| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | Tolmetin perturbation in NCI-H23 cell line (Tahoe Therapeutics) |
| Similar Terms | |
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200 genes differentially expressed following the Tolmetin_NCI-H23 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| HSP90AB1 | heat shock protein 90kDa alpha (cytosolic), class B member 1 | 0.0904165 |
| MYH9 | myosin, heavy chain 9, non-muscle | 0.0794509 |
| RAD51B | RAD51 paralog B | 0.0788498 |
| PABPC1 | poly(A) binding protein, cytoplasmic 1 | 0.0766723 |
| TPM2 | tropomyosin 2 (beta) | 0.0625784 |
| RPL3 | ribosomal protein L3 | 0.0617136 |
| TPM3 | tropomyosin 3 | 0.056676 |
| RPS12 | ribosomal protein S12 | 0.0502341 |
| HSPD1 | heat shock 60kDa protein 1 (chaperonin) | 0.0498004 |
| ANKRD36 | ankyrin repeat domain 36 | 0.0474338 |
| PRELID2 | PRELI domain containing 2 | 0.0460753 |
| PNN | pinin, desmosome associated protein | 0.0440709 |
| TPI1 | triosephosphate isomerase 1 | 0.0420314 |
| HNRNPA1 | heterogeneous nuclear ribonucleoprotein A1 | 0.0402591 |
| FNDC3B | fibronectin type III domain containing 3B | 0.0366848 |
| SYNE2 | spectrin repeat containing, nuclear envelope 2 | 0.0346898 |
| ANP32E | acidic (leucine-rich) nuclear phosphoprotein 32 family, member E | 0.034688 |
| HNRNPH1 | heterogeneous nuclear ribonucleoprotein H1 (H) | 0.0332869 |
| SYNCRIP | synaptotagmin binding, cytoplasmic RNA interacting protein | 0.0332335 |
| HNRNPA2B1 | heterogeneous nuclear ribonucleoprotein A2/B1 | 0.0328804 |
| XPOT | exportin, tRNA | 0.0326268 |
| KCNMA1 | potassium channel, calcium activated large conductance subfamily M alpha, member 1 | 0.0324775 |
| ENO1 | enolase 1, (alpha) | 0.0314558 |
| PTMA | prothymosin, alpha | 0.0312403 |
| CEP250 | centrosomal protein 250kDa | 0.0304994 |
| GBE1 | glucan (1,4-alpha-), branching enzyme 1 | 0.0296163 |
| NFE2L1 | nuclear factor, erythroid 2-like 1 | 0.0293451 |
| MYL6 | myosin, light chain 6, alkali, smooth muscle and non-muscle | 0.0290021 |
| SET | SET nuclear proto-oncogene | 0.0288543 |
| HDGF | hepatoma-derived growth factor | 0.0284429 |
| NFIA | nuclear factor I/A | 0.0279479 |
| CPNE1 | copine I | 0.026979 |
| HYOU1 | hypoxia up-regulated 1 | 0.0259969 |
| RPL23 | ribosomal protein L23 | 0.0258132 |
| POLR2B | polymerase (RNA) II (DNA directed) polypeptide B, 140kDa | 0.025783 |
| PCBP2 | poly(rC) binding protein 2 | 0.0251982 |
| ARGLU1 | arginine and glutamate rich 1 | 0.0247972 |
| MSN | moesin | 0.0241842 |
| NUP58 | nucleoporin 58 | 0.0239796 |
| DNAJC5 | DnaJ (Hsp40) homolog, subfamily C, member 5 | 0.0234392 |
| STMN1 | stathmin 1 | 0.0230394 |
| NUMA1 | nuclear mitotic apparatus protein 1 | 0.0224989 |
| MDM2 | MDM2 proto-oncogene, E3 ubiquitin protein ligase | 0.0224144 |
| RPS27 | ribosomal protein S27 | 0.0224114 |
| DSPP | dentin sialophosphoprotein | 0.0221277 |
| SRRM1 | serine/arginine repetitive matrix 1 | 0.0220024 |
| TNIP1 | TNFAIP3 interacting protein 1 | 0.0218651 |
| HUWE1 | HECT, UBA and WWE domain containing 1, E3 ubiquitin protein ligase | 0.0218279 |
| MSH6 | mutS homolog 6 | 0.0216927 |
| FLNB | filamin B, beta | 0.0215587 |
| OGT | O-linked N-acetylglucosamine (GlcNAc) transferase | 0.021481 |
| TFG | TRK-fused gene | 0.0212246 |
| HNRNPU | heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) | 0.0211439 |
| HNRNPH3 | heterogeneous nuclear ribonucleoprotein H3 (2H9) | 0.0211223 |
| PARD3 | par-3 family cell polarity regulator | 0.0210477 |
| SRRM2 | serine/arginine repetitive matrix 2 | 0.0210374 |
| YWHAG | tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, gamma | 0.0208676 |
| LUZP1 | leucine zipper protein 1 | 0.0207374 |
| RPL35A | ribosomal protein L35a | 0.0202732 |
| HNRNPA3 | heterogeneous nuclear ribonucleoprotein A3 | 0.0201951 |
| YWHAE | tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon | 0.0201364 |
| RPS15A | ribosomal protein S15a | 0.0200678 |
| EEF1G | eukaryotic translation elongation factor 1 gamma | 0.0198224 |
| SPPL3 | signal peptide peptidase like 3 | 0.0198004 |
| YES1 | YES proto-oncogene 1, Src family tyrosine kinase | 0.0197729 |
| PTMS | parathymosin | 0.0196456 |
| UBR5 | ubiquitin protein ligase E3 component n-recognin 5 | 0.0195947 |
| SRSF11 | serine/arginine-rich splicing factor 11 | 0.0191555 |
| EIF1 | eukaryotic translation initiation factor 1 | 0.0188914 |
| PRPF8 | pre-mRNA processing factor 8 | 0.0187846 |
| RAD23B | RAD23 homolog B (S. cerevisiae) | 0.0187548 |
| ERH | enhancer of rudimentary homolog (Drosophila) | 0.0187458 |
| RPL21 | ribosomal protein L21 | 0.0187333 |
| CPSF6 | cleavage and polyadenylation specific factor 6, 68kDa | 0.0187015 |
| SRSF5 | serine/arginine-rich splicing factor 5 | 0.0186063 |
| NCOR2 | nuclear receptor corepressor 2 | 0.0186013 |
| PLEC | plectin | 0.0184439 |
| FMNL2 | formin-like 2 | 0.0184041 |
| CEP70 | centrosomal protein 70kDa | 0.0183468 |
| MAP1B | microtubule-associated protein 1B | 0.018054 |
| ENAH | enabled homolog (Drosophila) | 0.0179741 |
| PPP3R1 | protein phosphatase 3, regulatory subunit B, alpha | 0.0177033 |
| MKRN1 | makorin ring finger protein 1 | 0.0175052 |
| BNIP3 | BCL2/adenovirus E1B 19kDa interacting protein 3 | 0.017422 |
| RNF145 | ring finger protein 145 | 0.017313 |
| KMT2E | lysine (K)-specific methyltransferase 2E | 0.0172297 |
| EIF4B | eukaryotic translation initiation factor 4B | 0.0171812 |
| WDFY3 | WD repeat and FYVE domain containing 3 | 0.0170586 |
| FKBP4 | FK506 binding protein 4, 59kDa | 0.0170437 |
| NDUFS4 | NADH dehydrogenase (ubiquinone) Fe-S protein 4, 18kDa (NADH-coenzyme Q reductase) | 0.0169886 |
| EIF3A | eukaryotic translation initiation factor 3, subunit A | 0.0168636 |
| HPS5 | Hermansky-Pudlak syndrome 5 | 0.0168013 |
| HSPA9 | heat shock 70kDa protein 9 (mortalin) | 0.0167688 |
| CAMTA1 | calmodulin binding transcription activator 1 | 0.0166961 |
| MIER1 | mesoderm induction early response 1, transcriptional regulator | 0.0166753 |
| PRRC2C | proline-rich coiled-coil 2C | 0.0164896 |
| SESN2 | sestrin 2 | 0.0164332 |
| TSR1 | TSR1, 20S rRNA accumulation, homolog (S. cerevisiae) | 0.0163367 |
| NCAPG2 | non-SMC condensin II complex, subunit G2 | 0.0162011 |
| MAT2A | methionine adenosyltransferase II, alpha | 0.0160424 |
| Symbol | Name | Standardized Value |
|---|---|---|
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | -0.374949 |
| TFPI2 | tissue factor pathway inhibitor 2 | -0.21417 |
| AKAP12 | A kinase (PRKA) anchor protein 12 | -0.193445 |
| YBX3 | Y box binding protein 3 | -0.104377 |
| HSPA5 | heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) | -0.0873194 |
| USP34 | ubiquitin specific peptidase 34 | -0.0772064 |
| SLC2A3 | solute carrier family 2 (facilitated glucose transporter), member 3 | -0.0688772 |
| ATP11A | ATPase, class VI, type 11A | -0.0595343 |
| ACTG1 | actin gamma 1 | -0.05692 |
| NF1 | neurofibromin 1 | -0.0565687 |
| DDX5 | DEAD (Asp-Glu-Ala-Asp) box helicase 5 | -0.0560396 |
| RAB7A | RAB7A, member RAS oncogene family | -0.0542107 |
| CCND2 | cyclin D2 | -0.0540745 |
| IGF2BP3 | insulin-like growth factor 2 mRNA binding protein 3 | -0.0525119 |
| ACTR2 | ARP2 actin-related protein 2 homolog (yeast) | -0.0517015 |
| GRAMD1B | GRAM domain containing 1B | -0.0486366 |
| ASH1L | ash1 (absent, small, or homeotic)-like (Drosophila) | -0.0483414 |
| ELL2 | elongation factor, RNA polymerase II, 2 | -0.048231 |
| KPNA4 | karyopherin alpha 4 (importin alpha 3) | -0.0480471 |
| TRIP12 | thyroid hormone receptor interactor 12 | -0.0467055 |
| VIM | vimentin | -0.0460956 |
| TM4SF1 | transmembrane 4 L six family member 1 | -0.0458078 |
| EGR1 | early growth response 1 | -0.045636 |
| OSMR | oncostatin M receptor | -0.0452673 |
| KTN1 | kinectin 1 (kinesin receptor) | -0.0438052 |
| TAOK1 | TAO kinase 1 | -0.0429632 |
| TRIO | trio Rho guanine nucleotide exchange factor | -0.0429153 |
| PARP14 | poly (ADP-ribose) polymerase family, member 14 | -0.0420391 |
| HERC4 | HECT and RLD domain containing E3 ubiquitin protein ligase 4 | -0.041757 |
| CNOT4 | CCR4-NOT transcription complex, subunit 4 | -0.0409205 |
| ATF6 | activating transcription factor 6 | -0.0405238 |
| NIPBL | Nipped-B homolog (Drosophila) | -0.0398166 |
| RPL38 | ribosomal protein L38 | -0.0393355 |
| NABP1 | nucleic acid binding protein 1 | -0.0392748 |
| EIF2AK2 | eukaryotic translation initiation factor 2-alpha kinase 2 | -0.0391227 |
| UBC | ubiquitin C | -0.03878 |
| TAS2R14 | taste receptor, type 2, member 14 | -0.0387469 |
| BSG | basigin (Ok blood group) | -0.0385975 |
| PLCB4 | phospholipase C, beta 4 | -0.0382996 |
| ARIH1 | ariadne RBR E3 ubiquitin protein ligase 1 | -0.037094 |
| TAX1BP1 | Tax1 (human T-cell leukemia virus type I) binding protein 1 | -0.0368858 |
| GOLGB1 | golgin B1 | -0.0368689 |
| RBM39 | RNA binding motif protein 39 | -0.0368632 |
| ITGA2 | integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) | -0.0363767 |
| AP3B1 | adaptor-related protein complex 3, beta 1 subunit | -0.0359895 |
| ARPC2 | actin related protein 2/3 complex, subunit 2, 34kDa | -0.035735 |
| MTHFD1L | methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1-like | -0.0348659 |
| DOCK5 | dedicator of cytokinesis 5 | -0.0342652 |
| PHF20 | PHD finger protein 20 | -0.0338586 |
| CLTC | clathrin, heavy chain (Hc) | -0.0337123 |
| SENP6 | SUMO1/sentrin specific peptidase 6 | -0.0333704 |
| CCT3 | chaperonin containing TCP1, subunit 3 (gamma) | -0.0332359 |
| KDM2A | lysine (K)-specific demethylase 2A | -0.0330253 |
| PHLDB2 | pleckstrin homology-like domain, family B, member 2 | -0.0329859 |
| PPP6R3 | protein phosphatase 6, regulatory subunit 3 | -0.0325901 |
| SHANK2 | SH3 and multiple ankyrin repeat domains 2 | -0.032495 |
| POLR2A | polymerase (RNA) II (DNA directed) polypeptide A, 220kDa | -0.0323928 |
| RPS21 | ribosomal protein S21 | -0.0318632 |
| CRK | v-crk avian sarcoma virus CT10 oncogene homolog | -0.0318593 |
| WNT2B | wingless-type MMTV integration site family, member 2B | -0.0316235 |
| EXT1 | exostosin glycosyltransferase 1 | -0.0316183 |
| CDK12 | cyclin-dependent kinase 12 | -0.0313067 |
| ASAP1 | ArfGAP with SH3 domain, ankyrin repeat and PH domain 1 | -0.0308877 |
| SMURF2 | SMAD specific E3 ubiquitin protein ligase 2 | -0.03067 |
| STAU1 | staufen double-stranded RNA binding protein 1 | -0.0304758 |
| LRRC23 | leucine rich repeat containing 23 | -0.0304361 |
| ATP1B3 | ATPase, Na+/K+ transporting, beta 3 polypeptide | -0.0303545 |
| ERC1 | ELKS/RAB6-interacting/CAST family member 1 | -0.0303083 |
| CSGALNACT1 | chondroitin sulfate N-acetylgalactosaminyltransferase 1 | -0.0302852 |
| RHEB | Ras homolog enriched in brain | -0.0302747 |
| EIF4G3 | eukaryotic translation initiation factor 4 gamma, 3 | -0.030158 |
| PRKDC | protein kinase, DNA-activated, catalytic polypeptide | -0.0300614 |
| MYL12A | myosin, light chain 12A, regulatory, non-sarcomeric | -0.0299343 |
| RPS8 | ribosomal protein S8 | -0.029921 |
| AGAP1 | ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 | -0.0299187 |
| NFE2L2 | nuclear factor, erythroid 2-like 2 | -0.0297599 |
| ANXA2 | annexin A2 | -0.0296891 |
| HNRNPC | heterogeneous nuclear ribonucleoprotein C (C1/C2) | -0.029647 |
| SRP72 | signal recognition particle 72kDa | -0.0296279 |
| ATP5F1B | ATP synthase F1 subunit beta | -0.0296057 |
| BRD2 | bromodomain containing 2 | -0.0291659 |
| MYPN | myopalladin | -0.02915 |
| STC1 | stanniocalcin 1 | -0.0291385 |
| COPB2 | coatomer protein complex, subunit beta 2 (beta prime) | -0.0290936 |
| RPLP1 | ribosomal protein, large, P1 | -0.0290722 |
| MSRB3 | methionine sulfoxide reductase B3 | -0.0287884 |
| CCND1 | cyclin D1 | -0.0282169 |
| BIRC6 | baculoviral IAP repeat containing 6 | -0.0281478 |
| POTEF | POTE ankyrin domain family, member F | -0.0280703 |
| CCT4 | chaperonin containing TCP1, subunit 4 (delta) | -0.0279972 |
| UBE3C | ubiquitin protein ligase E3C | -0.0277766 |
| IGF1R | insulin-like growth factor 1 receptor | -0.0277337 |
| ARL6IP1 | ADP-ribosylation factor-like 6 interacting protein 1 | -0.0274207 |
| NPM1 | nucleophosmin (nucleolar phosphoprotein B23, numatrin) | -0.0273525 |
| HLA-B | major histocompatibility complex, class I, B | -0.0271116 |
| TEAD1 | TEA domain family member 1 (SV40 transcriptional enhancer factor) | -0.0270352 |
| ZSWIM6 | zinc finger, SWIM-type containing 6 | -0.0269696 |
| DNAJA1 | DnaJ (Hsp40) homolog, subfamily A, member 1 | -0.0266888 |
| CAVIN1 | caveolae associated protein 1 | -0.0266122 |
| VCL | vinculin | -0.0265329 |
