| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | Tolmetin perturbation in A-427 cell line (Tahoe Therapeutics) |
| Similar Terms | |
| Downloads & Tools |
200 genes differentially expressed following the Tolmetin_A-427 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| HNRNPA2B1 | heterogeneous nuclear ribonucleoprotein A2/B1 | 0.113157 |
| AREG | amphiregulin | 0.100877 |
| KDM3A | lysine (K)-specific demethylase 3A | 0.0716926 |
| HSP90AB1 | heat shock protein 90kDa alpha (cytosolic), class B member 1 | 0.0677073 |
| HNRNPH1 | heterogeneous nuclear ribonucleoprotein H1 (H) | 0.0636021 |
| ERRFI1 | ERBB receptor feedback inhibitor 1 | 0.0611778 |
| PDE4D | phosphodiesterase 4D, cAMP-specific | 0.0609709 |
| NPM1 | nucleophosmin (nucleolar phosphoprotein B23, numatrin) | 0.0609427 |
| ITGB1 | integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) | 0.0608861 |
| EIF1 | eukaryotic translation initiation factor 1 | 0.0593792 |
| MYH9 | myosin, heavy chain 9, non-muscle | 0.057526 |
| RPL3 | ribosomal protein L3 | 0.0484567 |
| HNRNPA1 | heterogeneous nuclear ribonucleoprotein A1 | 0.0483926 |
| TPM3 | tropomyosin 3 | 0.0481506 |
| PDGFC | platelet derived growth factor C | 0.0478558 |
| MYL6 | myosin, light chain 6, alkali, smooth muscle and non-muscle | 0.0470728 |
| CPOX | coproporphyrinogen oxidase | 0.0464939 |
| RPS2 | ribosomal protein S2 | 0.0443742 |
| SRRM2 | serine/arginine repetitive matrix 2 | 0.0405541 |
| HNRNPU | heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) | 0.0401771 |
| EGLN1 | egl-9 family hypoxia-inducible factor 1 | 0.0397739 |
| DCBLD2 | discoidin, CUB and LCCL domain containing 2 | 0.0389107 |
| BIRC2 | baculoviral IAP repeat containing 2 | 0.0386624 |
| ASPH | aspartate beta-hydroxylase | 0.0372125 |
| NEK7 | NIMA-related kinase 7 | 0.0368624 |
| EIF4A2 | eukaryotic translation initiation factor 4A2 | 0.0367505 |
| YEATS2 | YEATS domain containing 2 | 0.0359557 |
| PNN | pinin, desmosome associated protein | 0.0358387 |
| TENM3 | teneurin transmembrane protein 3 | 0.035403 |
| TXNRD1 | thioredoxin reductase 1 | 0.0348537 |
| XPO1 | exportin 1 | 0.0344182 |
| NFE2L1 | nuclear factor, erythroid 2-like 1 | 0.0333874 |
| ZNF217 | zinc finger protein 217 | 0.033366 |
| CPNE1 | copine I | 0.033117 |
| TNPO1 | transportin 1 | 0.0330406 |
| APP | amyloid beta (A4) precursor protein | 0.0329649 |
| ANKRD36 | ankyrin repeat domain 36 | 0.0327208 |
| SPTBN1 | spectrin, beta, non-erythrocytic 1 | 0.0317943 |
| AHNAK | AHNAK nucleoprotein | 0.0309366 |
| CRISPLD1 | cysteine-rich secretory protein LCCL domain containing 1 | 0.0309147 |
| SET | SET nuclear proto-oncogene | 0.0303377 |
| KLC1 | kinesin light chain 1 | 0.0301676 |
| ANXA1 | annexin A1 | 0.0298393 |
| EEF1A1 | eukaryotic translation elongation factor 1 alpha 1 | 0.0292199 |
| SMYD3 | SET and MYND domain containing 3 | 0.0290654 |
| EZR | ezrin | 0.0290227 |
| SYNCRIP | synaptotagmin binding, cytoplasmic RNA interacting protein | 0.0287551 |
| MATR3 | matrin 3 | 0.0286137 |
| RPS12 | ribosomal protein S12 | 0.0282591 |
| HSPA8 | heat shock 70kDa protein 8 | 0.0281923 |
| RPS19 | ribosomal protein S19 | 0.0281125 |
| DSPP | dentin sialophosphoprotein | 0.0274694 |
| THOC1 | THO complex 1 | 0.0274417 |
| ECT2 | epithelial cell transforming 2 | 0.0271628 |
| XPOT | exportin, tRNA | 0.0270252 |
| MTAP | methylthioadenosine phosphorylase | 0.0270197 |
| STMN1 | stathmin 1 | 0.0268929 |
| USP9X | ubiquitin specific peptidase 9, X-linked | 0.0265937 |
| NKTR | natural killer cell triggering receptor | 0.0265474 |
| MDM2 | MDM2 proto-oncogene, E3 ubiquitin protein ligase | 0.0262602 |
| DSCAM | Down syndrome cell adhesion molecule | 0.0261927 |
| PDE4B | phosphodiesterase 4B, cAMP-specific | 0.025918 |
| PNISR | PNN-interacting serine/arginine-rich protein | 0.025492 |
| RPL4 | ribosomal protein L4 | 0.0252052 |
| SLC38A2 | solute carrier family 38, member 2 | 0.0250989 |
| DYNC1H1 | dynein, cytoplasmic 1, heavy chain 1 | 0.0243836 |
| PLEC | plectin | 0.024153 |
| TM9SF3 | transmembrane 9 superfamily member 3 | 0.0237468 |
| MIB1 | mindbomb E3 ubiquitin protein ligase 1 | 0.0234932 |
| POLR2B | polymerase (RNA) II (DNA directed) polypeptide B, 140kDa | 0.0233718 |
| NCKAP1 | NCK-associated protein 1 | 0.0232519 |
| PPP2R2A | protein phosphatase 2, regulatory subunit B, alpha | 0.0230279 |
| CALM2 | calmodulin 2 (phosphorylase kinase, delta) | 0.0229224 |
| NARS1 | asparaginyl-tRNA synthetase 1 | 0.0228573 |
| RPS15A | ribosomal protein S15a | 0.022794 |
| HNRNPR | heterogeneous nuclear ribonucleoprotein R | 0.0227181 |
| RASA2 | RAS p21 protein activator 2 | 0.022507 |
| YWHAG | tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, gamma | 0.0224298 |
| HSP90B1 | heat shock protein 90kDa beta (Grp94), member 1 | 0.0224041 |
| PTPN11 | protein tyrosine phosphatase, non-receptor type 11 | 0.0223664 |
| CTNNA1 | catenin (cadherin-associated protein), alpha 1, 102kDa | 0.0223601 |
| G3BP1 | GTPase activating protein (SH3 domain) binding protein 1 | 0.0223505 |
| DNAJC5 | DnaJ (Hsp40) homolog, subfamily C, member 5 | 0.0223037 |
| GASK1B | golgi associated kinase 1B | 0.0222934 |
| PPP1R15A | protein phosphatase 1, regulatory subunit 15A | 0.0222013 |
| RPS27A | ribosomal protein S27a | 0.0218201 |
| AFDN | afadin, adherens junction formation factor | 0.0216604 |
| DDX5 | DEAD (Asp-Glu-Ala-Asp) box helicase 5 | 0.0216251 |
| HNRNPH3 | heterogeneous nuclear ribonucleoprotein H3 (2H9) | 0.0215649 |
| RIMKLB | ribosomal modification protein rimK-like family member B | 0.0214685 |
| MIER1 | mesoderm induction early response 1, transcriptional regulator | 0.0212476 |
| FAR1 | fatty acyl CoA reductase 1 | 0.0212127 |
| CLTC | clathrin, heavy chain (Hc) | 0.0212037 |
| YME1L1 | YME1-like 1 ATPase | 0.0211535 |
| RPS6 | ribosomal protein S6 | 0.0210846 |
| FEZ2 | fasciculation and elongation protein zeta 2 (zygin II) | 0.0207824 |
| MED13L | mediator complex subunit 13-like | 0.0206973 |
| MYL12A | myosin, light chain 12A, regulatory, non-sarcomeric | 0.0206392 |
| STAT1 | signal transducer and activator of transcription 1, 91kDa | 0.0206357 |
| CCNL1 | cyclin L1 | 0.0206073 |
| Symbol | Name | Standardized Value |
|---|---|---|
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | -0.401919 |
| VIM | vimentin | -0.260844 |
| NLGN1 | neuroligin 1 | -0.155512 |
| SEMA3A | sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3A | -0.150881 |
| SCD | stearoyl-CoA desaturase (delta-9-desaturase) | -0.135345 |
| RAB7A | RAB7A, member RAS oncogene family | -0.120244 |
| HSP90AA1 | heat shock protein 90kDa alpha (cytosolic), class A member 1 | -0.116475 |
| HMGA2 | high mobility group AT-hook 2 | -0.0940855 |
| EGR1 | early growth response 1 | -0.0734378 |
| HMGA1 | high mobility group AT-hook 1 | -0.0629158 |
| HSPB1 | heat shock 27kDa protein 1 | -0.0612335 |
| ATP5F1B | ATP synthase F1 subunit beta | -0.0606808 |
| ACTG1 | actin gamma 1 | -0.0586545 |
| EHBP1 | EH domain binding protein 1 | -0.0553103 |
| TUBA1B | tubulin, alpha 1b | -0.0535537 |
| SLC7A11 | solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11 | -0.0535497 |
| ASH1L | ash1 (absent, small, or homeotic)-like (Drosophila) | -0.0518904 |
| ADIPOR2 | adiponectin receptor 2 | -0.049722 |
| FTL | ferritin, light polypeptide | -0.0491767 |
| POTEF | POTE ankyrin domain family, member F | -0.0478839 |
| ZSWIM6 | zinc finger, SWIM-type containing 6 | -0.0475816 |
| ZNF804A | zinc finger protein 804A | -0.0475581 |
| LOC102724023 | ES1 protein homolog, mitochondrial | -0.0464798 |
| PFN1 | profilin 1 | -0.0452493 |
| INTS6 | integrator complex subunit 6 | -0.0448618 |
| PHLDA1 | pleckstrin homology-like domain, family A, member 1 | -0.0437751 |
| S100A6 | S100 calcium binding protein A6 | -0.0435659 |
| SEMA3C | sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C | -0.0417898 |
| LDHA | lactate dehydrogenase A | -0.0401215 |
| CCND1 | cyclin D1 | -0.0395566 |
| GNB1 | guanine nucleotide binding protein (G protein), beta polypeptide 1 | -0.0358394 |
| SMURF2 | SMAD specific E3 ubiquitin protein ligase 2 | -0.0358126 |
| CUBN | cubilin (intrinsic factor-cobalamin receptor) | -0.0351573 |
| TFPI | tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor) | -0.034968 |
| PITPNC1 | phosphatidylinositol transfer protein, cytoplasmic 1 | -0.0348667 |
| RHOA | ras homolog family member A | -0.0346229 |
| STARD4 | StAR-related lipid transfer (START) domain containing 4 | -0.0342863 |
| REV3L | REV3-like, polymerase (DNA directed), zeta, catalytic subunit | -0.0339093 |
| NHSL1 | NHS-like 1 | -0.0336285 |
| MSRB3 | methionine sulfoxide reductase B3 | -0.0333577 |
| ARIH1 | ariadne RBR E3 ubiquitin protein ligase 1 | -0.0329747 |
| DHX36 | DEAH (Asp-Glu-Ala-His) box polypeptide 36 | -0.0328893 |
| FBXO11 | F-box protein 11 | -0.0313868 |
| ERO1A | endoplasmic reticulum oxidoreductase 1 alpha | -0.0313008 |
| AFF4 | AF4/FMR2 family, member 4 | -0.0312977 |
| RASAL2 | RAS protein activator like 2 | -0.0312569 |
| PTGES3 | prostaglandin E synthase 3 (cytosolic) | -0.0310506 |
| MMP12 | matrix metallopeptidase 12 | -0.0302967 |
| LRRC23 | leucine rich repeat containing 23 | -0.0300001 |
| PACS1 | phosphofurin acidic cluster sorting protein 1 | -0.0299644 |
| CSMD3 | CUB and Sushi multiple domains 3 | -0.02948 |
| RAB1A | RAB1A, member RAS oncogene family | -0.0293158 |
| ZNF638 | zinc finger protein 638 | -0.029235 |
| PPDPF | pancreatic progenitor cell differentiation and proliferation factor | -0.0291944 |
| HERC4 | HECT and RLD domain containing E3 ubiquitin protein ligase 4 | -0.028778 |
| DKK1 | dickkopf WNT signaling pathway inhibitor 1 | -0.0287125 |
| LRRTM4 | leucine rich repeat transmembrane neuronal 4 | -0.0278316 |
| RAB10 | RAB10, member RAS oncogene family | -0.0276176 |
| DTNA | dystrobrevin, alpha | -0.0275222 |
| DIP2B | DIP2 disco-interacting protein 2 homolog B (Drosophila) | -0.0274756 |
| PCDH9 | protocadherin 9 | -0.0272509 |
| PIK3R3 | phosphoinositide-3-kinase, regulatory subunit 3 (gamma) | -0.0272308 |
| SYT1 | synaptotagmin I | -0.0269559 |
| SRGAP1 | SLIT-ROBO Rho GTPase activating protein 1 | -0.0269014 |
| TNRC6B | trinucleotide repeat containing 6B | -0.0268769 |
| ACTR2 | ARP2 actin-related protein 2 homolog (yeast) | -0.0267776 |
| TAPBP | TAP binding protein (tapasin) | -0.026097 |
| CCT4 | chaperonin containing TCP1, subunit 4 (delta) | -0.0260818 |
| ANKRD17 | ankyrin repeat domain 17 | -0.0259639 |
| MGAT4C | MGAT4 family, member C | -0.0258974 |
| MAP1LC3B | microtubule-associated protein 1 light chain 3 beta | -0.0258958 |
| NUP98 | nucleoporin 98kDa | -0.0257863 |
| VDAC1 | voltage-dependent anion channel 1 | -0.0256752 |
| PCDH7 | protocadherin 7 | -0.02558 |
| TUBB | tubulin, beta class I | -0.0255507 |
| GSK3B | glycogen synthase kinase 3 beta | -0.0254839 |
| ALDH1A1 | aldehyde dehydrogenase 1 family, member A1 | -0.0253376 |
| ANKS1B | ankyrin repeat and sterile alpha motif domain containing 1B | -0.0252998 |
| GNAS | GNAS complex locus | -0.0252918 |
| TSC22D2 | TSC22 domain family, member 2 | -0.0252254 |
| KPNB1 | karyopherin (importin) beta 1 | -0.0251416 |
| ARID4B | AT rich interactive domain 4B (RBP1-like) | -0.0251219 |
| PHACTR4 | phosphatase and actin regulator 4 | -0.025114 |
| MBNL1 | muscleblind-like splicing regulator 1 | -0.0250174 |
| KDM2A | lysine (K)-specific demethylase 2A | -0.0250156 |
| DCAF7 | DDB1 and CUL4 associated factor 7 | -0.0248033 |
| PCF11 | PCF11 cleavage and polyadenylation factor subunit | -0.024468 |
| PEG10 | paternally expressed 10 | -0.0243534 |
| NUFIP2 | nuclear fragile X mental retardation protein interacting protein 2 | -0.0243458 |
| CUX1 | cut-like homeobox 1 | -0.0243396 |
| DDIT3 | DNA-damage-inducible transcript 3 | -0.0242843 |
| JMJD1C | jumonji domain containing 1C | -0.0242298 |
| S100A10 | S100 calcium binding protein A10 | -0.0237551 |
| UBE2B | ubiquitin-conjugating enzyme E2B | -0.0227039 |
| ERBIN | erbb2 interacting protein | -0.0225975 |
| HNRNPC | heterogeneous nuclear ribonucleoprotein C (C1/C2) | -0.0224565 |
| TOP2A | topoisomerase (DNA) II alpha 170kDa | -0.0222934 |
| RAB3GAP1 | RAB3 GTPase activating protein subunit 1 (catalytic) | -0.022198 |
| BCL6 | B-cell CLL/lymphoma 6 | -0.0220803 |
| ZMYM4 | zinc finger, MYM-type 4 | -0.0219955 |
