Tolmetin_HepG2/C3A Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Tolmetin perturbation in HepG2/C3A cell line (Tahoe Therapeutics)
Similar Terms
Downloads & Tools

Genes

200 genes differentially expressed following the Tolmetin_HepG2/C3A drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.115551
MYH9 myosin, heavy chain 9, non-muscle 0.0890559
TF transferrin 0.0888545
PLOD2 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 0.085273
VEGFA vascular endothelial growth factor A 0.0687216
RPL3 ribosomal protein L3 0.0607468
AKAP12 A kinase (PRKA) anchor protein 12 0.0558635
SPTBN1 spectrin, beta, non-erythrocytic 1 0.0551575
DSPP dentin sialophosphoprotein 0.0543085
CCNY cyclin Y 0.0535725
DDIT4 DNA-damage-inducible transcript 4 0.0530438
KDM3A lysine (K)-specific demethylase 3A 0.050662
AFDN afadin, adherens junction formation factor 0.0489269
FHIP1A FHF complex subunit HOOK interacting protein 1A 0.0473853
PPP1R15A protein phosphatase 1, regulatory subunit 15A 0.0460643
TNIP1 TNFAIP3 interacting protein 1 0.0452866
TNS1 tensin 1 0.0445966
PLIN2 perilipin 2 0.0436692
HIVEP2 human immunodeficiency virus type I enhancer binding protein 2 0.0413163
MYO1B myosin IB 0.0391794
NFE2L1 nuclear factor, erythroid 2-like 1 0.0390678
RPS2 ribosomal protein S2 0.0386054
INSIG2 insulin induced gene 2 0.0384907
HELZ helicase with zinc finger 0.0384835
RAB6A RAB6A, member RAS oncogene family 0.0384309
PDE8A phosphodiesterase 8A 0.0383359
UBA6 ubiquitin-like modifier activating enzyme 6 0.0365248
SOS1 son of sevenless homolog 1 (Drosophila) 0.0362084
DSCAM Down syndrome cell adhesion molecule 0.0361771
IGF2BP2 insulin-like growth factor 2 mRNA binding protein 2 0.0361087
BNIP3 BCL2/adenovirus E1B 19kDa interacting protein 3 0.0354467
ASPH aspartate beta-hydroxylase 0.0349284
PCBP2 poly(rC) binding protein 2 0.0343404
HSPA9 heat shock 70kDa protein 9 (mortalin) 0.0333408
FMNL2 formin-like 2 0.033198
CSDE1 cold shock domain containing E1, RNA-binding 0.0330868
ATP2B1 ATPase, Ca++ transporting, plasma membrane 1 0.0329317
RSRC2 arginine/serine-rich coiled-coil 2 0.0328416
SRRM2 serine/arginine repetitive matrix 2 0.0327178
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 0.0313015
WNK1 WNK lysine deficient protein kinase 1 0.0308737
RLF rearranged L-myc fusion 0.0306068
PGK1 phosphoglycerate kinase 1 0.0304758
GOLGA4 golgin A4 0.0304065
HNRNPA1 heterogeneous nuclear ribonucleoprotein A1 0.0298984
HOOK2 hook microtubule-tethering protein 2 0.0298206
SPTAN1 spectrin, alpha, non-erythrocytic 1 0.0297675
FAT1 FAT atypical cadherin 1 0.0296103
BNIP3L BCL2/adenovirus E1B 19kDa interacting protein 3-like 0.0290873
NDRG1 N-myc downstream regulated 1 0.0289366
NCOR1 nuclear receptor corepressor 1 0.0288087
EIF1 eukaryotic translation initiation factor 1 0.0285642
HNRNPU heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) 0.028385
XPOT exportin, tRNA 0.0280994
FLNB filamin B, beta 0.0280697
CHD7 chromodomain helicase DNA binding protein 7 0.0279901
SNX9 sorting nexin 9 0.0279601
ITPRID2 ITPR interacting domain containing 2 0.0278328
PTTG1IP pituitary tumor-transforming 1 interacting protein 0.0277801
ADAM17 ADAM metallopeptidase domain 17 0.0276166
OSBPL9 oxysterol binding protein-like 9 0.0274917
PDIA6 protein disulfide isomerase family A, member 6 0.0274422
TPD52 tumor protein D52 0.0273339
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 0.0267695
ATP13A3 ATPase type 13A3 0.0264681
NCKAP1 NCK-associated protein 1 0.0260884
TPI1 triosephosphate isomerase 1 0.0259322
P4HA1 prolyl 4-hydroxylase, alpha polypeptide I 0.0259291
DTNA dystrobrevin, alpha 0.0257946
PPP2R2A protein phosphatase 2, regulatory subunit B, alpha 0.0257816
ARRDC3 arrestin domain containing 3 0.0257521
ZFP36L1 ZFP36 ring finger protein-like 1 0.0256853
BRD2 bromodomain containing 2 0.0256266
WWC2 WW and C2 domain containing 2 0.0253915
ZFAND3 zinc finger, AN1-type domain 3 0.0250404
DNAJC5 DnaJ (Hsp40) homolog, subfamily C, member 5 0.0249919
CHD9 chromodomain helicase DNA binding protein 9 0.0248714
FBXO42 F-box protein 42 0.0244426
HYOU1 hypoxia up-regulated 1 0.0244051
RBPJ recombination signal binding protein for immunoglobulin kappa J region 0.0242969
CCNL1 cyclin L1 0.0242407
GBE1 glucan (1,4-alpha-), branching enzyme 1 0.0240841
RPS18 ribosomal protein S18 0.0240338
ATAD2B ATPase family, AAA domain containing 2B 0.0239006
CEP250 centrosomal protein 250kDa 0.0238783
DST dystonin 0.0237896
EGLN1 egl-9 family hypoxia-inducible factor 1 0.0236943
HSPA8 heat shock 70kDa protein 8 0.0236833
RPS15A ribosomal protein S15a 0.0235872
SERINC1 serine incorporator 1 0.0235238
SF3B1 splicing factor 3b, subunit 1, 155kDa 0.0235143
PACSIN2 protein kinase C and casein kinase substrate in neurons 2 0.0232767
FAM13A family with sequence similarity 13, member A 0.0231831
EEF1A1 eukaryotic translation elongation factor 1 alpha 1 0.0226997
YWHAG tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, gamma 0.0226962
RPS12 ribosomal protein S12 0.0226013
TPM3 tropomyosin 3 0.0224953
RNASET2 ribonuclease T2 0.0224202
YTHDC1 YTH domain containing 1 0.0222223
PRKAR1A protein kinase, cAMP-dependent, regulatory, type I, alpha 0.0222155

decreased expression

Symbol Name Standardized Value
APOB apolipoprotein B -0.247455
IGF2 insulin-like growth factor 2 -0.238658
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 -0.181092
FN1 fibronectin 1 -0.145237
GPC3 glypican 3 -0.138168
EHBP1 EH domain binding protein 1 -0.123351
LRMDA leucine rich melanocyte differentiation associated -0.116378
PLCB1 phospholipase C, beta 1 (phosphoinositide-specific) -0.113112
TM4SF1 transmembrane 4 L six family member 1 -0.0962973
C3 complement component 3 -0.0934843
LRRTM4 leucine rich repeat transmembrane neuronal 4 -0.0931581
TPT1 tumor protein, translationally-controlled 1 -0.089499
NKD1 naked cuticle homolog 1 (Drosophila) -0.0863565
MAML2 mastermind-like 2 (Drosophila) -0.082208
ACSL4 acyl-CoA synthetase long-chain family member 4 -0.0800941
ITPR2 inositol 1,4,5-trisphosphate receptor, type 2 -0.0796495
SERPINA3 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 3 -0.0745192
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.0671078
NPAS2 neuronal PAS domain protein 2 -0.0661172
ZMYND8 zinc finger, MYND-type containing 8 -0.0655926
SERPINA1 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 1 -0.0646855
PTCHD4 patched domain containing 4 -0.0595864
FRMD5 FERM domain containing 5 -0.0588564
MBNL3 muscleblind-like splicing regulator 3 -0.0538
TFPI tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor) -0.0530124
IMMP2L IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) -0.0513008
SOX5 SRY (sex determining region Y)-box 5 -0.0509378
ROCK2 Rho-associated, coiled-coil containing protein kinase 2 -0.0508783
NCOA7 nuclear receptor coactivator 7 -0.0506789
MAGI2 membrane associated guanylate kinase, WW and PDZ domain containing 2 -0.050056
TNFSF14 tumor necrosis factor (ligand) superfamily, member 14 -0.0499827
ZBTB20 zinc finger and BTB domain containing 20 -0.0487611
RPS24 ribosomal protein S24 -0.0483291
DNAH17 dynein, axonemal, heavy chain 17 -0.0475113
EGR1 early growth response 1 -0.046407
GPC6 glypican 6 -0.0462473
ELL2 elongation factor, RNA polymerase II, 2 -0.0461644
SLC6A14 solute carrier family 6 (amino acid transporter), member 14 -0.0439498
GPAM glycerol-3-phosphate acyltransferase, mitochondrial -0.0429069
SCD stearoyl-CoA desaturase (delta-9-desaturase) -0.0427438
OSMR oncostatin M receptor -0.0426269
TIMP1 TIMP metallopeptidase inhibitor 1 -0.0411106
A2M alpha-2-macroglobulin -0.0403857
VCL vinculin -0.0402662
ABTB3 ankyrin repeat and BTB domain containing 3 -0.0402206
FHIT fragile histidine triad -0.039471
EPAS1 endothelial PAS domain protein 1 -0.0373287
ARL6IP1 ADP-ribosylation factor-like 6 interacting protein 1 -0.0371469
UBE2D2 ubiquitin-conjugating enzyme E2D 2 -0.0362828
EML4 echinoderm microtubule associated protein like 4 -0.0362701
SYNJ2 synaptojanin 2 -0.0348221
GMDS GDP-mannose 4,6-dehydratase -0.0347137
SNTB1 syntrophin, beta 1 (dystrophin-associated protein A1, 59kDa, basic component 1) -0.0344537
RPS8 ribosomal protein S8 -0.0343259
ITGAV integrin, alpha V -0.0340714
EXT1 exostosin glycosyltransferase 1 -0.0336645
PERP PERP, TP53 apoptosis effector -0.0336568
GK glycerol kinase -0.0336558
MARCKS myristoylated alanine-rich protein kinase C substrate -0.0333637
SYN3 synapsin III -0.032339
ITGA2 integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) -0.0318605
AGO2 argonaute RISC catalytic component 2 -0.0318306
VPS54 vacuolar protein sorting 54 homolog (S. cerevisiae) -0.0306307
FARP1 FERM, RhoGEF (ARHGEF) and pleckstrin domain protein 1 (chondrocyte-derived) -0.030353
NPR2 natriuretic peptide receptor 2 -0.0303517
SDC4 syndecan 4 -0.0299645
STAU1 staufen double-stranded RNA binding protein 1 -0.0295074
HIF1A hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) -0.0292754
BCL2L1 BCL2-like 1 -0.0290273
DDX5 DEAD (Asp-Glu-Ala-Asp) box helicase 5 -0.0289044
PHF3 PHD finger protein 3 -0.0284077
PEG10 paternally expressed 10 -0.0280907
ACTN4 actinin, alpha 4 -0.0280166
PARD3 par-3 family cell polarity regulator -0.0276941
TAS2R14 taste receptor, type 2, member 14 -0.027451
MALRD1 MAM and LDL receptor class A domain containing 1 -0.027408
STAT1 signal transducer and activator of transcription 1, 91kDa -0.0273333
PEG3 paternally expressed 3 -0.0272221
RASGRF2 Ras protein-specific guanine nucleotide-releasing factor 2 -0.0269486
SVIL supervillin -0.0266986
RPL38 ribosomal protein L38 -0.0266788
MBD5 methyl-CpG binding domain protein 5 -0.0266561
KAZN kazrin, periplakin interacting protein -0.0265379
ARL5A ADP-ribosylation factor-like 5A -0.0261816
RRBP1 ribosome binding protein 1 -0.0261797
HS2ST1 heparan sulfate 2-O-sulfotransferase 1 -0.0257663
RPLP1 ribosomal protein, large, P1 -0.0257564
GLIS3 GLIS family zinc finger 3 -0.0256912
NFE2L2 nuclear factor, erythroid 2-like 2 -0.0256578
IER3 immediate early response 3 -0.0249872
KLF6 Kruppel-like factor 6 -0.0247827
TPM4 tropomyosin 4 -0.0247231
PDGFB platelet-derived growth factor beta polypeptide -0.0243534
RNF213 ring finger protein 213 -0.0243191
IGF1R insulin-like growth factor 1 receptor -0.024269
ABCC2 ATP-binding cassette, sub-family C (CFTR/MRP), member 2 -0.0241034
SLF2 SMC5-SMC6 complex localization factor 2 -0.023822
RAPGEF5 Rap guanine nucleotide exchange factor (GEF) 5 -0.0235932
MSI2 musashi RNA-binding protein 2 -0.0234416
IQSEC1 IQ motif and Sec7 domain 1 -0.0233383