Tolmetin_CHP-212 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Tolmetin perturbation in CHP-212 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Tolmetin_CHP-212 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.141874
DDX1 DEAD (Asp-Glu-Ala-Asp) box helicase 1 0.140834
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 0.098545
MEF2A myocyte enhancer factor 2A 0.0955504
PTMA prothymosin, alpha 0.0947377
MYH9 myosin, heavy chain 9, non-muscle 0.0772624
SEPTIN9 septin 9 0.0766795
HELZ helicase with zinc finger 0.0579084
RPS6 ribosomal protein S6 0.057648
GBE1 glucan (1,4-alpha-), branching enzyme 1 0.0575308
FAM13A family with sequence similarity 13, member A 0.0567017
PKM pyruvate kinase, muscle 0.0549773
PABPC1 poly(A) binding protein, cytoplasmic 1 0.0545312
HSPD1 heat shock 60kDa protein 1 (chaperonin) 0.0528097
RPL23 ribosomal protein L23 0.0526549
VIM vimentin 0.0504199
RBPJ recombination signal binding protein for immunoglobulin kappa J region 0.0498128
TMSB10 thymosin beta 10 0.0496713
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin) 0.0486215
DPH6 diphthamine biosynthesis 6 0.0483667
PGK1 phosphoglycerate kinase 1 0.0462169
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 0.0458024
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 0.0456299
ASPH aspartate beta-hydroxylase 0.0454883
RPS12 ribosomal protein S12 0.0447834
EIF1 eukaryotic translation initiation factor 1 0.0446188
RPS3 ribosomal protein S3 0.0429375
RPL37A ribosomal protein L37a 0.042906
B2M beta-2-microglobulin 0.0408179
RPL3 ribosomal protein L3 0.0405363
SET SET nuclear proto-oncogene 0.0394106
ITPRID2 ITPR interacting domain containing 2 0.0384123
FTL ferritin, light polypeptide 0.0383508
RPS19 ribosomal protein S19 0.0378987
PCBP2 poly(rC) binding protein 2 0.0377392
NUP58 nucleoporin 58 0.0376
NAP1L1 nucleosome assembly protein 1-like 1 0.0374122
TPI1 triosephosphate isomerase 1 0.0369072
CSDE1 cold shock domain containing E1, RNA-binding 0.0363298
ANKRD11 ankyrin repeat domain 11 0.0361188
CDH2 cadherin 2, type 1, N-cadherin (neuronal) 0.0354984
ENO1 enolase 1, (alpha) 0.0349209
SPTBN1 spectrin, beta, non-erythrocytic 1 0.0345239
HSPA8 heat shock 70kDa protein 8 0.0344429
NDRG1 N-myc downstream regulated 1 0.0341768
RPL35A ribosomal protein L35a 0.0340281
RPL34 ribosomal protein L34 0.0340123
RPS2 ribosomal protein S2 0.0337052
HDGF hepatoma-derived growth factor 0.0330929
HNRNPA1 heterogeneous nuclear ribonucleoprotein A1 0.0326851
TPM3 tropomyosin 3 0.0321738
MACF1 microtubule-actin crosslinking factor 1 0.0320938
TOP1 topoisomerase (DNA) I 0.0320074
NUCKS1 nuclear casein kinase and cyclin-dependent kinase substrate 1 0.0319357
EEF2 eukaryotic translation elongation factor 2 0.0318046
YWHAG tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, gamma 0.0315237
AKAP12 A kinase (PRKA) anchor protein 12 0.0314534
ENAH enabled homolog (Drosophila) 0.03139
ACTG1 actin gamma 1 0.0310569
KTN1 kinectin 1 (kinesin receptor) 0.0308981
EIF4A1 eukaryotic translation initiation factor 4A1 0.0308951
RPLP1 ribosomal protein, large, P1 0.0308043
CENPF centromere protein F, 350/400kDa 0.0301473
RPL7A ribosomal protein L7a 0.0301437
HILPDA hypoxia inducible lipid droplet-associated 0.0300607
EEF1G eukaryotic translation elongation factor 1 gamma 0.0300137
RPS17 ribosomal protein S17 0.0289678
PDIA3 protein disulfide isomerase family A, member 3 0.028808
LRRFIP1 leucine rich repeat (in FLII) interacting protein 1 0.028803
HMGA2 high mobility group AT-hook 2 0.0286085
PRRC2C proline-rich coiled-coil 2C 0.0283975
DNAJC5 DnaJ (Hsp40) homolog, subfamily C, member 5 0.0283852
CCNY cyclin Y 0.0279531
POTEF POTE ankyrin domain family, member F 0.0278453
TOP2A topoisomerase (DNA) II alpha 170kDa 0.0278166
RPL31 ribosomal protein L31 0.0275205
RPL26 ribosomal protein L26 0.0272141
BNIP3L BCL2/adenovirus E1B 19kDa interacting protein 3-like 0.0271864
BCAT1 branched chain amino-acid transaminase 1, cytosolic 0.0270549
RPL27 ribosomal protein L27 0.0270038
KDM3A lysine (K)-specific demethylase 3A 0.0269806
WDR45B WD repeat domain 45B 0.0268492
LIMCH1 LIM and calponin homology domains 1 0.0268278
NAV2 neuron navigator 2 0.0267162
NAMPT nicotinamide phosphoribosyltransferase 0.0265302
PPFIBP1 PTPRF interacting protein, binding protein 1 (liprin beta 1) 0.026322
HMGB2 high mobility group box 2 0.0263175
UBA6 ubiquitin-like modifier activating enzyme 6 0.026311
NES nestin 0.0260596
RPL18 ribosomal protein L18 0.025723
PALM2AKAP2 PALM2 and AKAP2 fusion 0.025683
SMURF2 SMAD specific E3 ubiquitin protein ligase 2 0.0256105
JPT1 Jupiter microtubule associated homolog 1 0.0255983
PPP1R15A protein phosphatase 1, regulatory subunit 15A 0.0254159
CTNNB1 catenin (cadherin-associated protein), beta 1, 88kDa 0.0254135
UACA uveal autoantigen with coiled-coil domains and ankyrin repeats 0.0250624
SCG2 secretogranin II 0.0250594
NFE2L1 nuclear factor, erythroid 2-like 1 0.0248657
APP amyloid beta (A4) precursor protein 0.0246791
VEGFA vascular endothelial growth factor A 0.0245038

decreased expression

Symbol Name Standardized Value
IGF2 insulin-like growth factor 2 -0.251714
LSAMP limbic system-associated membrane protein -0.209712
LGR5 leucine-rich repeat containing G protein-coupled receptor 5 -0.135758
VCL vinculin -0.134885
NRG1 neuregulin 1 -0.131501
TPST1 tyrosylprotein sulfotransferase 1 -0.109127
SYT1 synaptotagmin I -0.107422
TCF7L2 transcription factor 7-like 2 (T-cell specific, HMG-box) -0.0930957
EXT1 exostosin glycosyltransferase 1 -0.0924772
RBMS3 RNA binding motif, single stranded interacting protein 3 -0.0891345
NCAM2 neural cell adhesion molecule 2 -0.069858
LINGO2 leucine rich repeat and Ig domain containing 2 -0.0695239
FRMD4A FERM domain containing 4A -0.069364
MBD5 methyl-CpG binding domain protein 5 -0.0639747
LRFN5 leucine rich repeat and fibronectin type III domain containing 5 -0.0623147
KLHL13 kelch-like family member 13 -0.0601194
COL4A5 collagen, type IV, alpha 5 -0.0586064
AOPEP aminopeptidase O (putative) -0.0577213
NALF1 NALCN channel auxiliary factor 1 -0.0565746
PTPRD protein tyrosine phosphatase, receptor type, D -0.0540754
ZSWIM6 zinc finger, SWIM-type containing 6 -0.0527124
PSD3 pleckstrin and Sec7 domain containing 3 -0.052358
FNDC3A fibronectin type III domain containing 3A -0.0511707
SIK2 salt-inducible kinase 2 -0.0511478
TMTC2 transmembrane and tetratricopeptide repeat containing 2 -0.0502183
ADAMTS9 ADAM metallopeptidase with thrombospondin type 1 motif, 9 -0.0494143
PLPP1 phospholipid phosphatase 1 -0.0487771
BCAS3 breast carcinoma amplified sequence 3 -0.0483132
GLCCI1 glucocorticoid induced 1 -0.0482075
TLE4 transducin-like enhancer of split 4 -0.0479782
DLC1 DLC1 Rho GTPase activating protein -0.0479496
CACNA2D1 calcium channel, voltage-dependent, alpha 2/delta subunit 1 -0.0472151
ARID5B AT rich interactive domain 5B (MRF1-like) -0.0471521
MEIS2 Meis homeobox 2 -0.045598
ZNF804A zinc finger protein 804A -0.0449449
BPTF bromodomain PHD finger transcription factor -0.0430066
COL3A1 collagen, type III, alpha 1 -0.0420628
CACNB2 calcium channel, voltage-dependent, beta 2 subunit -0.0411672
IGF1R insulin-like growth factor 1 receptor -0.0410235
FAM107B family with sequence similarity 107, member B -0.0408229
GREM2 gremlin 2, DAN family BMP antagonist -0.0406182
TRIB2 tribbles pseudokinase 2 -0.040417
VMP1 vacuole membrane protein 1 -0.0403196
NPAS2 neuronal PAS domain protein 2 -0.040063
ZBTB20 zinc finger and BTB domain containing 20 -0.0399501
STAT3 signal transducer and activator of transcription 3 (acute-phase response factor) -0.0391863
TENT5A terminal nucleotidyltransferase 5A -0.0390939
RNF213 ring finger protein 213 -0.038813
PRKCA protein kinase C, alpha -0.0385734
COL1A1 collagen, type I, alpha 1 -0.0384637
PDE10A phosphodiesterase 10A -0.0376397
TRPS1 trichorhinophalangeal syndrome I -0.036686
TPM1 tropomyosin 1 (alpha) -0.0366287
PLEKHA5 pleckstrin homology domain containing, family A member 5 -0.0366136
NCOA7 nuclear receptor coactivator 7 -0.0364521
RALYL RALY RNA binding protein-like -0.0362381
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group) -0.0362247
CNTN4 contactin 4 -0.0362233
HAND2 heart and neural crest derivatives expressed 2 -0.0348968
PLCB1 phospholipase C, beta 1 (phosphoinositide-specific) -0.0346922
STK38L serine/threonine kinase 38 like -0.0345634
ADAMTS1 ADAM metallopeptidase with thrombospondin type 1 motif, 1 -0.0345449
FMN1 formin 1 -0.0339829
FNDC3B fibronectin type III domain containing 3B -0.0336673
GAB2 GRB2-associated binding protein 2 -0.0325844
RIGI RNA sensor RIG-I -0.0322698
CDH10 cadherin 10, type 2 (T2-cadherin) -0.0317908
ZC3H11A zinc finger CCCH-type containing 11A -0.0314929
CEMIP cell migration inducing protein, hyaluronan binding -0.0301384
ADARB1 adenosine deaminase, RNA-specific, B1 -0.0299309
NRIP1 nuclear receptor interacting protein 1 -0.0298823
SYNPO2 synaptopodin 2 -0.0297606
NBEA neurobeachin -0.029613
TANC1 tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 1 -0.0293733
ANKS1B ankyrin repeat and sterile alpha motif domain containing 1B -0.0293172
PDZRN3 PDZ domain containing ring finger 3 -0.0291355
MAPK10 mitogen-activated protein kinase 10 -0.0288289
UNC5C unc-5 homolog C (C. elegans) -0.0287638
ANTXR1 anthrax toxin receptor 1 -0.0286068
EXOC4 exocyst complex component 4 -0.0285998
ARHGAP24 Rho GTPase activating protein 24 -0.0285649
CADM1 cell adhesion molecule 1 -0.0279039
PTPN13 protein tyrosine phosphatase, non-receptor type 13 (APO-1/CD95 (Fas)-associated phosphatase) -0.0278423
STXBP5 syntaxin binding protein 5 (tomosyn) -0.0276954
ITPR2 inositol 1,4,5-trisphosphate receptor, type 2 -0.0275796
B3GALT1 UDP-Gal:betaGlcNAc beta 1,3-galactosyltransferase, polypeptide 1 -0.0270917
GPATCH8 G patch domain containing 8 -0.0270111
PTPRK protein tyrosine phosphatase, receptor type, K -0.026983
SLIT2 slit homolog 2 (Drosophila) -0.0269667
NREP neuronal regeneration related protein -0.0268527
TNFRSF19 tumor necrosis factor receptor superfamily, member 19 -0.0265332
PBX1 pre-B-cell leukemia homeobox 1 -0.0263384
NUFIP2 nuclear fragile X mental retardation protein interacting protein 2 -0.0262397
AKT3 v-akt murine thymoma viral oncogene homolog 3 -0.0258251
PDE3A phosphodiesterase 3A, cGMP-inhibited -0.0257397
PCNX1 pecanex 1 -0.025603
AEBP2 AE binding protein 2 -0.0254119
SH3PXD2B SH3 and PX domains 2B -0.0253285
LPP LIM domain containing preferred translocation partner in lipoma -0.0252021
NRP1 neuropilin 1 -0.0251649