| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | Tolcapone perturbation in SW 900 cell line (Tahoe Therapeutics) |
| Similar Terms | |
| Downloads & Tools |
200 genes differentially expressed following the Tolcapone_SW 900 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| TRIO | trio Rho guanine nucleotide exchange factor | 0.115572 |
| EXT1 | exostosin glycosyltransferase 1 | 0.0892024 |
| FNDC3B | fibronectin type III domain containing 3B | 0.0827672 |
| SMAD3 | SMAD family member 3 | 0.0604749 |
| HIVEP2 | human immunodeficiency virus type I enhancer binding protein 2 | 0.0583835 |
| HNRNPA2B1 | heterogeneous nuclear ribonucleoprotein A2/B1 | 0.05347 |
| NPM1 | nucleophosmin (nucleolar phosphoprotein B23, numatrin) | 0.0530736 |
| MYH9 | myosin, heavy chain 9, non-muscle | 0.0519188 |
| ZSWIM6 | zinc finger, SWIM-type containing 6 | 0.0508835 |
| GBE1 | glucan (1,4-alpha-), branching enzyme 1 | 0.0486917 |
| HSP90AA1 | heat shock protein 90kDa alpha (cytosolic), class A member 1 | 0.0461152 |
| PRELID2 | PRELI domain containing 2 | 0.0451965 |
| PTK2 | protein tyrosine kinase 2 | 0.0449794 |
| DOCK5 | dedicator of cytokinesis 5 | 0.0445806 |
| FLNA | filamin A, alpha | 0.0436418 |
| HSPA5 | heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) | 0.0434833 |
| ITGA2 | integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) | 0.0434098 |
| SPTBN1 | spectrin, beta, non-erythrocytic 1 | 0.0430254 |
| ERRFI1 | ERBB receptor feedback inhibitor 1 | 0.0424326 |
| CRIM1 | cysteine rich transmembrane BMP regulator 1 (chordin-like) | 0.0407389 |
| MAP4K4 | mitogen-activated protein kinase kinase kinase kinase 4 | 0.0397312 |
| PLOD2 | procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 | 0.0396973 |
| KCNMA1 | potassium channel, calcium activated large conductance subfamily M alpha, member 1 | 0.0395908 |
| LOXL2 | lysyl oxidase-like 2 | 0.0385577 |
| MACF1 | microtubule-actin crosslinking factor 1 | 0.0383833 |
| HELZ | helicase with zinc finger | 0.0378221 |
| APLP2 | amyloid beta (A4) precursor-like protein 2 | 0.0368968 |
| AGAP1 | ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 | 0.0368135 |
| DST | dystonin | 0.0366982 |
| TBC1D8 | TBC1 domain family, member 8 (with GRAM domain) | 0.0358657 |
| YWHAZ | tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta | 0.0357554 |
| ASPH | aspartate beta-hydroxylase | 0.0350338 |
| INTS6 | integrator complex subunit 6 | 0.0343284 |
| ACTN4 | actinin, alpha 4 | 0.0324206 |
| SHB | Src homology 2 domain containing adaptor protein B | 0.0318926 |
| EPS8 | epidermal growth factor receptor pathway substrate 8 | 0.0313928 |
| ERO1A | endoplasmic reticulum oxidoreductase 1 alpha | 0.0310341 |
| ATXN1 | ataxin 1 | 0.0308138 |
| SMYD3 | SET and MYND domain containing 3 | 0.0305721 |
| RUNX1 | runt-related transcription factor 1 | 0.0299971 |
| AHR | aryl hydrocarbon receptor | 0.0299823 |
| FAM13A | family with sequence similarity 13, member A | 0.029703 |
| CTBP2 | C-terminal binding protein 2 | 0.0296532 |
| GALNT2 | polypeptide N-acetylgalactosaminyltransferase 2 | 0.0291797 |
| ELL2 | elongation factor, RNA polymerase II, 2 | 0.0285138 |
| LHFPL2 | lipoma HMGIC fusion partner-like 2 | 0.0283863 |
| GPC6 | glypican 6 | 0.027664 |
| PDLIM5 | PDZ and LIM domain 5 | 0.0275139 |
| RCOR1 | REST corepressor 1 | 0.0272989 |
| ZC3H11A | zinc finger CCCH-type containing 11A | 0.0267587 |
| HSP90AB1 | heat shock protein 90kDa alpha (cytosolic), class B member 1 | 0.0262797 |
| MGAT5 | mannosyl (alpha-1,6-)-glycoprotein beta-1,6-N-acetyl-glucosaminyltransferase | 0.0262749 |
| DCBLD2 | discoidin, CUB and LCCL domain containing 2 | 0.0259139 |
| NDRG1 | N-myc downstream regulated 1 | 0.0258758 |
| RICTOR | RPTOR independent companion of MTOR, complex 2 | 0.0257185 |
| NRIP1 | nuclear receptor interacting protein 1 | 0.0256519 |
| RBM39 | RNA binding motif protein 39 | 0.0256313 |
| HIF1A | hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) | 0.0255869 |
| ASAP1 | ArfGAP with SH3 domain, ankyrin repeat and PH domain 1 | 0.0246822 |
| SVIL | supervillin | 0.0246173 |
| AEBP2 | AE binding protein 2 | 0.0245754 |
| NEDD4L | neural precursor cell expressed, developmentally down-regulated 4-like, E3 ubiquitin protein ligase | 0.0243153 |
| GPATCH2L | G patch domain containing 2-like | 0.0242533 |
| MYOF | myoferlin | 0.0241431 |
| OGA | O-GlcNAcase | 0.0239873 |
| USP12 | ubiquitin specific peptidase 12 | 0.0239541 |
| ANXA5 | annexin A5 | 0.0238409 |
| RNF145 | ring finger protein 145 | 0.0237214 |
| PPFIBP1 | PTPRF interacting protein, binding protein 1 (liprin beta 1) | 0.0236164 |
| HUWE1 | HECT, UBA and WWE domain containing 1, E3 ubiquitin protein ligase | 0.0233682 |
| UBR5 | ubiquitin protein ligase E3 component n-recognin 5 | 0.0232937 |
| GPRC5A | G protein-coupled receptor, class C, group 5, member A | 0.0231637 |
| CORO1C | coronin, actin binding protein, 1C | 0.0231324 |
| NPTN | neuroplastin | 0.0230758 |
| SEPTIN9 | septin 9 | 0.0230173 |
| TPM3 | tropomyosin 3 | 0.0228824 |
| FOSL2 | FOS-like antigen 2 | 0.0226719 |
| MCTP2 | multiple C2 domains, transmembrane 2 | 0.0220104 |
| ANKRD11 | ankyrin repeat domain 11 | 0.0220019 |
| NAP1L1 | nucleosome assembly protein 1-like 1 | 0.0219494 |
| TUFT1 | tuftelin 1 | 0.021776 |
| PFKP | phosphofructokinase, platelet | 0.0215234 |
| RASAL2 | RAS protein activator like 2 | 0.0214913 |
| EGFR | epidermal growth factor receptor | 0.0212871 |
| FLNB | filamin B, beta | 0.0212467 |
| COPA | coatomer protein complex, subunit alpha | 0.0211999 |
| HSPA8 | heat shock 70kDa protein 8 | 0.0210046 |
| ATF6 | activating transcription factor 6 | 0.0209749 |
| NDEL1 | nudE neurodevelopment protein 1-like 1 | 0.0209234 |
| ERBIN | erbb2 interacting protein | 0.0207209 |
| PLEC | plectin | 0.020695 |
| ZC3H12C | zinc finger CCCH-type containing 12C | 0.0206382 |
| SLC5A3 | solute carrier family 5 (sodium/myo-inositol cotransporter), member 3 | 0.0206038 |
| PUM2 | pumilio RNA-binding family member 2 | 0.0205832 |
| FMNL2 | formin-like 2 | 0.0204343 |
| FAT1 | FAT atypical cadherin 1 | 0.0204158 |
| RBFOX2 | RNA binding protein, fox-1 homolog (C. elegans) 2 | 0.0203371 |
| GRB10 | growth factor receptor-bound protein 10 | 0.0201422 |
| APP | amyloid beta (A4) precursor protein | 0.0200868 |
| HNRNPA1 | heterogeneous nuclear ribonucleoprotein A1 | 0.0199793 |
| Symbol | Name | Standardized Value |
|---|---|---|
| CYP1B1 | cytochrome P450, family 1, subfamily B, polypeptide 1 | -0.259223 |
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | -0.145778 |
| PTGS2 | prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase) | -0.140357 |
| NRG1 | neuregulin 1 | -0.130721 |
| PTMA | prothymosin, alpha | -0.102682 |
| FN1 | fibronectin 1 | -0.096311 |
| FTL | ferritin, light polypeptide | -0.0957593 |
| HLA-B | major histocompatibility complex, class I, B | -0.0742451 |
| HSP90B1 | heat shock protein 90kDa beta (Grp94), member 1 | -0.0725267 |
| TMSB10 | thymosin beta 10 | -0.0692314 |
| MT2A | metallothionein 2A | -0.0637529 |
| SQSTM1 | sequestosome 1 | -0.057864 |
| LOC102724023 | ES1 protein homolog, mitochondrial | -0.0567376 |
| ZFP36L1 | ZFP36 ring finger protein-like 1 | -0.0559274 |
| TPT1 | tumor protein, translationally-controlled 1 | -0.05458 |
| S100A6 | S100 calcium binding protein A6 | -0.0501284 |
| SOX4 | SRY (sex determining region Y)-box 4 | -0.049912 |
| IFI27 | interferon, alpha-inducible protein 27 | -0.0494591 |
| RAI14 | retinoic acid induced 14 | -0.0449943 |
| ACTG1 | actin gamma 1 | -0.0416253 |
| HMGA2 | high mobility group AT-hook 2 | -0.040156 |
| EGR1 | early growth response 1 | -0.0378063 |
| TMEM156 | transmembrane protein 156 | -0.037438 |
| SYT1 | synaptotagmin I | -0.0343659 |
| B2M | beta-2-microglobulin | -0.0342257 |
| FTH1 | ferritin, heavy polypeptide 1 | -0.0336006 |
| TMSB4X | thymosin beta 4, X-linked | -0.0334403 |
| ITGA1 | integrin, alpha 1 | -0.0330418 |
| RPL35A | ribosomal protein L35a | -0.0318931 |
| KLHL5 | kelch-like family member 5 | -0.0303415 |
| ZC3HAV1 | zinc finger CCCH-type, antiviral 1 | -0.029753 |
| SCD | stearoyl-CoA desaturase (delta-9-desaturase) | -0.0286624 |
| ZMYND8 | zinc finger, MYND-type containing 8 | -0.0280002 |
| GCC2 | GRIP and coiled-coil domain containing 2 | -0.0275156 |
| OSMR | oncostatin M receptor | -0.0268678 |
| IGFBP3 | insulin-like growth factor binding protein 3 | -0.0267994 |
| ETV1 | ets variant 1 | -0.0265456 |
| IER3 | immediate early response 3 | -0.0259451 |
| RPS6 | ribosomal protein S6 | -0.0257245 |
| RPL31 | ribosomal protein L31 | -0.0251084 |
| ENO2 | enolase 2 (gamma, neuronal) | -0.0244358 |
| SERPINE2 | serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2 | -0.0242023 |
| TMEM165 | transmembrane protein 165 | -0.0241919 |
| UBXN4 | UBX domain protein 4 | -0.0237373 |
| MX2 | MX dynamin-like GTPase 2 | -0.0218676 |
| TFPI2 | tissue factor pathway inhibitor 2 | -0.0217993 |
| HLA-A | major histocompatibility complex, class I, A | -0.0217696 |
| NAMPT | nicotinamide phosphoribosyltransferase | -0.0214555 |
| AOPEP | aminopeptidase O (putative) | -0.0208442 |
| IRF2BP2 | interferon regulatory factor 2 binding protein 2 | -0.0205802 |
| KCNQ5 | potassium channel, voltage gated KQT-like subfamily Q, member 5 | -0.0204421 |
| ARPC2 | actin related protein 2/3 complex, subunit 2, 34kDa | -0.0202899 |
| EIF1 | eukaryotic translation initiation factor 1 | -0.0194287 |
| IFI6 | interferon, alpha-inducible protein 6 | -0.0192012 |
| P4HA1 | prolyl 4-hydroxylase, alpha polypeptide I | -0.0190065 |
| RPL37A | ribosomal protein L37a | -0.0189676 |
| WSB1 | WD repeat and SOCS box containing 1 | -0.0187982 |
| DNAH5 | dynein, axonemal, heavy chain 5 | -0.0186553 |
| S100A10 | S100 calcium binding protein A10 | -0.0185044 |
| RPL38 | ribosomal protein L38 | -0.0179762 |
| TM4SF1 | transmembrane 4 L six family member 1 | -0.0179413 |
| JUN | jun proto-oncogene | -0.0176974 |
| RPL37 | ribosomal protein L37 | -0.0174625 |
| KPNB1 | karyopherin (importin) beta 1 | -0.0174247 |
| KRT81 | keratin 81, type II | -0.0173318 |
| ANKHD1 | ankyrin repeat and KH domain containing 1 | -0.0173058 |
| IL6 | interleukin 6 | -0.0172925 |
| LMNA | lamin A/C | -0.0167791 |
| IFITM1 | interferon induced transmembrane protein 1 | -0.0163839 |
| RBM25 | RNA binding motif protein 25 | -0.0163219 |
| CP | ceruloplasmin (ferroxidase) | -0.0162004 |
| IFI16 | interferon, gamma-inducible protein 16 | -0.0161258 |
| SRSF11 | serine/arginine-rich splicing factor 11 | -0.0160868 |
| SOS1 | son of sevenless homolog 1 (Drosophila) | -0.0160617 |
| CALU | calumenin | -0.0159753 |
| POTEF | POTE ankyrin domain family, member F | -0.0158438 |
| RPL34 | ribosomal protein L34 | -0.0158361 |
| TMED9 | transmembrane emp24 protein transport domain containing 9 | -0.0155243 |
| VDAC1 | voltage-dependent anion channel 1 | -0.0152992 |
| CHCHD2 | coiled-coil-helix-coiled-coil-helix domain containing 2 | -0.0149945 |
| RPS29 | ribosomal protein S29 | -0.0149303 |
| RPLP2 | ribosomal protein, large, P2 | -0.0146138 |
| TPR | translocated promoter region, nuclear basket protein | -0.0144601 |
| PIM3 | Pim-3 proto-oncogene, serine/threonine kinase | -0.0142533 |
| TSC22D1 | TSC22 domain family, member 1 | -0.0142139 |
| ADAM8 | ADAM metallopeptidase domain 8 | -0.0141355 |
| OASL | 2'-5'-oligoadenylate synthetase-like | -0.0141147 |
| DUSP6 | dual specificity phosphatase 6 | -0.0140448 |
| FRMD4A | FERM domain containing 4A | -0.0139813 |
| DDX18 | DEAD (Asp-Glu-Ala-Asp) box polypeptide 18 | -0.0135676 |
| GLIS3 | GLIS family zinc finger 3 | -0.0135659 |
| ETV6 | ets variant 6 | -0.0135045 |
| SERPINE1 | serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 | -0.0134826 |
| P4HB | prolyl 4-hydroxylase, beta polypeptide | -0.013385 |
| SERF2 | small EDRK-rich factor 2 | -0.0133602 |
| RPS8 | ribosomal protein S8 | -0.0133527 |
| SFRP1 | secreted frizzled-related protein 1 | -0.0133452 |
| GNPDA1 | glucosamine-6-phosphate deaminase 1 | -0.0132408 |
| SLC25A37 | solute carrier family 25 (mitochondrial iron transporter), member 37 | -0.0131608 |
| RPLP1 | ribosomal protein, large, P1 | -0.0131424 |
