| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | Tolcapone perturbation in NCI-H1792 cell line (Tahoe Therapeutics) |
| Similar Terms | |
| Downloads & Tools |
200 genes differentially expressed following the Tolcapone_NCI-H1792 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| SMAD3 | SMAD family member 3 | 0.137094 |
| EFNA5 | ephrin-A5 | 0.127453 |
| AKAP12 | A kinase (PRKA) anchor protein 12 | 0.104463 |
| FAM20C | family with sequence similarity 20, member C | 0.0955574 |
| NAV2 | neuron navigator 2 | 0.0912631 |
| ABTB2 | ankyrin repeat and BTB (POZ) domain containing 2 | 0.0873888 |
| LOXL2 | lysyl oxidase-like 2 | 0.0861417 |
| SOD2 | superoxide dismutase 2, mitochondrial | 0.0842261 |
| HIVEP2 | human immunodeficiency virus type I enhancer binding protein 2 | 0.0781257 |
| TRIO | trio Rho guanine nucleotide exchange factor | 0.0697883 |
| INTS6 | integrator complex subunit 6 | 0.0646099 |
| MAGI2 | membrane associated guanylate kinase, WW and PDZ domain containing 2 | 0.0640168 |
| SEPTIN9 | septin 9 | 0.0617066 |
| AGAP1 | ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 | 0.0607033 |
| MYH9 | myosin, heavy chain 9, non-muscle | 0.0582084 |
| ITPR1 | inositol 1,4,5-trisphosphate receptor, type 1 | 0.054131 |
| MYC | v-myc avian myelocytomatosis viral oncogene homolog | 0.052542 |
| GRB10 | growth factor receptor-bound protein 10 | 0.0492097 |
| HMGA2 | high mobility group AT-hook 2 | 0.0482798 |
| EXT1 | exostosin glycosyltransferase 1 | 0.0478054 |
| TGM2 | transglutaminase 2 | 0.0477544 |
| NEDD4L | neural precursor cell expressed, developmentally down-regulated 4-like, E3 ubiquitin protein ligase | 0.0475985 |
| GFPT2 | glutamine-fructose-6-phosphate transaminase 2 | 0.0464086 |
| PCBP2 | poly(rC) binding protein 2 | 0.0459716 |
| ZSWIM6 | zinc finger, SWIM-type containing 6 | 0.0441906 |
| AADAC | arylacetamide deacetylase | 0.0432244 |
| EGFR | epidermal growth factor receptor | 0.0428373 |
| RUNX1 | runt-related transcription factor 1 | 0.0428331 |
| PRELID2 | PRELI domain containing 2 | 0.0408557 |
| PLOD2 | procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 | 0.0404486 |
| ADAMTS14 | ADAM metallopeptidase with thrombospondin type 1 motif, 14 | 0.0400364 |
| GPRC5A | G protein-coupled receptor, class C, group 5, member A | 0.0396116 |
| ATXN1 | ataxin 1 | 0.0388216 |
| LHFPL2 | lipoma HMGIC fusion partner-like 2 | 0.0369472 |
| RARB | retinoic acid receptor, beta | 0.0364364 |
| ECE1 | endothelin converting enzyme 1 | 0.0363339 |
| SIPA1L1 | signal-induced proliferation-associated 1 like 1 | 0.0362524 |
| SQSTM1 | sequestosome 1 | 0.0359178 |
| HNRNPA1 | heterogeneous nuclear ribonucleoprotein A1 | 0.0351608 |
| PFKP | phosphofructokinase, platelet | 0.0336305 |
| ASPH | aspartate beta-hydroxylase | 0.0332612 |
| CEP250 | centrosomal protein 250kDa | 0.0330843 |
| LAMC1 | laminin, gamma 1 (formerly LAMB2) | 0.0323165 |
| FNDC3B | fibronectin type III domain containing 3B | 0.0322883 |
| KCNMA1 | potassium channel, calcium activated large conductance subfamily M alpha, member 1 | 0.0317676 |
| DYNC1H1 | dynein, cytoplasmic 1, heavy chain 1 | 0.0310643 |
| BACE2 | beta-site APP-cleaving enzyme 2 | 0.0307699 |
| EEF2 | eukaryotic translation elongation factor 2 | 0.0306313 |
| EEF1A1 | eukaryotic translation elongation factor 1 alpha 1 | 0.030236 |
| RPL31 | ribosomal protein L31 | 0.0297945 |
| DHRS3 | dehydrogenase/reductase (SDR family) member 3 | 0.0295063 |
| WWTR1 | WW domain containing transcription regulator 1 | 0.0293042 |
| MYO10 | myosin X | 0.0286456 |
| MCL1 | myeloid cell leukemia 1 | 0.0285542 |
| HIPK2 | homeodomain interacting protein kinase 2 | 0.0285465 |
| SHB | Src homology 2 domain containing adaptor protein B | 0.0283613 |
| APLP2 | amyloid beta (A4) precursor-like protein 2 | 0.0280843 |
| SDK1 | sidekick cell adhesion molecule 1 | 0.0269637 |
| HDAC9 | histone deacetylase 9 | 0.0269236 |
| RPL4 | ribosomal protein L4 | 0.0266024 |
| PFKFB4 | 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 4 | 0.0263647 |
| NFATC2 | nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 2 | 0.0263445 |
| TBC1D8 | TBC1 domain family, member 8 (with GRAM domain) | 0.0262075 |
| PYGL | phosphorylase, glycogen, liver | 0.026161 |
| MAML2 | mastermind-like 2 (Drosophila) | 0.0260093 |
| NDRG1 | N-myc downstream regulated 1 | 0.0259413 |
| RNF213 | ring finger protein 213 | 0.0256824 |
| BIRC3 | baculoviral IAP repeat containing 3 | 0.0252063 |
| FAM107B | family with sequence similarity 107, member B | 0.0251053 |
| NTN4 | netrin 4 | 0.0249568 |
| TMTC2 | transmembrane and tetratricopeptide repeat containing 2 | 0.0249089 |
| ZNF638 | zinc finger protein 638 | 0.0247209 |
| ASCC3 | activating signal cointegrator 1 complex subunit 3 | 0.0246713 |
| HNRNPA2B1 | heterogeneous nuclear ribonucleoprotein A2/B1 | 0.0246111 |
| PPFIBP1 | PTPRF interacting protein, binding protein 1 (liprin beta 1) | 0.0245787 |
| SLC5A3 | solute carrier family 5 (sodium/myo-inositol cotransporter), member 3 | 0.0243853 |
| GALNT18 | polypeptide N-acetylgalactosaminyltransferase 18 | 0.0243562 |
| SOS1 | son of sevenless homolog 1 (Drosophila) | 0.0243214 |
| AVIL | advillin | 0.0240593 |
| MYOF | myoferlin | 0.0236643 |
| ANGPTL4 | angiopoietin-like 4 | 0.0236461 |
| SLC6A6 | solute carrier family 6 (neurotransmitter transporter), member 6 | 0.0235534 |
| KSR1 | kinase suppressor of ras 1 | 0.0235185 |
| PLEC | plectin | 0.0232705 |
| IGF1R | insulin-like growth factor 1 receptor | 0.0232176 |
| CACNA2D3 | calcium channel, voltage-dependent, alpha 2/delta subunit 3 | 0.0231771 |
| PALM2AKAP2 | PALM2 and AKAP2 fusion | 0.0225307 |
| CRIM1 | cysteine rich transmembrane BMP regulator 1 (chordin-like) | 0.0224884 |
| EHBP1 | EH domain binding protein 1 | 0.0221544 |
| GLS2 | glutaminase 2 (liver, mitochondrial) | 0.021599 |
| FBXL13 | F-box and leucine-rich repeat protein 13 | 0.0215892 |
| NEBL | nebulette | 0.0214834 |
| HSP90B1 | heat shock protein 90kDa beta (Grp94), member 1 | 0.0213529 |
| FAM219A | family with sequence similarity 219, member A | 0.0213113 |
| CCSER1 | coiled-coil serine-rich protein 1 | 0.0212675 |
| PARP14 | poly (ADP-ribose) polymerase family, member 14 | 0.0211493 |
| SPSB1 | splA/ryanodine receptor domain and SOCS box containing 1 | 0.0207372 |
| DENND1A | DENN/MADD domain containing 1A | 0.0206377 |
| PTK2 | protein tyrosine kinase 2 | 0.0204593 |
| MAD1L1 | MAD1 mitotic arrest deficient-like 1 (yeast) | 0.0204239 |
| Symbol | Name | Standardized Value |
|---|---|---|
| NAMPT | nicotinamide phosphoribosyltransferase | -0.145446 |
| TMSB10 | thymosin beta 10 | -0.13042 |
| PTPN12 | protein tyrosine phosphatase, non-receptor type 12 | -0.113926 |
| PDE4D | phosphodiesterase 4D, cAMP-specific | -0.0924734 |
| CXCL8 | chemokine (C-X-C motif) ligand 8 | -0.0845459 |
| SERPINE2 | serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2 | -0.078898 |
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | -0.0783892 |
| S100A6 | S100 calcium binding protein A6 | -0.0714019 |
| OSMR | oncostatin M receptor | -0.0708974 |
| DPYD | dihydropyrimidine dehydrogenase | -0.066606 |
| RAB27B | RAB27B, member RAS oncogene family | -0.0652748 |
| TFPI2 | tissue factor pathway inhibitor 2 | -0.0612576 |
| CD55 | CD55 molecule, decay accelerating factor for complement (Cromer blood group) | -0.0595565 |
| GLCCI1 | glucocorticoid induced 1 | -0.0595302 |
| ZMYND8 | zinc finger, MYND-type containing 8 | -0.0549592 |
| SEMA3A | sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3A | -0.0535797 |
| ZFP36L1 | ZFP36 ring finger protein-like 1 | -0.0486813 |
| TIMP1 | TIMP metallopeptidase inhibitor 1 | -0.0484715 |
| NPC1 | Niemann-Pick disease, type C1 | -0.0473166 |
| PTGS2 | prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase) | -0.0471824 |
| STC1 | stanniocalcin 1 | -0.0466297 |
| POTEF | POTE ankyrin domain family, member F | -0.0449018 |
| NRP1 | neuropilin 1 | -0.0394852 |
| CYP1B1 | cytochrome P450, family 1, subfamily B, polypeptide 1 | -0.03927 |
| ZEB2 | zinc finger E-box binding homeobox 2 | -0.0391027 |
| RASSF8 | Ras association (RalGDS/AF-6) domain family (N-terminal) member 8 | -0.0389394 |
| LMAN1 | lectin, mannose-binding, 1 | -0.0385272 |
| EGR1 | early growth response 1 | -0.0377858 |
| RPS6KA3 | ribosomal protein S6 kinase, 90kDa, polypeptide 3 | -0.0376126 |
| TPT1 | tumor protein, translationally-controlled 1 | -0.0374565 |
| ANK3 | ankyrin 3, node of Ranvier (ankyrin G) | -0.0370457 |
| CD44 | CD44 molecule (Indian blood group) | -0.0362331 |
| HAS2 | hyaluronan synthase 2 | -0.0357543 |
| WSB1 | WD repeat and SOCS box containing 1 | -0.0356752 |
| SNX9 | sorting nexin 9 | -0.0355525 |
| MEF2A | myocyte enhancer factor 2A | -0.0348528 |
| RBPJ | recombination signal binding protein for immunoglobulin kappa J region | -0.0335889 |
| B2M | beta-2-microglobulin | -0.0334465 |
| IQGAP1 | IQ motif containing GTPase activating protein 1 | -0.033442 |
| ABCA1 | ATP-binding cassette, sub-family A (ABC1), member 1 | -0.0332239 |
| EDIL3 | EGF-like repeats and discoidin I-like domains 3 | -0.0330196 |
| JMJD1C | jumonji domain containing 1C | -0.0329945 |
| NRG1 | neuregulin 1 | -0.032604 |
| SPRED2 | sprouty-related, EVH1 domain containing 2 | -0.0324939 |
| RALA | v-ral simian leukemia viral oncogene homolog A (ras related) | -0.0322468 |
| RAB1A | RAB1A, member RAS oncogene family | -0.03211 |
| MAP1B | microtubule-associated protein 1B | -0.0319725 |
| TRPS1 | trichorhinophalangeal syndrome I | -0.0312041 |
| CEMIP | cell migration inducing protein, hyaluronan binding | -0.0303239 |
| VRK2 | vaccinia related kinase 2 | -0.0302951 |
| ARHGAP5 | Rho GTPase activating protein 5 | -0.0302495 |
| RAP1B | RAP1B, member of RAS oncogene family | -0.030173 |
| DNAJC1 | DnaJ (Hsp40) homolog, subfamily C, member 1 | -0.0301439 |
| NAV3 | neuron navigator 3 | -0.0295333 |
| HIF1A | hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) | -0.0293889 |
| KDM2A | lysine (K)-specific demethylase 2A | -0.0292184 |
| AKAP13 | A kinase (PRKA) anchor protein 13 | -0.0289962 |
| SOS2 | son of sevenless homolog 2 (Drosophila) | -0.0287305 |
| IGFBP3 | insulin-like growth factor binding protein 3 | -0.0284086 |
| PTMA | prothymosin, alpha | -0.0280528 |
| RBM39 | RNA binding motif protein 39 | -0.027827 |
| PNRC1 | proline-rich nuclear receptor coactivator 1 | -0.0278227 |
| RBMS1 | RNA binding motif, single stranded interacting protein 1 | -0.0277575 |
| LRRFIP1 | leucine rich repeat (in FLII) interacting protein 1 | -0.0273605 |
| ADAMTS6 | ADAM metallopeptidase with thrombospondin type 1 motif, 6 | -0.0272805 |
| CSGALNACT1 | chondroitin sulfate N-acetylgalactosaminyltransferase 1 | -0.0272518 |
| RNF24 | ring finger protein 24 | -0.0271916 |
| ABCA6 | ATP-binding cassette, sub-family A (ABC1), member 6 | -0.0271854 |
| TIMP3 | TIMP metallopeptidase inhibitor 3 | -0.0270752 |
| CLMP | CXADR-like membrane protein | -0.0267884 |
| IER3 | immediate early response 3 | -0.0266057 |
| NPEPPS | aminopeptidase puromycin sensitive | -0.0259858 |
| MAP1LC3B | microtubule-associated protein 1 light chain 3 beta | -0.0259753 |
| PRRC2C | proline-rich coiled-coil 2C | -0.025268 |
| CNOT2 | CCR4-NOT transcription complex, subunit 2 | -0.0252335 |
| FNBP1 | formin binding protein 1 | -0.0247125 |
| TPM4 | tropomyosin 4 | -0.0245912 |
| IL1B | interleukin 1, beta | -0.02452 |
| ARID3B | AT rich interactive domain 3B (BRIGHT-like) | -0.0244422 |
| ADAM28 | ADAM metallopeptidase domain 28 | -0.0240689 |
| NR3C1 | nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor) | -0.0239826 |
| FTL | ferritin, light polypeptide | -0.0237861 |
| ADAMTS12 | ADAM metallopeptidase with thrombospondin type 1 motif, 12 | -0.0237712 |
| ENO2 | enolase 2 (gamma, neuronal) | -0.0237546 |
| CDH2 | cadherin 2, type 1, N-cadherin (neuronal) | -0.023514 |
| FN1 | fibronectin 1 | -0.0234236 |
| PRRX1 | paired related homeobox 1 | -0.0234146 |
| MT2A | metallothionein 2A | -0.0233846 |
| HEG1 | heart development protein with EGF-like domains 1 | -0.0231547 |
| PRR16 | proline rich 16 | -0.0224311 |
| RNF149 | ring finger protein 149 | -0.0223736 |
| SOX4 | SRY (sex determining region Y)-box 4 | -0.0222572 |
| ANKRD12 | ankyrin repeat domain 12 | -0.0222156 |
| ITGAV | integrin, alpha V | -0.0219574 |
| PFN1 | profilin 1 | -0.0216617 |
| F3 | coagulation factor III (thromboplastin, tissue factor) | -0.021497 |
| RICTOR | RPTOR independent companion of MTOR, complex 2 | -0.021421 |
| CDCP1 | CUB domain containing protein 1 | -0.0210821 |
| MAP3K2 | mitogen-activated protein kinase kinase kinase 2 | -0.0209183 |
| COPA | coatomer protein complex, subunit alpha | -0.020876 |
