| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | Tolmetin perturbation in HS-578T cell line (Tahoe Therapeutics) |
| Similar Terms | |
| Downloads & Tools |
200 genes differentially expressed following the Tolmetin_HS-578T drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| MYH9 | myosin, heavy chain 9, non-muscle | 0.28425 |
| HSP90AB1 | heat shock protein 90kDa alpha (cytosolic), class B member 1 | 0.089838 |
| CXCL8 | chemokine (C-X-C motif) ligand 8 | 0.0639113 |
| PABPC1 | poly(A) binding protein, cytoplasmic 1 | 0.0546102 |
| PLEC | plectin | 0.0517727 |
| PPP1R15A | protein phosphatase 1, regulatory subunit 15A | 0.0491363 |
| EIF1 | eukaryotic translation initiation factor 1 | 0.048756 |
| RPL3 | ribosomal protein L3 | 0.0484432 |
| MSN | moesin | 0.0458383 |
| RPL23 | ribosomal protein L23 | 0.0445286 |
| PTMA | prothymosin, alpha | 0.0442424 |
| ENO1 | enolase 1, (alpha) | 0.0402812 |
| SPTBN1 | spectrin, beta, non-erythrocytic 1 | 0.0392059 |
| CALR | calreticulin | 0.0390298 |
| TMSB10 | thymosin beta 10 | 0.0373891 |
| TMSB4X | thymosin beta 4, X-linked | 0.0365883 |
| RPS3 | ribosomal protein S3 | 0.0360142 |
| ATP13A3 | ATPase type 13A3 | 0.0356148 |
| HNRNPA2B1 | heterogeneous nuclear ribonucleoprotein A2/B1 | 0.034824 |
| KMT2C | lysine (K)-specific methyltransferase 2C | 0.0339793 |
| MAP4K4 | mitogen-activated protein kinase kinase kinase kinase 4 | 0.0336945 |
| NFE2L1 | nuclear factor, erythroid 2-like 1 | 0.0317587 |
| CALM2 | calmodulin 2 (phosphorylase kinase, delta) | 0.0313108 |
| TOP2A | topoisomerase (DNA) II alpha 170kDa | 0.0310038 |
| EEF2 | eukaryotic translation elongation factor 2 | 0.030633 |
| APP | amyloid beta (A4) precursor protein | 0.0305182 |
| TPM2 | tropomyosin 2 (beta) | 0.0297406 |
| HSPD1 | heat shock 60kDa protein 1 (chaperonin) | 0.0295527 |
| CENPF | centromere protein F, 350/400kDa | 0.0294597 |
| KLF7 | Kruppel-like factor 7 (ubiquitous) | 0.0280892 |
| TPI1 | triosephosphate isomerase 1 | 0.0277206 |
| MIER1 | mesoderm induction early response 1, transcriptional regulator | 0.0275389 |
| MT2A | metallothionein 2A | 0.0275265 |
| MYL6 | myosin, light chain 6, alkali, smooth muscle and non-muscle | 0.0273609 |
| PJA2 | praja ring finger 2, E3 ubiquitin protein ligase | 0.0272736 |
| HNRNPH1 | heterogeneous nuclear ribonucleoprotein H1 (H) | 0.0270367 |
| RPL12 | ribosomal protein L12 | 0.0267979 |
| AHNAK | AHNAK nucleoprotein | 0.0266806 |
| PDIA6 | protein disulfide isomerase family A, member 6 | 0.0264727 |
| SRRM2 | serine/arginine repetitive matrix 2 | 0.0254 |
| SMC4 | structural maintenance of chromosomes 4 | 0.0250838 |
| RPL35A | ribosomal protein L35a | 0.024917 |
| DDIT4 | DNA-damage-inducible transcript 4 | 0.0247063 |
| AP2B1 | adaptor-related protein complex 2, beta 1 subunit | 0.0244463 |
| RPS20 | ribosomal protein S20 | 0.0242293 |
| SEPTIN7 | septin 7 | 0.0240789 |
| HYCC1 | hyccin PI4KA lipid kinase complex subunit 1 | 0.0239205 |
| RPL13A | ribosomal protein L13a | 0.0237261 |
| PHIP | pleckstrin homology domain interacting protein | 0.023492 |
| KLF6 | Kruppel-like factor 6 | 0.0233295 |
| RPS12 | ribosomal protein S12 | 0.0232282 |
| CKAP5 | cytoskeleton associated protein 5 | 0.022839 |
| ADAM17 | ADAM metallopeptidase domain 17 | 0.0226236 |
| PKM | pyruvate kinase, muscle | 0.0224746 |
| RASA3 | RAS p21 protein activator 3 | 0.0221596 |
| FMNL2 | formin-like 2 | 0.0218549 |
| IGF2BP2 | insulin-like growth factor 2 mRNA binding protein 2 | 0.0218079 |
| YES1 | YES proto-oncogene 1, Src family tyrosine kinase | 0.0214684 |
| LMNA | lamin A/C | 0.021464 |
| NAV2 | neuron navigator 2 | 0.0214178 |
| CLIC4 | chloride intracellular channel 4 | 0.0210567 |
| GOLGA4 | golgin A4 | 0.0210211 |
| TAF15 | TAF15 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 68kDa | 0.0209703 |
| BBX | bobby sox homolog (Drosophila) | 0.0207889 |
| CSDE1 | cold shock domain containing E1, RNA-binding | 0.0207387 |
| ARHGAP29 | Rho GTPase activating protein 29 | 0.0205443 |
| LGALS1 | lectin, galactoside-binding, soluble, 1 | 0.0204868 |
| RPS8 | ribosomal protein S8 | 0.020483 |
| RPS19 | ribosomal protein S19 | 0.020378 |
| RPS6 | ribosomal protein S6 | 0.0203005 |
| RACK1 | receptor for activated C kinase 1 | 0.0199673 |
| SEPTIN9 | septin 9 | 0.0198979 |
| UACA | uveal autoantigen with coiled-coil domains and ankyrin repeats | 0.0198842 |
| LPP | LIM domain containing preferred translocation partner in lipoma | 0.0198316 |
| EHBP1L1 | EH domain binding protein 1-like 1 | 0.0194491 |
| RPL26 | ribosomal protein L26 | 0.0194081 |
| ATP2C1 | ATPase, Ca++ transporting, type 2C, member 1 | 0.0193112 |
| SHB | Src homology 2 domain containing adaptor protein B | 0.0192884 |
| RPS2 | ribosomal protein S2 | 0.0192594 |
| GRB10 | growth factor receptor-bound protein 10 | 0.0192509 |
| ITPRID2 | ITPR interacting domain containing 2 | 0.0190753 |
| PCBP2 | poly(rC) binding protein 2 | 0.0190277 |
| RAD23B | RAD23 homolog B (S. cerevisiae) | 0.0187965 |
| FER | fer (fps/fes related) tyrosine kinase | 0.0186406 |
| RPL37A | ribosomal protein L37a | 0.0184386 |
| KIF2A | kinesin heavy chain member 2A | 0.0183513 |
| EZR | ezrin | 0.0182201 |
| PRRC2C | proline-rich coiled-coil 2C | 0.0180578 |
| RAPGEF2 | Rap guanine nucleotide exchange factor (GEF) 2 | 0.017963 |
| ERO1A | endoplasmic reticulum oxidoreductase 1 alpha | 0.0177759 |
| ADM | adrenomedullin | 0.0177683 |
| BHLHE40 | basic helix-loop-helix family, member e40 | 0.0176869 |
| H1-4 | H1.4 linker histone, cluster member | 0.0174785 |
| IER2 | immediate early response 2 | 0.0174708 |
| AKAP12 | A kinase (PRKA) anchor protein 12 | 0.0174299 |
| RPL36 | ribosomal protein L36 | 0.0174031 |
| ENAH | enabled homolog (Drosophila) | 0.0173904 |
| RPLP0 | ribosomal protein, large, P0 | 0.0173544 |
| HNRNPA1 | heterogeneous nuclear ribonucleoprotein A1 | 0.0173216 |
| DRAP1 | DR1-associated protein 1 (negative cofactor 2 alpha) | 0.0170235 |
| Symbol | Name | Standardized Value |
|---|---|---|
| FN1 | fibronectin 1 | -0.400236 |
| NDRG1 | N-myc downstream regulated 1 | -0.218029 |
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | -0.18086 |
| COL1A1 | collagen, type I, alpha 1 | -0.159708 |
| HSPA5 | heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) | -0.129311 |
| SERPINE1 | serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 | -0.127 |
| IGFBP3 | insulin-like growth factor binding protein 3 | -0.123388 |
| CD44 | CD44 molecule (Indian blood group) | -0.109904 |
| EXT1 | exostosin glycosyltransferase 1 | -0.0979516 |
| TGFBI | transforming growth factor, beta-induced, 68kDa | -0.0974431 |
| PLOD2 | procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 | -0.0813066 |
| COL1A2 | collagen, type I, alpha 2 | -0.080187 |
| SPARC | secreted protein, acidic, cysteine-rich (osteonectin) | -0.0780557 |
| CDH13 | cadherin 13 | -0.0750265 |
| VIM | vimentin | -0.0719721 |
| PSD3 | pleckstrin and Sec7 domain containing 3 | -0.0693032 |
| FNDC3B | fibronectin type III domain containing 3B | -0.0663218 |
| SPOCK1 | sparc/osteonectin, cwcv and kazal-like domains proteoglycan (testican) 1 | -0.0568089 |
| LOX | lysyl oxidase | -0.0487049 |
| TIMP3 | TIMP metallopeptidase inhibitor 3 | -0.0453966 |
| COL5A1 | collagen, type V, alpha 1 | -0.0440718 |
| TRIO | trio Rho guanine nucleotide exchange factor | -0.04382 |
| CALD1 | caldesmon 1 | -0.0392507 |
| ZC3HAV1 | zinc finger CCCH-type, antiviral 1 | -0.0371081 |
| ADAMTS6 | ADAM metallopeptidase with thrombospondin type 1 motif, 6 | -0.0361379 |
| GOLGB1 | golgin B1 | -0.0351336 |
| PARP14 | poly (ADP-ribose) polymerase family, member 14 | -0.0350959 |
| PFKFB4 | 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 4 | -0.0345076 |
| PDLIM5 | PDZ and LIM domain 5 | -0.0345068 |
| ANXA2 | annexin A2 | -0.0343473 |
| MARCKS | myristoylated alanine-rich protein kinase C substrate | -0.0337367 |
| COL6A1 | collagen, type VI, alpha 1 | -0.0336906 |
| ZBTB38 | zinc finger and BTB domain containing 38 | -0.0325735 |
| ZSWIM6 | zinc finger, SWIM-type containing 6 | -0.0324897 |
| SEMA5A | sema domain, seven thrombospondin repeats (type 1 and type 1-like), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 5A | -0.0324312 |
| DPYSL3 | dihydropyrimidinase-like 3 | -0.032032 |
| TRPS1 | trichorhinophalangeal syndrome I | -0.0318427 |
| SLC39A14 | solute carrier family 39 (zinc transporter), member 14 | -0.0303998 |
| CLINT1 | clathrin interactor 1 | -0.0303912 |
| COL7A1 | collagen, type VII, alpha 1 | -0.0298061 |
| TRAM1 | translocation associated membrane protein 1 | -0.0297597 |
| STC1 | stanniocalcin 1 | -0.0296911 |
| LDHA | lactate dehydrogenase A | -0.0289766 |
| GNB1 | guanine nucleotide binding protein (G protein), beta polypeptide 1 | -0.0286983 |
| LMAN1 | lectin, mannose-binding, 1 | -0.0285905 |
| IER3 | immediate early response 3 | -0.0280718 |
| CADM1 | cell adhesion molecule 1 | -0.0276023 |
| MTSS1 | metastasis suppressor 1 | -0.0273122 |
| BSG | basigin (Ok blood group) | -0.026686 |
| VCAN | versican | -0.0265581 |
| TAPBP | TAP binding protein (tapasin) | -0.0265538 |
| TPM1 | tropomyosin 1 (alpha) | -0.026157 |
| FTH1 | ferritin, heavy polypeptide 1 | -0.0260149 |
| P4HB | prolyl 4-hydroxylase, beta polypeptide | -0.0258845 |
| HLA-B | major histocompatibility complex, class I, B | -0.0254236 |
| NLRP1 | NLR family, pyrin domain containing 1 | -0.0237793 |
| DDX17 | DEAD (Asp-Glu-Ala-Asp) box helicase 17 | -0.0236965 |
| TMEM165 | transmembrane protein 165 | -0.0235553 |
| SUPT3H | suppressor of Ty 3 homolog (S. cerevisiae) | -0.0235521 |
| WWTR1 | WW domain containing transcription regulator 1 | -0.0232857 |
| RAB7A | RAB7A, member RAS oncogene family | -0.0232261 |
| JARID2 | jumonji, AT rich interactive domain 2 | -0.0228429 |
| RIGI | RNA sensor RIG-I | -0.0227871 |
| ZMAT4 | zinc finger, matrin-type 4 | -0.0224596 |
| SEC24A | SEC24 family member A | -0.0224338 |
| SAMD9 | sterile alpha motif domain containing 9 | -0.0222749 |
| GFPT2 | glutamine-fructose-6-phosphate transaminase 2 | -0.0219461 |
| SMAD3 | SMAD family member 3 | -0.02189 |
| SERPINE2 | serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2 | -0.0216736 |
| IFIT3 | interferon-induced protein with tetratricopeptide repeats 3 | -0.0212941 |
| ABI3BP | ABI family, member 3 (NESH) binding protein | -0.0212193 |
| CDH2 | cadherin 2, type 1, N-cadherin (neuronal) | -0.0211368 |
| POTEF | POTE ankyrin domain family, member F | -0.0210928 |
| FBN1 | fibrillin 1 | -0.0208623 |
| GLIS3 | GLIS family zinc finger 3 | -0.0208124 |
| AHR | aryl hydrocarbon receptor | -0.0206231 |
| EHD2 | EH-domain containing 2 | -0.0205424 |
| LOXL2 | lysyl oxidase-like 2 | -0.0204696 |
| CNTN5 | contactin 5 | -0.0203332 |
| FUS | FUS RNA binding protein | -0.0201641 |
| CALU | calumenin | -0.0199329 |
| KIF1B | kinesin family member 1B | -0.0198106 |
| USP34 | ubiquitin specific peptidase 34 | -0.0197389 |
| ITPR1 | inositol 1,4,5-trisphosphate receptor, type 1 | -0.0195504 |
| IARS1 | isoleucyl-tRNA synthetase 1 | -0.0194092 |
| MATR3 | matrin 3 | -0.0194083 |
| PTK2 | protein tyrosine kinase 2 | -0.0193277 |
| NABP1 | nucleic acid binding protein 1 | -0.0192566 |
| EGFR | epidermal growth factor receptor | -0.0191318 |
| SP100 | SP100 nuclear antigen | -0.0190834 |
| MAP1LC3B | microtubule-associated protein 1 light chain 3 beta | -0.0190211 |
| UBC | ubiquitin C | -0.0182748 |
| UBE2E2 | ubiquitin-conjugating enzyme E2E 2 | -0.0181419 |
| TAX1BP1 | Tax1 (human T-cell leukemia virus type I) binding protein 1 | -0.0181194 |
| MTDH | metadherin | -0.0180577 |
| SCFD1 | sec1 family domain containing 1 | -0.0179485 |
| CPQ | carboxypeptidase Q | -0.017941 |
| MAGT1 | magnesium transporter 1 | -0.0177926 |
| MYO9B | myosin IXB | -0.0177431 |
| NEDD4L | neural precursor cell expressed, developmentally down-regulated 4-like, E3 ubiquitin protein ligase | -0.017737 |
