Tolmetin_MIA PaCa-2 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Tolmetin perturbation in MIA PaCa-2 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Tolmetin_MIA PaCa-2 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) 0.175261
ERRFI1 ERBB receptor feedback inhibitor 1 0.171372
TXNRD1 thioredoxin reductase 1 0.147709
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.106299
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) 0.104794
SLC38A2 solute carrier family 38, member 2 0.0967189
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 0.0947834
TMSB4X thymosin beta 4, X-linked 0.0926723
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 0.0858461
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin) 0.0841557
AHNAK AHNAK nucleoprotein 0.0825046
MYH9 myosin, heavy chain 9, non-muscle 0.0762871
MACF1 microtubule-actin crosslinking factor 1 0.0754238
BCAR3 breast cancer anti-estrogen resistance 3 0.0736501
PABPC1 poly(A) binding protein, cytoplasmic 1 0.070086
CENPF centromere protein F, 350/400kDa 0.0699979
UAP1 UDP-N-acetylglucosamine pyrophosphorylase 1 0.0675055
SLC4A7 solute carrier family 4, sodium bicarbonate cotransporter, member 7 0.0667532
EEF2 eukaryotic translation elongation factor 2 0.0657514
APP amyloid beta (A4) precursor protein 0.0649092
STAT1 signal transducer and activator of transcription 1, 91kDa 0.0604808
TRIP12 thyroid hormone receptor interactor 12 0.0595698
PRKDC protein kinase, DNA-activated, catalytic polypeptide 0.0564619
DYNC1H1 dynein, cytoplasmic 1, heavy chain 1 0.0559726
SMURF2 SMAD specific E3 ubiquitin protein ligase 2 0.0555215
YWHAE tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon 0.0552463
CAPRIN2 caprin family member 2 0.0549197
ANKRD11 ankyrin repeat domain 11 0.0546536
YWHAZ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta 0.0520862
KDM3A lysine (K)-specific demethylase 3A 0.0517593
TOP2A topoisomerase (DNA) II alpha 170kDa 0.050179
AP2B1 adaptor-related protein complex 2, beta 1 subunit 0.0493197
TOP1 topoisomerase (DNA) I 0.0492298
EREG epiregulin 0.0490751
LOC112694756 uncharaterized LOC112694756 0.0484746
CANX calnexin 0.0477897
PGK1 phosphoglycerate kinase 1 0.0474128
SLC20A1 solute carrier family 20 (phosphate transporter), member 1 0.0467156
TM4SF1 transmembrane 4 L six family member 1 0.04612
MATR3 matrin 3 0.045394
YWHAQ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, theta 0.0451418
HNRNPU heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) 0.0450163
GARS1 glycyl-tRNA synthetase 1 0.0450054
PPP2R2A protein phosphatase 2, regulatory subunit B, alpha 0.0448439
MKI67 marker of proliferation Ki-67 0.0448175
RTN4 reticulon 4 0.0446165
CTNNA1 catenin (cadherin-associated protein), alpha 1, 102kDa 0.0442948
ADAM17 ADAM metallopeptidase domain 17 0.0440054
ZEB1 zinc finger E-box binding homeobox 1 0.0425328
EIF1 eukaryotic translation initiation factor 1 0.0424464
XPO1 exportin 1 0.0423296
PHLDB2 pleckstrin homology-like domain, family B, member 2 0.0423042
IGF2BP2 insulin-like growth factor 2 mRNA binding protein 2 0.042304
JMJD1C jumonji domain containing 1C 0.0420281
SPAG9 sperm associated antigen 9 0.0418712
ZFAND3 zinc finger, AN1-type domain 3 0.0417198
ASAP1 ArfGAP with SH3 domain, ankyrin repeat and PH domain 1 0.0417155
CSDE1 cold shock domain containing E1, RNA-binding 0.041694
RAI1 retinoic acid induced 1 0.0415485
HSPA8 heat shock 70kDa protein 8 0.0414475
NAMPT nicotinamide phosphoribosyltransferase 0.0414089
CLTC clathrin, heavy chain (Hc) 0.0414014
SYNCRIP synaptotagmin binding, cytoplasmic RNA interacting protein 0.0409715
SFPQ splicing factor proline/glutamine-rich 0.0409563
TMEM41B transmembrane protein 41B 0.0406966
USP9X ubiquitin specific peptidase 9, X-linked 0.0406847
IGF2BP3 insulin-like growth factor 2 mRNA binding protein 3 0.0403983
RERE arginine-glutamic acid dipeptide (RE) repeats 0.0400159
HDLBP high density lipoprotein binding protein 0.039964
SRGAP1 SLIT-ROBO Rho GTPase activating protein 1 0.03992
CKAP5 cytoskeleton associated protein 5 0.039634
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 0.0395979
MARCHF6 membrane associated ring-CH-type finger 6 0.0395903
ARHGAP5 Rho GTPase activating protein 5 0.0395888
UBR4 ubiquitin protein ligase E3 component n-recognin 4 0.0395418
DNAJB6 DnaJ (Hsp40) homolog, subfamily B, member 6 0.039321
TNPO1 transportin 1 0.0376959
CSNK1A1 casein kinase 1, alpha 1 0.0371274
PDIA6 protein disulfide isomerase family A, member 6 0.0370724
DNAJC5 DnaJ (Hsp40) homolog, subfamily C, member 5 0.0369791
LRPPRC leucine-rich pentatricopeptide repeat containing 0.0365604
CALM2 calmodulin 2 (phosphorylase kinase, delta) 0.0363882
PUM2 pumilio RNA-binding family member 2 0.0361927
UBR5 ubiquitin protein ligase E3 component n-recognin 5 0.0361511
KMT2C lysine (K)-specific methyltransferase 2C 0.0360666
ANKRD17 ankyrin repeat domain 17 0.0359602
WAC WW domain containing adaptor with coiled-coil 0.0357743
HSPD1 heat shock 60kDa protein 1 (chaperonin) 0.0353558
EEF1A1 eukaryotic translation elongation factor 1 alpha 1 0.0351205
EIF3A eukaryotic translation initiation factor 3, subunit A 0.035105
HSPA9 heat shock 70kDa protein 9 (mortalin) 0.0348582
YWHAG tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, gamma 0.0348514
GPRC5A G protein-coupled receptor, class C, group 5, member A 0.0345796
TM9SF3 transmembrane 9 superfamily member 3 0.0343303
HNRNPH1 heterogeneous nuclear ribonucleoprotein H1 (H) 0.0340167
SRRM2 serine/arginine repetitive matrix 2 0.0339901
IPO7 importin 7 0.0339556
RPL3 ribosomal protein L3 0.0337659
LUC7L2 LUC7-like 2 (S. cerevisiae) 0.0333737
DYRK1A dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1A 0.033368

decreased expression

Symbol Name Standardized Value
TP63 tumor protein p63 -0.12713
VIM vimentin -0.0974716
TMSB10 thymosin beta 10 -0.0904261
NFAT5 nuclear factor of activated T-cells 5, tonicity-responsive -0.0876171
HLA-B major histocompatibility complex, class I, B -0.08673
MT2A metallothionein 2A -0.0861649
SEMA3A sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3A -0.0842061
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.0819097
GBE1 glucan (1,4-alpha-), branching enzyme 1 -0.0816581
CD44 CD44 molecule (Indian blood group) -0.0803154
EFNA5 ephrin-A5 -0.074222
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 -0.0725457
RPL35A ribosomal protein L35a -0.0710497
FTL ferritin, light polypeptide -0.0694328
CADM2 cell adhesion molecule 2 -0.0672205
DLG1 discs, large homolog 1 (Drosophila) -0.0667116
TNS3 tensin 3 -0.0624466
ZDHHC14 zinc finger, DHHC-type containing 14 -0.0587553
ESYT2 extended synaptotagmin-like protein 2 -0.0581297
POTEF POTE ankyrin domain family, member F -0.0555033
HMGA1 high mobility group AT-hook 1 -0.0548981
HLA-A major histocompatibility complex, class I, A -0.0523669
RAB7A RAB7A, member RAS oncogene family -0.0519161
RPL37A ribosomal protein L37a -0.0498901
FTH1 ferritin, heavy polypeptide 1 -0.0496996
SEMA3C sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C -0.0494318
EPHA4 EPH receptor A4 -0.0493933
CSMD3 CUB and Sushi multiple domains 3 -0.0487652
IL1RAPL1 interleukin 1 receptor accessory protein-like 1 -0.0482163
RPS6 ribosomal protein S6 -0.0474146
RASSF8 Ras association (RalGDS/AF-6) domain family (N-terminal) member 8 -0.043864
RPL31 ribosomal protein L31 -0.0431225
RPL36 ribosomal protein L36 -0.043039
RPS8 ribosomal protein S8 -0.0416364
PTMA prothymosin, alpha -0.0415251
RPS19 ribosomal protein S19 -0.0414009
P4HB prolyl 4-hydroxylase, beta polypeptide -0.0410291
IMMP2L IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) -0.040937
RPS12 ribosomal protein S12 -0.0405163
ENO2 enolase 2 (gamma, neuronal) -0.039534
HSPG2 heparan sulfate proteoglycan 2 -0.0392873
MT1E metallothionein 1E -0.0368636
RPLP1 ribosomal protein, large, P1 -0.0367051
NFKBIA nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha -0.0365774
SDK1 sidekick cell adhesion molecule 1 -0.0357282
GNGT1 guanine nucleotide binding protein (G protein), gamma transducing activity polypeptide 1 -0.0355701
TIMP2 TIMP metallopeptidase inhibitor 2 -0.0353646
RPS29 ribosomal protein S29 -0.0352267
DST dystonin -0.0344697
P4HA1 prolyl 4-hydroxylase, alpha polypeptide I -0.0341871
B2M beta-2-microglobulin -0.0341245
ECE1 endothelin converting enzyme 1 -0.0328044
RNF213 ring finger protein 213 -0.0318937
HILPDA hypoxia inducible lipid droplet-associated -0.0317484
PFKFB4 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 4 -0.0312405
SERPINA3 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 3 -0.0311127
MYOF myoferlin -0.0306637
DNER delta/notch-like EGF repeat containing -0.0305639
RPL28 ribosomal protein L28 -0.030144
RPL9 ribosomal protein L9 -0.0295619
RPL37 ribosomal protein L37 -0.0288967
NDRG1 N-myc downstream regulated 1 -0.0288918
TGM2 transglutaminase 2 -0.0285925
WARS1 tryptophanyl-tRNA synthetase 1 -0.0282943
PLEKHA4 pleckstrin homology domain containing, family A (phosphoinositide binding specific) member 4 -0.0279923
EGR1 early growth response 1 -0.027944
RPLP2 ribosomal protein, large, P2 -0.0278361
WSB1 WD repeat and SOCS box containing 1 -0.0272855
SLC25A37 solute carrier family 25 (mitochondrial iron transporter), member 37 -0.0267731
IFITM1 interferon induced transmembrane protein 1 -0.0265015
ANKRD26 ankyrin repeat domain 26 -0.0259094
HDAC9 histone deacetylase 9 -0.0258444
RPS10 ribosomal protein S10 -0.0255963
PLOD1 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 1 -0.0255797
RPS27 ribosomal protein S27 -0.0255126
LOC102724023 ES1 protein homolog, mitochondrial -0.0254229
PCDH1 protocadherin 1 -0.0251954
AKAP9 A kinase (PRKA) anchor protein 9 -0.024823
MEF2A myocyte enhancer factor 2A -0.0247773
PIAS2 protein inhibitor of activated STAT, 2 -0.0244638
RPS3 ribosomal protein S3 -0.0244215
RPS23 ribosomal protein S23 -0.0243268
SLCO4A1 solute carrier organic anion transporter family, member 4A1 -0.0242755
ZMIZ2 zinc finger, MIZ-type containing 2 -0.0237473
RPL12 ribosomal protein L12 -0.0235046
GNPDA1 glucosamine-6-phosphate deaminase 1 -0.023034
HERC4 HECT and RLD domain containing E3 ubiquitin protein ligase 4 -0.0227417
RPL36A ribosomal protein L36a -0.0227144
RPS13 ribosomal protein S13 -0.0226784
TNFRSF6B tumor necrosis factor receptor superfamily, member 6b, decoy -0.0225662
DPYSL2 dihydropyrimidinase-like 2 -0.0221341
EPB41 erythrocyte membrane protein band 4.1 -0.0217491
CFAP299 cilia and flagella associated protein 299 -0.021688
SLK STE20-like kinase -0.0214883
ARL4C ADP-ribosylation factor-like 4C -0.0213135
SP100 SP100 nuclear antigen -0.0212968
CLIP2 CAP-GLY domain containing linker protein 2 -0.0212582
DYNC2I1 dynein 2 intermediate chain 1 -0.0209652
RPL26 ribosomal protein L26 -0.0208436
TRIM56 tripartite motif containing 56 -0.020468