| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | Tolcapone perturbation in SNU-423 cell line (Tahoe Therapeutics) |
| Similar Terms | |
| Downloads & Tools |
200 genes differentially expressed following the Tolcapone_SNU-423 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| HDAC9 | histone deacetylase 9 | 0.13136 |
| BICC1 | BicC family RNA binding protein 1 | 0.0783853 |
| FRMD4A | FERM domain containing 4A | 0.0761176 |
| KYNU | kynureninase | 0.0737045 |
| ZSWIM6 | zinc finger, SWIM-type containing 6 | 0.0720868 |
| COL6A3 | collagen, type VI, alpha 3 | 0.070593 |
| EXT1 | exostosin glycosyltransferase 1 | 0.0677471 |
| EPAS1 | endothelial PAS domain protein 1 | 0.0564526 |
| ZBTB38 | zinc finger and BTB domain containing 38 | 0.0543748 |
| INTS6 | integrator complex subunit 6 | 0.0458464 |
| ETS1 | v-ets avian erythroblastosis virus E26 oncogene homolog 1 | 0.0429156 |
| RNF213 | ring finger protein 213 | 0.0426666 |
| VCL | vinculin | 0.0424658 |
| SMAD3 | SMAD family member 3 | 0.0410171 |
| GPC6 | glypican 6 | 0.040263 |
| HIVEP2 | human immunodeficiency virus type I enhancer binding protein 2 | 0.0399811 |
| SEPTIN9 | septin 9 | 0.0399501 |
| IMMP2L | IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) | 0.0394926 |
| AKAP12 | A kinase (PRKA) anchor protein 12 | 0.0388177 |
| ZMIZ1 | zinc finger, MIZ-type containing 1 | 0.0380614 |
| TRIO | trio Rho guanine nucleotide exchange factor | 0.0376362 |
| HMGA2 | high mobility group AT-hook 2 | 0.0371193 |
| ATP2B1 | ATPase, Ca++ transporting, plasma membrane 1 | 0.0356522 |
| ABL2 | ABL proto-oncogene 2, non-receptor tyrosine kinase | 0.0355206 |
| SCD | stearoyl-CoA desaturase (delta-9-desaturase) | 0.0351266 |
| TBC1D8 | TBC1 domain family, member 8 (with GRAM domain) | 0.0350683 |
| TGM2 | transglutaminase 2 | 0.0347397 |
| SMYD3 | SET and MYND domain containing 3 | 0.0345039 |
| VEGFA | vascular endothelial growth factor A | 0.0339084 |
| KCNMA1 | potassium channel, calcium activated large conductance subfamily M alpha, member 1 | 0.0331982 |
| ATXN1 | ataxin 1 | 0.0318072 |
| DUSP10 | dual specificity phosphatase 10 | 0.031649 |
| NHS | Nance-Horan syndrome (congenital cataracts and dental anomalies) | 0.0314454 |
| TNS3 | tensin 3 | 0.0301838 |
| HERC4 | HECT and RLD domain containing E3 ubiquitin protein ligase 4 | 0.0297453 |
| LAMC1 | laminin, gamma 1 (formerly LAMB2) | 0.0294351 |
| RAD51B | RAD51 paralog B | 0.0292066 |
| FNIP1 | folliculin interacting protein 1 | 0.0289038 |
| IGFN1 | immunoglobulin-like and fibronectin type III domain containing 1 | 0.0288758 |
| WWOX | WW domain containing oxidoreductase | 0.0287432 |
| IL1RAPL1 | interleukin 1 receptor accessory protein-like 1 | 0.0287305 |
| JMJD1C | jumonji domain containing 1C | 0.0286497 |
| FHIT | fragile histidine triad | 0.0282991 |
| SHB | Src homology 2 domain containing adaptor protein B | 0.0275832 |
| IRAK2 | interleukin-1 receptor-associated kinase 2 | 0.0275185 |
| IQCJ-SCHIP1 | IQCJ-SCHIP1 readthrough | 0.0272205 |
| MAGI2 | membrane associated guanylate kinase, WW and PDZ domain containing 2 | 0.026381 |
| PPFIBP1 | PTPRF interacting protein, binding protein 1 (liprin beta 1) | 0.0263539 |
| MYOF | myoferlin | 0.0259516 |
| CPEB4 | cytoplasmic polyadenylation element binding protein 4 | 0.0255992 |
| TLE4 | transducin-like enhancer of split 4 | 0.0255547 |
| SOX9 | SRY (sex determining region Y)-box 9 | 0.0251804 |
| FMN1 | formin 1 | 0.0251722 |
| DUSP5 | dual specificity phosphatase 5 | 0.0238852 |
| FNDC3B | fibronectin type III domain containing 3B | 0.0237347 |
| NEDD4L | neural precursor cell expressed, developmentally down-regulated 4-like, E3 ubiquitin protein ligase | 0.0236913 |
| PMEPA1 | prostate transmembrane protein, androgen induced 1 | 0.0235506 |
| EGFR | epidermal growth factor receptor | 0.0233218 |
| VCAN | versican | 0.0228687 |
| RUNX1 | runt-related transcription factor 1 | 0.0227767 |
| MBNL1 | muscleblind-like splicing regulator 1 | 0.0225451 |
| RAB7A | RAB7A, member RAS oncogene family | 0.0224673 |
| PDE10A | phosphodiesterase 10A | 0.0224187 |
| TIMP2 | TIMP metallopeptidase inhibitor 2 | 0.021728 |
| CORO1C | coronin, actin binding protein, 1C | 0.0216053 |
| ZHX2 | zinc fingers and homeoboxes 2 | 0.0214358 |
| SIPA1L1 | signal-induced proliferation-associated 1 like 1 | 0.0213636 |
| SLC39A11 | solute carrier family 39, member 11 | 0.0212822 |
| RND3 | Rho family GTPase 3 | 0.0212388 |
| FBXL7 | F-box and leucine-rich repeat protein 7 | 0.0211673 |
| BCAR3 | breast cancer anti-estrogen resistance 3 | 0.0211442 |
| LOXL2 | lysyl oxidase-like 2 | 0.021088 |
| PDLIM5 | PDZ and LIM domain 5 | 0.0210736 |
| ITGA2 | integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) | 0.020323 |
| MBD5 | methyl-CpG binding domain protein 5 | 0.0202361 |
| NR3C1 | nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor) | 0.0200557 |
| KSR1 | kinase suppressor of ras 1 | 0.0198914 |
| PCLO | piccolo presynaptic cytomatrix protein | 0.019808 |
| EFNA5 | ephrin-A5 | 0.0197989 |
| TMEM132D | transmembrane protein 132D | 0.0196988 |
| CCNL1 | cyclin L1 | 0.0196082 |
| FNIP2 | folliculin interacting protein 2 | 0.0194983 |
| RASAL2 | RAS protein activator like 2 | 0.0192888 |
| FBXO32 | F-box protein 32 | 0.0192813 |
| GLIS3 | GLIS family zinc finger 3 | 0.0191478 |
| EPC2 | enhancer of polycomb homolog 2 (Drosophila) | 0.0191143 |
| PTPRK | protein tyrosine phosphatase, receptor type, K | 0.018997 |
| SPOCK1 | sparc/osteonectin, cwcv and kazal-like domains proteoglycan (testican) 1 | 0.01879 |
| UTRN | utrophin | 0.0187461 |
| AGAP1 | ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 | 0.0187064 |
| TUT7 | terminal uridylyl transferase 7 | 0.0186568 |
| ZFYVE16 | zinc finger, FYVE domain containing 16 | 0.018602 |
| FER | fer (fps/fes related) tyrosine kinase | 0.0184335 |
| TIAM2 | T-cell lymphoma invasion and metastasis 2 | 0.0181939 |
| UBASH3B | ubiquitin associated and SH3 domain containing B | 0.0181923 |
| VTI1A | vesicle transport through interaction with t-SNAREs 1A | 0.0181392 |
| SMURF2 | SMAD specific E3 ubiquitin protein ligase 2 | 0.0181039 |
| SLC4A7 | solute carrier family 4, sodium bicarbonate cotransporter, member 7 | 0.0181023 |
| SMAD2 | SMAD family member 2 | 0.017996 |
| RALGAPA2 | Ral GTPase activating protein, alpha subunit 2 (catalytic) | 0.0178454 |
| Symbol | Name | Standardized Value |
|---|---|---|
| VIM | vimentin | -0.308901 |
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | -0.144272 |
| HLA-B | major histocompatibility complex, class I, B | -0.131186 |
| HSP90B1 | heat shock protein 90kDa beta (Grp94), member 1 | -0.123326 |
| HSP90AB1 | heat shock protein 90kDa alpha (cytosolic), class B member 1 | -0.109798 |
| UBC | ubiquitin C | -0.0994792 |
| PTMA | prothymosin, alpha | -0.0940344 |
| IER3 | immediate early response 3 | -0.0908855 |
| PGK1 | phosphoglycerate kinase 1 | -0.0875167 |
| TPT1 | tumor protein, translationally-controlled 1 | -0.0850705 |
| RPS27A | ribosomal protein S27a | -0.0811593 |
| CANX | calnexin | -0.0797275 |
| SPARC | secreted protein, acidic, cysteine-rich (osteonectin) | -0.0772426 |
| ENO1 | enolase 1, (alpha) | -0.076344 |
| AHNAK | AHNAK nucleoprotein | -0.0724876 |
| ZNF292 | zinc finger protein 292 | -0.0712887 |
| HSPA5 | heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) | -0.0705296 |
| TMSB10 | thymosin beta 10 | -0.0663404 |
| ITGB1 | integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) | -0.0653693 |
| LDHA | lactate dehydrogenase A | -0.0623028 |
| HLA-E | major histocompatibility complex, class I, E | -0.0594412 |
| CALR | calreticulin | -0.0593534 |
| NPM1 | nucleophosmin (nucleolar phosphoprotein B23, numatrin) | -0.0581881 |
| NAMPT | nicotinamide phosphoribosyltransferase | -0.0558435 |
| EEF2 | eukaryotic translation elongation factor 2 | -0.0553066 |
| ELL2 | elongation factor, RNA polymerase II, 2 | -0.0547928 |
| ARL6IP1 | ADP-ribosylation factor-like 6 interacting protein 1 | -0.0547332 |
| PABPC1 | poly(A) binding protein, cytoplasmic 1 | -0.0546222 |
| ZMYND8 | zinc finger, MYND-type containing 8 | -0.054499 |
| MXI1 | MAX interactor 1, dimerization protein | -0.054288 |
| ADM | adrenomedullin | -0.0523471 |
| ANXA2 | annexin A2 | -0.0521782 |
| RPS3 | ribosomal protein S3 | -0.050522 |
| RPS24 | ribosomal protein S24 | -0.049934 |
| NAP1L1 | nucleosome assembly protein 1-like 1 | -0.0486383 |
| RPL23 | ribosomal protein L23 | -0.0478719 |
| KDM3A | lysine (K)-specific demethylase 3A | -0.0478039 |
| COL1A1 | collagen, type I, alpha 1 | -0.0471323 |
| CD44 | CD44 molecule (Indian blood group) | -0.046293 |
| EIF1 | eukaryotic translation initiation factor 1 | -0.045134 |
| KPNB1 | karyopherin (importin) beta 1 | -0.0443948 |
| MT2A | metallothionein 2A | -0.0437321 |
| TPM4 | tropomyosin 4 | -0.0434651 |
| TOP2A | topoisomerase (DNA) II alpha 170kDa | -0.043274 |
| SOD2 | superoxide dismutase 2, mitochondrial | -0.0430944 |
| FN1 | fibronectin 1 | -0.0428621 |
| MARCKS | myristoylated alanine-rich protein kinase C substrate | -0.0419869 |
| IGFBP3 | insulin-like growth factor binding protein 3 | -0.0419226 |
| P4HA1 | prolyl 4-hydroxylase, alpha polypeptide I | -0.0419022 |
| RBPJ | recombination signal binding protein for immunoglobulin kappa J region | -0.0410588 |
| B2M | beta-2-microglobulin | -0.0407397 |
| RPS8 | ribosomal protein S8 | -0.0407371 |
| FTL | ferritin, light polypeptide | -0.0402622 |
| GOLGA4 | golgin A4 | -0.0394833 |
| OGA | O-GlcNAcase | -0.0389188 |
| PNRC1 | proline-rich nuclear receptor coactivator 1 | -0.0385291 |
| WDFY1 | WD repeat and FYVE domain containing 1 | -0.0383478 |
| WSB1 | WD repeat and SOCS box containing 1 | -0.0382581 |
| JUN | jun proto-oncogene | -0.037319 |
| ERO1A | endoplasmic reticulum oxidoreductase 1 alpha | -0.0363813 |
| RTN4 | reticulon 4 | -0.0362894 |
| ARRDC3 | arrestin domain containing 3 | -0.0360709 |
| STC1 | stanniocalcin 1 | -0.0360667 |
| RAI14 | retinoic acid induced 14 | -0.0357916 |
| SLC38A1 | solute carrier family 38, member 1 | -0.0355034 |
| P4HA2 | prolyl 4-hydroxylase, alpha polypeptide II | -0.0351088 |
| BTG1 | B-cell translocation gene 1, anti-proliferative | -0.0348355 |
| RAI1 | retinoic acid induced 1 | -0.0344288 |
| SDC4 | syndecan 4 | -0.0340316 |
| BNIP3 | BCL2/adenovirus E1B 19kDa interacting protein 3 | -0.033987 |
| SEPTIN7 | septin 7 | -0.0334581 |
| ANLN | anillin, actin binding protein | -0.0318181 |
| RPS13 | ribosomal protein S13 | -0.0314854 |
| GNAS | GNAS complex locus | -0.0312321 |
| NUCKS1 | nuclear casein kinase and cyclin-dependent kinase substrate 1 | -0.0303556 |
| HIF1A | hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) | -0.0300666 |
| SRGN | serglycin | -0.0298971 |
| RPL37A | ribosomal protein L37a | -0.0298875 |
| LRRFIP1 | leucine rich repeat (in FLII) interacting protein 1 | -0.0298306 |
| MATR3 | matrin 3 | -0.0296353 |
| DDIT4 | DNA-damage-inducible transcript 4 | -0.0294454 |
| UGCG | UDP-glucose ceramide glucosyltransferase | -0.0284987 |
| RPLP2 | ribosomal protein, large, P2 | -0.0284649 |
| NDRG1 | N-myc downstream regulated 1 | -0.0282352 |
| CSDE1 | cold shock domain containing E1, RNA-binding | -0.0282282 |
| NT5C2 | 5'-nucleotidase, cytosolic II | -0.027276 |
| RPL36A | ribosomal protein L36a | -0.0271955 |
| CALU | calumenin | -0.0271189 |
| COL1A2 | collagen, type I, alpha 2 | -0.0270642 |
| THBS1 | thrombospondin 1 | -0.0268526 |
| RACK1 | receptor for activated C kinase 1 | -0.0264181 |
| KHDRBS1 | KH domain containing, RNA binding, signal transduction associated 1 | -0.026134 |
| P4HB | prolyl 4-hydroxylase, beta polypeptide | -0.0260977 |
| FAM162A | family with sequence similarity 162, member A | -0.0254734 |
| ARL4C | ADP-ribosylation factor-like 4C | -0.0252699 |
| PCBP2 | poly(rC) binding protein 2 | -0.0251986 |
| NPEPPS | aminopeptidase puromycin sensitive | -0.0251465 |
| RPS12 | ribosomal protein S12 | -0.0250532 |
| FUT11 | fucosyltransferase 11 (alpha (1,3) fucosyltransferase) | -0.0250455 |
| PJA2 | praja ring finger 2, E3 ubiquitin protein ligase | -0.024978 |
