Tolcapone_NCI-H2122 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Tolcapone perturbation in NCI-H2122 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Tolcapone_NCI-H2122 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
ITGA2 integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) 0.0984652
LAMC2 laminin, gamma 2 0.076657
SPTBN1 spectrin, beta, non-erythrocytic 1 0.0749928
FNDC3B fibronectin type III domain containing 3B 0.0736358
NR3C1 nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor) 0.0730246
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) 0.0706404
IMMP2L IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) 0.0704962
AKAP12 A kinase (PRKA) anchor protein 12 0.0655533
EGFR epidermal growth factor receptor 0.0634324
KRT17 keratin 17, type I 0.0631856
EFNA5 ephrin-A5 0.0619036
IGF1R insulin-like growth factor 1 receptor 0.0614907
SMAD3 SMAD family member 3 0.0599721
HERC4 HECT and RLD domain containing E3 ubiquitin protein ligase 4 0.0566041
NKD1 naked cuticle homolog 1 (Drosophila) 0.0552055
PLOD2 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 0.0534633
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.0532255
AFF1 AF4/FMR2 family, member 1 0.0527502
ARHGAP5 Rho GTPase activating protein 5 0.0517025
MT2A metallothionein 2A 0.0511725
HNRNPU heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) 0.0494305
MACF1 microtubule-actin crosslinking factor 1 0.0469433
TJP1 tight junction protein 1 0.0468337
BAIAP2L1 BAI1-associated protein 2-like 1 0.0463689
GBE1 glucan (1,4-alpha-), branching enzyme 1 0.0457099
SAMD4A sterile alpha motif domain containing 4A 0.0451032
ZSWIM6 zinc finger, SWIM-type containing 6 0.0449692
CRIM1 cysteine rich transmembrane BMP regulator 1 (chordin-like) 0.0439168
MED13L mediator complex subunit 13-like 0.0418521
KYNU kynureninase 0.0415036
DTNA dystrobrevin, alpha 0.0414864
ZMYM2 zinc finger, MYM-type 2 0.0402449
LMO7 LIM domain 7 0.0400947
MYH9 myosin, heavy chain 9, non-muscle 0.039539
IGF2BP2 insulin-like growth factor 2 mRNA binding protein 2 0.0390883
ELL2 elongation factor, RNA polymerase II, 2 0.0388993
PHLDB2 pleckstrin homology-like domain, family B, member 2 0.0373321
TBC1D8 TBC1 domain family, member 8 (with GRAM domain) 0.036914
RPL19 ribosomal protein L19 0.0363433
GLS2 glutaminase 2 (liver, mitochondrial) 0.0353906
SBF2 SET binding factor 2 0.0352015
ARIH1 ariadne RBR E3 ubiquitin protein ligase 1 0.035183
FLNB filamin B, beta 0.0348168
IGF2BP3 insulin-like growth factor 2 mRNA binding protein 3 0.0345658
DSPP dentin sialophosphoprotein 0.0345293
ABTB2 ankyrin repeat and BTB (POZ) domain containing 2 0.0345017
SMYD3 SET and MYND domain containing 3 0.0336358
STK17A serine/threonine kinase 17a 0.033275
PLEC plectin 0.032876
CLIP1 CAP-GLY domain containing linker protein 1 0.0326968
RPS12 ribosomal protein S12 0.0326025
RND3 Rho family GTPase 3 0.0324304
AKT3 v-akt murine thymoma viral oncogene homolog 3 0.0317527
NALF1 NALCN channel auxiliary factor 1 0.0316812
TNFAIP8 tumor necrosis factor, alpha-induced protein 8 0.0315715
MPRIP myosin phosphatase Rho interacting protein 0.0313807
MAST4 microtubule associated serine/threonine kinase family member 4 0.0313404
CDCP1 CUB domain containing protein 1 0.0310609
SYNE2 spectrin repeat containing, nuclear envelope 2 0.0309575
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) 0.030683
EXT1 exostosin glycosyltransferase 1 0.0302708
RICTOR RPTOR independent companion of MTOR, complex 2 0.0300534
RAPGEF6 Rap guanine nucleotide exchange factor (GEF) 6 0.0300183
RPS3 ribosomal protein S3 0.0299972
MRPS6 mitochondrial ribosomal protein S6 0.0298123
KCNK1 potassium channel, two pore domain subfamily K, member 1 0.0296863
SH3KBP1 SH3-domain kinase binding protein 1 0.0295638
ASH1L ash1 (absent, small, or homeotic)-like (Drosophila) 0.0295117
VEGFC vascular endothelial growth factor C 0.0294584
YTHDC1 YTH domain containing 1 0.0287737
CD59 CD59 molecule, complement regulatory protein 0.0287578
SOX9 SRY (sex determining region Y)-box 9 0.0283404
KCNH8 potassium channel, voltage gated eag related subfamily H, member 8 0.0279123
ARB2A ARB2 cotranscriptional regulator A 0.027887
JMJD1C jumonji domain containing 1C 0.0274239
ALCAM activated leukocyte cell adhesion molecule 0.027423
FOSL1 FOS-like antigen 1 0.0274052
AREG amphiregulin 0.0273562
PPP2R2C protein phosphatase 2, regulatory subunit B, gamma 0.0273131
GIGYF2 GRB10 interacting GYF protein 2 0.0271718
NAV2 neuron navigator 2 0.0271631
RUNX1 runt-related transcription factor 1 0.0270117
KLF6 Kruppel-like factor 6 0.0268185
BCAR3 breast cancer anti-estrogen resistance 3 0.0265817
PMAIP1 phorbol-12-myristate-13-acetate-induced protein 1 0.0264567
ETS1 v-ets avian erythroblastosis virus E26 oncogene homolog 1 0.0264393
LHFPL6 LHFPL tetraspan subfamily member 6 0.026438
RNF213 ring finger protein 213 0.0261941
RNF145 ring finger protein 145 0.026175
AHNAK2 AHNAK nucleoprotein 2 0.0261378
HECTD1 HECT domain containing E3 ubiquitin protein ligase 1 0.0261141
ABL2 ABL proto-oncogene 2, non-receptor tyrosine kinase 0.0261036
IER5 immediate early response 5 0.0260052
WNK1 WNK lysine deficient protein kinase 1 0.0259555
WWOX WW domain containing oxidoreductase 0.0258912
ERC2 ELKS/RAB6-interacting/CAST family member 2 0.0258747
KAT6A K(lysine) acetyltransferase 6A 0.0257946
OASL 2'-5'-oligoadenylate synthetase-like 0.0257701
HNRNPA1 heterogeneous nuclear ribonucleoprotein A1 0.0254442
DYNC1H1 dynein, cytoplasmic 1, heavy chain 1 0.0253145

decreased expression

Symbol Name Standardized Value
PDE4D phosphodiesterase 4D, cAMP-specific -0.120332
SLC7A2 solute carrier family 7 (cationic amino acid transporter, y+ system), member 2 -0.0962292
GRB10 growth factor receptor-bound protein 10 -0.093909
ATOSA atos homolog A -0.0849402
MMAB methylmalonic aciduria (cobalamin deficiency) cblB type -0.0766311
PITPNC1 phosphatidylinositol transfer protein, cytoplasmic 1 -0.0731241
ERO1A endoplasmic reticulum oxidoreductase 1 alpha -0.0649094
SCD stearoyl-CoA desaturase (delta-9-desaturase) -0.0624435
TXNRD1 thioredoxin reductase 1 -0.0616604
SRPK2 SRSF protein kinase 2 -0.0524701
IFIT2 interferon-induced protein with tetratricopeptide repeats 2 -0.0519663
FDPS farnesyl diphosphate synthase -0.0519088
FAM107B family with sequence similarity 107, member B -0.0515881
NAMPT nicotinamide phosphoribosyltransferase -0.0515427
GPCPD1 glycerophosphocholine phosphodiesterase GDE1 homolog (S. cerevisiae) -0.0501253
EPS8 epidermal growth factor receptor pathway substrate 8 -0.050047
GCLC glutamate-cysteine ligase, catalytic subunit -0.0499996
TRA2A transformer 2 alpha homolog (Drosophila) -0.0497193
B4GALT5 UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 5 -0.0494015
RIOK3 RIO kinase 3 -0.0486033
TNPO1 transportin 1 -0.0485344
SREBF2 sterol regulatory element binding transcription factor 2 -0.0474721
TAX1BP1 Tax1 (human T-cell leukemia virus type I) binding protein 1 -0.046443
ZMYND8 zinc finger, MYND-type containing 8 -0.046205
KMT2E lysine (K)-specific methyltransferase 2E -0.0458211
MKLN1 muskelin 1, intracellular mediator containing kelch motifs -0.0457895
HMGCS1 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble) -0.045635
ATP2C2 ATPase, Ca++ transporting, type 2C, member 2 -0.0454236
ATXN2 ataxin 2 -0.0435881
PIAS1 protein inhibitor of activated STAT, 1 -0.0431766
TCF7L2 transcription factor 7-like 2 (T-cell specific, HMG-box) -0.0430081
NCOA3 nuclear receptor coactivator 3 -0.042711
CYP51A1 cytochrome P450, family 51, subfamily A, polypeptide 1 -0.0417491
ACSL3 acyl-CoA synthetase long-chain family member 3 -0.0416934
MDM2 MDM2 proto-oncogene, E3 ubiquitin protein ligase -0.0399191
ANKRD12 ankyrin repeat domain 12 -0.0398405
FN1 fibronectin 1 -0.0392316
YWHAZ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta -0.0380586
S100A8 S100 calcium binding protein A8 -0.0377947
STAU1 staufen double-stranded RNA binding protein 1 -0.0376322
DICER1 dicer 1, ribonuclease type III -0.0376266
MYO6 myosin VI -0.0373117
TC2N tandem C2 domains, nuclear -0.0372901
H3-3B H3.3 histone B -0.0371485
RPL23 ribosomal protein L23 -0.0360702
PIK3C2A phosphatidylinositol-4-phosphate 3-kinase, catalytic subunit type 2 alpha -0.0358526
RAB11FIP1 RAB11 family interacting protein 1 (class I) -0.0358037
ELF3 E74-like factor 3 (ets domain transcription factor, epithelial-specific ) -0.0357016
CSGALNACT1 chondroitin sulfate N-acetylgalactosaminyltransferase 1 -0.0355177
NPTN neuroplastin -0.0352425
UBE2H ubiquitin-conjugating enzyme E2H -0.0352238
SLC6A6 solute carrier family 6 (neurotransmitter transporter), member 6 -0.0350903
CLINT1 clathrin interactor 1 -0.0347388
USP3 ubiquitin specific peptidase 3 -0.0343264
PRKRIP1 PRKR interacting protein 1 (IL11 inducible) -0.0341519
FTH1 ferritin, heavy polypeptide 1 -0.0339152
CTNNB1 catenin (cadherin-associated protein), beta 1, 88kDa -0.0333591
SPSB1 splA/ryanodine receptor domain and SOCS box containing 1 -0.0333422
PTGES2 prostaglandin E synthase 2 -0.0333304
FTL ferritin, light polypeptide -0.0332236
PDE3A phosphodiesterase 3A, cGMP-inhibited -0.0329675
ZNF644 zinc finger protein 644 -0.0329227
ITGA5 integrin, alpha 5 (fibronectin receptor, alpha polypeptide) -0.0328588
MUC16 mucin 16, cell surface associated -0.0326853
PTBP3 polypyrimidine tract binding protein 3 -0.0326588
HELZ helicase with zinc finger -0.0325769
SMCHD1 structural maintenance of chromosomes flexible hinge domain containing 1 -0.0318475
RBPJ recombination signal binding protein for immunoglobulin kappa J region -0.0316678
LRBA LPS-responsive vesicle trafficking, beach and anchor containing -0.0314417
ARID4B AT rich interactive domain 4B (RBP1-like) -0.0314295
ARHGEF12 Rho guanine nucleotide exchange factor (GEF) 12 -0.0313831
TMEM41B transmembrane protein 41B -0.0313768
NPEPPS aminopeptidase puromycin sensitive -0.0313456
TAOK3 TAO kinase 3 -0.0312009
SVIL supervillin -0.0309514
LMTK2 lemur tyrosine kinase 2 -0.0305473
SNX9 sorting nexin 9 -0.0304899
RBMS3 RNA binding motif, single stranded interacting protein 3 -0.0300446
BBX bobby sox homolog (Drosophila) -0.0299122
UBXN4 UBX domain protein 4 -0.0298285
SMG1 SMG1 phosphatidylinositol 3-kinase-related kinase -0.029564
TMEM123 transmembrane protein 123 -0.0294967
NCOA7 nuclear receptor coactivator 7 -0.0294054
EPSTI1 epithelial stromal interaction 1 (breast) -0.0292069
FNBP1L formin binding protein 1-like -0.0291073
LGALS3 lectin, galactoside-binding, soluble, 3 -0.0289789
MSMO1 methylsterol monooxygenase 1 -0.0289343
KIF13B kinesin family member 13B -0.0288849
SMG7 SMG7 nonsense mediated mRNA decay factor -0.0283737
POTEF POTE ankyrin domain family, member F -0.0283039
USP34 ubiquitin specific peptidase 34 -0.0282843
TRRAP transformation/transcription domain-associated protein -0.028275
KDM7A lysine (K)-specific demethylase 7A -0.028074
MIS18BP1 MIS18 binding protein 1 -0.0279901
ADAM17 ADAM metallopeptidase domain 17 -0.0278937
SPAG9 sperm associated antigen 9 -0.0278835
CEACAM6 carcinoembryonic antigen-related cell adhesion molecule 6 (non-specific cross reacting antigen) -0.027767
MAP4K5 mitogen-activated protein kinase kinase kinase kinase 5 -0.027699
SEMA3A sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3A -0.0276537
CEACAM5 carcinoembryonic antigen-related cell adhesion molecule 5 -0.0274676