| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | Tolcapone perturbation in SNU-1 cell line (Tahoe Therapeutics) |
| Similar Terms | |
| Downloads & Tools |
200 genes differentially expressed following the Tolcapone_SNU-1 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| PDE4D | phosphodiesterase 4D, cAMP-specific | 0.0805047 |
| PDGFC | platelet derived growth factor C | 0.078537 |
| TJP1 | tight junction protein 1 | 0.07268 |
| PDE4B | phosphodiesterase 4B, cAMP-specific | 0.0658404 |
| CRIM1 | cysteine rich transmembrane BMP regulator 1 (chordin-like) | 0.062653 |
| HDAC9 | histone deacetylase 9 | 0.0624002 |
| ZNF608 | zinc finger protein 608 | 0.0544955 |
| NFAT5 | nuclear factor of activated T-cells 5, tonicity-responsive | 0.0527249 |
| SOX6 | SRY (sex determining region Y)-box 6 | 0.0508137 |
| ZEB1 | zinc finger E-box binding homeobox 1 | 0.050062 |
| EGFR | epidermal growth factor receptor | 0.0491291 |
| FLNB | filamin B, beta | 0.046013 |
| SSBP2 | single-stranded DNA binding protein 2 | 0.0459646 |
| SLC38A2 | solute carrier family 38, member 2 | 0.0422059 |
| ZFAND3 | zinc finger, AN1-type domain 3 | 0.0416403 |
| ECT2 | epithelial cell transforming 2 | 0.0403198 |
| TSC22D1 | TSC22 domain family, member 1 | 0.0403083 |
| TMEM65 | transmembrane protein 65 | 0.0397913 |
| BMP2K | BMP2 inducible kinase | 0.0395648 |
| GOLGA4 | golgin A4 | 0.0380848 |
| SLC7A1 | solute carrier family 7 (cationic amino acid transporter, y+ system), member 1 | 0.0363674 |
| LPP | LIM domain containing preferred translocation partner in lipoma | 0.0362281 |
| TRIO | trio Rho guanine nucleotide exchange factor | 0.0357344 |
| GLI2 | GLI family zinc finger 2 | 0.0352463 |
| ENOX1 | ecto-NOX disulfide-thiol exchanger 1 | 0.0329275 |
| FBLN2 | fibulin 2 | 0.0308663 |
| ZMYM2 | zinc finger, MYM-type 2 | 0.0307258 |
| PICALM | phosphatidylinositol binding clathrin assembly protein | 0.0304892 |
| USP34 | ubiquitin specific peptidase 34 | 0.0302369 |
| ANKRD11 | ankyrin repeat domain 11 | 0.0302322 |
| PYGB | phosphorylase, glycogen; brain | 0.0292923 |
| PRELID2 | PRELI domain containing 2 | 0.0290083 |
| AHCYL2 | adenosylhomocysteinase-like 2 | 0.0288648 |
| NPAS2 | neuronal PAS domain protein 2 | 0.0285466 |
| KDM6A | lysine (K)-specific demethylase 6A | 0.0284657 |
| PPP2R2A | protein phosphatase 2, regulatory subunit B, alpha | 0.0282755 |
| CTIF | CBP80/20-dependent translation initiation factor | 0.0282667 |
| KDM4C | lysine (K)-specific demethylase 4C | 0.0282434 |
| BIRC6 | baculoviral IAP repeat containing 6 | 0.0282201 |
| DYRK1A | dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1A | 0.0281187 |
| SYNE2 | spectrin repeat containing, nuclear envelope 2 | 0.027626 |
| GARS1 | glycyl-tRNA synthetase 1 | 0.0276223 |
| TGFBR3 | transforming growth factor, beta receptor III | 0.0275319 |
| KLF3 | Kruppel-like factor 3 (basic) | 0.0273668 |
| RNF145 | ring finger protein 145 | 0.0273062 |
| TBL1XR1 | transducin (beta)-like 1 X-linked receptor 1 | 0.0273006 |
| DOCK3 | dedicator of cytokinesis 3 | 0.0271377 |
| NBAS | neuroblastoma amplified sequence | 0.0271218 |
| ANK2 | ankyrin 2, neuronal | 0.0264992 |
| VCL | vinculin | 0.0263481 |
| EVI5 | ecotropic viral integration site 5 | 0.0262052 |
| MBNL1 | muscleblind-like splicing regulator 1 | 0.026011 |
| SRPK2 | SRSF protein kinase 2 | 0.0255295 |
| ATP13A3 | ATPase type 13A3 | 0.0253288 |
| FOXP1 | forkhead box P1 | 0.0252453 |
| TBL1X | transducin (beta)-like 1X-linked | 0.0251504 |
| NUP58 | nucleoporin 58 | 0.0251483 |
| TBC1D5 | TBC1 domain family, member 5 | 0.0249451 |
| SAMD4A | sterile alpha motif domain containing 4A | 0.0248148 |
| TEAD1 | TEA domain family member 1 (SV40 transcriptional enhancer factor) | 0.0243596 |
| KMT2C | lysine (K)-specific methyltransferase 2C | 0.0243256 |
| GLI3 | GLI family zinc finger 3 | 0.0243109 |
| DHFR | dihydrofolate reductase | 0.0242225 |
| ENTPD6 | ectonucleoside triphosphate diphosphohydrolase 6 (putative) | 0.0240688 |
| CYTH3 | cytohesin 3 | 0.0239378 |
| ADAM9 | ADAM metallopeptidase domain 9 | 0.023881 |
| BRWD1 | bromodomain and WD repeat domain containing 1 | 0.0237441 |
| RBM33 | RNA binding motif protein 33 | 0.0236396 |
| ARID1B | AT rich interactive domain 1B (SWI1-like) | 0.0235495 |
| ELF2 | E74-like factor 2 (ets domain transcription factor) | 0.023537 |
| EFNA5 | ephrin-A5 | 0.0234654 |
| RTN4 | reticulon 4 | 0.0233643 |
| RBM39 | RNA binding motif protein 39 | 0.023244 |
| SMYD3 | SET and MYND domain containing 3 | 0.0232246 |
| QKI | QKI, KH domain containing, RNA binding | 0.0230891 |
| SCLT1 | sodium channel and clathrin linker 1 | 0.0230619 |
| TRIM25 | tripartite motif containing 25 | 0.0230345 |
| FAT1 | FAT atypical cadherin 1 | 0.0228795 |
| NCEH1 | neutral cholesterol ester hydrolase 1 | 0.0228655 |
| SMAD6 | SMAD family member 6 | 0.0227225 |
| ROCK1 | Rho-associated, coiled-coil containing protein kinase 1 | 0.0224713 |
| CRY1 | cryptochrome circadian clock 1 | 0.0224065 |
| SPTAN1 | spectrin, alpha, non-erythrocytic 1 | 0.0222929 |
| MEF2A | myocyte enhancer factor 2A | 0.0222317 |
| VPS13B | vacuolar protein sorting 13 homolog B (yeast) | 0.0219361 |
| SMC5 | structural maintenance of chromosomes 5 | 0.0218447 |
| POU2F1 | POU class 2 homeobox 1 | 0.0218029 |
| UBR5 | ubiquitin protein ligase E3 component n-recognin 5 | 0.0216869 |
| RB1CC1 | RB1-inducible coiled-coil 1 | 0.0216825 |
| PLK2 | polo-like kinase 2 | 0.0212574 |
| CHD1 | chromodomain helicase DNA binding protein 1 | 0.0211737 |
| DOCK5 | dedicator of cytokinesis 5 | 0.0209833 |
| ZNF644 | zinc finger protein 644 | 0.0209815 |
| STRN3 | striatin, calmodulin binding protein 3 | 0.020905 |
| RBM26 | RNA binding motif protein 26 | 0.0205952 |
| ARGLU1 | arginine and glutamate rich 1 | 0.0203383 |
| SFPQ | splicing factor proline/glutamine-rich | 0.0202768 |
| LUC7L2 | LUC7-like 2 (S. cerevisiae) | 0.020175 |
| PSME4 | proteasome (prosome, macropain) activator subunit 4 | 0.0201674 |
| DICER1 | dicer 1, ribonuclease type III | 0.0201503 |
| Symbol | Name | Standardized Value |
|---|---|---|
| PTMA | prothymosin, alpha | -0.382748 |
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | -0.323314 |
| RPS6 | ribosomal protein S6 | -0.166106 |
| PKM | pyruvate kinase, muscle | -0.0931187 |
| BMP10 | bone morphogenetic protein 10 | -0.0922286 |
| TMSB4X | thymosin beta 4, X-linked | -0.0911207 |
| RPL35A | ribosomal protein L35a | -0.0903869 |
| TPT1 | tumor protein, translationally-controlled 1 | -0.0879341 |
| RPS8 | ribosomal protein S8 | -0.0877294 |
| AHNAK | AHNAK nucleoprotein | -0.0863918 |
| RPL34 | ribosomal protein L34 | -0.0805102 |
| HSP90AA1 | heat shock protein 90kDa alpha (cytosolic), class A member 1 | -0.0739465 |
| RPL31 | ribosomal protein L31 | -0.0556313 |
| RPS13 | ribosomal protein S13 | -0.0547752 |
| HSPB1 | heat shock 27kDa protein 1 | -0.0516077 |
| ACTG1 | actin gamma 1 | -0.0495695 |
| CALM2 | calmodulin 2 (phosphorylase kinase, delta) | -0.049023 |
| KPNB1 | karyopherin (importin) beta 1 | -0.0487608 |
| RPS25 | ribosomal protein S25 | -0.0483523 |
| RPLP1 | ribosomal protein, large, P1 | -0.0469695 |
| TM4SF1 | transmembrane 4 L six family member 1 | -0.0432598 |
| RPS19 | ribosomal protein S19 | -0.0413352 |
| CCND1 | cyclin D1 | -0.0411392 |
| S100A10 | S100 calcium binding protein A10 | -0.0410495 |
| ANXA1 | annexin A1 | -0.0402751 |
| PABPC1 | poly(A) binding protein, cytoplasmic 1 | -0.0401317 |
| ENO1 | enolase 1, (alpha) | -0.0398585 |
| RPS23 | ribosomal protein S23 | -0.0377558 |
| RPL5 | ribosomal protein L5 | -0.0371385 |
| RPL4 | ribosomal protein L4 | -0.036524 |
| S100A9 | S100 calcium binding protein A9 | -0.0360601 |
| RPL8 | ribosomal protein L8 | -0.0359159 |
| EIF1 | eukaryotic translation initiation factor 1 | -0.035636 |
| RPLP2 | ribosomal protein, large, P2 | -0.034931 |
| RPS29 | ribosomal protein S29 | -0.0342287 |
| LDHA | lactate dehydrogenase A | -0.0341854 |
| RPL12 | ribosomal protein L12 | -0.0333418 |
| RPL38 | ribosomal protein L38 | -0.0332495 |
| RSL1D1 | ribosomal L1 domain containing 1 | -0.032623 |
| RPS27A | ribosomal protein S27a | -0.0320793 |
| SQSTM1 | sequestosome 1 | -0.0314348 |
| RPL32 | ribosomal protein L32 | -0.031036 |
| MKI67 | marker of proliferation Ki-67 | -0.0310108 |
| MINDY2 | MINDY lysine 48 deubiquitinase 2 | -0.0308326 |
| TAS2R14 | taste receptor, type 2, member 14 | -0.0305282 |
| RACK1 | receptor for activated C kinase 1 | -0.0303547 |
| RPL7A | ribosomal protein L7a | -0.0299736 |
| ASPH | aspartate beta-hydroxylase | -0.0297801 |
| TPM4 | tropomyosin 4 | -0.0297438 |
| RPS16 | ribosomal protein S16 | -0.0290086 |
| RPL10A | ribosomal protein L10a | -0.0286204 |
| IRF2BP2 | interferon regulatory factor 2 binding protein 2 | -0.0280794 |
| EEF2 | eukaryotic translation elongation factor 2 | -0.0277906 |
| S100A4 | S100 calcium binding protein A4 | -0.0277819 |
| YWHAB | tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta | -0.0274476 |
| ZMYND8 | zinc finger, MYND-type containing 8 | -0.0271115 |
| RPL15 | ribosomal protein L15 | -0.0265701 |
| HSP90B1 | heat shock protein 90kDa beta (Grp94), member 1 | -0.0265417 |
| BNIP3 | BCL2/adenovirus E1B 19kDa interacting protein 3 | -0.0258894 |
| RPS24 | ribosomal protein S24 | -0.0257478 |
| RPS5 | ribosomal protein S5 | -0.025731 |
| RPL26 | ribosomal protein L26 | -0.0252873 |
| SERPINB1 | serpin peptidase inhibitor, clade B (ovalbumin), member 1 | -0.0250937 |
| RPS3 | ribosomal protein S3 | -0.0249574 |
| RLF | rearranged L-myc fusion | -0.0243886 |
| ARL4C | ADP-ribosylation factor-like 4C | -0.0240711 |
| RPS17 | ribosomal protein S17 | -0.0240491 |
| VIM | vimentin | -0.0237983 |
| KTN1 | kinectin 1 (kinesin receptor) | -0.0237516 |
| ADAM10 | ADAM metallopeptidase domain 10 | -0.0237437 |
| RPL37A | ribosomal protein L37a | -0.0237428 |
| CCNH | cyclin H | -0.0237423 |
| RPL9 | ribosomal protein L9 | -0.0235968 |
| PDE7B | phosphodiesterase 7B | -0.0234879 |
| YWHAZ | tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta | -0.0231721 |
| EBNA1BP2 | EBNA1 binding protein 2 | -0.0231645 |
| RPL27A | ribosomal protein L27a | -0.0230265 |
| ALDH3A2 | aldehyde dehydrogenase 3 family, member A2 | -0.022961 |
| HSPD1 | heat shock 60kDa protein 1 (chaperonin) | -0.0229237 |
| PGK1 | phosphoglycerate kinase 1 | -0.0227994 |
| INPP4B | inositol polyphosphate-4-phosphatase, type II, 105kDa | -0.0226457 |
| HNRNPA2B1 | heterogeneous nuclear ribonucleoprotein A2/B1 | -0.0221993 |
| TUBA1B | tubulin, alpha 1b | -0.0219967 |
| RPL35 | ribosomal protein L35 | -0.0218766 |
| ITGA10 | integrin, alpha 10 | -0.0218298 |
| PSD3 | pleckstrin and Sec7 domain containing 3 | -0.0216822 |
| LDHB | lactate dehydrogenase B | -0.0214929 |
| LOC102724023 | ES1 protein homolog, mitochondrial | -0.0213035 |
| RPS14 | ribosomal protein S14 | -0.0211947 |
| RPS27 | ribosomal protein S27 | -0.0211729 |
| ENOSF1 | enolase superfamily member 1 | -0.0210523 |
| WDR45B | WD repeat domain 45B | -0.0209824 |
| FN1 | fibronectin 1 | -0.020975 |
| KHDRBS1 | KH domain containing, RNA binding, signal transduction associated 1 | -0.0208179 |
| NAP1L1 | nucleosome assembly protein 1-like 1 | -0.0208106 |
| RPL36A | ribosomal protein L36a | -0.0207722 |
| DUSP6 | dual specificity phosphatase 6 | -0.0206784 |
| RPLP0 | ribosomal protein, large, P0 | -0.0206515 |
| DLG1 | discs, large homolog 1 (Drosophila) | -0.0205985 |
| PDS5A | PDS5 cohesin associated factor A | -0.0205269 |
