Tolmetin_NCI-H2122 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Tolmetin perturbation in NCI-H2122 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Tolmetin_NCI-H2122 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 0.233028
ELL2 elongation factor, RNA polymerase II, 2 0.139444
PNISR PNN-interacting serine/arginine-rich protein 0.0910972
KMT2E lysine (K)-specific methyltransferase 2E 0.0834146
FMNL2 formin-like 2 0.083123
CDC73 cell division cycle 73 0.079877
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.0791947
DNAJC5 DnaJ (Hsp40) homolog, subfamily C, member 5 0.0791324
ZNF292 zinc finger protein 292 0.0781446
PDE4D phosphodiesterase 4D, cAMP-specific 0.0752902
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 0.0700065
RPL4 ribosomal protein L4 0.0627338
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) 0.0619244
MYO1B myosin IB 0.0612157
ACSL3 acyl-CoA synthetase long-chain family member 3 0.0610962
PRKG1 protein kinase, cGMP-dependent, type I 0.05829
MYH9 myosin, heavy chain 9, non-muscle 0.0572544
HSPH1 heat shock 105kDa/110kDa protein 1 0.0564297
ABL2 ABL proto-oncogene 2, non-receptor tyrosine kinase 0.0550512
PDE8A phosphodiesterase 8A 0.0538017
NALF1 NALCN channel auxiliary factor 1 0.0528675
PPP2R2A protein phosphatase 2, regulatory subunit B, alpha 0.052614
HSPA8 heat shock 70kDa protein 8 0.051785
SFPQ splicing factor proline/glutamine-rich 0.0516146
HIVEP2 human immunodeficiency virus type I enhancer binding protein 2 0.050266
DDX1 DEAD (Asp-Glu-Ala-Asp) box helicase 1 0.0487827
HSPA9 heat shock 70kDa protein 9 (mortalin) 0.0485596
CNOT2 CCR4-NOT transcription complex, subunit 2 0.0483988
GOLGA4 golgin A4 0.0481529
NGLY1 N-glycanase 1 0.0479402
COPB1 coatomer protein complex, subunit beta 1 0.0471442
SGIP1 SH3-domain GRB2-like (endophilin) interacting protein 1 0.0469834
AKAP12 A kinase (PRKA) anchor protein 12 0.0465806
RDX radixin 0.046456
FAM13A family with sequence similarity 13, member A 0.0464172
MINDY2 MINDY lysine 48 deubiquitinase 2 0.046336
SRSF11 serine/arginine-rich splicing factor 11 0.0456767
CADM1 cell adhesion molecule 1 0.0453405
WAC WW domain containing adaptor with coiled-coil 0.0452954
SEPTIN9 septin 9 0.0449314
CTNND1 catenin (cadherin-associated protein), delta 1 0.0445806
HIF1A hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) 0.044452
CCNL1 cyclin L1 0.0437275
MBD5 methyl-CpG binding domain protein 5 0.0435399
PDPK1 3-phosphoinositide dependent protein kinase 1 0.0433346
CALD1 caldesmon 1 0.0433272
FN1 fibronectin 1 0.0433042
ITGA5 integrin, alpha 5 (fibronectin receptor, alpha polypeptide) 0.0428839
MACF1 microtubule-actin crosslinking factor 1 0.0426938
SMARCC1 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily c, member 1 0.0426601
YWHAE tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon 0.0425522
PEG10 paternally expressed 10 0.0424126
KDM6A lysine (K)-specific demethylase 6A 0.0423717
PPP6R3 protein phosphatase 6, regulatory subunit 3 0.0421195
TNKS2 tankyrase, TRF1-interacting ankyrin-related ADP-ribose polymerase 2 0.0420237
MCL1 myeloid cell leukemia 1 0.0419273
MLLT10 myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 10 0.0418867
DNAJB1 DnaJ (Hsp40) homolog, subfamily B, member 1 0.0414832
SOS1 son of sevenless homolog 1 (Drosophila) 0.0411452
CNKSR3 CNKSR family member 3 0.0411253
LRBA LPS-responsive vesicle trafficking, beach and anchor containing 0.0407788
STRN3 striatin, calmodulin binding protein 3 0.0397832
ARL6IP1 ADP-ribosylation factor-like 6 interacting protein 1 0.0392422
ANKRD17 ankyrin repeat domain 17 0.0390357
ELF3 E74-like factor 3 (ets domain transcription factor, epithelial-specific ) 0.0388141
EGFR epidermal growth factor receptor 0.0387596
RABGEF1 RAB guanine nucleotide exchange factor (GEF) 1 0.0384417
LAMA4 laminin, alpha 4 0.0383774
SET SET nuclear proto-oncogene 0.0382656
ABHD17C abhydrolase domain containing 17C 0.0379972
MXI1 MAX interactor 1, dimerization protein 0.0374095
DST dystonin 0.0372456
AHNAK AHNAK nucleoprotein 0.0372316
NCOR1 nuclear receptor corepressor 1 0.0369657
SLC38A2 solute carrier family 38, member 2 0.0367675
FHIP1A FHF complex subunit HOOK interacting protein 1A 0.036634
EPB41L2 erythrocyte membrane protein band 4.1-like 2 0.036402
LRRFIP1 leucine rich repeat (in FLII) interacting protein 1 0.0361756
FNDC3B fibronectin type III domain containing 3B 0.0361358
RSRC2 arginine/serine-rich coiled-coil 2 0.0360888
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin) 0.0358079
RBFOX2 RNA binding protein, fox-1 homolog (C. elegans) 2 0.0357071
PRPF40A PRP40 pre-mRNA processing factor 40 homolog A (S. cerevisiae) 0.0356553
RLIM ring finger protein, LIM domain interacting 0.0354717
YWHAZ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta 0.0351492
VMP1 vacuole membrane protein 1 0.034803
CCNK cyclin K 0.0347169
RLF rearranged L-myc fusion 0.0346533
ACBD6 acyl-CoA binding domain containing 6 0.0344131
SRGAP1 SLIT-ROBO Rho GTPase activating protein 1 0.0343869
SBF2 SET binding factor 2 0.0343227
PLOD2 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 0.0341115
UVRAG UV radiation resistance associated 0.0340956
VGLL4 vestigial-like family member 4 0.0339831
YTHDF3 YTH N(6)-methyladenosine RNA binding protein 3 0.0333898
SPAG9 sperm associated antigen 9 0.0333817
NCKAP1 NCK-associated protein 1 0.0333617
FAM168A family with sequence similarity 168, member A 0.0332187
USP47 ubiquitin specific peptidase 47 0.0332077
ITPR2 inositol 1,4,5-trisphosphate receptor, type 2 0.0327926

decreased expression

Symbol Name Standardized Value
VIM vimentin -0.166545
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.151799
TM4SF1 transmembrane 4 L six family member 1 -0.111235
TPT1 tumor protein, translationally-controlled 1 -0.105592
MT2A metallothionein 2A -0.102515
TMSB10 thymosin beta 10 -0.100326
ZC3HAV1 zinc finger CCCH-type, antiviral 1 -0.0977126
FTL ferritin, light polypeptide -0.0922006
LMO7 LIM domain 7 -0.0920528
CALU calumenin -0.0841342
RPL19 ribosomal protein L19 -0.0761666
ERO1A endoplasmic reticulum oxidoreductase 1 alpha -0.0759581
HLA-B major histocompatibility complex, class I, B -0.0755947
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.0743635
JMJD1C jumonji domain containing 1C -0.0735498
S100A10 S100 calcium binding protein A10 -0.0712564
RIGI RNA sensor RIG-I -0.0694361
NAP1L1 nucleosome assembly protein 1-like 1 -0.0689827
AK1 adenylate kinase 1 -0.0687873
PRKCA protein kinase C, alpha -0.0682003
RPL11 ribosomal protein L11 -0.0645195
PDIA3 protein disulfide isomerase family A, member 3 -0.0633879
UBE2H ubiquitin-conjugating enzyme E2H -0.0631103
KRT19 keratin 19, type I -0.0630987
SEC31A SEC31 homolog A (S. cerevisiae) -0.0627215
B2M beta-2-microglobulin -0.0624899
RPL35A ribosomal protein L35a -0.0606809
RPS19 ribosomal protein S19 -0.0603056
MYO1E myosin IE -0.0593909
GNAS GNAS complex locus -0.0592729
ESYT2 extended synaptotagmin-like protein 2 -0.0576395
SLMAP sarcolemma associated protein -0.0576281
ZNFX1 zinc finger, NFX1-type containing 1 -0.0572188
ZMYND8 zinc finger, MYND-type containing 8 -0.0568176
NDRG1 N-myc downstream regulated 1 -0.0541498
MBNL1 muscleblind-like splicing regulator 1 -0.053682
SRPK2 SRSF protein kinase 2 -0.0531599
RPL34 ribosomal protein L34 -0.0521943
TAF15 TAF15 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 68kDa -0.0508995
IFIT2 interferon-induced protein with tetratricopeptide repeats 2 -0.0502094
MAP2K1 mitogen-activated protein kinase kinase 1 -0.0498881
TXNIP thioredoxin interacting protein -0.0497802
CELF1 CUGBP, Elav-like family member 1 -0.0483249
ZNF638 zinc finger protein 638 -0.0476379
NF1 neurofibromin 1 -0.0456563
SMURF1 SMAD specific E3 ubiquitin protein ligase 1 -0.045347
P4HA1 prolyl 4-hydroxylase, alpha polypeptide I -0.0439836
CD44 CD44 molecule (Indian blood group) -0.0430888
SLC38A1 solute carrier family 38, member 1 -0.0427065
SLC25A36 solute carrier family 25 (pyrimidine nucleotide carrier), member 36 -0.0426266
AFAP1 actin filament associated protein 1 -0.0425438
ARHGAP21 Rho GTPase activating protein 21 -0.0424478
GRB10 growth factor receptor-bound protein 10 -0.0423434
NFAT5 nuclear factor of activated T-cells 5, tonicity-responsive -0.042308
TPI1 triosephosphate isomerase 1 -0.0413349
BAIAP2L1 BAI1-associated protein 2-like 1 -0.0412847
LIMA1 LIM domain and actin binding 1 -0.0410916
BNIP3 BCL2/adenovirus E1B 19kDa interacting protein 3 -0.0408977
MAGI2 membrane associated guanylate kinase, WW and PDZ domain containing 2 -0.040691
ITGA2 integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) -0.0406235
ZSWIM6 zinc finger, SWIM-type containing 6 -0.0404532
S100A9 S100 calcium binding protein A9 -0.040345
CYP1B1 cytochrome P450, family 1, subfamily B, polypeptide 1 -0.0402618
MDM2 MDM2 proto-oncogene, E3 ubiquitin protein ligase -0.0399266
PSD3 pleckstrin and Sec7 domain containing 3 -0.0395318
RPL23 ribosomal protein L23 -0.0391309
DDX60 DEAD (Asp-Glu-Ala-Asp) box polypeptide 60 -0.038922
FLNB filamin B, beta -0.0388788
RPLP0 ribosomal protein, large, P0 -0.0387387
ADAM17 ADAM metallopeptidase domain 17 -0.0385608
AP3B1 adaptor-related protein complex 3, beta 1 subunit -0.0383403
MLLT3 myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 3 -0.0379799
MKLN1 muskelin 1, intracellular mediator containing kelch motifs -0.0371032
BTG1 B-cell translocation gene 1, anti-proliferative -0.036957
EZR ezrin -0.0368667
TMEM165 transmembrane protein 165 -0.0367906
LAMB3 laminin, beta 3 -0.0367107
NEBL nebulette -0.0366406
SFTPA2 surfactant protein A2 -0.0366334
RPL17-C18ORF32 RPL17-C18orf32 readthrough -0.035658
GCC2 GRIP and coiled-coil domain containing 2 -0.0355973
MYO6 myosin VI -0.0347232
GNPDA1 glucosamine-6-phosphate deaminase 1 -0.0344794
USP9X ubiquitin specific peptidase 9, X-linked -0.0340352
TAF1D TATA box binding protein (TBP)-associated factor, RNA polymerase I, D, 41kDa -0.0338077
KMT2A lysine (K)-specific methyltransferase 2A -0.0331247
RNF149 ring finger protein 149 -0.0331106
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 -0.0330896
NCOA3 nuclear receptor coactivator 3 -0.0329137
IGFBP3 insulin-like growth factor binding protein 3 -0.0326681
SP100 SP100 nuclear antigen -0.0323911
FTH1 ferritin, heavy polypeptide 1 -0.0321189
NME7 NME/NM23 family member 7 -0.0321048
RPS8 ribosomal protein S8 -0.0320586
PFKFB3 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 3 -0.0318051
RPS25 ribosomal protein S25 -0.0312782
RAB7A RAB7A, member RAS oncogene family -0.0310151
ASPH aspartate beta-hydroxylase -0.0307765
CMIP c-Maf inducing protein -0.0303887
CDK13 cyclin-dependent kinase 13 -0.0303237