| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | Tolmetin perturbation in NCI-H2347 cell line (Tahoe Therapeutics) |
| Similar Terms | |
| Downloads & Tools |
200 genes differentially expressed following the Tolmetin_NCI-H2347 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| MYH9 | myosin, heavy chain 9, non-muscle | 0.252775 |
| HSP90AB1 | heat shock protein 90kDa alpha (cytosolic), class B member 1 | 0.218648 |
| HSP90B1 | heat shock protein 90kDa beta (Grp94), member 1 | 0.199119 |
| PABPC1 | poly(A) binding protein, cytoplasmic 1 | 0.155647 |
| MSN | moesin | 0.114568 |
| TMSB4X | thymosin beta 4, X-linked | 0.104347 |
| PTMA | prothymosin, alpha | 0.0952598 |
| DSPP | dentin sialophosphoprotein | 0.0949834 |
| LAMC2 | laminin, gamma 2 | 0.0864896 |
| HNRNPA1 | heterogeneous nuclear ribonucleoprotein A1 | 0.0852924 |
| CTNNB1 | catenin (cadherin-associated protein), beta 1, 88kDa | 0.0836191 |
| PPP1R15A | protein phosphatase 1, regulatory subunit 15A | 0.0816367 |
| YWHAZ | tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta | 0.0799533 |
| NPM1 | nucleophosmin (nucleolar phosphoprotein B23, numatrin) | 0.0773762 |
| ASPH | aspartate beta-hydroxylase | 0.0742081 |
| HNRNPA2B1 | heterogeneous nuclear ribonucleoprotein A2/B1 | 0.0717043 |
| PGK1 | phosphoglycerate kinase 1 | 0.0685202 |
| RPL3 | ribosomal protein L3 | 0.0680604 |
| HMGB2 | high mobility group box 2 | 0.0653503 |
| EIF1 | eukaryotic translation initiation factor 1 | 0.0632104 |
| HSPA8 | heat shock 70kDa protein 8 | 0.0627889 |
| TPM3 | tropomyosin 3 | 0.0608523 |
| HSP90AA1 | heat shock protein 90kDa alpha (cytosolic), class A member 1 | 0.0608186 |
| CALR | calreticulin | 0.0606992 |
| PLEC | plectin | 0.0589485 |
| RPS3 | ribosomal protein S3 | 0.0566271 |
| ERO1A | endoplasmic reticulum oxidoreductase 1 alpha | 0.0560183 |
| TPI1 | triosephosphate isomerase 1 | 0.0552228 |
| RNF145 | ring finger protein 145 | 0.0551096 |
| MYL6 | myosin, light chain 6, alkali, smooth muscle and non-muscle | 0.0549401 |
| FXR1 | fragile X mental retardation, autosomal homolog 1 | 0.0536216 |
| RPS2 | ribosomal protein S2 | 0.052511 |
| MAP4K5 | mitogen-activated protein kinase kinase kinase kinase 5 | 0.0521804 |
| CALM2 | calmodulin 2 (phosphorylase kinase, delta) | 0.0511681 |
| TSC22D2 | TSC22 domain family, member 2 | 0.0505627 |
| BNIP3L | BCL2/adenovirus E1B 19kDa interacting protein 3-like | 0.050063 |
| PDIA6 | protein disulfide isomerase family A, member 6 | 0.0500033 |
| HNRNPH1 | heterogeneous nuclear ribonucleoprotein H1 (H) | 0.0496215 |
| TACSTD2 | tumor-associated calcium signal transducer 2 | 0.049555 |
| EEF2 | eukaryotic translation elongation factor 2 | 0.0476167 |
| NUP58 | nucleoporin 58 | 0.0473284 |
| TOP2A | topoisomerase (DNA) II alpha 170kDa | 0.0463056 |
| BHLHE40 | basic helix-loop-helix family, member e40 | 0.0462824 |
| HNRNPU | heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) | 0.0448532 |
| RAD23B | RAD23 homolog B (S. cerevisiae) | 0.0440723 |
| RPS12 | ribosomal protein S12 | 0.0439008 |
| EEF1G | eukaryotic translation elongation factor 1 gamma | 0.0435916 |
| PCBP2 | poly(rC) binding protein 2 | 0.0428969 |
| MIER1 | mesoderm induction early response 1, transcriptional regulator | 0.0428721 |
| APLP2 | amyloid beta (A4) precursor-like protein 2 | 0.0427424 |
| DYRK1A | dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1A | 0.0424432 |
| ENO1 | enolase 1, (alpha) | 0.0423779 |
| RPL23 | ribosomal protein L23 | 0.0421023 |
| TNIP1 | TNFAIP3 interacting protein 1 | 0.0420143 |
| ELF3 | E74-like factor 3 (ets domain transcription factor, epithelial-specific ) | 0.0416485 |
| ITGB1 | integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) | 0.0410153 |
| SPTBN1 | spectrin, beta, non-erythrocytic 1 | 0.0407054 |
| RBPJ | recombination signal binding protein for immunoglobulin kappa J region | 0.040493 |
| HNRNPDL | heterogeneous nuclear ribonucleoprotein D-like | 0.0403787 |
| PKM | pyruvate kinase, muscle | 0.0390589 |
| HDGF | hepatoma-derived growth factor | 0.0386112 |
| G0S2 | G0/G1 switch 2 | 0.0381862 |
| EEF1A1 | eukaryotic translation elongation factor 1 alpha 1 | 0.038121 |
| CCNL1 | cyclin L1 | 0.037307 |
| SET | SET nuclear proto-oncogene | 0.0372683 |
| HSPD1 | heat shock 60kDa protein 1 (chaperonin) | 0.0369574 |
| LAMB3 | laminin, beta 3 | 0.0366913 |
| NAMPT | nicotinamide phosphoribosyltransferase | 0.0362306 |
| KDM3A | lysine (K)-specific demethylase 3A | 0.0357077 |
| APP | amyloid beta (A4) precursor protein | 0.0354248 |
| UBA6 | ubiquitin-like modifier activating enzyme 6 | 0.0353398 |
| GPX4 | glutathione peroxidase 4 | 0.0348684 |
| FAM13A | family with sequence similarity 13, member A | 0.0345737 |
| USP3 | ubiquitin specific peptidase 3 | 0.03454 |
| NCKAP1 | NCK-associated protein 1 | 0.0340464 |
| RPSA | ribosomal protein SA | 0.0336116 |
| DNAJC5 | DnaJ (Hsp40) homolog, subfamily C, member 5 | 0.0328302 |
| ADAM9 | ADAM metallopeptidase domain 9 | 0.0322725 |
| SRRM2 | serine/arginine repetitive matrix 2 | 0.0321552 |
| GRB10 | growth factor receptor-bound protein 10 | 0.0317057 |
| YWHAE | tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon | 0.031383 |
| EIF4G2 | eukaryotic translation initiation factor 4 gamma, 2 | 0.0309524 |
| PAPOLA | poly(A) polymerase alpha | 0.0309426 |
| RPS6 | ribosomal protein S6 | 0.0307766 |
| KRT18 | keratin 18, type I | 0.0304536 |
| EZR | ezrin | 0.030439 |
| RIOK3 | RIO kinase 3 | 0.0304041 |
| TFG | TRK-fused gene | 0.0303892 |
| RSRC2 | arginine/serine-rich coiled-coil 2 | 0.0301596 |
| H1-4 | H1.4 linker histone, cluster member | 0.0301272 |
| HUWE1 | HECT, UBA and WWE domain containing 1, E3 ubiquitin protein ligase | 0.0297715 |
| CCNG2 | cyclin G2 | 0.0295643 |
| B2M | beta-2-microglobulin | 0.028931 |
| IRF6 | interferon regulatory factor 6 | 0.0287543 |
| ATP13A3 | ATPase type 13A3 | 0.0285538 |
| PNN | pinin, desmosome associated protein | 0.0284989 |
| FNDC3B | fibronectin type III domain containing 3B | 0.0281131 |
| GARS1 | glycyl-tRNA synthetase 1 | 0.0278626 |
| RPL12 | ribosomal protein L12 | 0.0274049 |
| ANXA1 | annexin A1 | 0.0272119 |
| Symbol | Name | Standardized Value |
|---|---|---|
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | -0.210924 |
| ITGA2 | integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) | -0.109621 |
| EFNA5 | ephrin-A5 | -0.0939767 |
| SAMD4A | sterile alpha motif domain containing 4A | -0.086922 |
| EXT1 | exostosin glycosyltransferase 1 | -0.0738622 |
| ACTG1 | actin gamma 1 | -0.0690262 |
| ZSWIM6 | zinc finger, SWIM-type containing 6 | -0.067659 |
| LMO7 | LIM domain 7 | -0.0659215 |
| NDRG1 | N-myc downstream regulated 1 | -0.0621129 |
| HSPA5 | heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) | -0.059141 |
| LIMCH1 | LIM and calponin homology domains 1 | -0.0589641 |
| FN1 | fibronectin 1 | -0.0585692 |
| RAB7A | RAB7A, member RAS oncogene family | -0.0580449 |
| TPT1 | tumor protein, translationally-controlled 1 | -0.0517777 |
| TM4SF1 | transmembrane 4 L six family member 1 | -0.051492 |
| GBE1 | glucan (1,4-alpha-), branching enzyme 1 | -0.0501411 |
| TMEM165 | transmembrane protein 165 | -0.047649 |
| FBXO34 | F-box protein 34 | -0.0459151 |
| SEC31A | SEC31 homolog A (S. cerevisiae) | -0.0445561 |
| AP3B1 | adaptor-related protein complex 3, beta 1 subunit | -0.0437492 |
| CD55 | CD55 molecule, decay accelerating factor for complement (Cromer blood group) | -0.0417839 |
| FNIP1 | folliculin interacting protein 1 | -0.0411682 |
| PLSCR1 | phospholipid scramblase 1 | -0.0391751 |
| CEP350 | centrosomal protein 350kDa | -0.0391136 |
| ERBIN | erbb2 interacting protein | -0.0390769 |
| ANXA2 | annexin A2 | -0.038382 |
| MYO1E | myosin IE | -0.0381169 |
| PALLD | palladin, cytoskeletal associated protein | -0.0379752 |
| ARIH1 | ariadne RBR E3 ubiquitin protein ligase 1 | -0.0375278 |
| RRBP1 | ribosome binding protein 1 | -0.0371921 |
| PARP14 | poly (ADP-ribose) polymerase family, member 14 | -0.0359143 |
| CDCP1 | CUB domain containing protein 1 | -0.035611 |
| ZBTB20 | zinc finger and BTB domain containing 20 | -0.0355475 |
| OSMR | oncostatin M receptor | -0.0347176 |
| GOLGA4 | golgin A4 | -0.034667 |
| RALGPS2 | Ral GEF with PH domain and SH3 binding motif 2 | -0.0341889 |
| ATXN1 | ataxin 1 | -0.0338467 |
| FBXO32 | F-box protein 32 | -0.0337759 |
| ARID4B | AT rich interactive domain 4B (RBP1-like) | -0.0334828 |
| LPP | LIM domain containing preferred translocation partner in lipoma | -0.0331114 |
| SMURF1 | SMAD specific E3 ubiquitin protein ligase 1 | -0.0328206 |
| ZC3HAV1 | zinc finger CCCH-type, antiviral 1 | -0.0326673 |
| PATJ | PATJ crumbs cell polarity complex component | -0.0325632 |
| RAB11FIP1 | RAB11 family interacting protein 1 (class I) | -0.0314785 |
| RPL35A | ribosomal protein L35a | -0.0306562 |
| KMT2C | lysine (K)-specific methyltransferase 2C | -0.030383 |
| RNF19A | ring finger protein 19A, RBR E3 ubiquitin protein ligase | -0.0299675 |
| VCL | vinculin | -0.0298922 |
| UBE2H | ubiquitin-conjugating enzyme E2H | -0.0297692 |
| BLZF1 | basic leucine zipper nuclear factor 1 | -0.029455 |
| ATP11A | ATPase, class VI, type 11A | -0.0293984 |
| RPS24 | ribosomal protein S24 | -0.0293205 |
| CCND1 | cyclin D1 | -0.0290799 |
| MAP3K9 | mitogen-activated protein kinase kinase kinase 9 | -0.0290352 |
| PTBP3 | polypyrimidine tract binding protein 3 | -0.0287052 |
| BASP1 | brain abundant, membrane attached signal protein 1 | -0.028531 |
| RAB1A | RAB1A, member RAS oncogene family | -0.0285223 |
| ABL2 | ABL proto-oncogene 2, non-receptor tyrosine kinase | -0.028345 |
| FGD4 | FYVE, RhoGEF and PH domain containing 4 | -0.0282 |
| PDLIM5 | PDZ and LIM domain 5 | -0.0281886 |
| CASK | calcium/calmodulin-dependent serine protein kinase (MAGUK family) | -0.0280364 |
| CTNND1 | catenin (cadherin-associated protein), delta 1 | -0.0277079 |
| SMURF2 | SMAD specific E3 ubiquitin protein ligase 2 | -0.0276118 |
| AFF1 | AF4/FMR2 family, member 1 | -0.0272568 |
| IGFBP3 | insulin-like growth factor binding protein 3 | -0.0272435 |
| CENPE | centromere protein E, 312kDa | -0.0272234 |
| ALCAM | activated leukocyte cell adhesion molecule | -0.0271693 |
| OGA | O-GlcNAcase | -0.027145 |
| NUMB | numb homolog (Drosophila) | -0.0269727 |
| MAP4 | microtubule-associated protein 4 | -0.0268968 |
| SEMA3A | sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3A | -0.0268597 |
| ARHGAP5 | Rho GTPase activating protein 5 | -0.0268283 |
| FBXL2 | F-box and leucine-rich repeat protein 2 | -0.0267398 |
| SCFD1 | sec1 family domain containing 1 | -0.0265896 |
| UBAP1 | ubiquitin associated protein 1 | -0.0265668 |
| TRIO | trio Rho guanine nucleotide exchange factor | -0.026477 |
| TMEM263 | transmembrane protein 263 | -0.026234 |
| ELL2 | elongation factor, RNA polymerase II, 2 | -0.0259521 |
| CAB39 | calcium binding protein 39 | -0.025876 |
| LOXL2 | lysyl oxidase-like 2 | -0.0258642 |
| TPM4 | tropomyosin 4 | -0.0250095 |
| PPP2R3A | protein phosphatase 2, regulatory subunit B'', alpha | -0.0246875 |
| NEDD4L | neural precursor cell expressed, developmentally down-regulated 4-like, E3 ubiquitin protein ligase | -0.0246475 |
| SEC22A | SEC22 vesicle trafficking protein homolog A (S. cerevisiae) | -0.0246474 |
| JARID2 | jumonji, AT rich interactive domain 2 | -0.0243614 |
| MCTP2 | multiple C2 domains, transmembrane 2 | -0.0243214 |
| AFF4 | AF4/FMR2 family, member 4 | -0.0238083 |
| ANTXR2 | anthrax toxin receptor 2 | -0.0237345 |
| KDM2A | lysine (K)-specific demethylase 2A | -0.0236023 |
| RPL30 | ribosomal protein L30 | -0.0235575 |
| EGR1 | early growth response 1 | -0.0234781 |
| NF1 | neurofibromin 1 | -0.0232611 |
| GOLGB1 | golgin B1 | -0.0231422 |
| RASAL2 | RAS protein activator like 2 | -0.0231113 |
| CTSD | cathepsin D | -0.0229406 |
| TANC2 | tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 2 | -0.0228187 |
| HLA-E | major histocompatibility complex, class I, E | -0.0227922 |
| HLA-B | major histocompatibility complex, class I, B | -0.0227529 |
| RPL38 | ribosomal protein L38 | -0.0223124 |
| DLG1 | discs, large homolog 1 (Drosophila) | -0.0222458 |
