| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | Tolmetin perturbation in NCI-H1573 cell line (Tahoe Therapeutics) |
| Similar Terms | |
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200 genes differentially expressed following the Tolmetin_NCI-H1573 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| MYH9 | myosin, heavy chain 9, non-muscle | 0.104233 |
| ASPH | aspartate beta-hydroxylase | 0.0951361 |
| PLEC | plectin | 0.0656581 |
| PGK1 | phosphoglycerate kinase 1 | 0.0583054 |
| HSP90AB1 | heat shock protein 90kDa alpha (cytosolic), class B member 1 | 0.0489707 |
| HYOU1 | hypoxia up-regulated 1 | 0.0468931 |
| EIF1 | eukaryotic translation initiation factor 1 | 0.0451791 |
| TOP1 | topoisomerase (DNA) I | 0.0449878 |
| RPL3 | ribosomal protein L3 | 0.0438111 |
| HNRNPA2B1 | heterogeneous nuclear ribonucleoprotein A2/B1 | 0.0427304 |
| SRRM2 | serine/arginine repetitive matrix 2 | 0.0407006 |
| RPS3 | ribosomal protein S3 | 0.0405308 |
| CES1 | carboxylesterase 1 | 0.0397156 |
| GRAMD1B | GRAM domain containing 1B | 0.0376655 |
| ARGLU1 | arginine and glutamate rich 1 | 0.0372094 |
| PPP1R15A | protein phosphatase 1, regulatory subunit 15A | 0.0369783 |
| ANKRD10 | ankyrin repeat domain 10 | 0.0369745 |
| HSPA8 | heat shock 70kDa protein 8 | 0.0334245 |
| MKI67 | marker of proliferation Ki-67 | 0.0328678 |
| HNRNPU | heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) | 0.0319559 |
| TXNRD1 | thioredoxin reductase 1 | 0.0312798 |
| DSPP | dentin sialophosphoprotein | 0.0310221 |
| PABPC1 | poly(A) binding protein, cytoplasmic 1 | 0.0303968 |
| HNRNPH1 | heterogeneous nuclear ribonucleoprotein H1 (H) | 0.030072 |
| RAD21 | RAD21 homolog (S. pombe) | 0.0290022 |
| ACIN1 | apoptotic chromatin condensation inducer 1 | 0.0280049 |
| RPL23 | ribosomal protein L23 | 0.0279355 |
| KLC1 | kinesin light chain 1 | 0.0273556 |
| HSPD1 | heat shock 60kDa protein 1 (chaperonin) | 0.0269049 |
| ADAM17 | ADAM metallopeptidase domain 17 | 0.0268658 |
| LAMB3 | laminin, beta 3 | 0.0260224 |
| ANKRD11 | ankyrin repeat domain 11 | 0.0256617 |
| UBE2O | ubiquitin-conjugating enzyme E2O | 0.0254148 |
| ECT2 | epithelial cell transforming 2 | 0.024913 |
| HNRNPA1 | heterogeneous nuclear ribonucleoprotein A1 | 0.0245674 |
| MYOF | myoferlin | 0.0239969 |
| KDM3A | lysine (K)-specific demethylase 3A | 0.0239114 |
| USP9X | ubiquitin specific peptidase 9, X-linked | 0.0239037 |
| THSD4 | thrombospondin, type I, domain containing 4 | 0.0237675 |
| DYNC1H1 | dynein, cytoplasmic 1, heavy chain 1 | 0.0235001 |
| NCKAP1 | NCK-associated protein 1 | 0.0232866 |
| ITGB1 | integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) | 0.0226507 |
| TPI1 | triosephosphate isomerase 1 | 0.0225355 |
| RPL4 | ribosomal protein L4 | 0.0224518 |
| AHNAK | AHNAK nucleoprotein | 0.0220906 |
| EEF1G | eukaryotic translation elongation factor 1 gamma | 0.0220352 |
| TES | testin LIM domain protein | 0.0219481 |
| RUNX1 | runt-related transcription factor 1 | 0.0217468 |
| SHB | Src homology 2 domain containing adaptor protein B | 0.0215846 |
| RBPJ | recombination signal binding protein for immunoglobulin kappa J region | 0.0212588 |
| RNF145 | ring finger protein 145 | 0.0206645 |
| NPTN | neuroplastin | 0.0206365 |
| SLC38A2 | solute carrier family 38, member 2 | 0.0204101 |
| SRSF5 | serine/arginine-rich splicing factor 5 | 0.0203081 |
| LANCL2 | LanC lantibiotic synthetase component C-like 2 (bacterial) | 0.0202325 |
| CDC73 | cell division cycle 73 | 0.0196268 |
| NUP58 | nucleoporin 58 | 0.0195223 |
| OLA1 | Obg-like ATPase 1 | 0.0194579 |
| ATP13A3 | ATPase type 13A3 | 0.0192829 |
| NFE2L1 | nuclear factor, erythroid 2-like 1 | 0.0191751 |
| PRKAR1A | protein kinase, cAMP-dependent, regulatory, type I, alpha | 0.0187074 |
| CASC3 | cancer susceptibility candidate 3 | 0.0183152 |
| CENPF | centromere protein F, 350/400kDa | 0.0181166 |
| ITPRID2 | ITPR interacting domain containing 2 | 0.0181077 |
| KDM6A | lysine (K)-specific demethylase 6A | 0.0180356 |
| RAD23B | RAD23 homolog B (S. cerevisiae) | 0.0180096 |
| BCAR3 | breast cancer anti-estrogen resistance 3 | 0.0179587 |
| SPTBN1 | spectrin, beta, non-erythrocytic 1 | 0.0179123 |
| CSDE1 | cold shock domain containing E1, RNA-binding | 0.0178852 |
| SLC6A6 | solute carrier family 6 (neurotransmitter transporter), member 6 | 0.0176791 |
| PM20D1 | peptidase M20 domain containing 1 | 0.0175805 |
| YWHAE | tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon | 0.0175566 |
| TPM3 | tropomyosin 3 | 0.0171429 |
| CAPZA2 | capping protein (actin filament) muscle Z-line, alpha 2 | 0.0166479 |
| NAMPT | nicotinamide phosphoribosyltransferase | 0.0165709 |
| CPNE1 | copine I | 0.016542 |
| TOP2A | topoisomerase (DNA) II alpha 170kDa | 0.0165322 |
| PNN | pinin, desmosome associated protein | 0.0165191 |
| ROBO1 | roundabout, axon guidance receptor, homolog 1 (Drosophila) | 0.016128 |
| LIF | leukemia inhibitory factor | 0.0159574 |
| PPP2R2A | protein phosphatase 2, regulatory subunit B, alpha | 0.0156658 |
| EIF3E | eukaryotic translation initiation factor 3, subunit E | 0.0153974 |
| TOP2B | topoisomerase (DNA) II beta 180kDa | 0.0153613 |
| DDX5 | DEAD (Asp-Glu-Ala-Asp) box helicase 5 | 0.0153579 |
| ZFC3H1 | zinc finger, C3H1-type containing | 0.0151287 |
| SGO2 | shugoshin 2 | 0.0150833 |
| SEMA4B | sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4B | 0.015054 |
| SRSF1 | serine/arginine-rich splicing factor 1 | 0.0149645 |
| RPS15A | ribosomal protein S15a | 0.0149246 |
| RLIM | ring finger protein, LIM domain interacting | 0.0148954 |
| LPCAT2 | lysophosphatidylcholine acyltransferase 2 | 0.0148931 |
| TSC22D2 | TSC22 domain family, member 2 | 0.0147704 |
| CALM2 | calmodulin 2 (phosphorylase kinase, delta) | 0.0146321 |
| DHX15 | DEAH (Asp-Glu-Ala-His) box helicase 15 | 0.0145553 |
| PJA2 | praja ring finger 2, E3 ubiquitin protein ligase | 0.0145183 |
| DYNC1LI2 | dynein, cytoplasmic 1, light intermediate chain 2 | 0.0145062 |
| DDX39B | DEAD (Asp-Glu-Ala-Asp) box polypeptide 39B | 0.0144692 |
| USP7 | ubiquitin specific peptidase 7 (herpes virus-associated) | 0.014422 |
| NGLY1 | N-glycanase 1 | 0.01435 |
| LUC7L3 | LUC7-like 3 (S. cerevisiae) | 0.014123 |
| Symbol | Name | Standardized Value |
|---|---|---|
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | -0.511704 |
| ERO1A | endoplasmic reticulum oxidoreductase 1 alpha | -0.326718 |
| NDRG1 | N-myc downstream regulated 1 | -0.192368 |
| EGFR | epidermal growth factor receptor | -0.157546 |
| EGR1 | early growth response 1 | -0.11267 |
| ARIH1 | ariadne RBR E3 ubiquitin protein ligase 1 | -0.0697082 |
| SEMA3C | sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C | -0.0687821 |
| DDX17 | DEAD (Asp-Glu-Ala-Asp) box helicase 17 | -0.064808 |
| CD55 | CD55 molecule, decay accelerating factor for complement (Cromer blood group) | -0.0624528 |
| P4HA1 | prolyl 4-hydroxylase, alpha polypeptide I | -0.0599512 |
| BTG1 | B-cell translocation gene 1, anti-proliferative | -0.0596874 |
| FTH1 | ferritin, heavy polypeptide 1 | -0.0589785 |
| PHLDA1 | pleckstrin homology-like domain, family A, member 1 | -0.0524654 |
| ZMYND8 | zinc finger, MYND-type containing 8 | -0.0520646 |
| LDHA | lactate dehydrogenase A | -0.051695 |
| LRP1B | low density lipoprotein receptor-related protein 1B | -0.0514048 |
| PITPNC1 | phosphatidylinositol transfer protein, cytoplasmic 1 | -0.0513318 |
| S100A10 | S100 calcium binding protein A10 | -0.047072 |
| TMEM165 | transmembrane protein 165 | -0.0470567 |
| SEC31A | SEC31 homolog A (S. cerevisiae) | -0.0456462 |
| GPRC5A | G protein-coupled receptor, class C, group 5, member A | -0.0455588 |
| JMJD1C | jumonji domain containing 1C | -0.0454451 |
| GOLGB1 | golgin B1 | -0.0449871 |
| GBE1 | glucan (1,4-alpha-), branching enzyme 1 | -0.0445171 |
| TANC2 | tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 2 | -0.0445061 |
| EFNA5 | ephrin-A5 | -0.0444609 |
| RAB1A | RAB1A, member RAS oncogene family | -0.0425349 |
| CAV2 | caveolin 2 | -0.0419063 |
| TMSB10 | thymosin beta 10 | -0.0417806 |
| MYO1E | myosin IE | -0.0408116 |
| IGFBP3 | insulin-like growth factor binding protein 3 | -0.0398302 |
| PTGS2 | prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase) | -0.0397877 |
| ANXA2 | annexin A2 | -0.038911 |
| RAB7A | RAB7A, member RAS oncogene family | -0.0376163 |
| BLZF1 | basic leucine zipper nuclear factor 1 | -0.0374223 |
| MCL1 | myeloid cell leukemia 1 | -0.0371267 |
| CST3 | cystatin C | -0.0366167 |
| PHLDB2 | pleckstrin homology-like domain, family B, member 2 | -0.0359705 |
| SLC38A1 | solute carrier family 38, member 1 | -0.0339926 |
| ZBTB20 | zinc finger and BTB domain containing 20 | -0.03353 |
| LMO7 | LIM domain 7 | -0.0326205 |
| ACTG1 | actin gamma 1 | -0.032478 |
| CEACAM5 | carcinoembryonic antigen-related cell adhesion molecule 5 | -0.0322318 |
| TMTC2 | transmembrane and tetratricopeptide repeat containing 2 | -0.0319766 |
| NFKBIA | nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha | -0.0313217 |
| TPT1 | tumor protein, translationally-controlled 1 | -0.0312588 |
| PDIA3 | protein disulfide isomerase family A, member 3 | -0.0308996 |
| OSMR | oncostatin M receptor | -0.0307664 |
| P4HB | prolyl 4-hydroxylase, beta polypeptide | -0.0303968 |
| NFKBIZ | nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, zeta | -0.0300089 |
| POTEF | POTE ankyrin domain family, member F | -0.0291792 |
| MON2 | MON2 homolog (S. cerevisiae) | -0.0289501 |
| AKAP9 | A kinase (PRKA) anchor protein 9 | -0.0289178 |
| ZNF638 | zinc finger protein 638 | -0.028794 |
| EGLN3 | egl-9 family hypoxia-inducible factor 3 | -0.0281867 |
| RAD51B | RAD51 paralog B | -0.0280915 |
| PTPN12 | protein tyrosine phosphatase, non-receptor type 12 | -0.027838 |
| AGAP1 | ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 | -0.0277971 |
| PTEN | phosphatase and tensin homolog | -0.0275208 |
| USP34 | ubiquitin specific peptidase 34 | -0.0274827 |
| NFKB1 | nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 | -0.0272745 |
| HMGA1 | high mobility group AT-hook 1 | -0.0272666 |
| OFD1 | oral-facial-digital syndrome 1 | -0.0272421 |
| CDCP1 | CUB domain containing protein 1 | -0.0270257 |
| TNRC6B | trinucleotide repeat containing 6B | -0.0267184 |
| CXCL8 | chemokine (C-X-C motif) ligand 8 | -0.0256238 |
| HLA-B | major histocompatibility complex, class I, B | -0.0254949 |
| FRY | furry homolog (Drosophila) | -0.0253126 |
| MORF4L2 | mortality factor 4 like 2 | -0.0253113 |
| GPHN | gephyrin | -0.0251905 |
| KDM2A | lysine (K)-specific demethylase 2A | -0.0247425 |
| CANX | calnexin | -0.0246925 |
| NPC1 | Niemann-Pick disease, type C1 | -0.0246266 |
| PKM | pyruvate kinase, muscle | -0.024559 |
| FNDC3B | fibronectin type III domain containing 3B | -0.0245209 |
| FNIP1 | folliculin interacting protein 1 | -0.0243733 |
| GRB10 | growth factor receptor-bound protein 10 | -0.0243495 |
| ANKRD12 | ankyrin repeat domain 12 | -0.0242562 |
| STC1 | stanniocalcin 1 | -0.0242089 |
| PTPRD | protein tyrosine phosphatase, receptor type, D | -0.0239332 |
| VEGFA | vascular endothelial growth factor A | -0.0238404 |
| USP53 | ubiquitin specific peptidase 53 | -0.0237723 |
| SUMF1 | sulfatase modifying factor 1 | -0.0234234 |
| PACS1 | phosphofurin acidic cluster sorting protein 1 | -0.0230253 |
| PATJ | PATJ crumbs cell polarity complex component | -0.0228623 |
| LRBA | LPS-responsive vesicle trafficking, beach and anchor containing | -0.0226936 |
| AGR2 | anterior gradient 2 | -0.022502 |
| SOD2 | superoxide dismutase 2, mitochondrial | -0.0224869 |
| BAZ2A | bromodomain adjacent to zinc finger domain, 2A | -0.0223629 |
| SPAG9 | sperm associated antigen 9 | -0.0222526 |
| ARF4 | ADP-ribosylation factor 4 | -0.0222485 |
| ANKHD1 | ankyrin repeat and KH domain containing 1 | -0.0221089 |
| GOLGA4 | golgin A4 | -0.0220746 |
| ELF2 | E74-like factor 2 (ets domain transcription factor) | -0.0220669 |
| DOCK5 | dedicator of cytokinesis 5 | -0.0220311 |
| NSUN6 | NOP2/Sun domain family, member 6 | -0.0220024 |
| BPTF | bromodomain PHD finger transcription factor | -0.0219263 |
| ERC2 | ELKS/RAB6-interacting/CAST family member 2 | -0.0218852 |
| CAV1 | caveolin 1, caveolae protein, 22kDa | -0.0216129 |
| KRT7 | keratin 7, type II | -0.0215307 |
