| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | Tolcapone perturbation in SW 1271 cell line (Tahoe Therapeutics) |
| Similar Terms | |
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200 genes differentially expressed following the Tolcapone_SW 1271 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| HSP90B1 | heat shock protein 90kDa beta (Grp94), member 1 | 0.0907762 |
| SMAD3 | SMAD family member 3 | 0.0874738 |
| HSP90AA1 | heat shock protein 90kDa alpha (cytosolic), class A member 1 | 0.0683979 |
| HNRNPA2B1 | heterogeneous nuclear ribonucleoprotein A2/B1 | 0.0583379 |
| CRIM1 | cysteine rich transmembrane BMP regulator 1 (chordin-like) | 0.0561115 |
| ZSWIM6 | zinc finger, SWIM-type containing 6 | 0.0551379 |
| MACF1 | microtubule-actin crosslinking factor 1 | 0.0533442 |
| HIVEP2 | human immunodeficiency virus type I enhancer binding protein 2 | 0.0532468 |
| MYH9 | myosin, heavy chain 9, non-muscle | 0.0525445 |
| DSCAM | Down syndrome cell adhesion molecule | 0.0487611 |
| SQSTM1 | sequestosome 1 | 0.045626 |
| HSP90AB1 | heat shock protein 90kDa alpha (cytosolic), class B member 1 | 0.0455264 |
| LOC112694756 | uncharaterized LOC112694756 | 0.0443782 |
| HNRNPU | heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) | 0.0405066 |
| MBNL2 | muscleblind-like splicing regulator 2 | 0.0402199 |
| ARL15 | ADP-ribosylation factor-like 15 | 0.0397158 |
| TBC1D8 | TBC1 domain family, member 8 (with GRAM domain) | 0.0392516 |
| GOLGB1 | golgin B1 | 0.0392041 |
| SPTAN1 | spectrin, alpha, non-erythrocytic 1 | 0.0391694 |
| IL6ST | interleukin 6 signal transducer | 0.0382029 |
| PALM2AKAP2 | PALM2 and AKAP2 fusion | 0.0379127 |
| INTS6 | integrator complex subunit 6 | 0.0377008 |
| KIF5B | kinesin family member 5B | 0.0373408 |
| AKAP9 | A kinase (PRKA) anchor protein 9 | 0.0366567 |
| ATXN1 | ataxin 1 | 0.0363528 |
| PHF3 | PHD finger protein 3 | 0.0361124 |
| BICD1 | bicaudal D homolog 1 (Drosophila) | 0.0358674 |
| ELL2 | elongation factor, RNA polymerase II, 2 | 0.0350882 |
| PBX3 | pre-B-cell leukemia homeobox 3 | 0.0348666 |
| FNIP1 | folliculin interacting protein 1 | 0.0339336 |
| PHF20 | PHD finger protein 20 | 0.0337555 |
| NFAT5 | nuclear factor of activated T-cells 5, tonicity-responsive | 0.0335842 |
| YAP1 | Yes-associated protein 1 | 0.0335124 |
| TXNRD1 | thioredoxin reductase 1 | 0.0333224 |
| DYNC1H1 | dynein, cytoplasmic 1, heavy chain 1 | 0.0331246 |
| FLNA | filamin A, alpha | 0.0331021 |
| CEP250 | centrosomal protein 250kDa | 0.0325507 |
| PITPNC1 | phosphatidylinositol transfer protein, cytoplasmic 1 | 0.0324996 |
| HSPA8 | heat shock 70kDa protein 8 | 0.0324647 |
| NUMA1 | nuclear mitotic apparatus protein 1 | 0.0319069 |
| HNRNPA1 | heterogeneous nuclear ribonucleoprotein A1 | 0.0315168 |
| SLC38A2 | solute carrier family 38, member 2 | 0.0312876 |
| CTNNA1 | catenin (cadherin-associated protein), alpha 1, 102kDa | 0.0309003 |
| BHLHE40 | basic helix-loop-helix family, member e40 | 0.0308594 |
| KIAA1958 | KIAA1958 | 0.0308417 |
| UBR5 | ubiquitin protein ligase E3 component n-recognin 5 | 0.0305391 |
| CANX | calnexin | 0.0303876 |
| BIRC3 | baculoviral IAP repeat containing 3 | 0.0303426 |
| NAP1L1 | nucleosome assembly protein 1-like 1 | 0.0298953 |
| DDX5 | DEAD (Asp-Glu-Ala-Asp) box helicase 5 | 0.0291553 |
| ZEB1 | zinc finger E-box binding homeobox 1 | 0.028595 |
| ABL1 | ABL proto-oncogene 1, non-receptor tyrosine kinase | 0.0284589 |
| CALU | calumenin | 0.0282166 |
| PDE4D | phosphodiesterase 4D, cAMP-specific | 0.0278231 |
| ARHGEF12 | Rho guanine nucleotide exchange factor (GEF) 12 | 0.027812 |
| BDP1 | B double prime 1, subunit of RNA polymerase III transcription initiation factor IIIB | 0.0276923 |
| DGKD | diacylglycerol kinase, delta 130kDa | 0.0270069 |
| RALY | RALY heterogeneous nuclear ribonucleoprotein | 0.0267221 |
| APLP2 | amyloid beta (A4) precursor-like protein 2 | 0.0264562 |
| AHNAK | AHNAK nucleoprotein | 0.0264493 |
| ARIH1 | ariadne RBR E3 ubiquitin protein ligase 1 | 0.0262247 |
| ANO6 | anoctamin 6 | 0.0261873 |
| ALCAM | activated leukocyte cell adhesion molecule | 0.0261177 |
| NT5E | 5'-nucleotidase, ecto (CD73) | 0.0260532 |
| NAV2 | neuron navigator 2 | 0.0260061 |
| PRKDC | protein kinase, DNA-activated, catalytic polypeptide | 0.0259387 |
| SPTBN1 | spectrin, beta, non-erythrocytic 1 | 0.0258058 |
| SEMA3A | sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3A | 0.0257157 |
| PMEPA1 | prostate transmembrane protein, androgen induced 1 | 0.0257053 |
| YWHAE | tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon | 0.025468 |
| BASP1 | brain abundant, membrane attached signal protein 1 | 0.0253261 |
| FMNL2 | formin-like 2 | 0.0250578 |
| SAMD4A | sterile alpha motif domain containing 4A | 0.0249249 |
| TPX2 | TPX2, microtubule-associated | 0.0248287 |
| SERINC1 | serine incorporator 1 | 0.0246097 |
| PYGL | phosphorylase, glycogen, liver | 0.0245947 |
| USP9X | ubiquitin specific peptidase 9, X-linked | 0.0243698 |
| SLC2A3 | solute carrier family 2 (facilitated glucose transporter), member 3 | 0.0243414 |
| YLPM1 | YLP motif containing 1 | 0.0242789 |
| UBR4 | ubiquitin protein ligase E3 component n-recognin 4 | 0.0241923 |
| CLTC | clathrin, heavy chain (Hc) | 0.0241471 |
| TJP1 | tight junction protein 1 | 0.0240947 |
| DST | dystonin | 0.0240785 |
| RB1CC1 | RB1-inducible coiled-coil 1 | 0.0240518 |
| SCD | stearoyl-CoA desaturase (delta-9-desaturase) | 0.0237835 |
| IPO7 | importin 7 | 0.0235882 |
| SREK1 | splicing regulatory glutamine/lysine-rich protein 1 | 0.0231689 |
| SATB2 | SATB homeobox 2 | 0.0231595 |
| CKAP2 | cytoskeleton associated protein 2 | 0.023088 |
| ZNF292 | zinc finger protein 292 | 0.0229599 |
| RPL4 | ribosomal protein L4 | 0.022956 |
| MCL1 | myeloid cell leukemia 1 | 0.0229554 |
| SERBP1 | SERPINE1 mRNA binding protein 1 | 0.0224821 |
| PCBP2 | poly(rC) binding protein 2 | 0.0221752 |
| EIF4G2 | eukaryotic translation initiation factor 4 gamma, 2 | 0.0221084 |
| NPC1 | Niemann-Pick disease, type C1 | 0.0220759 |
| PLAUR | plasminogen activator, urokinase receptor | 0.0219069 |
| SFTPA2 | surfactant protein A2 | 0.021891 |
| PPP1R15A | protein phosphatase 1, regulatory subunit 15A | 0.021887 |
| STAT3 | signal transducer and activator of transcription 3 (acute-phase response factor) | 0.0218622 |
| Symbol | Name | Standardized Value |
|---|---|---|
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | -0.13107 |
| ZC3HAV1 | zinc finger CCCH-type, antiviral 1 | -0.0860476 |
| POTEF | POTE ankyrin domain family, member F | -0.0616027 |
| TPT1 | tumor protein, translationally-controlled 1 | -0.0593623 |
| SERPINE2 | serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2 | -0.057265 |
| FTH1 | ferritin, heavy polypeptide 1 | -0.0521023 |
| PTMA | prothymosin, alpha | -0.048789 |
| LRRFIP1 | leucine rich repeat (in FLII) interacting protein 1 | -0.0454336 |
| SLC25A37 | solute carrier family 25 (mitochondrial iron transporter), member 37 | -0.04486 |
| N4BP2L2 | NEDD4 binding protein 2-like 2 | -0.0405408 |
| TMSB10 | thymosin beta 10 | -0.0403397 |
| DDX60 | DEAD (Asp-Glu-Ala-Asp) box polypeptide 60 | -0.0348522 |
| IER3 | immediate early response 3 | -0.0339325 |
| RPL35A | ribosomal protein L35a | -0.033764 |
| ZBTB20 | zinc finger and BTB domain containing 20 | -0.0337217 |
| NALCN | sodium leak channel, non selective | -0.032704 |
| NPEPPS | aminopeptidase puromycin sensitive | -0.0323528 |
| HLA-B | major histocompatibility complex, class I, B | -0.0318442 |
| TANC2 | tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 2 | -0.0313695 |
| MARCKS | myristoylated alanine-rich protein kinase C substrate | -0.0310021 |
| TRPC4AP | transient receptor potential cation channel, subfamily C, member 4 associated protein | -0.0287729 |
| TIMP1 | TIMP metallopeptidase inhibitor 1 | -0.0283993 |
| ZFHX3 | zinc finger homeobox 3 | -0.028013 |
| MAPKAP1 | mitogen-activated protein kinase associated protein 1 | -0.0279494 |
| UBE2E2 | ubiquitin-conjugating enzyme E2E 2 | -0.0273272 |
| S100A6 | S100 calcium binding protein A6 | -0.0270792 |
| WARS1 | tryptophanyl-tRNA synthetase 1 | -0.0269096 |
| IFIT2 | interferon-induced protein with tetratricopeptide repeats 2 | -0.0260607 |
| MTHFD1L | methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1-like | -0.025838 |
| CELF1 | CUGBP, Elav-like family member 1 | -0.0258165 |
| LMO7 | LIM domain 7 | -0.0256561 |
| PARD3 | par-3 family cell polarity regulator | -0.0249563 |
| CXCL8 | chemokine (C-X-C motif) ligand 8 | -0.0248821 |
| CNOT2 | CCR4-NOT transcription complex, subunit 2 | -0.0248176 |
| CD2AP | CD2-associated protein | -0.0247431 |
| OPTN | optineurin | -0.0242082 |
| EXOC6B | exocyst complex component 6B | -0.0241177 |
| RPS23 | ribosomal protein S23 | -0.0240191 |
| UNC13A | unc-13 homolog A (C. elegans) | -0.023746 |
| RAI14 | retinoic acid induced 14 | -0.0234579 |
| IFI44 | interferon-induced protein 44 | -0.0234426 |
| ENO1 | enolase 1, (alpha) | -0.0233601 |
| B2M | beta-2-microglobulin | -0.0233253 |
| ZMYND8 | zinc finger, MYND-type containing 8 | -0.0230442 |
| MYO10 | myosin X | -0.0227875 |
| H3-3B | H3.3 histone B | -0.0226968 |
| PHLDB2 | pleckstrin homology-like domain, family B, member 2 | -0.0225664 |
| BTBD9 | BTB (POZ) domain containing 9 | -0.0225452 |
| S100A10 | S100 calcium binding protein A10 | -0.0223526 |
| PAG1 | phosphoprotein membrane anchor with glycosphingolipid microdomains 1 | -0.0222493 |
| ERC1 | ELKS/RAB6-interacting/CAST family member 1 | -0.0221059 |
| HLA-A | major histocompatibility complex, class I, A | -0.0219947 |
| RBM25 | RNA binding motif protein 25 | -0.0218903 |
| POM121C | POM121 transmembrane nucleoporin C | -0.0218507 |
| RPS21 | ribosomal protein S21 | -0.0218231 |
| LDHA | lactate dehydrogenase A | -0.0217412 |
| RPS6 | ribosomal protein S6 | -0.0213572 |
| SRGAP1 | SLIT-ROBO Rho GTPase activating protein 1 | -0.0213459 |
| ARID2 | AT rich interactive domain 2 (ARID, RFX-like) | -0.0211151 |
| TMBIM1 | transmembrane BAX inhibitor motif containing 1 | -0.0211065 |
| OASL | 2'-5'-oligoadenylate synthetase-like | -0.0210545 |
| GNPDA1 | glucosamine-6-phosphate deaminase 1 | -0.0207646 |
| STXBP5 | syntaxin binding protein 5 (tomosyn) | -0.0207459 |
| PTPRG | protein tyrosine phosphatase, receptor type, G | -0.0206578 |
| PRR16 | proline rich 16 | -0.0205835 |
| ANXA2 | annexin A2 | -0.0205148 |
| S100A9 | S100 calcium binding protein A9 | -0.020138 |
| GNAS | GNAS complex locus | -0.0201329 |
| ERBIN | erbb2 interacting protein | -0.0196919 |
| USP3 | ubiquitin specific peptidase 3 | -0.0196668 |
| CHCHD2 | coiled-coil-helix-coiled-coil-helix domain containing 2 | -0.0194284 |
| FRMD6 | FERM domain containing 6 | -0.0194069 |
| RPL36 | ribosomal protein L36 | -0.0193442 |
| BPTF | bromodomain PHD finger transcription factor | -0.0191637 |
| MAP4K4 | mitogen-activated protein kinase kinase kinase kinase 4 | -0.0191559 |
| RNF149 | ring finger protein 149 | -0.0190701 |
| IGF2 | insulin-like growth factor 2 | -0.0189131 |
| ETFA | electron-transfer-flavoprotein, alpha polypeptide | -0.0188008 |
| CASP4 | caspase 4, apoptosis-related cysteine peptidase | -0.0186507 |
| PPIG | peptidylprolyl isomerase G (cyclophilin G) | -0.0185502 |
| DYNLRB1 | dynein, light chain, roadblock-type 1 | -0.0184269 |
| NPR2 | natriuretic peptide receptor 2 | -0.0183361 |
| PTPN14 | protein tyrosine phosphatase, non-receptor type 14 | -0.0182247 |
| PODXL | podocalyxin-like | -0.0181346 |
| IFITM3 | interferon induced transmembrane protein 3 | -0.0181304 |
| PTP4A2 | protein tyrosine phosphatase type IVA, member 2 | -0.0180828 |
| THSD4 | thrombospondin, type I, domain containing 4 | -0.0180778 |
| RPS16 | ribosomal protein S16 | -0.0180161 |
| CCAR1 | cell division cycle and apoptosis regulator 1 | -0.0179961 |
| HILPDA | hypoxia inducible lipid droplet-associated | -0.0179216 |
| ZFC3H1 | zinc finger, C3H1-type containing | -0.0179021 |
| JAZF1 | JAZF zinc finger 1 | -0.0178434 |
| RIPK1 | receptor (TNFRSF)-interacting serine-threonine kinase 1 | -0.017823 |
| ODR4 | odr-4 GPCR localization factor homolog | -0.017721 |
| RSAD2 | radical S-adenosyl methionine domain containing 2 | -0.0175763 |
| ZKSCAN1 | zinc finger with KRAB and SCAN domains 1 | -0.0173146 |
| IMMP2L | IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) | -0.0172827 |
| POMP | proteasome maturation protein | -0.017228 |
| ALKBH1 | alkB, alkylation repair homolog 1 (E. coli) | -0.0172104 |
| TPM4 | tropomyosin 4 | -0.0171067 |
