| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | Tolcapone perturbation in NCI-H2030 cell line (Tahoe Therapeutics) |
| Similar Terms | |
| Downloads & Tools |
200 genes differentially expressed following the Tolcapone_NCI-H2030 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| RPL19 | ribosomal protein L19 | 0.204535 |
| AKAP12 | A kinase (PRKA) anchor protein 12 | 0.135943 |
| SAMD4A | sterile alpha motif domain containing 4A | 0.105547 |
| MCL1 | myeloid cell leukemia 1 | 0.0949958 |
| DYNC1H1 | dynein, cytoplasmic 1, heavy chain 1 | 0.0887279 |
| MYH9 | myosin, heavy chain 9, non-muscle | 0.0833383 |
| SMOC1 | SPARC related modular calcium binding 1 | 0.0791721 |
| PLOD2 | procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 | 0.075177 |
| HIVEP2 | human immunodeficiency virus type I enhancer binding protein 2 | 0.0647255 |
| SPTBN1 | spectrin, beta, non-erythrocytic 1 | 0.0643077 |
| PPP1R15A | protein phosphatase 1, regulatory subunit 15A | 0.0641482 |
| FLNB | filamin B, beta | 0.0628455 |
| HSP90AB1 | heat shock protein 90kDa alpha (cytosolic), class B member 1 | 0.0613424 |
| HNRNPA1 | heterogeneous nuclear ribonucleoprotein A1 | 0.0612069 |
| ERRFI1 | ERBB receptor feedback inhibitor 1 | 0.0587775 |
| RPL3 | ribosomal protein L3 | 0.0584455 |
| FMNL2 | formin-like 2 | 0.0582074 |
| PYGL | phosphorylase, glycogen, liver | 0.0573047 |
| SOD2 | superoxide dismutase 2, mitochondrial | 0.0571796 |
| MACF1 | microtubule-actin crosslinking factor 1 | 0.0558707 |
| PITPNC1 | phosphatidylinositol transfer protein, cytoplasmic 1 | 0.0535643 |
| MT2A | metallothionein 2A | 0.0530955 |
| CMIP | c-Maf inducing protein | 0.0522207 |
| FLNA | filamin A, alpha | 0.051784 |
| FAM107B | family with sequence similarity 107, member B | 0.0512063 |
| RPS12 | ribosomal protein S12 | 0.0501943 |
| HSPA8 | heat shock 70kDa protein 8 | 0.0483758 |
| TPM3 | tropomyosin 3 | 0.0481295 |
| PDE4D | phosphodiesterase 4D, cAMP-specific | 0.047304 |
| ZSWIM6 | zinc finger, SWIM-type containing 6 | 0.0469389 |
| PLEC | plectin | 0.0459959 |
| TRIO | trio Rho guanine nucleotide exchange factor | 0.0446091 |
| BNIP3L | BCL2/adenovirus E1B 19kDa interacting protein 3-like | 0.0439185 |
| ATP11A | ATPase, class VI, type 11A | 0.0421949 |
| ARIH1 | ariadne RBR E3 ubiquitin protein ligase 1 | 0.0417247 |
| DOCK4 | dedicator of cytokinesis 4 | 0.0412981 |
| APLP2 | amyloid beta (A4) precursor-like protein 2 | 0.04126 |
| FNDC3B | fibronectin type III domain containing 3B | 0.041202 |
| WAC | WW domain containing adaptor with coiled-coil | 0.040295 |
| CRIM1 | cysteine rich transmembrane BMP regulator 1 (chordin-like) | 0.0402701 |
| EPAS1 | endothelial PAS domain protein 1 | 0.0395659 |
| GBE1 | glucan (1,4-alpha-), branching enzyme 1 | 0.0394517 |
| HLA-A | major histocompatibility complex, class I, A | 0.0390517 |
| BMP6 | bone morphogenetic protein 6 | 0.0373506 |
| EIF1 | eukaryotic translation initiation factor 1 | 0.0370568 |
| DOCK5 | dedicator of cytokinesis 5 | 0.0354247 |
| MGAT5 | mannosyl (alpha-1,6-)-glycoprotein beta-1,6-N-acetyl-glucosaminyltransferase | 0.0352294 |
| PTPRJ | protein tyrosine phosphatase, receptor type, J | 0.0351017 |
| APP | amyloid beta (A4) precursor protein | 0.0347381 |
| UBASH3B | ubiquitin associated and SH3 domain containing B | 0.0344171 |
| EGFR | epidermal growth factor receptor | 0.0336796 |
| MAP4K4 | mitogen-activated protein kinase kinase kinase kinase 4 | 0.0332311 |
| GOLGB1 | golgin B1 | 0.0328137 |
| IGFBP3 | insulin-like growth factor binding protein 3 | 0.0327477 |
| BRD2 | bromodomain containing 2 | 0.0327147 |
| RPS17 | ribosomal protein S17 | 0.032116 |
| HNRNPA2B1 | heterogeneous nuclear ribonucleoprotein A2/B1 | 0.0320245 |
| SMAD3 | SMAD family member 3 | 0.0318953 |
| FOS | FBJ murine osteosarcoma viral oncogene homolog | 0.0317589 |
| HNRNPU | heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) | 0.0317574 |
| EXT1 | exostosin glycosyltransferase 1 | 0.0316797 |
| ATXN1 | ataxin 1 | 0.03154 |
| ANKRD11 | ankyrin repeat domain 11 | 0.0312848 |
| NEDD4L | neural precursor cell expressed, developmentally down-regulated 4-like, E3 ubiquitin protein ligase | 0.0312385 |
| LPP | LIM domain containing preferred translocation partner in lipoma | 0.0306128 |
| HLA-E | major histocompatibility complex, class I, E | 0.0302742 |
| PFKP | phosphofructokinase, platelet | 0.029512 |
| ELL2 | elongation factor, RNA polymerase II, 2 | 0.0290451 |
| TAF15 | TAF15 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 68kDa | 0.0284533 |
| NDRG1 | N-myc downstream regulated 1 | 0.0283245 |
| HDLBP | high density lipoprotein binding protein | 0.0280708 |
| RPS27 | ribosomal protein S27 | 0.0280244 |
| TIMP1 | TIMP metallopeptidase inhibitor 1 | 0.027833 |
| AGAP1 | ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 | 0.0273361 |
| MSN | moesin | 0.0271162 |
| CTBP2 | C-terminal binding protein 2 | 0.0268218 |
| PHLDB2 | pleckstrin homology-like domain, family B, member 2 | 0.0265883 |
| RPL26 | ribosomal protein L26 | 0.0265712 |
| RICTOR | RPTOR independent companion of MTOR, complex 2 | 0.0263808 |
| TLN1 | talin 1 | 0.0263544 |
| EEF1G | eukaryotic translation elongation factor 1 gamma | 0.0259501 |
| GOLGA4 | golgin A4 | 0.0258628 |
| ZC3H11A | zinc finger CCCH-type containing 11A | 0.0257481 |
| ACTN1 | actinin, alpha 1 | 0.0254899 |
| LOXL2 | lysyl oxidase-like 2 | 0.0253484 |
| HYOU1 | hypoxia up-regulated 1 | 0.0251474 |
| GALNT2 | polypeptide N-acetylgalactosaminyltransferase 2 | 0.0251275 |
| SFTPA2 | surfactant protein A2 | 0.0249303 |
| DIP2C | DIP2 disco-interacting protein 2 homolog C (Drosophila) | 0.0247494 |
| NUMA1 | nuclear mitotic apparatus protein 1 | 0.0247422 |
| PPP6R3 | protein phosphatase 6, regulatory subunit 3 | 0.0246478 |
| TMF1 | TATA element modulatory factor 1 | 0.0245714 |
| KLC1 | kinesin light chain 1 | 0.0245363 |
| HNRNPUL2 | heterogeneous nuclear ribonucleoprotein U-like 2 | 0.0244692 |
| HLA-C | major histocompatibility complex, class I, C | 0.0243456 |
| LAMC2 | laminin, gamma 2 | 0.0241498 |
| SFPQ | splicing factor proline/glutamine-rich | 0.0241395 |
| PTPRM | protein tyrosine phosphatase, receptor type, M | 0.0239895 |
| AATF | apoptosis antagonizing transcription factor | 0.0239649 |
| EEF1A1 | eukaryotic translation elongation factor 1 alpha 1 | 0.0238289 |
| Symbol | Name | Standardized Value |
|---|---|---|
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | -0.287512 |
| TXNRD1 | thioredoxin reductase 1 | -0.145238 |
| IGF2 | insulin-like growth factor 2 | -0.141081 |
| ACTG1 | actin gamma 1 | -0.104532 |
| HSP90AA1 | heat shock protein 90kDa alpha (cytosolic), class A member 1 | -0.0828013 |
| PABPC1 | poly(A) binding protein, cytoplasmic 1 | -0.0780972 |
| GRAMD1B | GRAM domain containing 1B | -0.0771154 |
| PTMA | prothymosin, alpha | -0.0664557 |
| TFPI2 | tissue factor pathway inhibitor 2 | -0.0607951 |
| TPM4 | tropomyosin 4 | -0.0578408 |
| RTN4 | reticulon 4 | -0.0548805 |
| POTEF | POTE ankyrin domain family, member F | -0.0535687 |
| TMSB10 | thymosin beta 10 | -0.0519299 |
| FTH1 | ferritin, heavy polypeptide 1 | -0.0492416 |
| CYP1B1 | cytochrome P450, family 1, subfamily B, polypeptide 1 | -0.0492244 |
| NQO1 | NAD(P)H dehydrogenase, quinone 1 | -0.0484172 |
| EGR1 | early growth response 1 | -0.0450433 |
| HDAC9 | histone deacetylase 9 | -0.0428297 |
| RPS21 | ribosomal protein S21 | -0.0426118 |
| AP2B1 | adaptor-related protein complex 2, beta 1 subunit | -0.042584 |
| FTL | ferritin, light polypeptide | -0.0424248 |
| PFN1 | profilin 1 | -0.0415895 |
| BABAM2 | BRISC and BRCA1 A complex member 2 | -0.0408295 |
| IER3 | immediate early response 3 | -0.0405616 |
| FGB | fibrinogen beta chain | -0.0390422 |
| MAP3K20 | mitogen-activated protein kinase kinase kinase 20 | -0.0389022 |
| IGFBP4 | insulin-like growth factor binding protein 4 | -0.0378955 |
| OSMR | oncostatin M receptor | -0.0372328 |
| SEMA3A | sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3A | -0.0371223 |
| ROBO2 | roundabout, axon guidance receptor, homolog 2 (Drosophila) | -0.0366254 |
| KPNB1 | karyopherin (importin) beta 1 | -0.0366037 |
| SRGN | serglycin | -0.0360256 |
| WDR43 | WD repeat domain 43 | -0.0359447 |
| SLC7A11 | solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11 | -0.0343581 |
| TM4SF1 | transmembrane 4 L six family member 1 | -0.0343217 |
| ATP5F1B | ATP synthase F1 subunit beta | -0.0332723 |
| RHOA | ras homolog family member A | -0.0328509 |
| PM20D1 | peptidase M20 domain containing 1 | -0.0325148 |
| MAP1B | microtubule-associated protein 1B | -0.0317288 |
| RPS29 | ribosomal protein S29 | -0.0313647 |
| DEK | DEK proto-oncogene | -0.0311297 |
| YY1 | YY1 transcription factor | -0.0310244 |
| AK1 | adenylate kinase 1 | -0.030372 |
| BICC1 | BicC family RNA binding protein 1 | -0.0302557 |
| NOP58 | NOP58 ribonucleoprotein | -0.0296102 |
| KHDRBS1 | KH domain containing, RNA binding, signal transduction associated 1 | -0.0291658 |
| RPS6 | ribosomal protein S6 | -0.0291121 |
| RPS15 | ribosomal protein S15 | -0.0288151 |
| SOX4 | SRY (sex determining region Y)-box 4 | -0.0285022 |
| MAP1LC3B | microtubule-associated protein 1 light chain 3 beta | -0.0280738 |
| NRG1 | neuregulin 1 | -0.0267169 |
| CA2 | carbonic anhydrase II | -0.0266767 |
| THSD4 | thrombospondin, type I, domain containing 4 | -0.0266172 |
| NUCKS1 | nuclear casein kinase and cyclin-dependent kinase substrate 1 | -0.0265082 |
| ZMYND8 | zinc finger, MYND-type containing 8 | -0.0264484 |
| NCOA7 | nuclear receptor coactivator 7 | -0.0256982 |
| GNAS | GNAS complex locus | -0.0255713 |
| TOP2A | topoisomerase (DNA) II alpha 170kDa | -0.0255655 |
| RPL8 | ribosomal protein L8 | -0.0252169 |
| PLS3 | plastin 3 | -0.0247172 |
| PPIB | peptidylprolyl isomerase B (cyclophilin B) | -0.0246746 |
| PTP4A1 | protein tyrosine phosphatase type IVA, member 1 | -0.0238587 |
| PKM | pyruvate kinase, muscle | -0.0238193 |
| ACTR2 | ARP2 actin-related protein 2 homolog (yeast) | -0.0238079 |
| RPL35A | ribosomal protein L35a | -0.0237405 |
| S100A10 | S100 calcium binding protein A10 | -0.0236039 |
| S100A6 | S100 calcium binding protein A6 | -0.0235828 |
| CAPZA1 | capping protein (actin filament) muscle Z-line, alpha 1 | -0.0234919 |
| PDIA3 | protein disulfide isomerase family A, member 3 | -0.023414 |
| ANKRD28 | ankyrin repeat domain 28 | -0.0234126 |
| CAP1 | CAP, adenylate cyclase-associated protein 1 (yeast) | -0.0233359 |
| PNISR | PNN-interacting serine/arginine-rich protein | -0.0231607 |
| LOC102724023 | ES1 protein homolog, mitochondrial | -0.0230794 |
| RPS27A | ribosomal protein S27a | -0.0229354 |
| HSP90B1 | heat shock protein 90kDa beta (Grp94), member 1 | -0.0226157 |
| MORF4L1 | mortality factor 4 like 1 | -0.022466 |
| ZNF804A | zinc finger protein 804A | -0.022414 |
| PSMA7 | proteasome (prosome, macropain) subunit, alpha type, 7 | -0.0216126 |
| RPL38 | ribosomal protein L38 | -0.0214612 |
| NAMPT | nicotinamide phosphoribosyltransferase | -0.0213702 |
| TMEM123 | transmembrane protein 123 | -0.021097 |
| MIS18BP1 | MIS18 binding protein 1 | -0.0210739 |
| ARPC2 | actin related protein 2/3 complex, subunit 2, 34kDa | -0.0208366 |
| NAALADL2 | N-acetylated alpha-linked acidic dipeptidase-like 2 | -0.0206629 |
| HMGB1 | high mobility group box 1 | -0.0204652 |
| MAP4K5 | mitogen-activated protein kinase kinase kinase kinase 5 | -0.0203815 |
| GCLM | glutamate-cysteine ligase, modifier subunit | -0.0202956 |
| CCT4 | chaperonin containing TCP1, subunit 4 (delta) | -0.020257 |
| CHN1 | chimerin 1 | -0.0200253 |
| PSMD14 | proteasome (prosome, macropain) 26S subunit, non-ATPase, 14 | -0.0199339 |
| NSUN6 | NOP2/Sun domain family, member 6 | -0.0199215 |
| MTHFD1L | methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1-like | -0.019817 |
| TUBB | tubulin, beta class I | -0.0197173 |
| RAN | RAN, member RAS oncogene family | -0.0191876 |
| CENPE | centromere protein E, 312kDa | -0.0191625 |
| TRMT112 | tRNA methyltransferase 11-2 homolog (S. cerevisiae) | -0.0191244 |
| KHDC4 | KH domain containing 4, pre-mRNA splicing factor | -0.0190649 |
| SLC4A7 | solute carrier family 4, sodium bicarbonate cotransporter, member 7 | -0.0189659 |
| THBS1 | thrombospondin 1 | -0.0189589 |
| HSPB1 | heat shock 27kDa protein 1 | -0.0189306 |
