| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | Tolcapone perturbation in NCI-H661 cell line (Tahoe Therapeutics) |
| Similar Terms | |
| Downloads & Tools |
200 genes differentially expressed following the Tolcapone_NCI-H661 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| TRIO | trio Rho guanine nucleotide exchange factor | 0.123065 |
| TENM3 | teneurin transmembrane protein 3 | 0.100063 |
| UACA | uveal autoantigen with coiled-coil domains and ankyrin repeats | 0.0974148 |
| COL5A2 | collagen, type V, alpha 2 | 0.0769329 |
| TSC22D2 | TSC22 domain family, member 2 | 0.0717498 |
| DST | dystonin | 0.0704564 |
| HSP90AB1 | heat shock protein 90kDa alpha (cytosolic), class B member 1 | 0.0682155 |
| ZNF292 | zinc finger protein 292 | 0.0630721 |
| KMT2E | lysine (K)-specific methyltransferase 2E | 0.0604946 |
| ITGAV | integrin, alpha V | 0.0597249 |
| ZFAND3 | zinc finger, AN1-type domain 3 | 0.0549797 |
| ANKRD33B | ankyrin repeat domain 33B | 0.0503719 |
| RAPGEF2 | Rap guanine nucleotide exchange factor (GEF) 2 | 0.0495436 |
| RLF | rearranged L-myc fusion | 0.0475356 |
| SPTBN1 | spectrin, beta, non-erythrocytic 1 | 0.0454927 |
| PTPN12 | protein tyrosine phosphatase, non-receptor type 12 | 0.0454861 |
| NFKBIA | nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha | 0.0453073 |
| BLTP1 | bridge-like lipid transfer protein family member 1 | 0.045232 |
| CCNL1 | cyclin L1 | 0.0447514 |
| LAMC1 | laminin, gamma 1 (formerly LAMB2) | 0.0434091 |
| PRPF8 | pre-mRNA processing factor 8 | 0.0402728 |
| ITGB1 | integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) | 0.0394061 |
| MTF2 | metal response element binding transcription factor 2 | 0.0390767 |
| AGAP1 | ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 | 0.0390232 |
| ZSWIM6 | zinc finger, SWIM-type containing 6 | 0.0382123 |
| ADAM9 | ADAM metallopeptidase domain 9 | 0.0381333 |
| FAT1 | FAT atypical cadherin 1 | 0.0378165 |
| MED13L | mediator complex subunit 13-like | 0.0377858 |
| USP3 | ubiquitin specific peptidase 3 | 0.0376745 |
| NTM | neurotrimin | 0.0370801 |
| FXR1 | fragile X mental retardation, autosomal homolog 1 | 0.0370447 |
| FN1 | fibronectin 1 | 0.0368662 |
| FBXO11 | F-box protein 11 | 0.0366827 |
| FER | fer (fps/fes related) tyrosine kinase | 0.0366649 |
| LUC7L3 | LUC7-like 3 (S. cerevisiae) | 0.0361793 |
| KDM5B | lysine (K)-specific demethylase 5B | 0.0361298 |
| MRPS30 | mitochondrial ribosomal protein S30 | 0.0352195 |
| HDAC9 | histone deacetylase 9 | 0.0341756 |
| RBM33 | RNA binding motif protein 33 | 0.0339918 |
| NCOR2 | nuclear receptor corepressor 2 | 0.0335719 |
| ARID4B | AT rich interactive domain 4B (RBP1-like) | 0.0332717 |
| SCAF8 | SR-related CTD-associated factor 8 | 0.0324214 |
| CPNE8 | copine VIII | 0.032369 |
| PRRC2B | proline-rich coiled-coil 2B | 0.0320107 |
| GPBP1 | GC-rich promoter binding protein 1 | 0.0319606 |
| RABGAP1L | RAB GTPase activating protein 1-like | 0.0318616 |
| HIVEP2 | human immunodeficiency virus type I enhancer binding protein 2 | 0.0313963 |
| MKLN1 | muskelin 1, intracellular mediator containing kelch motifs | 0.031177 |
| SRGAP1 | SLIT-ROBO Rho GTPase activating protein 1 | 0.031127 |
| JMJD1C | jumonji domain containing 1C | 0.0306737 |
| NCKAP1 | NCK-associated protein 1 | 0.0306417 |
| NUP58 | nucleoporin 58 | 0.0304358 |
| PCM1 | pericentriolar material 1 | 0.030253 |
| BBX | bobby sox homolog (Drosophila) | 0.0301135 |
| DNAH14 | dynein, axonemal, heavy chain 14 | 0.0298353 |
| EEF1A1 | eukaryotic translation elongation factor 1 alpha 1 | 0.0297184 |
| STRN3 | striatin, calmodulin binding protein 3 | 0.029688 |
| DHFR | dihydrofolate reductase | 0.029686 |
| CDC73 | cell division cycle 73 | 0.0290465 |
| RBM39 | RNA binding motif protein 39 | 0.0284507 |
| CRISPLD1 | cysteine-rich secretory protein LCCL domain containing 1 | 0.028371 |
| ABL2 | ABL proto-oncogene 2, non-receptor tyrosine kinase | 0.0282539 |
| AKAP13 | A kinase (PRKA) anchor protein 13 | 0.0280259 |
| NRXN1 | neurexin 1 | 0.0278404 |
| HNRNPA1 | heterogeneous nuclear ribonucleoprotein A1 | 0.0276109 |
| PPP3CA | protein phosphatase 3, catalytic subunit, alpha isozyme | 0.0274859 |
| RERE | arginine-glutamic acid dipeptide (RE) repeats | 0.0274696 |
| DOCK5 | dedicator of cytokinesis 5 | 0.0272029 |
| BNIP3 | BCL2/adenovirus E1B 19kDa interacting protein 3 | 0.0271896 |
| OSBPL8 | oxysterol binding protein-like 8 | 0.026992 |
| SCAF11 | SR-related CTD-associated factor 11 | 0.0269184 |
| FAM168A | family with sequence similarity 168, member A | 0.0268693 |
| SOS2 | son of sevenless homolog 2 (Drosophila) | 0.0267061 |
| SCAF4 | SR-related CTD-associated factor 4 | 0.0265888 |
| OSBPL9 | oxysterol binding protein-like 9 | 0.0265528 |
| LRBA | LPS-responsive vesicle trafficking, beach and anchor containing | 0.026372 |
| PRKCI | protein kinase C, iota | 0.0262304 |
| WDR43 | WD repeat domain 43 | 0.0262176 |
| PPP4R1 | protein phosphatase 4, regulatory subunit 1 | 0.0261282 |
| NFAT5 | nuclear factor of activated T-cells 5, tonicity-responsive | 0.0260502 |
| IGF2BP2 | insulin-like growth factor 2 mRNA binding protein 2 | 0.0259739 |
| PICALM | phosphatidylinositol binding clathrin assembly protein | 0.0259335 |
| XPO1 | exportin 1 | 0.0257625 |
| DDAH1 | dimethylarginine dimethylaminohydrolase 1 | 0.0255587 |
| SPAG16 | sperm associated antigen 16 | 0.0253895 |
| PCBP2 | poly(rC) binding protein 2 | 0.0251648 |
| FMNL2 | formin-like 2 | 0.025113 |
| KLC1 | kinesin light chain 1 | 0.0250866 |
| CUL3 | cullin 3 | 0.0249275 |
| FOXN3 | forkhead box N3 | 0.0248681 |
| NAA15 | N(alpha)-acetyltransferase 15, NatA auxiliary subunit | 0.02465 |
| PRR16 | proline rich 16 | 0.0245491 |
| CREBBP | CREB binding protein | 0.0244828 |
| PCLO | piccolo presynaptic cytomatrix protein | 0.0243805 |
| HYCC1 | hyccin PI4KA lipid kinase complex subunit 1 | 0.024255 |
| EGLN1 | egl-9 family hypoxia-inducible factor 1 | 0.0240911 |
| QKI | QKI, KH domain containing, RNA binding | 0.0240906 |
| METAP2 | methionyl aminopeptidase 2 | 0.0240771 |
| NRIP1 | nuclear receptor interacting protein 1 | 0.0239153 |
| PRKAG2 | protein kinase, AMP-activated, gamma 2 non-catalytic subunit | 0.0238817 |
| Symbol | Name | Standardized Value |
|---|---|---|
| HSPA5 | heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) | -0.184608 |
| ADGRL2 | adhesion G protein-coupled receptor L2 | -0.142474 |
| IMMP2L | IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) | -0.117702 |
| PTMA | prothymosin, alpha | -0.116444 |
| PCDH9 | protocadherin 9 | -0.106981 |
| ROBO1 | roundabout, axon guidance receptor, homolog 1 (Drosophila) | -0.103373 |
| TMSB10 | thymosin beta 10 | -0.0944978 |
| CTNNA2 | catenin (cadherin-associated protein), alpha 2 | -0.0808686 |
| PARD3B | par-3 family cell polarity regulator beta | -0.0672912 |
| ACTG1 | actin gamma 1 | -0.0651073 |
| WSB1 | WD repeat and SOCS box containing 1 | -0.0650807 |
| IRF2BP2 | interferon regulatory factor 2 binding protein 2 | -0.0627228 |
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | -0.0607883 |
| SIPA1L3 | signal-induced proliferation-associated 1 like 3 | -0.0591169 |
| HSP90B1 | heat shock protein 90kDa beta (Grp94), member 1 | -0.0564981 |
| FOXP2 | forkhead box P2 | -0.0562753 |
| KCNQ5 | potassium channel, voltage gated KQT-like subfamily Q, member 5 | -0.0548256 |
| TPT1 | tumor protein, translationally-controlled 1 | -0.0545907 |
| CTNNA3 | catenin (cadherin-associated protein), alpha 3 | -0.0542375 |
| TUT4 | terminal uridylyl transferase 4 | -0.0538643 |
| RPS16 | ribosomal protein S16 | -0.0533404 |
| PRELID2 | PRELI domain containing 2 | -0.0532071 |
| NFIA | nuclear factor I/A | -0.0521442 |
| KDM3A | lysine (K)-specific demethylase 3A | -0.0515659 |
| CALR | calreticulin | -0.0512753 |
| MYL12B | myosin, light chain 12B, regulatory | -0.0480193 |
| B2M | beta-2-microglobulin | -0.0477746 |
| CDH10 | cadherin 10, type 2 (T2-cadherin) | -0.047557 |
| HNRNPA2B1 | heterogeneous nuclear ribonucleoprotein A2/B1 | -0.0464471 |
| NRG1 | neuregulin 1 | -0.0461142 |
| PBX3 | pre-B-cell leukemia homeobox 3 | -0.0453 |
| VIM | vimentin | -0.0451922 |
| COL3A1 | collagen, type III, alpha 1 | -0.0446752 |
| CAMTA1 | calmodulin binding transcription activator 1 | -0.0441642 |
| SFRP4 | secreted frizzled-related protein 4 | -0.043887 |
| PLEKHA5 | pleckstrin homology domain containing, family A member 5 | -0.0438616 |
| FAM177A1 | family with sequence similarity 177, member A1 | -0.043784 |
| BAZ1A | bromodomain adjacent to zinc finger domain, 1A | -0.0434238 |
| RPS27A | ribosomal protein S27a | -0.0432668 |
| LRRC4C | leucine rich repeat containing 4C | -0.0418508 |
| SEMA3A | sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3A | -0.0417124 |
| HCN1 | hyperpolarization activated cyclic nucleotide gated potassium channel 1 | -0.0409918 |
| NACA | nascent polypeptide-associated complex alpha subunit | -0.0409595 |
| KIAA1328 | KIAA1328 | -0.0406082 |
| RBMS3 | RNA binding motif, single stranded interacting protein 3 | -0.0405434 |
| RPS6 | ribosomal protein S6 | -0.0401915 |
| P4HA1 | prolyl 4-hydroxylase, alpha polypeptide I | -0.0398967 |
| SMYD3 | SET and MYND domain containing 3 | -0.0392175 |
| NEBL | nebulette | -0.0383353 |
| AHNAK | AHNAK nucleoprotein | -0.0382494 |
| SNX6 | sorting nexin 6 | -0.0379509 |
| ANK2 | ankyrin 2, neuronal | -0.0376706 |
| CSMD3 | CUB and Sushi multiple domains 3 | -0.0373731 |
| RPL32 | ribosomal protein L32 | -0.0371663 |
| RPL35A | ribosomal protein L35a | -0.0358928 |
| ZNF217 | zinc finger protein 217 | -0.0358247 |
| HSPD1 | heat shock 60kDa protein 1 (chaperonin) | -0.0352773 |
| LRRN3 | leucine rich repeat neuronal 3 | -0.0351105 |
| ISG15 | ISG15 ubiquitin-like modifier | -0.0350475 |
| KCTD16 | potassium channel tetramerization domain containing 16 | -0.0349715 |
| RPS8 | ribosomal protein S8 | -0.034518 |
| SSR3 | signal sequence receptor, gamma (translocon-associated protein gamma) | -0.0342363 |
| KPNB1 | karyopherin (importin) beta 1 | -0.0338177 |
| NF1 | neurofibromin 1 | -0.0336433 |
| TFRC | transferrin receptor | -0.033211 |
| RDX | radixin | -0.0328211 |
| ELAVL3 | ELAV like neuron-specific RNA binding protein 3 | -0.0320216 |
| PPFIA1 | protein tyrosine phosphatase, receptor type, f polypeptide (PTPRF), interacting protein (liprin), alpha 1 | -0.0313771 |
| NR2F1 | nuclear receptor subfamily 2, group F, member 1 | -0.0313329 |
| TENM2 | teneurin transmembrane protein 2 | -0.0312973 |
| ARL6IP1 | ADP-ribosylation factor-like 6 interacting protein 1 | -0.031236 |
| SOX2 | SRY (sex determining region Y)-box 2 | -0.0311103 |
| RPLP0 | ribosomal protein, large, P0 | -0.0310815 |
| ENO1 | enolase 1, (alpha) | -0.031064 |
| RAD21 | RAD21 homolog (S. pombe) | -0.0307478 |
| RSL1D1 | ribosomal L1 domain containing 1 | -0.0305121 |
| RPL9 | ribosomal protein L9 | -0.0302431 |
| PPP1R12A | protein phosphatase 1, regulatory subunit 12A | -0.0301792 |
| ARF1 | ADP-ribosylation factor 1 | -0.0296188 |
| ZEB2 | zinc finger E-box binding homeobox 2 | -0.0294021 |
| PHF21A | PHD finger protein 21A | -0.0293329 |
| SGO2 | shugoshin 2 | -0.0290958 |
| EIF1 | eukaryotic translation initiation factor 1 | -0.0289377 |
| SYT1 | synaptotagmin I | -0.0287551 |
| RPL37 | ribosomal protein L37 | -0.0287345 |
| TOX | thymocyte selection-associated high mobility group box | -0.0284621 |
| DENND1A | DENN/MADD domain containing 1A | -0.0284335 |
| CDH4 | cadherin 4, type 1, R-cadherin (retinal) | -0.0283634 |
| MARCKS | myristoylated alanine-rich protein kinase C substrate | -0.0282741 |
| RPL19 | ribosomal protein L19 | -0.0281239 |
| PGAP1 | post-GPI attachment to proteins 1 | -0.0280125 |
| SRP72 | signal recognition particle 72kDa | -0.027444 |
| MEIS2 | Meis homeobox 2 | -0.0274162 |
| PRRC2C | proline-rich coiled-coil 2C | -0.0272103 |
| RPL38 | ribosomal protein L38 | -0.0271073 |
| PTGES3 | prostaglandin E synthase 3 (cytosolic) | -0.0270459 |
| EIF5B | eukaryotic translation initiation factor 5B | -0.0270439 |
| FBXL2 | F-box and leucine-rich repeat protein 2 | -0.0266867 |
| RACK1 | receptor for activated C kinase 1 | -0.0266862 |
| CAP1 | CAP, adenylate cyclase-associated protein 1 (yeast) | -0.0266719 |
