Tolcapone_SW 1088 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Tolcapone perturbation in SW 1088 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Tolcapone_SW 1088 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
COL6A3 collagen, type VI, alpha 3 0.272272
MYH9 myosin, heavy chain 9, non-muscle 0.0936447
ZSWIM6 zinc finger, SWIM-type containing 6 0.0848981
IGFBP3 insulin-like growth factor binding protein 3 0.0819131
HMGA2 high mobility group AT-hook 2 0.0797232
AGAP1 ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 0.0766618
TNS3 tensin 3 0.0731649
FN1 fibronectin 1 0.0683488
HIPK2 homeodomain interacting protein kinase 2 0.065573
NRXN3 neurexin 3 0.0644234
STC1 stanniocalcin 1 0.0621446
VEGFC vascular endothelial growth factor C 0.0598152
KYNU kynureninase 0.0588782
PSD3 pleckstrin and Sec7 domain containing 3 0.058565
ITGA2 integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) 0.0569821
GLIS3 GLIS family zinc finger 3 0.0560539
AKAP12 A kinase (PRKA) anchor protein 12 0.0544212
CDH13 cadherin 13 0.051844
COL5A1 collagen, type V, alpha 1 0.0500907
FNDC3B fibronectin type III domain containing 3B 0.0499907
EXT1 exostosin glycosyltransferase 1 0.0480027
MACF1 microtubule-actin crosslinking factor 1 0.0455078
EGFR epidermal growth factor receptor 0.0447847
GOLGB1 golgin B1 0.0445858
SEC31A SEC31 homolog A (S. cerevisiae) 0.044382
EFNA5 ephrin-A5 0.0435703
IMMP2L IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) 0.04304
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 0.0421644
PTGES2 prostaglandin E synthase 2 0.042039
PLOD2 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 0.0420302
MICAL2 microtubule associated monooxygenase, calponin and LIM domain containing 2 0.0414995
FNIP1 folliculin interacting protein 1 0.0414554
LOXL2 lysyl oxidase-like 2 0.0413674
ATXN1 ataxin 1 0.0408845
COL7A1 collagen, type VII, alpha 1 0.040158
INTS6 integrator complex subunit 6 0.0400102
SMAD3 SMAD family member 3 0.0391096
PFKFB4 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 4 0.0385205
TRIO trio Rho guanine nucleotide exchange factor 0.0378413
HDLBP high density lipoprotein binding protein 0.0377611
LAMB1 laminin, beta 1 0.0377246
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 0.0375543
MYOF myoferlin 0.0375115
RERE arginine-glutamic acid dipeptide (RE) repeats 0.0373265
FLNA filamin A, alpha 0.0371719
MKLN1 muskelin 1, intracellular mediator containing kelch motifs 0.036919
PMEPA1 prostate transmembrane protein, androgen induced 1 0.0368514
SPOCK1 sparc/osteonectin, cwcv and kazal-like domains proteoglycan (testican) 1 0.0360007
PRKCA protein kinase C, alpha 0.0350274
SEPTIN9 septin 9 0.0346082
NR3C1 nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor) 0.0345172
PKM pyruvate kinase, muscle 0.0344397
FTH1 ferritin, heavy polypeptide 1 0.0344204
SPTBN1 spectrin, beta, non-erythrocytic 1 0.0342859
MBD5 methyl-CpG binding domain protein 5 0.0342747
GSE1 Gse1 coiled-coil protein 0.0338118
ARHGAP24 Rho GTPase activating protein 24 0.0321065
ITGB3BP integrin beta 3 binding protein (beta3-endonexin) 0.0313995
ACTN4 actinin, alpha 4 0.0310136
LHFPL2 lipoma HMGIC fusion partner-like 2 0.0307839
DNAH11 dynein, axonemal, heavy chain 11 0.0307136
MBNL1 muscleblind-like splicing regulator 1 0.0306212
JARID2 jumonji, AT rich interactive domain 2 0.0303123
GFPT1 glutamine--fructose-6-phosphate transaminase 1 0.0302138
GLS2 glutaminase 2 (liver, mitochondrial) 0.0300756
FAM20C family with sequence similarity 20, member C 0.0295504
SND1 staphylococcal nuclease and tudor domain containing 1 0.0294234
NAV1 neuron navigator 1 0.0292788
DSCAM Down syndrome cell adhesion molecule 0.0292395
ROBO1 roundabout, axon guidance receptor, homolog 1 (Drosophila) 0.0291716
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.0290342
ANO6 anoctamin 6 0.0288896
CRIM1 cysteine rich transmembrane BMP regulator 1 (chordin-like) 0.0284504
UBR5 ubiquitin protein ligase E3 component n-recognin 5 0.0280021
F3 coagulation factor III (thromboplastin, tissue factor) 0.0279764
LRRFIP1 leucine rich repeat (in FLII) interacting protein 1 0.0277544
CD44 CD44 molecule (Indian blood group) 0.0271026
LIMS1 LIM and senescent cell antigen-like domains 1 0.0268826
CTNNA1 catenin (cadherin-associated protein), alpha 1, 102kDa 0.0268143
TBC1D5 TBC1 domain family, member 5 0.0267864
ALK anaplastic lymphoma receptor tyrosine kinase 0.0267546
SLC4A7 solute carrier family 4, sodium bicarbonate cotransporter, member 7 0.0266584
TFPI tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor) 0.0264241
CDH11 cadherin 11, type 2, OB-cadherin (osteoblast) 0.0264226
BACE2 beta-site APP-cleaving enzyme 2 0.0260891
SETBP1 SET binding protein 1 0.026073
BBS9 Bardet-Biedl syndrome 9 0.0260018
XPO1 exportin 1 0.0258215
ANKRD17 ankyrin repeat domain 17 0.0257355
ATP2B1 ATPase, Ca++ transporting, plasma membrane 1 0.0257268
SMYD3 SET and MYND domain containing 3 0.025697
GFPT2 glutamine-fructose-6-phosphate transaminase 2 0.0253637
AHR aryl hydrocarbon receptor 0.0253466
ITPR1 inositol 1,4,5-trisphosphate receptor, type 1 0.0252869
GNB1 guanine nucleotide binding protein (G protein), beta polypeptide 1 0.0252232
FBXL7 F-box and leucine-rich repeat protein 7 0.0250516
NCOR2 nuclear receptor corepressor 2 0.0248362
RBFOX2 RNA binding protein, fox-1 homolog (C. elegans) 2 0.0245248
TEAD1 TEA domain family member 1 (SV40 transcriptional enhancer factor) 0.0242721
RUNX1 runt-related transcription factor 1 0.0242253

decreased expression

Symbol Name Standardized Value
HLA-B major histocompatibility complex, class I, B -0.129231
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.110078
TMSB10 thymosin beta 10 -0.0980122
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.0955177
B2M beta-2-microglobulin -0.0880707
MT2A metallothionein 2A -0.0869165
SPARC secreted protein, acidic, cysteine-rich (osteonectin) -0.0713306
TPT1 tumor protein, translationally-controlled 1 -0.0589796
COL1A2 collagen, type I, alpha 2 -0.0535544
COL1A1 collagen, type I, alpha 1 -0.0521944
PTMA prothymosin, alpha -0.0473758
ZC3HAV1 zinc finger CCCH-type, antiviral 1 -0.0470648
FTL ferritin, light polypeptide -0.0447043
CALR calreticulin -0.0395359
SDC4 syndecan 4 -0.0388749
H3-3B H3.3 histone B -0.0388293
RPL11 ribosomal protein L11 -0.0369365
SERPINE2 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2 -0.036778
HLA-C major histocompatibility complex, class I, C -0.0324928
RPL34 ribosomal protein L34 -0.0305934
RPS12 ribosomal protein S12 -0.0305657
HIF1A hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) -0.0291888
S100A10 S100 calcium binding protein A10 -0.0285848
MARCHF6 membrane associated ring-CH-type finger 6 -0.028459
RPS27A ribosomal protein S27a -0.0282569
HLA-A major histocompatibility complex, class I, A -0.0282258
ATP13A3 ATPase type 13A3 -0.02767
S100A6 S100 calcium binding protein A6 -0.0268278
GNAS GNAS complex locus -0.0263149
RPL35A ribosomal protein L35a -0.0259742
TMEM158 transmembrane protein 158 (gene/pseudogene) -0.0257804
RPS24 ribosomal protein S24 -0.0256395
RPL31 ribosomal protein L31 -0.0249428
PGK1 phosphoglycerate kinase 1 -0.0241124
CALD1 caldesmon 1 -0.0233854
EGR1 early growth response 1 -0.0231719
ACTG1 actin gamma 1 -0.0229925
TFPI2 tissue factor pathway inhibitor 2 -0.022977
SEC22A SEC22 vesicle trafficking protein homolog A (S. cerevisiae) -0.0228074
RAB6A RAB6A, member RAS oncogene family -0.0225638
GOLGA4 golgin A4 -0.0222936
VIM vimentin -0.022235
UGCG UDP-glucose ceramide glucosyltransferase -0.0213215
TAF1D TATA box binding protein (TBP)-associated factor, RNA polymerase I, D, 41kDa -0.0212727
TIMP1 TIMP metallopeptidase inhibitor 1 -0.0212645
COL3A1 collagen, type III, alpha 1 -0.0212251
RPS6 ribosomal protein S6 -0.0208842
RPLP2 ribosomal protein, large, P2 -0.0208145
S100A9 S100 calcium binding protein A9 -0.0206728
CALU calumenin -0.0202273
RPL5 ribosomal protein L5 -0.0202073
RPL27A ribosomal protein L27a -0.0201855
RSAD2 radical S-adenosyl methionine domain containing 2 -0.0199679
RPL36 ribosomal protein L36 -0.0198797
ATF6 activating transcription factor 6 -0.0196396
FAM162A family with sequence similarity 162, member A -0.0196166
TAX1BP1 Tax1 (human T-cell leukemia virus type I) binding protein 1 -0.0193666
RPS3 ribosomal protein S3 -0.0188465
EPS8 epidermal growth factor receptor pathway substrate 8 -0.0187798
RPL4 ribosomal protein L4 -0.0184353
RPS13 ribosomal protein S13 -0.0184224
CYP1B1 cytochrome P450, family 1, subfamily B, polypeptide 1 -0.0183861
PIK3C2A phosphatidylinositol-4-phosphate 3-kinase, catalytic subunit type 2 alpha -0.0183323
HOOK2 hook microtubule-tethering protein 2 -0.0182357
RBM25 RNA binding motif protein 25 -0.0182079
VCAN versican -0.0181774
NOP58 NOP58 ribonucleoprotein -0.0181744
EIF1 eukaryotic translation initiation factor 1 -0.018101
RACK1 receptor for activated C kinase 1 -0.0180146
IFIT3 interferon-induced protein with tetratricopeptide repeats 3 -0.0180037
SEPTIN2 septin 2 -0.0179084
ZFC3H1 zinc finger, C3H1-type containing -0.0177274
RPL37A ribosomal protein L37a -0.0175032
CHCHD2 coiled-coil-helix-coiled-coil-helix domain containing 2 -0.0174555
WSB1 WD repeat and SOCS box containing 1 -0.0174332
ZC3H15 zinc finger CCCH-type containing 15 -0.0173127
EIF5B eukaryotic translation initiation factor 5B -0.0172146
KLF6 Kruppel-like factor 6 -0.0170945
RPL19 ribosomal protein L19 -0.0169403
GORASP2 golgi reassembly stacking protein 2, 55kDa -0.0169188
ADM adrenomedullin -0.0166514
TOMM7 translocase of outer mitochondrial membrane 7 homolog (yeast) -0.0164482
RSF1 remodeling and spacing factor 1 -0.0164438
KMT2A lysine (K)-specific methyltransferase 2A -0.0163261
AUTS2 autism susceptibility candidate 2 -0.016294
PLAUR plasminogen activator, urokinase receptor -0.016249
TM9SF3 transmembrane 9 superfamily member 3 -0.0161322
POTEF POTE ankyrin domain family, member F -0.0159582
ENO1 enolase 1, (alpha) -0.015934
HNRNPR heterogeneous nuclear ribonucleoprotein R -0.0158302
RPS21 ribosomal protein S21 -0.0157771
ENO2 enolase 2 (gamma, neuronal) -0.0157699
RPL9 ribosomal protein L9 -0.0154442
GRB10 growth factor receptor-bound protein 10 -0.0152983
NRG1 neuregulin 1 -0.0152978
GPRC5A G protein-coupled receptor, class C, group 5, member A -0.0150785
TPM4 tropomyosin 4 -0.0149181
RPS15 ribosomal protein S15 -0.0147538
TP53 tumor protein p53 -0.014649
EMP3 epithelial membrane protein 3 -0.0146426