Tolcapone_NCI-H2347 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Tolcapone perturbation in NCI-H2347 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Tolcapone_NCI-H2347 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
PABPC1 poly(A) binding protein, cytoplasmic 1 0.238453
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 0.12335
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.121743
IGFBP3 insulin-like growth factor binding protein 3 0.0948822
EXT1 exostosin glycosyltransferase 1 0.0917592
NR3C1 nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor) 0.0871655
ALCAM activated leukocyte cell adhesion molecule 0.0862534
TSC22D2 TSC22 domain family, member 2 0.0825358
HNRNPA1 heterogeneous nuclear ribonucleoprotein A1 0.0776715
HMGA1 high mobility group AT-hook 1 0.0764822
ELL2 elongation factor, RNA polymerase II, 2 0.0757151
FHIP1A FHF complex subunit HOOK interacting protein 1A 0.075668
DSPP dentin sialophosphoprotein 0.0672524
MSN moesin 0.0662357
TRIO trio Rho guanine nucleotide exchange factor 0.0651226
ZSWIM6 zinc finger, SWIM-type containing 6 0.0651025
GPRC5A G protein-coupled receptor, class C, group 5, member A 0.0643435
TMF1 TATA element modulatory factor 1 0.0642713
ABL2 ABL proto-oncogene 2, non-receptor tyrosine kinase 0.0642112
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 0.0631482
APLP2 amyloid beta (A4) precursor-like protein 2 0.0629467
FTL ferritin, light polypeptide 0.0607566
SETD5 SET domain containing 5 0.0589356
GBE1 glucan (1,4-alpha-), branching enzyme 1 0.0574975
ARIH1 ariadne RBR E3 ubiquitin protein ligase 1 0.0565554
EIF1 eukaryotic translation initiation factor 1 0.0553892
VEGFA vascular endothelial growth factor A 0.0550642
ABTB2 ankyrin repeat and BTB (POZ) domain containing 2 0.054754
LMO7 LIM domain 7 0.0532461
MAP4K4 mitogen-activated protein kinase kinase kinase kinase 4 0.0519922
ERRFI1 ERBB receptor feedback inhibitor 1 0.0507218
RCOR1 REST corepressor 1 0.0500345
MCL1 myeloid cell leukemia 1 0.0499977
MACC1 metastasis associated in colon cancer 1 0.0493327
GPBP1 GC-rich promoter binding protein 1 0.0490983
DTNA dystrobrevin, alpha 0.0487087
ATP2B4 ATPase, Ca++ transporting, plasma membrane 4 0.0477532
EGFR epidermal growth factor receptor 0.0472793
PGBD5 piggyBac transposable element derived 5 0.0466343
VGLL3 vestigial-like family member 3 0.0465538
BRD2 bromodomain containing 2 0.0462521
NR3C2 nuclear receptor subfamily 3, group C, member 2 0.0462054
TJP1 tight junction protein 1 0.0456173
CTNNB1 catenin (cadherin-associated protein), beta 1, 88kDa 0.0442907
MYO6 myosin VI 0.0442488
PTK2 protein tyrosine kinase 2 0.0429687
DST dystonin 0.0427954
RPL7 ribosomal protein L7 0.0427336
PPP1R15A protein phosphatase 1, regulatory subunit 15A 0.0425809
NEDD4L neural precursor cell expressed, developmentally down-regulated 4-like, E3 ubiquitin protein ligase 0.0425694
FAM13A family with sequence similarity 13, member A 0.0423738
PPARD peroxisome proliferator-activated receptor delta 0.0419729
CSNK1A1 casein kinase 1, alpha 1 0.0418409
MYH9 myosin, heavy chain 9, non-muscle 0.0417504
LAMB3 laminin, beta 3 0.0409736
MACF1 microtubule-actin crosslinking factor 1 0.040645
EFNA5 ephrin-A5 0.0395352
SLC2A1 solute carrier family 2 (facilitated glucose transporter), member 1 0.0394778
ZBTB38 zinc finger and BTB domain containing 38 0.0391348
ASAP1 ArfGAP with SH3 domain, ankyrin repeat and PH domain 1 0.0388814
NFKBIZ nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, zeta 0.0388277
SLC2A3 solute carrier family 2 (facilitated glucose transporter), member 3 0.0385578
SMAD3 SMAD family member 3 0.0379111
HIVEP2 human immunodeficiency virus type I enhancer binding protein 2 0.0374682
AKAP13 A kinase (PRKA) anchor protein 13 0.0374532
DUSP5 dual specificity phosphatase 5 0.0374215
ARHGAP42 Rho GTPase activating protein 42 0.0369538
DUSP10 dual specificity phosphatase 10 0.0368424
DCBLD2 discoidin, CUB and LCCL domain containing 2 0.0361886
SGMS2 sphingomyelin synthase 2 0.0359114
EEF1G eukaryotic translation elongation factor 1 gamma 0.0357714
EPS8 epidermal growth factor receptor pathway substrate 8 0.0352399
VIM vimentin 0.0351656
SMURF1 SMAD specific E3 ubiquitin protein ligase 1 0.0350687
GRAMD2B GRAM domain containing 2B 0.0349937
PRRC2C proline-rich coiled-coil 2C 0.0349577
SPSB1 splA/ryanodine receptor domain and SOCS box containing 1 0.0348527
BHLHE40 basic helix-loop-helix family, member e40 0.0348219
WNK1 WNK lysine deficient protein kinase 1 0.03449
TPM3 tropomyosin 3 0.0342994
IL6ST interleukin 6 signal transducer 0.0342027
RPL19 ribosomal protein L19 0.0339486
HLA-A major histocompatibility complex, class I, A 0.0336757
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group) 0.0335903
SEMA3B sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3B 0.0329217
RSRC2 arginine/serine-rich coiled-coil 2 0.0328929
CLIP4 CAP-GLY domain containing linker protein family, member 4 0.0327392
KTN1 kinectin 1 (kinesin receptor) 0.0324373
EZR ezrin 0.0321562
DSTN destrin (actin depolymerizing factor) 0.032099
SPAG9 sperm associated antigen 9 0.0318806
ARRDC3 arrestin domain containing 3 0.0318577
MGAT5 mannosyl (alpha-1,6-)-glycoprotein beta-1,6-N-acetyl-glucosaminyltransferase 0.0318004
WWTR1 WW domain containing transcription regulator 1 0.0317388
CTBP2 C-terminal binding protein 2 0.0316909
MIDEAS mitotic deacetylase associated SANT domain protein 0.0313629
HELZ helicase with zinc finger 0.0313211
DOCK5 dedicator of cytokinesis 5 0.0311893
OCLN occludin 0.031119
PPARG peroxisome proliferator-activated receptor gamma 0.0308545

decreased expression

Symbol Name Standardized Value
UBC ubiquitin C -0.191942
AHNAK AHNAK nucleoprotein -0.174386
TMSB10 thymosin beta 10 -0.162627
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.14195
LPP LIM domain containing preferred translocation partner in lipoma -0.13606
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.134969
PTMA prothymosin, alpha -0.121403
ASPH aspartate beta-hydroxylase -0.115178
WSB1 WD repeat and SOCS box containing 1 -0.0719871
RPS27A ribosomal protein S27a -0.071911
LAMC2 laminin, gamma 2 -0.0678347
TM4SF1 transmembrane 4 L six family member 1 -0.0637788
KRT7 keratin 7, type II -0.0603297
ENO1 enolase 1, (alpha) -0.0571094
SDC4 syndecan 4 -0.0559066
ACTG1 actin gamma 1 -0.0546993
EPCAM epithelial cell adhesion molecule -0.0546521
PARP14 poly (ADP-ribose) polymerase family, member 14 -0.0501138
AP3B1 adaptor-related protein complex 3, beta 1 subunit -0.049281
S100A6 S100 calcium binding protein A6 -0.0488541
TPT1 tumor protein, translationally-controlled 1 -0.0470856
LIMCH1 LIM and calponin homology domains 1 -0.0466917
TMSB4X thymosin beta 4, X-linked -0.0452015
RRBP1 ribosome binding protein 1 -0.0441657
S100A10 S100 calcium binding protein A10 -0.0431972
CCND1 cyclin D1 -0.039355
COL1A1 collagen, type I, alpha 1 -0.0384422
KRT8 keratin 8, type II -0.0380911
TMEM263 transmembrane protein 263 -0.0359941
RPL23 ribosomal protein L23 -0.0358255
MARCHF6 membrane associated ring-CH-type finger 6 -0.0357722
RPL34 ribosomal protein L34 -0.0352648
ZNF217 zinc finger protein 217 -0.0343951
CDC50A cell division cycle 50 P4-ATPase accessory subunit A -0.0331786
LY6E lymphocyte antigen 6 complex, locus E -0.0331221
H1-0 H1.0 linker histone -0.0329635
RPL8 ribosomal protein L8 -0.0310892
NAP1L4 nucleosome assembly protein 1-like 4 -0.0302812
OGA O-GlcNAcase -0.0302631
VCL vinculin -0.0300843
HMGB2 high mobility group box 2 -0.0300576
POTEF POTE ankyrin domain family, member F -0.0294919
ANKLE2 ankyrin repeat and LEM domain containing 2 -0.0280786
MDK midkine (neurite growth-promoting factor 2) -0.0280118
NT5C2 5'-nucleotidase, cytosolic II -0.0277675
RAD21 RAD21 homolog (S. pombe) -0.0273106
IFIT3 interferon-induced protein with tetratricopeptide repeats 3 -0.0271421
MYL6 myosin, light chain 6, alkali, smooth muscle and non-muscle -0.026936
RBMS3 RNA binding motif, single stranded interacting protein 3 -0.0268387
IFIH1 interferon induced with helicase C domain 1 -0.0267695
TBL1XR1 transducin (beta)-like 1 X-linked receptor 1 -0.0266544
LOC112694756 uncharaterized LOC112694756 -0.0263418
MAML2 mastermind-like 2 (Drosophila) -0.0260323
CYRIB CYFIP related Rac1 interactor B -0.0259258
NUCKS1 nuclear casein kinase and cyclin-dependent kinase substrate 1 -0.0256047
KCNQ5 potassium channel, voltage gated KQT-like subfamily Q, member 5 -0.0255091
SPATS2L spermatogenesis associated, serine-rich 2-like -0.0254379
GNAS GNAS complex locus -0.0251099
SQSTM1 sequestosome 1 -0.02494
RBM39 RNA binding motif protein 39 -0.024889
CD2AP CD2-associated protein -0.0247657
DDX60L DEAD (Asp-Glu-Ala-Asp) box polypeptide 60-like -0.0244498
KDM5B lysine (K)-specific demethylase 5B -0.0240566
IFI16 interferon, gamma-inducible protein 16 -0.0240423
CALM2 calmodulin 2 (phosphorylase kinase, delta) -0.0240091
RPS21 ribosomal protein S21 -0.0239737
CALU calumenin -0.0239088
CTSD cathepsin D -0.023526
DDX60 DEAD (Asp-Glu-Ala-Asp) box polypeptide 60 -0.0234313
FUT8 fucosyltransferase 8 (alpha (1,6) fucosyltransferase) -0.0231668
PDIA4 protein disulfide isomerase family A, member 4 -0.0229908
HNRNPH1 heterogeneous nuclear ribonucleoprotein H1 (H) -0.0228632
NAMPT nicotinamide phosphoribosyltransferase -0.0218731
MYL12A myosin, light chain 12A, regulatory, non-sarcomeric -0.02184
MBOAT2 membrane bound O-acyltransferase domain containing 2 -0.0217476
IFRD1 interferon-related developmental regulator 1 -0.0216941
FRMD5 FERM domain containing 5 -0.0216325
HLA-B major histocompatibility complex, class I, B -0.0216294
FBXO34 F-box protein 34 -0.0210862
ANXA2 annexin A2 -0.0206363
RIGI RNA sensor RIG-I -0.0205285
CCNI cyclin I -0.0202963
EIF4A2 eukaryotic translation initiation factor 4A2 -0.0202168
WTAP Wilms tumor 1 associated protein -0.0201765
DDX3X DEAD (Asp-Glu-Ala-Asp) box helicase 3, X-linked -0.0199748
ATP2A2 ATPase, Ca++ transporting, cardiac muscle, slow twitch 2 -0.0199728
PPP2CA protein phosphatase 2, catalytic subunit, alpha isozyme -0.0198488
IER3 immediate early response 3 -0.0198215
SMURF2 SMAD specific E3 ubiquitin protein ligase 2 -0.0197967
RPLP2 ribosomal protein, large, P2 -0.0197782
FAM162A family with sequence similarity 162, member A -0.01971
LNPEP leucyl/cystinyl aminopeptidase -0.0196395
SLC38A1 solute carrier family 38, member 1 -0.0192628
TRAF3 TNF receptor-associated factor 3 -0.0192312
SP100 SP100 nuclear antigen -0.0191685
NPC2 Niemann-Pick disease, type C2 -0.0191268
ARB2A ARB2 cotranscriptional regulator A -0.0191204
CALM3 calmodulin 3 (phosphorylase kinase, delta) -0.0191017
ARFGEF2 ADP-ribosylation factor guanine nucleotide-exchange factor 2 (brefeldin A-inhibited) -0.0190276
PDCD6IP programmed cell death 6 interacting protein -0.0188372