamine--fructose-6-phosphate transaminase 1 | -0.0214524 |
| RPL37 | ribosomal protein L37 | -0.0206924 |
| RPL36A | ribosomal protein L36a | -0.0202512 |
| RPS21 | ribosomal protein S21 | -0.0202367 |
| PTMA | prothymosin, alpha | -0.0201113 |
| ATP1B1 | ATPase, Na+/K+ transporting, beta 1 polypeptide | -0.0200418 |
| UQCRB | ubiquinol-cytochrome c reductase binding protein | -0.0199732 |
| KPNB1 | karyopherin (importin) beta 1 | -0.0198307 |
| MTDH | metadherin | -0.019749 |
| S100A10 | S100 calcium binding protein A10 | -0.0195002 |
| TPM4 | tropomyosin 4 | -0.0193657 |
| CAV2 | caveolin 2 | -0.0192855 |
| RPS19 | ribosomal protein S19 | -0.01901 |
| PDXDC1 | pyridoxal-dependent decarboxylase domain containing 1 | -0.0189335 |
| RPL36 | ribosomal protein L36 | -0.0188915 |
| RPL38 | ribosomal protein L38 | -0.0187333 |
| RPL11 | ribosomal protein L11 | -0.0186298 |
| VDAC1 | voltage-dependent anion channel 1 | -0.018515 |
| TM4SF1 | transmembrane 4 L six family member 1 | -0.0184809 |
| SLC25A37 | solute carrier family 25 (mitochondrial iron transporter), member 37 | -0.0183237 |
| C15ORF48 | chromosome 15 open reading frame 48 | -0.0183066 |
| FOSL1 | FOS-like antigen 1 | -0.0183017 |
| RPS16 | ribosomal protein S16 | -0.0182226 |
| RPS13 | ribosomal protein S13 | -0.0175756 |
| TMTC2 | transmembrane and tetratricopeptide repeat containing 2 | -0.0173065 |
| COX4I1 | cytochrome c oxidase subunit IV isoform 1 | -0.0170263 |
| RPL23 | ribosomal protein L23 | -0.0169137 |
| ACBD3 | acyl-CoA binding domain containing 3 | -0.0166027 |
| AGR2 | anterior gradient 2 | -0.0161774 |
| SDC4 | syndecan 4 | -0.0158804 |
| TCF25 | transcription factor 25 (basic helix-loop-helix) | -0.0158478 |
| ENO2 | enolase 2 (gamma, neuronal) | -0.0158239 |
| ATP5MG | ATP synthase membrane subunit g | -0.0158159 |
| EIF2S2 | eukaryotic translation initiation factor 2, subunit 2 beta, 38kDa | -0.0156602 |
| ELF3 | E74-like factor 3 (ets domain transcription factor, epithelial-specific ) | -0.0155528 |
| ARL6IP1 | ADP-ribosylation factor-like 6 interacting protein 1 | -0.0155166 |
| ATRX | alpha thalassemia/mental retardation syndrome X-linked | -0.0154376 |
| SMIM14 | small integral membrane protein 14 | -0.0153808 |
| EPS8 | epidermal growth factor receptor pathway substrate 8 | -0.015349 |
| TMEM87A | transmembrane protein 87A | -0.0152743 |
| HMGA1 | high mobility group AT-hook 1 | -0.0149296 |
| ZC3HAV1 | zinc finger CCCH-type, antiviral 1 | -0.0147397 |
