| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | Tolcapone perturbation in NCI-H23 cell line (Tahoe Therapeutics) |
| Similar Terms | |
| Downloads & Tools |
200 genes differentially expressed following the Tolcapone_NCI-H23 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| HERC4 | HECT and RLD domain containing E3 ubiquitin protein ligase 4 | 0.137108 |
| GRAMD1B | GRAM domain containing 1B | 0.105267 |
| DOCK5 | dedicator of cytokinesis 5 | 0.0860954 |
| SEMA3C | sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C | 0.079271 |
| NFAT5 | nuclear factor of activated T-cells 5, tonicity-responsive | 0.0759334 |
| KPNA4 | karyopherin alpha 4 (importin alpha 3) | 0.0708275 |
| HIVEP2 | human immunodeficiency virus type I enhancer binding protein 2 | 0.0686034 |
| INTS6 | integrator complex subunit 6 | 0.0664187 |
| PDLIM5 | PDZ and LIM domain 5 | 0.0656803 |
| ATP1B3 | ATPase, Na+/K+ transporting, beta 3 polypeptide | 0.0630477 |
| PPP6R3 | protein phosphatase 6, regulatory subunit 3 | 0.0618766 |
| RAB7A | RAB7A, member RAS oncogene family | 0.061398 |
| ELL2 | elongation factor, RNA polymerase II, 2 | 0.0595447 |
| VCL | vinculin | 0.0583049 |
| SYNE2 | spectrin repeat containing, nuclear envelope 2 | 0.0571331 |
| ZFAND3 | zinc finger, AN1-type domain 3 | 0.0542987 |
| ZSWIM6 | zinc finger, SWIM-type containing 6 | 0.0496538 |
| PCBP2 | poly(rC) binding protein 2 | 0.0484649 |
| CLIP1 | CAP-GLY domain containing linker protein 1 | 0.0482879 |
| FBXO11 | F-box protein 11 | 0.0480822 |
| LRPPRC | leucine-rich pentatricopeptide repeat containing | 0.0475781 |
| NIPBL | Nipped-B homolog (Drosophila) | 0.0475537 |
| SFPQ | splicing factor proline/glutamine-rich | 0.0473616 |
| TRIP12 | thyroid hormone receptor interactor 12 | 0.0457002 |
| EIF4G3 | eukaryotic translation initiation factor 4 gamma, 3 | 0.0456732 |
| EXOC6B | exocyst complex component 6B | 0.0447528 |
| MDGA2 | MAM domain containing glycosylphosphatidylinositol anchor 2 | 0.0432246 |
| BRAF | B-Raf proto-oncogene, serine/threonine kinase | 0.0431225 |
| MCL1 | myeloid cell leukemia 1 | 0.0428522 |
| WNK1 | WNK lysine deficient protein kinase 1 | 0.0426042 |
| WWOX | WW domain containing oxidoreductase | 0.0414437 |
| HOMER1 | homer scaffolding protein 1 | 0.0407021 |
| CDK17 | cyclin-dependent kinase 17 | 0.0401488 |
| ADIPOR2 | adiponectin receptor 2 | 0.0399328 |
| IGF1R | insulin-like growth factor 1 receptor | 0.0393097 |
| SND1 | staphylococcal nuclease and tudor domain containing 1 | 0.0387928 |
| MCTP1 | multiple C2 domains, transmembrane 1 | 0.0386995 |
| PRKCE | protein kinase C, epsilon | 0.0375879 |
| JMJD1C | jumonji domain containing 1C | 0.0375394 |
| TEAD1 | TEA domain family member 1 (SV40 transcriptional enhancer factor) | 0.0373323 |
| SPRED2 | sprouty-related, EVH1 domain containing 2 | 0.0372173 |
| GSK3B | glycogen synthase kinase 3 beta | 0.0369288 |
| SETX | senataxin | 0.0368726 |
| THSD4 | thrombospondin, type I, domain containing 4 | 0.0364713 |
| ANKRD17 | ankyrin repeat domain 17 | 0.0364694 |
| CNOT4 | CCR4-NOT transcription complex, subunit 4 | 0.036016 |
| EXT1 | exostosin glycosyltransferase 1 | 0.0355853 |
| CALD1 | caldesmon 1 | 0.0353732 |
| ATF6 | activating transcription factor 6 | 0.0353074 |
| SETD5 | SET domain containing 5 | 0.0348012 |
| SPAG9 | sperm associated antigen 9 | 0.0336513 |
| RICTOR | RPTOR independent companion of MTOR, complex 2 | 0.0336121 |
| YAP1 | Yes-associated protein 1 | 0.0333956 |
| DST | dystonin | 0.0331538 |
| PTPN12 | protein tyrosine phosphatase, non-receptor type 12 | 0.0330863 |
| NLGN1 | neuroligin 1 | 0.0326671 |
| DSCAM | Down syndrome cell adhesion molecule | 0.0323111 |
| NCAPG2 | non-SMC condensin II complex, subunit G2 | 0.0322716 |
| SLC38A2 | solute carrier family 38, member 2 | 0.0314412 |
| TFPI | tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor) | 0.0312176 |
| CUL3 | cullin 3 | 0.0311572 |
| GBE1 | glucan (1,4-alpha-), branching enzyme 1 | 0.0303794 |
| ZFC3H1 | zinc finger, C3H1-type containing | 0.0303215 |
| ITGB1 | integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) | 0.0297083 |
| PHLDB2 | pleckstrin homology-like domain, family B, member 2 | 0.029571 |
| AKT3 | v-akt murine thymoma viral oncogene homolog 3 | 0.0293047 |
| TXNRD1 | thioredoxin reductase 1 | 0.0286222 |
| HDAC9 | histone deacetylase 9 | 0.0284361 |
| ATP2B1 | ATPase, Ca++ transporting, plasma membrane 1 | 0.0283126 |
| SLC4A7 | solute carrier family 4, sodium bicarbonate cotransporter, member 7 | 0.028176 |
| ETNK1 | ethanolamine kinase 1 | 0.0280074 |
| WDR43 | WD repeat domain 43 | 0.0279963 |
| NF1 | neurofibromin 1 | 0.0279903 |
| MARCHF4 | membrane associated ring-CH-type finger 4 | 0.0278758 |
| EXOC4 | exocyst complex component 4 | 0.0278649 |
| N4BP2L2 | NEDD4 binding protein 2-like 2 | 0.0278373 |
| NBAS | neuroblastoma amplified sequence | 0.0277059 |
| VMP1 | vacuole membrane protein 1 | 0.0276841 |
| VTI1A | vesicle transport through interaction with t-SNAREs 1A | 0.0275759 |
| VPS13B | vacuolar protein sorting 13 homolog B (yeast) | 0.0275038 |
| MED13 | mediator complex subunit 13 | 0.0274754 |
| RRM2 | ribonucleotide reductase M2 | 0.0271481 |
| SNAP25 | synaptosomal-associated protein, 25kDa | 0.027009 |
| PUM2 | pumilio RNA-binding family member 2 | 0.0269589 |
| CPNE1 | copine I | 0.0267377 |
| RALY | RALY heterogeneous nuclear ribonucleoprotein | 0.0265198 |
| TRA2A | transformer 2 alpha homolog (Drosophila) | 0.0265079 |
| UBR4 | ubiquitin protein ligase E3 component n-recognin 4 | 0.0264079 |
| MMP12 | matrix metallopeptidase 12 | 0.0261474 |
| GNB1 | guanine nucleotide binding protein (G protein), beta polypeptide 1 | 0.0260797 |
| ERC1 | ELKS/RAB6-interacting/CAST family member 1 | 0.0259982 |
| RAPGEF6 | Rap guanine nucleotide exchange factor (GEF) 6 | 0.0259714 |
| HSP90AB1 | heat shock protein 90kDa alpha (cytosolic), class B member 1 | 0.0258834 |
| TIPARP | TCDD-inducible poly(ADP-ribose) polymerase | 0.0258653 |
| RBM39 | RNA binding motif protein 39 | 0.0255527 |
| CAPRIN2 | caprin family member 2 | 0.0254904 |
| TBK1 | TANK-binding kinase 1 | 0.0254345 |
| SVIL | supervillin | 0.0252587 |
| RCOR1 | REST corepressor 1 | 0.0252328 |
| FLNA | filamin A, alpha | 0.0249139 |
| Symbol | Name | Standardized Value |
|---|---|---|
| AKAP12 | A kinase (PRKA) anchor protein 12 | -0.194072 |
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | -0.12958 |
| HSPA5 | heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) | -0.0982931 |
| VIM | vimentin | -0.0882994 |
| PTMA | prothymosin, alpha | -0.0703249 |
| TMSB10 | thymosin beta 10 | -0.0655555 |
| RPL37 | ribosomal protein L37 | -0.0655449 |
| PABPC1 | poly(A) binding protein, cytoplasmic 1 | -0.0608521 |
| SLC2A3 | solute carrier family 2 (facilitated glucose transporter), member 3 | -0.0603671 |
| HSP90B1 | heat shock protein 90kDa beta (Grp94), member 1 | -0.0603354 |
| ERO1A | endoplasmic reticulum oxidoreductase 1 alpha | -0.0567876 |
| RPS3 | ribosomal protein S3 | -0.0565983 |
| KTN1 | kinectin 1 (kinesin receptor) | -0.05533 |
| RPS27 | ribosomal protein S27 | -0.0547321 |
| MT2A | metallothionein 2A | -0.0538914 |
| RPS8 | ribosomal protein S8 | -0.0528258 |
| RPL26 | ribosomal protein L26 | -0.0512329 |
| AHNAK | AHNAK nucleoprotein | -0.0467066 |
| RPL37A | ribosomal protein L37a | -0.044801 |
| RPS12 | ribosomal protein S12 | -0.042589 |
| ACTG1 | actin gamma 1 | -0.0416962 |
| ERRFI1 | ERBB receptor feedback inhibitor 1 | -0.0412254 |
| CANX | calnexin | -0.0385611 |
| RPLP1 | ribosomal protein, large, P1 | -0.0368882 |
| TPI1 | triosephosphate isomerase 1 | -0.0350778 |
| SBF2 | SET binding factor 2 | -0.0345007 |
| RPL12 | ribosomal protein L12 | -0.0343913 |
| RPL19 | ribosomal protein L19 | -0.0340748 |
| RPS6 | ribosomal protein S6 | -0.0338608 |
| RSF1 | remodeling and spacing factor 1 | -0.0322849 |
| RACK1 | receptor for activated C kinase 1 | -0.0319294 |
| RPL31 | ribosomal protein L31 | -0.0317146 |
| TPT1 | tumor protein, translationally-controlled 1 | -0.0317102 |
| RPS29 | ribosomal protein S29 | -0.0313625 |
| MTHFD1L | methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1-like | -0.0309923 |
| RPL35A | ribosomal protein L35a | -0.0305657 |
| MYL12A | myosin, light chain 12A, regulatory, non-sarcomeric | -0.0304616 |
| EGR1 | early growth response 1 | -0.0296778 |
| RPS19 | ribosomal protein S19 | -0.0286079 |
| ENO1 | enolase 1, (alpha) | -0.0284729 |
| PGK1 | phosphoglycerate kinase 1 | -0.0281855 |
| RPL36 | ribosomal protein L36 | -0.0278532 |
| FTL | ferritin, light polypeptide | -0.0278385 |
| NAP1L1 | nucleosome assembly protein 1-like 1 | -0.0278006 |
| RSL1D1 | ribosomal L1 domain containing 1 | -0.0276076 |
| KMT2A | lysine (K)-specific methyltransferase 2A | -0.027538 |
| HLA-B | major histocompatibility complex, class I, B | -0.0270797 |
| SMARCC1 | SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily c, member 1 | -0.0270165 |
| EIF1 | eukaryotic translation initiation factor 1 | -0.0269675 |
| ZMYND8 | zinc finger, MYND-type containing 8 | -0.0268797 |
| RPS24 | ribosomal protein S24 | -0.0265058 |
| TFPI2 | tissue factor pathway inhibitor 2 | -0.0263004 |
| WSB1 | WD repeat and SOCS box containing 1 | -0.0257478 |
| KRT18 | keratin 18, type I | -0.0255854 |
| RPS27A | ribosomal protein S27a | -0.0252782 |
| RPL34 | ribosomal protein L34 | -0.0248221 |
| RPLP2 | ribosomal protein, large, P2 | -0.024612 |
| EEF1G | eukaryotic translation elongation factor 1 gamma | -0.0243212 |
| ASAP1 | ArfGAP with SH3 domain, ankyrin repeat and PH domain 1 | -0.024201 |
| NACA | nascent polypeptide-associated complex alpha subunit | -0.0241439 |
| STAT1 | signal transducer and activator of transcription 1, 91kDa | -0.0241103 |
| RPL5 | ribosomal protein L5 | -0.0240042 |
| RPL23 | ribosomal protein L23 | -0.0238317 |
| SET | SET nuclear proto-oncogene | -0.023791 |
| LOC102724023 | ES1 protein homolog, mitochondrial | -0.0236085 |
| CALR | calreticulin | -0.0227007 |
| SF3B1 | splicing factor 3b, subunit 1, 155kDa | -0.0223918 |
| SLC25A37 | solute carrier family 25 (mitochondrial iron transporter), member 37 | -0.0219352 |
| CAVIN1 | caveolae associated protein 1 | -0.0218319 |
| TMEM165 | transmembrane protein 165 | -0.0216631 |
| NAMPT | nicotinamide phosphoribosyltransferase | -0.0216432 |
| ENOSF1 | enolase superfamily member 1 | -0.0216242 |
| IFI6 | interferon, alpha-inducible protein 6 | -0.0214068 |
| PDIA3 | protein disulfide isomerase family A, member 3 | -0.0213382 |
| HLA-E | major histocompatibility complex, class I, E | -0.0212749 |
| LMAN1 | lectin, mannose-binding, 1 | -0.0212212 |
| ITPR2 | inositol 1,4,5-trisphosphate receptor, type 2 | -0.0212029 |
| TANC2 | tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 2 | -0.0211416 |
| PRKRIP1 | PRKR interacting protein 1 (IL11 inducible) | -0.0211059 |
| STAT3 | signal transducer and activator of transcription 3 (acute-phase response factor) | -0.0208915 |
| PITPNC1 | phosphatidylinositol transfer protein, cytoplasmic 1 | -0.0207923 |
| RPS21 | ribosomal protein S21 | -0.0207339 |
| IER3 | immediate early response 3 | -0.0207191 |
| H1-0 | H1.0 linker histone | -0.0206767 |
| SCAF11 | SR-related CTD-associated factor 11 | -0.0206432 |
| RPL17-C18ORF32 | RPL17-C18orf32 readthrough | -0.0206088 |
| RPS25 | ribosomal protein S25 | -0.0204976 |
| RPL35 | ribosomal protein L35 | -0.0203067 |
| RPL38 | ribosomal protein L38 | -0.0198548 |
| MAP4 | microtubule-associated protein 4 | -0.0198063 |
| S100A10 | S100 calcium binding protein A10 | -0.0197469 |
| EPRS1 | glutamyl-prolyl-tRNA synthetase 1 | -0.0196331 |
| GNL2 | guanine nucleotide binding protein-like 2 (nucleolar) | -0.0194849 |
| BRWD3 | bromodomain and WD repeat domain containing 3 | -0.0194178 |
| LOC112694756 | uncharaterized LOC112694756 | -0.0193497 |
| RPL8 | ribosomal protein L8 | -0.0193152 |
| YBX1 | Y box binding protein 1 | -0.0192685 |
| RPS14 | ribosomal protein S14 | -0.0191961 |
| KDM3A | lysine (K)-specific demethylase 3A | -0.0190104 |
| EML4 | echinoderm microtubule associated protein like 4 | -0.0189766 |
