| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | Tolmetin perturbation in NCI-H460 cell line (Tahoe Therapeutics) |
| Similar Terms | |
| Downloads & Tools |
200 genes differentially expressed following the Tolmetin_NCI-H460 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| ASPH | aspartate beta-hydroxylase | 0.193365 |
| CDH11 | cadherin 11, type 2, OB-cadherin (osteoblast) | 0.176661 |
| HSP90B1 | heat shock protein 90kDa beta (Grp94), member 1 | 0.165405 |
| DST | dystonin | 0.135619 |
| TRIO | trio Rho guanine nucleotide exchange factor | 0.117093 |
| HSPA5 | heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) | 0.114263 |
| SPTBN1 | spectrin, beta, non-erythrocytic 1 | 0.111151 |
| DYNC1H1 | dynein, cytoplasmic 1, heavy chain 1 | 0.109412 |
| EFNA5 | ephrin-A5 | 0.0981043 |
| HSP90AB1 | heat shock protein 90kDa alpha (cytosolic), class B member 1 | 0.0914006 |
| PSD3 | pleckstrin and Sec7 domain containing 3 | 0.0902428 |
| HNRNPA2B1 | heterogeneous nuclear ribonucleoprotein A2/B1 | 0.0846097 |
| MCL1 | myeloid cell leukemia 1 | 0.0811001 |
| EPB41L3 | erythrocyte membrane protein band 4.1-like 3 | 0.0799928 |
| RPL3 | ribosomal protein L3 | 0.0799256 |
| GRAMD1B | GRAM domain containing 1B | 0.0737441 |
| ITPRID2 | ITPR interacting domain containing 2 | 0.0729656 |
| MYH9 | myosin, heavy chain 9, non-muscle | 0.0710186 |
| PDE10A | phosphodiesterase 10A | 0.0699001 |
| PGK1 | phosphoglycerate kinase 1 | 0.0695638 |
| GBE1 | glucan (1,4-alpha-), branching enzyme 1 | 0.068813 |
| HSPD1 | heat shock 60kDa protein 1 (chaperonin) | 0.0670867 |
| LIMCH1 | LIM and calponin homology domains 1 | 0.0633481 |
| MYOF | myoferlin | 0.0630011 |
| FNDC3B | fibronectin type III domain containing 3B | 0.062493 |
| NAMPT | nicotinamide phosphoribosyltransferase | 0.0615111 |
| SAMD4A | sterile alpha motif domain containing 4A | 0.0606805 |
| MSN | moesin | 0.0603806 |
| CRIM1 | cysteine rich transmembrane BMP regulator 1 (chordin-like) | 0.0603223 |
| HSPA8 | heat shock 70kDa protein 8 | 0.0591643 |
| PM20D1 | peptidase M20 domain containing 1 | 0.0589233 |
| NPM1 | nucleophosmin (nucleolar phosphoprotein B23, numatrin) | 0.0586953 |
| HNRNPA1 | heterogeneous nuclear ribonucleoprotein A1 | 0.0576431 |
| DCBLD2 | discoidin, CUB and LCCL domain containing 2 | 0.0555808 |
| ATP2B1 | ATPase, Ca++ transporting, plasma membrane 1 | 0.054812 |
| DOCK4 | dedicator of cytokinesis 4 | 0.0545982 |
| CANX | calnexin | 0.0521936 |
| PABPC1 | poly(A) binding protein, cytoplasmic 1 | 0.0513738 |
| HNRNPU | heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) | 0.0513218 |
| EEF1A1 | eukaryotic translation elongation factor 1 alpha 1 | 0.0507065 |
| EIF1 | eukaryotic translation initiation factor 1 | 0.0499885 |
| SPTAN1 | spectrin, alpha, non-erythrocytic 1 | 0.0497051 |
| CXCL8 | chemokine (C-X-C motif) ligand 8 | 0.0495695 |
| PYGL | phosphorylase, glycogen, liver | 0.0495675 |
| FLNB | filamin B, beta | 0.047921 |
| ERRFI1 | ERBB receptor feedback inhibitor 1 | 0.047481 |
| TGFBR1 | transforming growth factor, beta receptor 1 | 0.0460504 |
| BZW1 | basic leucine zipper and W2 domains 1 | 0.0459131 |
| HYOU1 | hypoxia up-regulated 1 | 0.0446601 |
| TPM3 | tropomyosin 3 | 0.0445605 |
| KYNU | kynureninase | 0.0445168 |
| PJA2 | praja ring finger 2, E3 ubiquitin protein ligase | 0.0436907 |
| USP9X | ubiquitin specific peptidase 9, X-linked | 0.043391 |
| AGAP1 | ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 | 0.043307 |
| LAMC1 | laminin, gamma 1 (formerly LAMB2) | 0.0429244 |
| COL8A1 | collagen, type VIII, alpha 1 | 0.0428417 |
| SRRM2 | serine/arginine repetitive matrix 2 | 0.0425392 |
| CALR | calreticulin | 0.0419638 |
| SLC38A2 | solute carrier family 38, member 2 | 0.0415358 |
| TNIP1 | TNFAIP3 interacting protein 1 | 0.0409543 |
| AHNAK | AHNAK nucleoprotein | 0.0407457 |
| APP | amyloid beta (A4) precursor protein | 0.0406294 |
| MDM2 | MDM2 proto-oncogene, E3 ubiquitin protein ligase | 0.0404465 |
| HNRNPH1 | heterogeneous nuclear ribonucleoprotein H1 (H) | 0.0397616 |
| PDIA6 | protein disulfide isomerase family A, member 6 | 0.0394636 |
| PCBP3 | poly(rC) binding protein 3 | 0.0390569 |
| TMSB4X | thymosin beta 4, X-linked | 0.0388575 |
| ANXA1 | annexin A1 | 0.0388119 |
| ENO1 | enolase 1, (alpha) | 0.0387317 |
| CTSC | cathepsin C | 0.0378676 |
| HDLBP | high density lipoprotein binding protein | 0.0378415 |
| RPS2 | ribosomal protein S2 | 0.0378195 |
| SPOCK1 | sparc/osteonectin, cwcv and kazal-like domains proteoglycan (testican) 1 | 0.0378012 |
| PDIA4 | protein disulfide isomerase family A, member 4 | 0.0374094 |
| PPFIA4 | protein tyrosine phosphatase, receptor type, f polypeptide (PTPRF), interacting protein (liprin), alpha 4 | 0.037316 |
| RPL4 | ribosomal protein L4 | 0.0371277 |
| EEF2 | eukaryotic translation elongation factor 2 | 0.0368441 |
| ITGB1 | integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) | 0.0367824 |
| NFE2L1 | nuclear factor, erythroid 2-like 1 | 0.0366419 |
| CUL4B | cullin 4B | 0.036258 |
| COL5A2 | collagen, type V, alpha 2 | 0.0361406 |
| YWHAZ | tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta | 0.035988 |
| RGS2 | regulator of G-protein signaling 2 | 0.0357726 |
| APLP2 | amyloid beta (A4) precursor-like protein 2 | 0.0355949 |
| H1-4 | H1.4 linker histone, cluster member | 0.0355624 |
| DNAJC5 | DnaJ (Hsp40) homolog, subfamily C, member 5 | 0.0349849 |
| NRCAM | neuronal cell adhesion molecule | 0.0345252 |
| NONO | non-POU domain containing, octamer-binding | 0.0339813 |
| KDM3A | lysine (K)-specific demethylase 3A | 0.0337289 |
| PRELID2 | PRELI domain containing 2 | 0.0334797 |
| HUWE1 | HECT, UBA and WWE domain containing 1, E3 ubiquitin protein ligase | 0.0333837 |
| RPH3AL | rabphilin 3A-like (without C2 domains) | 0.0332885 |
| PRKAR1A | protein kinase, cAMP-dependent, regulatory, type I, alpha | 0.0332024 |
| EZR | ezrin | 0.0331805 |
| EIF4A1 | eukaryotic translation initiation factor 4A1 | 0.0331005 |
| ANKRD11 | ankyrin repeat domain 11 | 0.0329927 |
| SERPINE2 | serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2 | 0.0322833 |
| NCOR2 | nuclear receptor corepressor 2 | 0.0321651 |
| OGA | O-GlcNAcase | 0.0320457 |
| SOD2 | superoxide dismutase 2, mitochondrial | 0.031956 |
| Symbol | Name | Standardized Value |
|---|---|---|
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | -0.173728 |
| CYP1B1 | cytochrome P450, family 1, subfamily B, polypeptide 1 | -0.110149 |
| VIM | vimentin | -0.0949845 |
| RPLP1 | ribosomal protein, large, P1 | -0.0716901 |
| CD55 | CD55 molecule, decay accelerating factor for complement (Cromer blood group) | -0.0702665 |
| FTL | ferritin, light polypeptide | -0.0626362 |
| FTH1 | ferritin, heavy polypeptide 1 | -0.0589036 |
| TMSB10 | thymosin beta 10 | -0.049169 |
| PLCB1 | phospholipase C, beta 1 (phosphoinositide-specific) | -0.0444038 |
| TFPI2 | tissue factor pathway inhibitor 2 | -0.0440184 |
| RPL35A | ribosomal protein L35a | -0.0423368 |
| SEMA3A | sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3A | -0.0413251 |
| DPP10 | dipeptidyl-peptidase 10 (non-functional) | -0.0386679 |
| RPL9 | ribosomal protein L9 | -0.0375694 |
| ZC3HAV1 | zinc finger CCCH-type, antiviral 1 | -0.0372339 |
| RPS6 | ribosomal protein S6 | -0.0367354 |
| TPT1 | tumor protein, translationally-controlled 1 | -0.0361012 |
| ATP5F1B | ATP synthase F1 subunit beta | -0.0360682 |
| WARS1 | tryptophanyl-tRNA synthetase 1 | -0.0345788 |
| RPS24 | ribosomal protein S24 | -0.0344575 |
| RPL31 | ribosomal protein L31 | -0.0338565 |
| COL4A5 | collagen, type IV, alpha 5 | -0.032432 |
| PTPN12 | protein tyrosine phosphatase, non-receptor type 12 | -0.0318257 |
| S100A6 | S100 calcium binding protein A6 | -0.0316494 |
| SOX4 | SRY (sex determining region Y)-box 4 | -0.0312825 |
| POTEF | POTE ankyrin domain family, member F | -0.0298466 |
| HLA-B | major histocompatibility complex, class I, B | -0.0292826 |
| TM4SF1 | transmembrane 4 L six family member 1 | -0.0289486 |
| RPLP2 | ribosomal protein, large, P2 | -0.0280958 |
| RPL36A | ribosomal protein L36a | -0.0276856 |
| NT5C2 | 5'-nucleotidase, cytosolic II | -0.0271467 |
| HSP90AA1 | heat shock protein 90kDa alpha (cytosolic), class A member 1 | -0.0258961 |
| BTG1 | B-cell translocation gene 1, anti-proliferative | -0.0257297 |
| RPS29 | ribosomal protein S29 | -0.0252264 |
| S100A10 | S100 calcium binding protein A10 | -0.0251805 |
| BCAS3 | breast carcinoma amplified sequence 3 | -0.025031 |
| OSMR | oncostatin M receptor | -0.0248748 |
| TIMP1 | TIMP metallopeptidase inhibitor 1 | -0.0247185 |
| MFSD12 | major facilitator superfamily domain containing 12 | -0.0246179 |
| LAMA5 | laminin, alpha 5 | -0.0245927 |
| RPS23 | ribosomal protein S23 | -0.0242628 |
| RPL37A | ribosomal protein L37a | -0.0241978 |
| RPS13 | ribosomal protein S13 | -0.0236665 |
| PITPNC1 | phosphatidylinositol transfer protein, cytoplasmic 1 | -0.0236287 |
| VDAC1 | voltage-dependent anion channel 1 | -0.0235207 |
| RPL28 | ribosomal protein L28 | -0.0233659 |
| EGR1 | early growth response 1 | -0.0230687 |
| RPL39 | ribosomal protein L39 | -0.0230514 |
| TNFAIP3 | tumor necrosis factor, alpha-induced protein 3 | -0.0229838 |
| RPLP0 | ribosomal protein, large, P0 | -0.0223906 |
| BSG | basigin (Ok blood group) | -0.0222812 |
| RBMS3 | RNA binding motif, single stranded interacting protein 3 | -0.0220763 |
| NALF1 | NALCN channel auxiliary factor 1 | -0.0218594 |
| GNGT1 | guanine nucleotide binding protein (G protein), gamma transducing activity polypeptide 1 | -0.0215923 |
| RPS28 | ribosomal protein S28 | -0.0215054 |
| RPS14 | ribosomal protein S14 | -0.0214203 |
| RPL38 | ribosomal protein L38 | -0.0210567 |
| PFN1 | profilin 1 | -0.0208244 |
| AKR1C1 | aldo-keto reductase family 1, member C1 | -0.0208045 |
| LSAMP | limbic system-associated membrane protein | -0.0203254 |
| PDLIM5 | PDZ and LIM domain 5 | -0.0202306 |
| TBCA | tubulin folding cofactor A | -0.0197534 |
| RPS16 | ribosomal protein S16 | -0.0195893 |
| RPL36 | ribosomal protein L36 | -0.0195155 |
| SLC7A2 | solute carrier family 7 (cationic amino acid transporter, y+ system), member 2 | -0.0193722 |
| IFIH1 | interferon induced with helicase C domain 1 | -0.0192873 |
| P3H2 | prolyl 3-hydroxylase 2 | -0.0190498 |
| HLA-A | major histocompatibility complex, class I, A | -0.0190255 |
| NDRG1 | N-myc downstream regulated 1 | -0.0188585 |
| RPL26 | ribosomal protein L26 | -0.0185936 |
| ERC2 | ELKS/RAB6-interacting/CAST family member 2 | -0.0185637 |
| TMEM165 | transmembrane protein 165 | -0.0183829 |
| HMGA1 | high mobility group AT-hook 1 | -0.0182522 |
| FNDC3A | fibronectin type III domain containing 3A | -0.0181465 |
| RPL12 | ribosomal protein L12 | -0.0181249 |
| RPS21 | ribosomal protein S21 | -0.0181081 |
| RPS25 | ribosomal protein S25 | -0.018047 |
| RPL30 | ribosomal protein L30 | -0.0179167 |
| IER3 | immediate early response 3 | -0.0177978 |
| ABLIM1 | actin binding LIM protein 1 | -0.0177145 |
| RPS27 | ribosomal protein S27 | -0.0175034 |
| DDX60 | DEAD (Asp-Glu-Ala-Asp) box polypeptide 60 | -0.017385 |
| UBE2R2 | ubiquitin-conjugating enzyme E2R 2 | -0.0172121 |
| ATRX | alpha thalassemia/mental retardation syndrome X-linked | -0.0172019 |
| TUBA1B | tubulin, alpha 1b | -0.017082 |
| SLC25A6 | solute carrier family 25 (mitochondrial carrier; adenine nucleotide translocator), member 6 | -0.0166692 |
| MAP3K2 | mitogen-activated protein kinase kinase kinase 2 | -0.0160267 |
| PCDH15 | protocadherin-related 15 | -0.0158898 |
| CLMP | CXADR-like membrane protein | -0.0157419 |
| RPS19 | ribosomal protein S19 | -0.0157393 |
| ISG15 | ISG15 ubiquitin-like modifier | -0.0155918 |
| TGFBI | transforming growth factor, beta-induced, 68kDa | -0.0154504 |
| PERP | PERP, TP53 apoptosis effector | -0.0154001 |
| IMMP2L | IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) | -0.0152454 |
| S100A11 | S100 calcium binding protein A11 | -0.0151175 |
| ULK1 | unc-51 like autophagy activating kinase 1 | -0.0150817 |
| DGKD | diacylglycerol kinase, delta 130kDa | -0.0150592 |
| RANBP17 | RAN binding protein 17 | -0.0149664 |
| DHRSX | dehydrogenase/reductase (SDR family) X-linked | -0.0148975 |
| RPL34 | ribosomal protein L34 | -0.0148535 |
