Tolmetin_NCI-H596 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Tolmetin perturbation in NCI-H596 cell line (Tahoe Therapeutics)
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Genes

73 genes differentially expressed following the Tolmetin_NCI-H596 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
AKAP12 A kinase (PRKA) anchor protein 12 0.499993
MYH9 myosin, heavy chain 9, non-muscle 0.172311
TOP1 topoisomerase (DNA) I 0.15698
PTPRN2 protein tyrosine phosphatase, receptor type, N polypeptide 2 0.14339
RPS6 ribosomal protein S6 0.141015
ANXA1 annexin A1 0.140673
DNAJC5 DnaJ (Hsp40) homolog, subfamily C, member 5 0.130885
PABPC1 poly(A) binding protein, cytoplasmic 1 0.129652
HILPDA hypoxia inducible lipid droplet-associated 0.112377
PGK1 phosphoglycerate kinase 1 0.103455
ENO1 enolase 1, (alpha) 0.102387
PDE4D phosphodiesterase 4D, cAMP-specific 0.0971735
NAP1L1 nucleosome assembly protein 1-like 1 0.0905728
FLNB filamin B, beta 0.0844367
NKD1 naked cuticle homolog 1 (Drosophila) 0.0824371
DDX1 DEAD (Asp-Glu-Ala-Asp) box helicase 1 0.0791811
STC1 stanniocalcin 1 0.0726576
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 0.0628101
JMJD1C jumonji domain containing 1C 0.0575796
TMSB10 thymosin beta 10 0.0530946
EGFR epidermal growth factor receptor 0.0520301
TBC1D22A TBC1 domain family, member 22A 0.049321
MAP1B microtubule-associated protein 1B 0.0481771
LMBR1 limb development membrane protein 1 0.0477079
NFAT5 nuclear factor of activated T-cells 5, tonicity-responsive 0.0381551
ASPH aspartate beta-hydroxylase 0.035015
ZNF608 zinc finger protein 608 0.0244021
BIRC6 baculoviral IAP repeat containing 6 0.0199219
CDH13 cadherin 13 0.0195068
RPL37A ribosomal protein L37a 0.0142197
RPS3 ribosomal protein S3 0.0108816
NDRG1 N-myc downstream regulated 1 0.00819354
LDHA lactate dehydrogenase A 0.00554356
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) 0.00412451

decreased expression

Symbol Name Standardized Value
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.191954
NAMPT nicotinamide phosphoribosyltransferase -0.160095
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 -0.153005
GBE1 glucan (1,4-alpha-), branching enzyme 1 -0.148316
CXCL8 chemokine (C-X-C motif) ligand 8 -0.125421
NALF1 NALCN channel auxiliary factor 1 -0.120113
VIM vimentin -0.117954
RORA RAR-related orphan receptor A -0.109512
HMGA2 high mobility group AT-hook 2 -0.10042
RAP1B RAP1B, member of RAS oncogene family -0.0946057
PTMA prothymosin, alpha -0.0928709
MT2A metallothionein 2A -0.0927563
IGFBP3 insulin-like growth factor binding protein 3 -0.0899044
FNDC3B fibronectin type III domain containing 3B -0.088104
TRIO trio Rho guanine nucleotide exchange factor -0.0818243
EXT1 exostosin glycosyltransferase 1 -0.0792274
TPT1 tumor protein, translationally-controlled 1 -0.0743646
MED13L mediator complex subunit 13-like -0.0695137
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 -0.0694403
RABGEF1 RAB guanine nucleotide exchange factor (GEF) 1 -0.0692884
MYCBP2 MYC binding protein 2, E3 ubiquitin protein ligase -0.0636346
PSD3 pleckstrin and Sec7 domain containing 3 -0.058046
FN1 fibronectin 1 -0.0503975
PEG10 paternally expressed 10 -0.0457413
PRRC2C proline-rich coiled-coil 2C -0.043485
CADM2 cell adhesion molecule 2 -0.042265
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.0410646
RPS8 ribosomal protein S8 -0.0392713
RPS12 ribosomal protein S12 -0.0379656
PDE10A phosphodiesterase 10A -0.0299945
ANKRD11 ankyrin repeat domain 11 -0.0285996
PTK2 protein tyrosine kinase 2 -0.0275123
ERO1A endoplasmic reticulum oxidoreductase 1 alpha -0.0231565
SGIP1 SH3-domain GRB2-like (endophilin) interacting protein 1 -0.0187891
GOLGB1 golgin B1 -0.0129141
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 -0.0127261
EIF1 eukaryotic translation initiation factor 1 -0.011079
RPL23 ribosomal protein L23 -8.71732E-4
EFNA5 ephrin-A5 -2.76183E-4