| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | Tolmetin perturbation in NCI-H2030 cell line (Tahoe Therapeutics) |
| Similar Terms | |
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200 genes differentially expressed following the Tolmetin_NCI-H2030 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| PM20D1 | peptidase M20 domain containing 1 | 0.171333 |
| GRAMD1B | GRAM domain containing 1B | 0.166148 |
| TXNRD1 | thioredoxin reductase 1 | 0.116094 |
| PDE4D | phosphodiesterase 4D, cAMP-specific | 0.102286 |
| HSP90AB1 | heat shock protein 90kDa alpha (cytosolic), class B member 1 | 0.0750162 |
| HNRNPA2B1 | heterogeneous nuclear ribonucleoprotein A2/B1 | 0.0618807 |
| SLC38A2 | solute carrier family 38, member 2 | 0.0544377 |
| TPM3 | tropomyosin 3 | 0.0517304 |
| MYH9 | myosin, heavy chain 9, non-muscle | 0.0504335 |
| HSPA8 | heat shock 70kDa protein 8 | 0.049878 |
| SPTBN1 | spectrin, beta, non-erythrocytic 1 | 0.0461618 |
| ITGB1 | integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) | 0.0441909 |
| WWOX | WW domain containing oxidoreductase | 0.0439134 |
| PABPC1 | poly(A) binding protein, cytoplasmic 1 | 0.0436655 |
| SEMA3C | sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C | 0.0428261 |
| TOP2A | topoisomerase (DNA) II alpha 170kDa | 0.042202 |
| BICC1 | BicC family RNA binding protein 1 | 0.0391262 |
| NPM1 | nucleophosmin (nucleolar phosphoprotein B23, numatrin) | 0.0389867 |
| ASPH | aspartate beta-hydroxylase | 0.0385763 |
| PRKDC | protein kinase, DNA-activated, catalytic polypeptide | 0.037281 |
| RPL3 | ribosomal protein L3 | 0.037133 |
| CALM2 | calmodulin 2 (phosphorylase kinase, delta) | 0.0366751 |
| FGB | fibrinogen beta chain | 0.0364136 |
| RPL4 | ribosomal protein L4 | 0.0337875 |
| NQO1 | NAD(P)H dehydrogenase, quinone 1 | 0.0325754 |
| RAD21 | RAD21 homolog (S. pombe) | 0.0314771 |
| HSPD1 | heat shock 60kDa protein 1 (chaperonin) | 0.0313196 |
| HNRNPA1 | heterogeneous nuclear ribonucleoprotein A1 | 0.0303503 |
| RPS2 | ribosomal protein S2 | 0.0301332 |
| CYP24A1 | cytochrome P450, family 24, subfamily A, polypeptide 1 | 0.0288332 |
| SYNCRIP | synaptotagmin binding, cytoplasmic RNA interacting protein | 0.0275463 |
| PPP3CA | protein phosphatase 3, catalytic subunit, alpha isozyme | 0.0273828 |
| IGF1R | insulin-like growth factor 1 receptor | 0.0273497 |
| ECT2 | epithelial cell transforming 2 | 0.0267921 |
| TBC1D5 | TBC1 domain family, member 5 | 0.0262641 |
| YWHAZ | tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta | 0.0254538 |
| BIRC3 | baculoviral IAP repeat containing 3 | 0.025379 |
| DYNC1H1 | dynein, cytoplasmic 1, heavy chain 1 | 0.0250663 |
| TFPI2 | tissue factor pathway inhibitor 2 | 0.0246647 |
| HNRNPU | heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) | 0.0243977 |
| YWHAE | tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon | 0.0240745 |
| CENPF | centromere protein F, 350/400kDa | 0.0236492 |
| PPP1R15A | protein phosphatase 1, regulatory subunit 15A | 0.023536 |
| WDR43 | WD repeat domain 43 | 0.0232383 |
| RTN4 | reticulon 4 | 0.022884 |
| NTN4 | netrin 4 | 0.02278 |
| THBS1 | thrombospondin 1 | 0.0221927 |
| NOLC1 | nucleolar and coiled-body phosphoprotein 1 | 0.0221923 |
| CCT5 | chaperonin containing TCP1, subunit 5 (epsilon) | 0.0221185 |
| HNRNPH1 | heterogeneous nuclear ribonucleoprotein H1 (H) | 0.0220885 |
| MYL6 | myosin, light chain 6, alkali, smooth muscle and non-muscle | 0.0216659 |
| SPIDR | scaffolding protein involved in DNA repair | 0.0216095 |
| DNAJC5 | DnaJ (Hsp40) homolog, subfamily C, member 5 | 0.021237 |
| AHR | aryl hydrocarbon receptor | 0.0208731 |
| BIRC2 | baculoviral IAP repeat containing 2 | 0.0208053 |
| RPS4Y1 | ribosomal protein S4, Y-linked 1 | 0.0207863 |
| MKI67 | marker of proliferation Ki-67 | 0.0206643 |
| NAMPT | nicotinamide phosphoribosyltransferase | 0.0205015 |
| YBX3 | Y box binding protein 3 | 0.0204583 |
| TPX2 | TPX2, microtubule-associated | 0.0204555 |
| ADGRG6 | adhesion G protein-coupled receptor G6 | 0.020116 |
| DST | dystonin | 0.0200949 |
| EEF1A1 | eukaryotic translation elongation factor 1 alpha 1 | 0.0200645 |
| EFNA5 | ephrin-A5 | 0.0196182 |
| RRM2 | ribonucleotide reductase M2 | 0.0192295 |
| AHNAK | AHNAK nucleoprotein | 0.0186952 |
| AP2B1 | adaptor-related protein complex 2, beta 1 subunit | 0.0185629 |
| ANLN | anillin, actin binding protein | 0.0185407 |
| ARHGEF12 | Rho guanine nucleotide exchange factor (GEF) 12 | 0.0183203 |
| TTC28 | tetratricopeptide repeat domain 28 | 0.0183113 |
| TM4SF1 | transmembrane 4 L six family member 1 | 0.0182311 |
| NEGR1 | neuronal growth regulator 1 | 0.0180695 |
| CPNE1 | copine I | 0.0180224 |
| SRRM2 | serine/arginine repetitive matrix 2 | 0.0178604 |
| FAT1 | FAT atypical cadherin 1 | 0.0177767 |
| PFDN2 | prefoldin subunit 2 | 0.0176002 |
| NRG1 | neuregulin 1 | 0.0175262 |
| LRMDA | leucine rich melanocyte differentiation associated | 0.0174592 |
| KYNU | kynureninase | 0.0172312 |
| ACTR3 | ARP3 actin-related protein 3 homolog (yeast) | 0.0172097 |
| HMGB2 | high mobility group box 2 | 0.0169045 |
| MIS18BP1 | MIS18 binding protein 1 | 0.0163129 |
| ENAH | enabled homolog (Drosophila) | 0.016263 |
| YWHAQ | tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, theta | 0.0161315 |
| SPAG5 | sperm associated antigen 5 | 0.0161062 |
| XRCC6 | X-ray repair complementing defective repair in Chinese hamster cells 6 | 0.0160973 |
| ANKRD28 | ankyrin repeat domain 28 | 0.0160366 |
| GLIS3 | GLIS family zinc finger 3 | 0.0159327 |
| RAD51B | RAD51 paralog B | 0.0159074 |
| TPI1 | triosephosphate isomerase 1 | 0.0158752 |
| SYNE2 | spectrin repeat containing, nuclear envelope 2 | 0.0158468 |
| MAML3 | mastermind-like 3 (Drosophila) | 0.0157571 |
| NUMA1 | nuclear mitotic apparatus protein 1 | 0.0157569 |
| HYOU1 | hypoxia up-regulated 1 | 0.0157497 |
| DLGAP5 | discs, large (Drosophila) homolog-associated protein 5 | 0.0157093 |
| XPO1 | exportin 1 | 0.015663 |
| UTRN | utrophin | 0.015638 |
| CSGALNACT1 | chondroitin sulfate N-acetylgalactosaminyltransferase 1 | 0.0156049 |
| SMC4 | structural maintenance of chromosomes 4 | 0.0155624 |
| SP3 | Sp3 transcription factor | 0.0154948 |
| Symbol | Name | Standardized Value |
|---|---|---|
| MT2A | metallothionein 2A | -0.391744 |
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | -0.268841 |
| ERO1A | endoplasmic reticulum oxidoreductase 1 alpha | -0.182485 |
| VIM | vimentin | -0.132693 |
| IGF2 | insulin-like growth factor 2 | -0.10756 |
| FTH1 | ferritin, heavy polypeptide 1 | -0.101152 |
| IGFBP3 | insulin-like growth factor binding protein 3 | -0.0989459 |
| TMSB10 | thymosin beta 10 | -0.0816429 |
| FTL | ferritin, light polypeptide | -0.0791649 |
| P4HB | prolyl 4-hydroxylase, beta polypeptide | -0.0699467 |
| FMNL2 | formin-like 2 | -0.0619016 |
| HLA-B | major histocompatibility complex, class I, B | -0.0581739 |
| S100A6 | S100 calcium binding protein A6 | -0.0561199 |
| IER3 | immediate early response 3 | -0.0557106 |
| FLNB | filamin B, beta | -0.0536126 |
| PYGL | phosphorylase, glycogen, liver | -0.0522755 |
| NDRG1 | N-myc downstream regulated 1 | -0.0517168 |
| ARIH1 | ariadne RBR E3 ubiquitin protein ligase 1 | -0.0494851 |
| NFAT5 | nuclear factor of activated T-cells 5, tonicity-responsive | -0.0485814 |
| NOP58 | NOP58 ribonucleoprotein | -0.048325 |
| HLA-A | major histocompatibility complex, class I, A | -0.0478242 |
| LOC102724023 | ES1 protein homolog, mitochondrial | -0.0476963 |
| ACTG1 | actin gamma 1 | -0.0474114 |
| RAB7A | RAB7A, member RAS oncogene family | -0.045871 |
| RPLP1 | ribosomal protein, large, P1 | -0.0434592 |
| RBM25 | RNA binding motif protein 25 | -0.0427663 |
| WAC | WW domain containing adaptor with coiled-coil | -0.0412318 |
| PLOD2 | procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 | -0.0407662 |
| HSPA5 | heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) | -0.0380271 |
| IL6 | interleukin 6 | -0.0371144 |
| SMURF2 | SMAD specific E3 ubiquitin protein ligase 2 | -0.0366702 |
| GPRC5A | G protein-coupled receptor, class C, group 5, member A | -0.0351314 |
| COPA | coatomer protein complex, subunit alpha | -0.0349759 |
| DOCK4 | dedicator of cytokinesis 4 | -0.0348121 |
| RAB1A | RAB1A, member RAS oncogene family | -0.0337795 |
| CMIP | c-Maf inducing protein | -0.0337068 |
| FOSB | FBJ murine osteosarcoma viral oncogene homolog B | -0.0331731 |
| UGCG | UDP-glucose ceramide glucosyltransferase | -0.032918 |
| RBM39 | RNA binding motif protein 39 | -0.0325728 |
| KDM5B | lysine (K)-specific demethylase 5B | -0.0324242 |
| POTEF | POTE ankyrin domain family, member F | -0.0318705 |
| ZNF207 | zinc finger protein 207 | -0.0313039 |
| MLLT10 | myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 10 | -0.031241 |
| ITCH | itchy E3 ubiquitin protein ligase | -0.0312229 |
| PUM2 | pumilio RNA-binding family member 2 | -0.0308273 |
| S100A10 | S100 calcium binding protein A10 | -0.0305778 |
| RPS6 | ribosomal protein S6 | -0.0302215 |
| GOLGA4 | golgin A4 | -0.0297354 |
| ARF4 | ADP-ribosylation factor 4 | -0.0289827 |
| GLG1 | golgi glycoprotein 1 | -0.0289488 |
| SERPINE2 | serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2 | -0.0287533 |
| RPS8 | ribosomal protein S8 | -0.0283825 |
| RABGEF1 | RAB guanine nucleotide exchange factor (GEF) 1 | -0.0282452 |
| HM13 | histocompatibility (minor) 13 | -0.0280906 |
| RPL35A | ribosomal protein L35a | -0.0280725 |
| EGFR | epidermal growth factor receptor | -0.0271262 |
| NPEPPS | aminopeptidase puromycin sensitive | -0.0270511 |
| MAP1LC3B | microtubule-associated protein 1 light chain 3 beta | -0.0269142 |
| LDHA | lactate dehydrogenase A | -0.0267941 |
| SRP54 | signal recognition particle 54kDa | -0.0267553 |
| ELL2 | elongation factor, RNA polymerase II, 2 | -0.0266903 |
| SEC31A | SEC31 homolog A (S. cerevisiae) | -0.0261549 |
| TRA2A | transformer 2 alpha homolog (Drosophila) | -0.0258452 |
| NEMF | nuclear export mediator factor | -0.0258125 |
| PARD3 | par-3 family cell polarity regulator | -0.0258101 |
| SLC2A3 | solute carrier family 2 (facilitated glucose transporter), member 3 | -0.0256344 |
| UBASH3B | ubiquitin associated and SH3 domain containing B | -0.0255689 |
| STAT3 | signal transducer and activator of transcription 3 (acute-phase response factor) | -0.0255494 |
| RICTOR | RPTOR independent companion of MTOR, complex 2 | -0.0254552 |
| MORF4L2 | mortality factor 4 like 2 | -0.0251771 |
| PTPRJ | protein tyrosine phosphatase, receptor type, J | -0.0250043 |
| CD99 | CD99 molecule | -0.0248636 |
| LGALS1 | lectin, galactoside-binding, soluble, 1 | -0.024758 |
| HERPUD1 | homocysteine-inducible, endoplasmic reticulum stress-inducible, ubiquitin-like domain member 1 | -0.0245009 |
| C15ORF48 | chromosome 15 open reading frame 48 | -0.0244643 |
| FBXO11 | F-box protein 11 | -0.0242822 |
| PDIA3 | protein disulfide isomerase family A, member 3 | -0.0240463 |
| HNRNPC | heterogeneous nuclear ribonucleoprotein C (C1/C2) | -0.0239802 |
| BIRC6 | baculoviral IAP repeat containing 6 | -0.0239784 |
| HLA-E | major histocompatibility complex, class I, E | -0.0239653 |
| RPL31 | ribosomal protein L31 | -0.0239301 |
| FOS | FBJ murine osteosarcoma viral oncogene homolog | -0.023761 |
| HMGA1 | high mobility group AT-hook 1 | -0.0237142 |
| P4HA1 | prolyl 4-hydroxylase, alpha polypeptide I | -0.0235724 |
| HSP90B1 | heat shock protein 90kDa beta (Grp94), member 1 | -0.0234618 |
| TRIO | trio Rho guanine nucleotide exchange factor | -0.0233916 |
| KTN1 | kinectin 1 (kinesin receptor) | -0.0232947 |
| POLR2A | polymerase (RNA) II (DNA directed) polypeptide A, 220kDa | -0.0231839 |
| TANC2 | tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 2 | -0.0230889 |
| RPL37A | ribosomal protein L37a | -0.0229957 |
| KCMF1 | potassium channel modulatory factor 1 | -0.0227547 |
| EPAS1 | endothelial PAS domain protein 1 | -0.0222799 |
| NUMB | numb homolog (Drosophila) | -0.021985 |
| ERBIN | erbb2 interacting protein | -0.0219339 |
| PPFIBP1 | PTPRF interacting protein, binding protein 1 (liprin beta 1) | -0.0218854 |
| KMT2E | lysine (K)-specific methyltransferase 2E | -0.0217458 |
| MYADM | myeloid-associated differentiation marker | -0.0215608 |
| ZFAND3 | zinc finger, AN1-type domain 3 | -0.0215016 |
| MYO1E | myosin IE | -0.0213835 |
| PFN1 | profilin 1 | -0.0212647 |
