| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | Tolcapone perturbation in NCI-H596 cell line (Tahoe Therapeutics) |
| Similar Terms | |
| Downloads & Tools |
200 genes differentially expressed following the Tolcapone_NCI-H596 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| COL5A2 | collagen, type V, alpha 2 | 0.110397 |
| RPL7 | ribosomal protein L7 | 0.108966 |
| ASAP2 | ArfGAP with SH3 domain, ankyrin repeat and PH domain 2 | 0.107313 |
| DOCK5 | dedicator of cytokinesis 5 | 0.0994555 |
| MYO10 | myosin X | 0.0976937 |
| MMAB | methylmalonic aciduria (cobalamin deficiency) cblB type | 0.0945014 |
| EFNA5 | ephrin-A5 | 0.0944902 |
| MGAT5 | mannosyl (alpha-1,6-)-glycoprotein beta-1,6-N-acetyl-glucosaminyltransferase | 0.0923959 |
| KYNU | kynureninase | 0.0896628 |
| ITGA2 | integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) | 0.0890506 |
| GNPDA1 | glucosamine-6-phosphate deaminase 1 | 0.0843045 |
| CD55 | CD55 molecule, decay accelerating factor for complement (Cromer blood group) | 0.0835401 |
| EZR | ezrin | 0.0801052 |
| EGFR | epidermal growth factor receptor | 0.0784216 |
| NKD1 | naked cuticle homolog 1 (Drosophila) | 0.0782891 |
| PDE4D | phosphodiesterase 4D, cAMP-specific | 0.0759202 |
| GBE1 | glucan (1,4-alpha-), branching enzyme 1 | 0.0755583 |
| MAP4K4 | mitogen-activated protein kinase kinase kinase kinase 4 | 0.074552 |
| ITGB1 | integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) | 0.0724013 |
| APBB2 | amyloid beta (A4) precursor protein-binding, family B, member 2 | 0.071801 |
| ERRFI1 | ERBB receptor feedback inhibitor 1 | 0.0705077 |
| SLC5A3 | solute carrier family 5 (sodium/myo-inositol cotransporter), member 3 | 0.0704494 |
| FMNL2 | formin-like 2 | 0.07013 |
| PDE3A | phosphodiesterase 3A, cGMP-inhibited | 0.0697847 |
| TAF1D | TATA box binding protein (TBP)-associated factor, RNA polymerase I, D, 41kDa | 0.0683313 |
| TFDP2 | transcription factor Dp-2 (E2F dimerization partner 2) | 0.0661376 |
| FTL | ferritin, light polypeptide | 0.0653199 |
| SBF2 | SET binding factor 2 | 0.0651 |
| MACF1 | microtubule-actin crosslinking factor 1 | 0.0639632 |
| PTGS2 | prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase) | 0.0607218 |
| FLNB | filamin B, beta | 0.0594813 |
| ZNF638 | zinc finger protein 638 | 0.0583311 |
| SIPA1L1 | signal-induced proliferation-associated 1 like 1 | 0.0576622 |
| PITPNC1 | phosphatidylinositol transfer protein, cytoplasmic 1 | 0.0571559 |
| VIM | vimentin | 0.0563824 |
| RUNX1 | runt-related transcription factor 1 | 0.0547413 |
| AKAP12 | A kinase (PRKA) anchor protein 12 | 0.054432 |
| IGFBP3 | insulin-like growth factor binding protein 3 | 0.0542479 |
| TTC3 | tetratricopeptide repeat domain 3 | 0.0532042 |
| HIVEP2 | human immunodeficiency virus type I enhancer binding protein 2 | 0.0529538 |
| NAP1L1 | nucleosome assembly protein 1-like 1 | 0.0526846 |
| OGA | O-GlcNAcase | 0.0518819 |
| ABL2 | ABL proto-oncogene 2, non-receptor tyrosine kinase | 0.0507224 |
| SAMD4A | sterile alpha motif domain containing 4A | 0.0476222 |
| SMURF1 | SMAD specific E3 ubiquitin protein ligase 1 | 0.0473321 |
| EXT1 | exostosin glycosyltransferase 1 | 0.0469082 |
| BMPR2 | bone morphogenetic protein receptor, type II (serine/threonine kinase) | 0.0444156 |
| ZFC3H1 | zinc finger, C3H1-type containing | 0.0425426 |
| DSCAM | Down syndrome cell adhesion molecule | 0.0424748 |
| USP34 | ubiquitin specific peptidase 34 | 0.042439 |
| NFAT5 | nuclear factor of activated T-cells 5, tonicity-responsive | 0.0421418 |
| ITCH | itchy E3 ubiquitin protein ligase | 0.0415917 |
| GOLGA4 | golgin A4 | 0.0391685 |
| GLIS3 | GLIS family zinc finger 3 | 0.0384453 |
| GOLGB1 | golgin B1 | 0.0375899 |
| SCD | stearoyl-CoA desaturase (delta-9-desaturase) | 0.0369423 |
| GMDS | GDP-mannose 4,6-dehydratase | 0.0360786 |
| MIB1 | mindbomb E3 ubiquitin protein ligase 1 | 0.0359462 |
| PYGL | phosphorylase, glycogen, liver | 0.0354645 |
| PM20D1 | peptidase M20 domain containing 1 | 0.0354012 |
| MMP1 | matrix metallopeptidase 1 | 0.0345567 |
| LIMCH1 | LIM and calponin homology domains 1 | 0.0340275 |
| TRIO | trio Rho guanine nucleotide exchange factor | 0.0334811 |
| ARHGAP5 | Rho GTPase activating protein 5 | 0.033113 |
| PRKG1 | protein kinase, cGMP-dependent, type I | 0.0326721 |
| BCAS3 | breast carcinoma amplified sequence 3 | 0.0310076 |
| ENO1 | enolase 1, (alpha) | 0.0298977 |
| RPS19 | ribosomal protein S19 | 0.0294775 |
| AKAP13 | A kinase (PRKA) anchor protein 13 | 0.0290998 |
| ANO6 | anoctamin 6 | 0.0290461 |
| FOXP1 | forkhead box P1 | 0.0280917 |
| PPP1R15A | protein phosphatase 1, regulatory subunit 15A | 0.0280559 |
| RPL13A | ribosomal protein L13a | 0.027876 |
| HERC4 | HECT and RLD domain containing E3 ubiquitin protein ligase 4 | 0.027427 |
| PLEKHA5 | pleckstrin homology domain containing, family A member 5 | 0.0269696 |
| RPL19 | ribosomal protein L19 | 0.0267912 |
| P4HA1 | prolyl 4-hydroxylase, alpha polypeptide I | 0.0262883 |
| ASPH | aspartate beta-hydroxylase | 0.0259454 |
| TPT1 | tumor protein, translationally-controlled 1 | 0.0251205 |
| KDM4C | lysine (K)-specific demethylase 4C | 0.0241617 |
| STC1 | stanniocalcin 1 | 0.0241026 |
| RAD51B | RAD51 paralog B | 0.0240842 |
| TPM4 | tropomyosin 4 | 0.0234535 |
| NPM1 | nucleophosmin (nucleolar phosphoprotein B23, numatrin) | 0.0231897 |
| KMT2C | lysine (K)-specific methyltransferase 2C | 0.0229812 |
| YWHAZ | tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta | 0.0222154 |
| AGAP1 | ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 | 0.0214304 |
| LRBA | LPS-responsive vesicle trafficking, beach and anchor containing | 0.0210434 |
| LRRFIP1 | leucine rich repeat (in FLII) interacting protein 1 | 0.0205247 |
| COL6A3 | collagen, type VI, alpha 3 | 0.0198353 |
| MYOF | myoferlin | 0.0192161 |
| CD44 | CD44 molecule (Indian blood group) | 0.0185401 |
| GRB10 | growth factor receptor-bound protein 10 | 0.0183769 |
| BIRC6 | baculoviral IAP repeat containing 6 | 0.0181074 |
| HNRNPC | heterogeneous nuclear ribonucleoprotein C (C1/C2) | 0.0174214 |
| INTS6 | integrator complex subunit 6 | 0.0158424 |
| RICTOR | RPTOR independent companion of MTOR, complex 2 | 0.0147943 |
| S100A6 | S100 calcium binding protein A6 | 0.0147787 |
| SEPTIN9 | septin 9 | 0.0146067 |
| AKAP9 | A kinase (PRKA) anchor protein 9 | 0.0141906 |
| Symbol | Name | Standardized Value |
|---|---|---|
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | -0.356058 |
| PTMA | prothymosin, alpha | -0.155901 |
| NDRG1 | N-myc downstream regulated 1 | -0.153925 |
| UBC | ubiquitin C | -0.142472 |
| FN1 | fibronectin 1 | -0.106457 |
| HSPA5 | heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) | -0.102833 |
| PGK1 | phosphoglycerate kinase 1 | -0.100899 |
| ZBTB20 | zinc finger and BTB domain containing 20 | -0.0995989 |
| CXCL8 | chemokine (C-X-C motif) ligand 8 | -0.089808 |
| PKM | pyruvate kinase, muscle | -0.0894389 |
| RPS3 | ribosomal protein S3 | -0.0892199 |
| ANXA2 | annexin A2 | -0.088928 |
| CCNI | cyclin I | -0.0878357 |
| NAMPT | nicotinamide phosphoribosyltransferase | -0.0857923 |
| RTN4 | reticulon 4 | -0.0831715 |
| HSP90AB1 | heat shock protein 90kDa alpha (cytosolic), class B member 1 | -0.0800937 |
| DST | dystonin | -0.0765396 |
| ZNF292 | zinc finger protein 292 | -0.0687892 |
| MYO6 | myosin VI | -0.0685101 |
| ADAM10 | ADAM metallopeptidase domain 10 | -0.0681614 |
| IMMP2L | IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) | -0.0681604 |
| NUP58 | nucleoporin 58 | -0.0646757 |
| LDHA | lactate dehydrogenase A | -0.059945 |
| ZSWIM6 | zinc finger, SWIM-type containing 6 | -0.0592114 |
| RNASE1 | ribonuclease, RNase A family, 1 (pancreatic) | -0.0588964 |
| PTK2 | protein tyrosine kinase 2 | -0.0588202 |
| RPS27A | ribosomal protein S27a | -0.0583053 |
| PDE10A | phosphodiesterase 10A | -0.0578159 |
| RPL9 | ribosomal protein L9 | -0.0564673 |
| GLS2 | glutaminase 2 (liver, mitochondrial) | -0.0520209 |
| TMTC2 | transmembrane and tetratricopeptide repeat containing 2 | -0.05158 |
| SRRM2 | serine/arginine repetitive matrix 2 | -0.0515179 |
| FNDC3A | fibronectin type III domain containing 3A | -0.0510988 |
| EIF2AK2 | eukaryotic translation initiation factor 2-alpha kinase 2 | -0.0505774 |
| TNKS | tankyrase, TRF1-interacting ankyrin-related ADP-ribose polymerase | -0.0502534 |
| RPL23 | ribosomal protein L23 | -0.0496591 |
| RLF | rearranged L-myc fusion | -0.0493763 |
| COG5 | component of oligomeric golgi complex 5 | -0.048831 |
| GPHN | gephyrin | -0.0475497 |
| SETD5 | SET domain containing 5 | -0.0468001 |
| ATF6 | activating transcription factor 6 | -0.045021 |
| SMYD3 | SET and MYND domain containing 3 | -0.0443307 |
| GPC6 | glypican 6 | -0.0432862 |
| ACTN4 | actinin, alpha 4 | -0.043155 |
| PLCB1 | phospholipase C, beta 1 (phosphoinositide-specific) | -0.0428925 |
| SPTBN1 | spectrin, beta, non-erythrocytic 1 | -0.0426673 |
| ATXN1 | ataxin 1 | -0.0421597 |
| FMN1 | formin 1 | -0.0400383 |
| ACTG1 | actin gamma 1 | -0.0394565 |
| SEMA3A | sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3A | -0.0392409 |
| HSP90AA1 | heat shock protein 90kDa alpha (cytosolic), class A member 1 | -0.038327 |
| ARHGEF12 | Rho guanine nucleotide exchange factor (GEF) 12 | -0.0374638 |
| ADAM9 | ADAM metallopeptidase domain 9 | -0.0372764 |
| ELOF1 | elongation factor 1 homolog (S. cerevisiae) | -0.0362148 |
| ROCK1 | Rho-associated, coiled-coil containing protein kinase 1 | -0.0361512 |
| CNOT4 | CCR4-NOT transcription complex, subunit 4 | -0.0355528 |
| TPI1 | triosephosphate isomerase 1 | -0.0351546 |
| RNF213 | ring finger protein 213 | -0.033932 |
| RPL31 | ribosomal protein L31 | -0.0306728 |
| CTNNA1 | catenin (cadherin-associated protein), alpha 1, 102kDa | -0.029518 |
| ATP11A | ATPase, class VI, type 11A | -0.0294787 |
| KDM3A | lysine (K)-specific demethylase 3A | -0.0263811 |
| RAB2A | RAB2A, member RAS oncogene family | -0.0263348 |
| HNRNPH1 | heterogeneous nuclear ribonucleoprotein H1 (H) | -0.0254363 |
| POLR2A | polymerase (RNA) II (DNA directed) polypeptide A, 220kDa | -0.0247505 |
| ERO1A | endoplasmic reticulum oxidoreductase 1 alpha | -0.0244235 |
| WAC | WW domain containing adaptor with coiled-coil | -0.0241846 |
| XRN2 | 5'-3' exoribonuclease 2 | -0.0238423 |
| ARID4B | AT rich interactive domain 4B (RBP1-like) | -0.0234222 |
| GSK3B | glycogen synthase kinase 3 beta | -0.0221942 |
| UBR5 | ubiquitin protein ligase E3 component n-recognin 5 | -0.0206588 |
| RPS6 | ribosomal protein S6 | -0.020544 |
| RPL11 | ribosomal protein L11 | -0.0196471 |
| SMAD3 | SMAD family member 3 | -0.0193294 |
| ARID1B | AT rich interactive domain 1B (SWI1-like) | -0.0192559 |
| TAX1BP1 | Tax1 (human T-cell leukemia virus type I) binding protein 1 | -0.0190068 |
| RPS8 | ribosomal protein S8 | -0.0186348 |
| SLC2A3 | solute carrier family 2 (facilitated glucose transporter), member 3 | -0.0180469 |
| HMGA2 | high mobility group AT-hook 2 | -0.017988 |
| MED13L | mediator complex subunit 13-like | -0.0178062 |
| RPS12 | ribosomal protein S12 | -0.0161085 |
| ANKHD1 | ankyrin repeat and KH domain containing 1 | -0.0159925 |
| RPL37 | ribosomal protein L37 | -0.0156739 |
| BBX | bobby sox homolog (Drosophila) | -0.0155686 |
| ZNF608 | zinc finger protein 608 | -0.0147108 |
| RPL37A | ribosomal protein L37a | -0.0145319 |
| HNRNPA2B1 | heterogeneous nuclear ribonucleoprotein A2/B1 | -0.0129312 |
| FTH1 | ferritin, heavy polypeptide 1 | -0.0125162 |
| RPS16 | ribosomal protein S16 | -0.0123374 |
| PEG10 | paternally expressed 10 | -0.0122368 |
| CALM1 | calmodulin 1 (phosphorylase kinase, delta) | -0.0121207 |
| RAB7A | RAB7A, member RAS oncogene family | -0.0118286 |
| HELZ | helicase with zinc finger | -0.0107959 |
| JMJD1C | jumonji domain containing 1C | -0.0106042 |
| ANKRD17 | ankyrin repeat domain 17 | -0.0100043 |
| DNER | delta/notch-like EGF repeat containing | -0.00989452 |
| SLC38A1 | solute carrier family 38, member 1 | -0.00942048 |
| SET | SET nuclear proto-oncogene | -0.00934825 |
| CADM2 | cell adhesion molecule 2 | -0.00920844 |
| ROBO1 | roundabout, axon guidance receptor, homolog 1 (Drosophila) | -0.00889863 |
