| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | Tolmetin perturbation in A-172 cell line (Tahoe Therapeutics) |
| Similar Terms | |
| Downloads & Tools |
200 genes differentially expressed following the Tolmetin_A-172 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| FBN1 | fibrillin 1 | 0.172919 |
| DCBLD2 | discoidin, CUB and LCCL domain containing 2 | 0.15691 |
| SPARC | secreted protein, acidic, cysteine-rich (osteonectin) | 0.136287 |
| FNDC3B | fibronectin type III domain containing 3B | 0.124029 |
| MYH9 | myosin, heavy chain 9, non-muscle | 0.0644177 |
| TNIP1 | TNFAIP3 interacting protein 1 | 0.0632799 |
| DST | dystonin | 0.0623206 |
| SOD2 | superoxide dismutase 2, mitochondrial | 0.060873 |
| COL1A2 | collagen, type I, alpha 2 | 0.058292 |
| GPC6 | glypican 6 | 0.0574483 |
| DPYSL3 | dihydropyrimidinase-like 3 | 0.0557542 |
| ATP13A3 | ATPase type 13A3 | 0.0541983 |
| AKT3 | v-akt murine thymoma viral oncogene homolog 3 | 0.0523768 |
| NHS | Nance-Horan syndrome (congenital cataracts and dental anomalies) | 0.0496264 |
| AUTS2 | autism susceptibility candidate 2 | 0.0488131 |
| GLS2 | glutaminase 2 (liver, mitochondrial) | 0.0480041 |
| CD44 | CD44 molecule (Indian blood group) | 0.0471237 |
| PICALM | phosphatidylinositol binding clathrin assembly protein | 0.0462819 |
| COL8A1 | collagen, type VIII, alpha 1 | 0.0441034 |
| FMNL2 | formin-like 2 | 0.0439225 |
| SLC8A1 | solute carrier family 8 (sodium/calcium exchanger), member 1 | 0.0428351 |
| B2M | beta-2-microglobulin | 0.0428248 |
| SBF2 | SET binding factor 2 | 0.0420918 |
| STAT1 | signal transducer and activator of transcription 1, 91kDa | 0.0416555 |
| PSD3 | pleckstrin and Sec7 domain containing 3 | 0.0412245 |
| USP9X | ubiquitin specific peptidase 9, X-linked | 0.0406931 |
| RICTOR | RPTOR independent companion of MTOR, complex 2 | 0.040349 |
| KIFAP3 | kinesin-associated protein 3 | 0.0397617 |
| ADAM17 | ADAM metallopeptidase domain 17 | 0.0393074 |
| COL3A1 | collagen, type III, alpha 1 | 0.0374782 |
| UBC | ubiquitin C | 0.0373604 |
| ITGB1 | integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) | 0.037072 |
| OGA | O-GlcNAcase | 0.0364653 |
| YWHAQ | tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, theta | 0.0359189 |
| HUWE1 | HECT, UBA and WWE domain containing 1, E3 ubiquitin protein ligase | 0.0357499 |
| ITPRID2 | ITPR interacting domain containing 2 | 0.0357217 |
| NUCKS1 | nuclear casein kinase and cyclin-dependent kinase substrate 1 | 0.0354613 |
| PRELID2 | PRELI domain containing 2 | 0.0353057 |
| ANKRD10 | ankyrin repeat domain 10 | 0.0336083 |
| ARRDC3 | arrestin domain containing 3 | 0.0335546 |
| SETD5 | SET domain containing 5 | 0.0332753 |
| PLOD2 | procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 | 0.0332227 |
| DENND5A | DENN/MADD domain containing 5A | 0.0328632 |
| ZNF148 | zinc finger protein 148 | 0.0323172 |
| ADAR | adenosine deaminase, RNA-specific | 0.0316686 |
| VCL | vinculin | 0.0304856 |
| NAP1L1 | nucleosome assembly protein 1-like 1 | 0.0303987 |
| P4HA1 | prolyl 4-hydroxylase, alpha polypeptide I | 0.0302462 |
| UBE2E1 | ubiquitin-conjugating enzyme E2E 1 | 0.0301452 |
| SSBP2 | single-stranded DNA binding protein 2 | 0.0295466 |
| SDK1 | sidekick cell adhesion molecule 1 | 0.0294253 |
| HNRNPU | heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) | 0.0290002 |
| SMG1 | SMG1 phosphatidylinositol 3-kinase-related kinase | 0.0287076 |
| NEK7 | NIMA-related kinase 7 | 0.0286341 |
| CDH2 | cadherin 2, type 1, N-cadherin (neuronal) | 0.0284454 |
| CYLD | cylindromatosis (turban tumor syndrome) | 0.0280529 |
| ABCA1 | ATP-binding cassette, sub-family A (ABC1), member 1 | 0.0278101 |
| CTNNA1 | catenin (cadherin-associated protein), alpha 1, 102kDa | 0.0275686 |
| RAD23B | RAD23 homolog B (S. cerevisiae) | 0.0273679 |
| MAP4 | microtubule-associated protein 4 | 0.0272969 |
| CAMSAP2 | calmodulin regulated spectrin-associated protein family, member 2 | 0.026796 |
| NT5C2 | 5'-nucleotidase, cytosolic II | 0.0264923 |
| OPTN | optineurin | 0.0264558 |
| TFG | TRK-fused gene | 0.0262116 |
| DCAF6 | DDB1 and CUL4 associated factor 6 | 0.0261277 |
| PCGF5 | polycomb group ring finger 5 | 0.0260928 |
| UAP1 | UDP-N-acetylglucosamine pyrophosphorylase 1 | 0.0260865 |
| PTPRJ | protein tyrosine phosphatase, receptor type, J | 0.0260845 |
| NFE2L1 | nuclear factor, erythroid 2-like 1 | 0.025969 |
| SRRM2 | serine/arginine repetitive matrix 2 | 0.0257046 |
| MBNL2 | muscleblind-like splicing regulator 2 | 0.0256899 |
| NAMPT | nicotinamide phosphoribosyltransferase | 0.025654 |
| ATP2C1 | ATPase, Ca++ transporting, type 2C, member 1 | 0.0254794 |
| KDM6A | lysine (K)-specific demethylase 6A | 0.0254511 |
| FRMD5 | FERM domain containing 5 | 0.0252262 |
| NCKAP1 | NCK-associated protein 1 | 0.0245935 |
| MEF2A | myocyte enhancer factor 2A | 0.0245596 |
| XPO1 | exportin 1 | 0.0241228 |
| TSC22D2 | TSC22 domain family, member 2 | 0.0240578 |
| EIF2AK2 | eukaryotic translation initiation factor 2-alpha kinase 2 | 0.0240496 |
| SPTBN1 | spectrin, beta, non-erythrocytic 1 | 0.0239116 |
| CDC73 | cell division cycle 73 | 0.0231955 |
| GNGT1 | guanine nucleotide binding protein (G protein), gamma transducing activity polypeptide 1 | 0.0230825 |
| LCOR | ligand dependent nuclear receptor corepressor | 0.0230236 |
| BNIP3L | BCL2/adenovirus E1B 19kDa interacting protein 3-like | 0.0228944 |
| AFDN | afadin, adherens junction formation factor | 0.022821 |
| SFTPA2 | surfactant protein A2 | 0.0227928 |
| SEMA3C | sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C | 0.0227563 |
| WTAP | Wilms tumor 1 associated protein | 0.0226811 |
| WDFY3 | WD repeat and FYVE domain containing 3 | 0.0226229 |
| RNF145 | ring finger protein 145 | 0.0224931 |
| ZC3H11A | zinc finger CCCH-type containing 11A | 0.0224863 |
| UBE2E2 | ubiquitin-conjugating enzyme E2E 2 | 0.0222747 |
| TRIM22 | tripartite motif containing 22 | 0.0221689 |
| FSD1L | fibronectin type III and SPRY domain containing 1-like | 0.0221319 |
| ADAM19 | ADAM metallopeptidase domain 19 | 0.0221079 |
| MLLT10 | myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 10 | 0.0220735 |
| KDM3A | lysine (K)-specific demethylase 3A | 0.0219469 |
| IFIH1 | interferon induced with helicase C domain 1 | 0.021844 |
| WAC | WW domain containing adaptor with coiled-coil | 0.0218358 |
| Symbol | Name | Standardized Value |
|---|---|---|
| IGFBP3 | insulin-like growth factor binding protein 3 | -0.299892 |
| VIM | vimentin | -0.272741 |
| CDH13 | cadherin 13 | -0.176929 |
| AKAP12 | A kinase (PRKA) anchor protein 12 | -0.169448 |
| PODXL | podocalyxin-like | -0.143982 |
| COL5A1 | collagen, type V, alpha 1 | -0.129195 |
| ADAMTS6 | ADAM metallopeptidase with thrombospondin type 1 motif, 6 | -0.124883 |
| HSPA5 | heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) | -0.0976689 |
| HSP90B1 | heat shock protein 90kDa beta (Grp94), member 1 | -0.092871 |
| SLC39A11 | solute carrier family 39, member 11 | -0.0916959 |
| EGFR | epidermal growth factor receptor | -0.0860402 |
| ABI3BP | ABI family, member 3 (NESH) binding protein | -0.0802673 |
| SERPINE1 | serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 | -0.0796358 |
| TRIO | trio Rho guanine nucleotide exchange factor | -0.0784032 |
| TPM4 | tropomyosin 4 | -0.070828 |
| SIPA1L3 | signal-induced proliferation-associated 1 like 3 | -0.0689183 |
| SLC38A1 | solute carrier family 38, member 1 | -0.0681694 |
| NDRG1 | N-myc downstream regulated 1 | -0.0661002 |
| CSTB | cystatin B (stefin B) | -0.0638872 |
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | -0.0621372 |
| CCND1 | cyclin D1 | -0.0590431 |
| RPS6KA2 | ribosomal protein S6 kinase, 90kDa, polypeptide 2 | -0.0507804 |
| LOX | lysyl oxidase | -0.0501072 |
| ABL2 | ABL proto-oncogene 2, non-receptor tyrosine kinase | -0.0481778 |
| DGKG | diacylglycerol kinase, gamma 90kDa | -0.0475305 |
| CACNA2D3 | calcium channel, voltage-dependent, alpha 2/delta subunit 3 | -0.047527 |
| FN1 | fibronectin 1 | -0.0461663 |
| S100A6 | S100 calcium binding protein A6 | -0.0460558 |
| LMNA | lamin A/C | -0.0457402 |
| DLG1 | discs, large homolog 1 (Drosophila) | -0.0422232 |
| FLT1 | fms-related tyrosine kinase 1 | -0.041621 |
| RABGEF1 | RAB guanine nucleotide exchange factor (GEF) 1 | -0.0395649 |
| CAVIN1 | caveolae associated protein 1 | -0.0391389 |
| HS3ST3A1 | heparan sulfate (glucosamine) 3-O-sulfotransferase 3A1 | -0.0390718 |
| CANX | calnexin | -0.0387486 |
| HLA-B | major histocompatibility complex, class I, B | -0.0384913 |
| ARHGEF10 | Rho guanine nucleotide exchange factor (GEF) 10 | -0.0383985 |
| DCLK2 | doublecortin-like kinase 2 | -0.0373885 |
| RRBP1 | ribosome binding protein 1 | -0.0373637 |
| ITGA3 | integrin, alpha 3 (antigen CD49C, alpha 3 subunit of VLA-3 receptor) | -0.0369578 |
| EFNA5 | ephrin-A5 | -0.0364233 |
| MDM2 | MDM2 proto-oncogene, E3 ubiquitin protein ligase | -0.0352399 |
| PRKAG2 | protein kinase, AMP-activated, gamma 2 non-catalytic subunit | -0.0332874 |
| P4HB | prolyl 4-hydroxylase, beta polypeptide | -0.0330923 |
| ZMYND8 | zinc finger, MYND-type containing 8 | -0.0325877 |
| PTMA | prothymosin, alpha | -0.0323519 |
| GADD45A | growth arrest and DNA-damage-inducible, alpha | -0.0318085 |
| KCNQ5 | potassium channel, voltage gated KQT-like subfamily Q, member 5 | -0.031112 |
| ANKRD30B | ankyrin repeat domain 30B | -0.0309492 |
| TMSB10 | thymosin beta 10 | -0.0298688 |
| AHNAK2 | AHNAK nucleoprotein 2 | -0.0290843 |
| MSI2 | musashi RNA-binding protein 2 | -0.0288182 |
| SYTL3 | synaptotagmin-like 3 | -0.0288122 |
| RNF168 | ring finger protein 168, E3 ubiquitin protein ligase | -0.0286796 |
| FTL | ferritin, light polypeptide | -0.0281449 |
| HM13 | histocompatibility (minor) 13 | -0.0279945 |
| F3 | coagulation factor III (thromboplastin, tissue factor) | -0.0277567 |
| S100A10 | S100 calcium binding protein A10 | -0.0272717 |
| ULK1 | unc-51 like autophagy activating kinase 1 | -0.0265535 |
| THBS2 | thrombospondin 2 | -0.0265497 |
| LIMS1 | LIM and senescent cell antigen-like domains 1 | -0.0262162 |
| LOXL2 | lysyl oxidase-like 2 | -0.026044 |
| SORBS2 | sorbin and SH3 domain containing 2 | -0.0258144 |
| LRRFIP1 | leucine rich repeat (in FLII) interacting protein 1 | -0.0255198 |
| SASH1 | SAM and SH3 domain containing 1 | -0.0254053 |
| BTG1 | B-cell translocation gene 1, anti-proliferative | -0.0252482 |
| PBX3 | pre-B-cell leukemia homeobox 3 | -0.0250355 |
| VDAC1 | voltage-dependent anion channel 1 | -0.0247561 |
| LDHA | lactate dehydrogenase A | -0.0247386 |
| FLNB | filamin B, beta | -0.0247001 |
| PLXNA2 | plexin A2 | -0.0241174 |
| SLFN5 | schlafen family member 5 | -0.0238675 |
| MRPS6 | mitochondrial ribosomal protein S6 | -0.0235705 |
| IGFN1 | immunoglobulin-like and fibronectin type III domain containing 1 | -0.0234321 |
| GDF15 | growth differentiation factor 15 | -0.0229442 |
| AGAP1 | ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 | -0.0229299 |
| IRF2BP2 | interferon regulatory factor 2 binding protein 2 | -0.0228765 |
| BACE2 | beta-site APP-cleaving enzyme 2 | -0.0223286 |
| MAPKAP1 | mitogen-activated protein kinase associated protein 1 | -0.022217 |
| S100A11 | S100 calcium binding protein A11 | -0.0222077 |
| TM4SF1 | transmembrane 4 L six family member 1 | -0.0221893 |
| LOC112694756 | uncharaterized LOC112694756 | -0.0219558 |
| FRMD4A | FERM domain containing 4A | -0.0218999 |
| MYADM | myeloid-associated differentiation marker | -0.0217701 |
| GTF2IRD1 | GTF2I repeat domain containing 1 | -0.0217193 |
| PRKRIP1 | PRKR interacting protein 1 (IL11 inducible) | -0.0214691 |
| BHLHE40 | basic helix-loop-helix family, member e40 | -0.0213334 |
| ACER3 | alkaline ceramidase 3 | -0.0212216 |
| RND3 | Rho family GTPase 3 | -0.0210117 |
| MACF1 | microtubule-actin crosslinking factor 1 | -0.0206187 |
| LMAN1 | lectin, mannose-binding, 1 | -0.0203995 |
| TPT1 | tumor protein, translationally-controlled 1 | -0.0202493 |
| DOCK5 | dedicator of cytokinesis 5 | -0.020107 |
| RPLP1 | ribosomal protein, large, P1 | -0.020034 |
| HLA-E | major histocompatibility complex, class I, E | -0.0199065 |
| MARCKS | myristoylated alanine-rich protein kinase C substrate | -0.0198289 |
| RPS27 | ribosomal protein S27 | -0.0196934 |
| CD99 | CD99 molecule | -0.0196335 |
| CMIP | c-Maf inducing protein | -0.0196247 |
| CDPF1 | cysteine-rich, DPF motif domain containing 1 | -0.0195102 |
