Tolcapone_NCI-H460 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Tolcapone perturbation in NCI-H460 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Tolcapone_NCI-H460 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
GDA guanine deaminase 0.145721
EFNA5 ephrin-A5 0.138673
PM20D1 peptidase M20 domain containing 1 0.133132
COL8A1 collagen, type VIII, alpha 1 0.131783
CDH11 cadherin 11, type 2, OB-cadherin (osteoblast) 0.129288
MYOF myoferlin 0.120117
TRIO trio Rho guanine nucleotide exchange factor 0.118108
KYNU kynureninase 0.114583
NAMPT nicotinamide phosphoribosyltransferase 0.102155
TXNRD1 thioredoxin reductase 1 0.0992504
ASPH aspartate beta-hydroxylase 0.0947374
PDE10A phosphodiesterase 10A 0.0923622
DST dystonin 0.0875833
EPB41L3 erythrocyte membrane protein band 4.1-like 3 0.0858284
PDLIM5 PDZ and LIM domain 5 0.0845113
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) 0.0807698
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 0.0795817
GRAMD1B GRAM domain containing 1B 0.0725128
SPOCK1 sparc/osteonectin, cwcv and kazal-like domains proteoglycan (testican) 1 0.0724834
LIMCH1 LIM and calponin homology domains 1 0.0724251
PSD3 pleckstrin and Sec7 domain containing 3 0.070254
DOCK4 dedicator of cytokinesis 4 0.0664999
HERC4 HECT and RLD domain containing E3 ubiquitin protein ligase 4 0.0659305
CRIM1 cysteine rich transmembrane BMP regulator 1 (chordin-like) 0.0644693
ELL2 elongation factor, RNA polymerase II, 2 0.0633374
CXCL8 chemokine (C-X-C motif) ligand 8 0.0628292
FMNL2 formin-like 2 0.0586669
SCD stearoyl-CoA desaturase (delta-9-desaturase) 0.0586169
SAMD4A sterile alpha motif domain containing 4A 0.0580645
OGA O-GlcNAcase 0.0577778
SPTBN1 spectrin, beta, non-erythrocytic 1 0.0563677
TGFBR1 transforming growth factor, beta receptor 1 0.0563529
NRCAM neuronal cell adhesion molecule 0.0562066
RASSF8 Ras association (RalGDS/AF-6) domain family (N-terminal) member 8 0.0560068
SRGAP1 SLIT-ROBO Rho GTPase activating protein 1 0.0554753
FLNB filamin B, beta 0.0542156
ASH1L ash1 (absent, small, or homeotic)-like (Drosophila) 0.0540902
MDM2 MDM2 proto-oncogene, E3 ubiquitin protein ligase 0.0522798
TBC1D8 TBC1 domain family, member 8 (with GRAM domain) 0.0518127
MCL1 myeloid cell leukemia 1 0.051645
NEK7 NIMA-related kinase 7 0.0514039
LAMA1 laminin, alpha 1 0.0510877
SH3KBP1 SH3-domain kinase binding protein 1 0.0508983
BIRC6 baculoviral IAP repeat containing 6 0.0507344
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.0497153
PTEN phosphatase and tensin homolog 0.0490442
CSGALNACT1 chondroitin sulfate N-acetylgalactosaminyltransferase 1 0.0490371
ANTXR1 anthrax toxin receptor 1 0.0490355
FN1 fibronectin 1 0.0484245
ABL2 ABL proto-oncogene 2, non-receptor tyrosine kinase 0.0484019
NPAS2 neuronal PAS domain protein 2 0.0483949
DCBLD2 discoidin, CUB and LCCL domain containing 2 0.0482429
SLC44A1 solute carrier family 44 (choline transporter), member 1 0.048021
SLC7A11 solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11 0.0478808
LAMC1 laminin, gamma 1 (formerly LAMB2) 0.0459562
PLEKHA5 pleckstrin homology domain containing, family A member 5 0.0453381
RBM39 RNA binding motif protein 39 0.0433443
PRRC2C proline-rich coiled-coil 2C 0.0433091
RTN4 reticulon 4 0.0432084
JMJD1C jumonji domain containing 1C 0.0430578
ZC3HAV1 zinc finger CCCH-type, antiviral 1 0.0415724
PDE4D phosphodiesterase 4D, cAMP-specific 0.0410782
PCBP2 poly(rC) binding protein 2 0.0410741
COL4A6 collagen, type IV, alpha 6 0.0404233
AVL9 AVL9 homolog (S. cerevisiase) 0.0399075
CTIF CBP80/20-dependent translation initiation factor 0.0392789
SPAG9 sperm associated antigen 9 0.0377758
ZSWIM6 zinc finger, SWIM-type containing 6 0.0375166
ZEB2 zinc finger E-box binding homeobox 2 0.0373067
FNDC3B fibronectin type III domain containing 3B 0.0372411
MGAT5 mannosyl (alpha-1,6-)-glycoprotein beta-1,6-N-acetyl-glucosaminyltransferase 0.0368164
NF1 neurofibromin 1 0.0366762
DYNC1H1 dynein, cytoplasmic 1, heavy chain 1 0.0364842
PLCB4 phospholipase C, beta 4 0.0362477
DNER delta/notch-like EGF repeat containing 0.0361644
VCL vinculin 0.0358289
DGKD diacylglycerol kinase, delta 130kDa 0.0356213
USP34 ubiquitin specific peptidase 34 0.0355899
PABPC1 poly(A) binding protein, cytoplasmic 1 0.035571
IGF2BP3 insulin-like growth factor 2 mRNA binding protein 3 0.0355207
KMT2C lysine (K)-specific methyltransferase 2C 0.0354588
PHF20 PHD finger protein 20 0.0352563
COL5A2 collagen, type V, alpha 2 0.0351574
GPRC5A G protein-coupled receptor, class C, group 5, member A 0.0348401
SNCA synuclein, alpha (non A4 component of amyloid precursor) 0.0346943
USP9X ubiquitin specific peptidase 9, X-linked 0.0338685
GOLGA4 golgin A4 0.0334378
ANKRD17 ankyrin repeat domain 17 0.0333416
PBX1 pre-B-cell leukemia homeobox 1 0.0330124
COL4A5 collagen, type IV, alpha 5 0.0328967
AKAP13 A kinase (PRKA) anchor protein 13 0.0327366
TAOK1 TAO kinase 1 0.032444
PTK2 protein tyrosine kinase 2 0.0321077
SMOC1 SPARC related modular calcium binding 1 0.031956
ZFAND3 zinc finger, AN1-type domain 3 0.0319023
CARD16 caspase recruitment domain family, member 16 0.0317911
ERRFI1 ERBB receptor feedback inhibitor 1 0.0317709
CANX calnexin 0.0316121
WWTR1 WW domain containing transcription regulator 1 0.0315161
PDE7B phosphodiesterase 7B 0.0309029

decreased expression

Symbol Name Standardized Value
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group) -0.171779
VIM vimentin -0.108223
RPS6 ribosomal protein S6 -0.0811035
TPT1 tumor protein, translationally-controlled 1 -0.0793394
PDE3A phosphodiesterase 3A, cGMP-inhibited -0.0792198
RPLP1 ribosomal protein, large, P1 -0.0760703
DPP10 dipeptidyl-peptidase 10 (non-functional) -0.0696076
CDH13 cadherin 13 -0.0660265
RPS8 ribosomal protein S8 -0.0603852
RPL31 ribosomal protein L31 -0.056786
RPL37A ribosomal protein L37a -0.0521266
RPL26 ribosomal protein L26 -0.0504539
LSAMP limbic system-associated membrane protein -0.0499997
RPL35A ribosomal protein L35a -0.0491724
RPS12 ribosomal protein S12 -0.049163
RPL12 ribosomal protein L12 -0.0486676
RPS19 ribosomal protein S19 -0.048596
TMSB10 thymosin beta 10 -0.0473651
RPS24 ribosomal protein S24 -0.044563
WARS1 tryptophanyl-tRNA synthetase 1 -0.0444917
RPL34 ribosomal protein L34 -0.0424602
PTMA prothymosin, alpha -0.0418994
RPS27 ribosomal protein S27 -0.0389164
RPL9 ribosomal protein L9 -0.0369696
RPL19 ribosomal protein L19 -0.0353532
NCKAP5 NCK-associated protein 5 -0.0352909
RPL37 ribosomal protein L37 -0.0345332
RPS14 ribosomal protein S14 -0.0343981
PLCB1 phospholipase C, beta 1 (phosphoinositide-specific) -0.0333905
RPLP2 ribosomal protein, large, P2 -0.0318944
RPL36A ribosomal protein L36a -0.0310698
RPS17 ribosomal protein S17 -0.0301806
TENM3 teneurin transmembrane protein 3 -0.028315
SOX4 SRY (sex determining region Y)-box 4 -0.0278255
RPS3 ribosomal protein S3 -0.0271465
RPS29 ribosomal protein S29 -0.0268481
SOX6 SRY (sex determining region Y)-box 6 -0.0267986
TTC28 tetratricopeptide repeat domain 28 -0.0263946
RPS27A ribosomal protein S27a -0.0258158
RPS13 ribosomal protein S13 -0.0255873
OASL 2'-5'-oligoadenylate synthetase-like -0.0251362
FTL ferritin, light polypeptide -0.024967
RPL38 ribosomal protein L38 -0.0249259
RPS23 ribosomal protein S23 -0.0249213
RPL23 ribosomal protein L23 -0.0246895
RPL35 ribosomal protein L35 -0.0243782
RPL36 ribosomal protein L36 -0.0243304
DHRSX dehydrogenase/reductase (SDR family) X-linked -0.0231986
RAD51B RAD51 paralog B -0.0221759
HLA-B major histocompatibility complex, class I, B -0.0219046
RPL7A ribosomal protein L7a -0.0218776
RACK1 receptor for activated C kinase 1 -0.0216728
LRRFIP1 leucine rich repeat (in FLII) interacting protein 1 -0.0215832
IFIH1 interferon induced with helicase C domain 1 -0.0206936
RPLP0 ribosomal protein, large, P0 -0.0204099
CADM2 cell adhesion molecule 2 -0.0198893
ADGRD1 adhesion G protein-coupled receptor D1 -0.0186094
MT2A metallothionein 2A -0.0184051
RPL28 ribosomal protein L28 -0.0180599
RPS21 ribosomal protein S21 -0.0180087
IMMP2L IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) -0.0178293
RPL27 ribosomal protein L27 -0.0178082
RPS16 ribosomal protein S16 -0.0176752
RPS2 ribosomal protein S2 -0.0169153
PRELID2 PRELI domain containing 2 -0.016807
SLCO1C1 solute carrier organic anion transporter family, member 1C1 -0.0167222
RPL32 ribosomal protein L32 -0.0166464
PCDH9 protocadherin 9 -0.0165313
RPL30 ribosomal protein L30 -0.0162931
RPL5 ribosomal protein L5 -0.0161548
ASTN2 astrotactin 2 -0.0160623
RPS25 ribosomal protein S25 -0.0159051
SEMA3D sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3D -0.0158838
LAMA5 laminin, alpha 5 -0.0157699
RPL11 ribosomal protein L11 -0.0156153
PCDH15 protocadherin-related 15 -0.0154059
RPS28 ribosomal protein S28 -0.0152705
AEBP2 AE binding protein 2 -0.0150921
RPL39 ribosomal protein L39 -0.0150379
IFIT3 interferon-induced protein with tetratricopeptide repeats 3 -0.0147921
RPL17-C18ORF32 RPL17-C18orf32 readthrough -0.0145452
CTNND2 catenin (cadherin-associated protein), delta 2 -0.014252
RBFOX1 RNA binding protein, fox-1 homolog (C. elegans) 1 -0.0142286
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 -0.0141685
GABRE gamma-aminobutyric acid (GABA) A receptor, epsilon -0.0140768
ERC2 ELKS/RAB6-interacting/CAST family member 2 -0.0140762
SVIL supervillin -0.0140212
RPS15 ribosomal protein S15 -0.0139125
DNAH11 dynein, axonemal, heavy chain 11 -0.0130426
PRSS23 protease, serine, 23 -0.0129562
UNC5D unc-5 homolog D (C. elegans) -0.0129274
ATP5F1E ATP synthase F1 subunit epsilon -0.0128664
TOMM7 translocase of outer mitochondrial membrane 7 homolog (yeast) -0.0127633
SHANK2 SH3 and multiple ankyrin repeat domains 2 -0.0126118
EEF1B2 eukaryotic translation elongation factor 1 beta 2 -0.0125606
CCDC68 coiled-coil domain containing 68 -0.0124728
AUTS2 autism susceptibility candidate 2 -0.0123503
ESM1 endothelial cell-specific molecule 1 -0.0122507
RPS11 ribosomal protein S11 -0.0120354
FSTL4 follistatin-like 4 -0.0120289