| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | Tolmetin perturbation in NCI-H661 cell line (Tahoe Therapeutics) |
| Similar Terms | |
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200 genes differentially expressed following the Tolmetin_NCI-H661 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| HSPD1 | heat shock 60kDa protein 1 (chaperonin) | 0.124375 |
| RPS2 | ribosomal protein S2 | 0.082016 |
| MYH9 | myosin, heavy chain 9, non-muscle | 0.0764537 |
| PABPC1 | poly(A) binding protein, cytoplasmic 1 | 0.0598267 |
| RPS6 | ribosomal protein S6 | 0.0580514 |
| HSP90AB1 | heat shock protein 90kDa alpha (cytosolic), class B member 1 | 0.05786 |
| RPS12 | ribosomal protein S12 | 0.0558305 |
| EIF1 | eukaryotic translation initiation factor 1 | 0.0515255 |
| HNRNPA2B1 | heterogeneous nuclear ribonucleoprotein A2/B1 | 0.0506024 |
| RPL3 | ribosomal protein L3 | 0.0480644 |
| TPM3 | tropomyosin 3 | 0.0455884 |
| TMSB4X | thymosin beta 4, X-linked | 0.045357 |
| H1-4 | H1.4 linker histone, cluster member | 0.0451521 |
| TSC22D2 | TSC22 domain family, member 2 | 0.0417972 |
| SMC3 | structural maintenance of chromosomes 3 | 0.0340531 |
| NFKBIA | nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha | 0.0311967 |
| KTN1 | kinectin 1 (kinesin receptor) | 0.0306108 |
| RPL35A | ribosomal protein L35a | 0.0280637 |
| MIER1 | mesoderm induction early response 1, transcriptional regulator | 0.0270051 |
| EIF5B | eukaryotic translation initiation factor 5B | 0.0266472 |
| KIF1C | kinesin family member 1C | 0.0262919 |
| RSRC2 | arginine/serine-rich coiled-coil 2 | 0.0262035 |
| RPL21 | ribosomal protein L21 | 0.0252171 |
| EIF4G1 | eukaryotic translation initiation factor 4 gamma, 1 | 0.0250421 |
| CD55 | CD55 molecule, decay accelerating factor for complement (Cromer blood group) | 0.024597 |
| RPL13A | ribosomal protein L13a | 0.0244388 |
| RPL19 | ribosomal protein L19 | 0.023774 |
| PDE10A | phosphodiesterase 10A | 0.0237443 |
| RPL37A | ribosomal protein L37a | 0.0232659 |
| ENAH | enabled homolog (Drosophila) | 0.0232374 |
| KMT2E | lysine (K)-specific methyltransferase 2E | 0.0231683 |
| ZNF217 | zinc finger protein 217 | 0.0228367 |
| MT2A | metallothionein 2A | 0.0224028 |
| H1-2 | H1.2 linker histone, cluster member | 0.0224012 |
| RBM25 | RNA binding motif protein 25 | 0.0223764 |
| RPS19 | ribosomal protein S19 | 0.0223334 |
| HSP90AA1 | heat shock protein 90kDa alpha (cytosolic), class A member 1 | 0.0221668 |
| HEY1 | hes-related family bHLH transcription factor with YRPW motif 1 | 0.0221342 |
| MSN | moesin | 0.0211377 |
| CITED2 | Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 2 | 0.0209808 |
| RPL36 | ribosomal protein L36 | 0.0209093 |
| BRD4 | bromodomain containing 4 | 0.0205826 |
| HIF1A | hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) | 0.0205236 |
| PRELID3B | PRELI domain containing 3B | 0.0205003 |
| RPS26 | ribosomal protein S26 | 0.0203575 |
| RPLP0 | ribosomal protein, large, P0 | 0.0203127 |
| DDIT4 | DNA-damage-inducible transcript 4 | 0.020301 |
| SNRPB | small nuclear ribonucleoprotein polypeptides B and B1 | 0.0200991 |
| PLK2 | polo-like kinase 2 | 0.019963 |
| RPL12 | ribosomal protein L12 | 0.0199041 |
| ITPR2 | inositol 1,4,5-trisphosphate receptor, type 2 | 0.019469 |
| RPS15A | ribosomal protein S15a | 0.0193064 |
| SRRM1 | serine/arginine repetitive matrix 1 | 0.0192767 |
| EFNA5 | ephrin-A5 | 0.0192239 |
| KCNQ5 | potassium channel, voltage gated KQT-like subfamily Q, member 5 | 0.0191668 |
| EGFR | epidermal growth factor receptor | 0.0191326 |
| RPS20 | ribosomal protein S20 | 0.018795 |
| RPL7 | ribosomal protein L7 | 0.0187894 |
| MAP4K5 | mitogen-activated protein kinase kinase kinase kinase 5 | 0.0187351 |
| RPL9 | ribosomal protein L9 | 0.018601 |
| RPL7A | ribosomal protein L7a | 0.0185746 |
| GOLGA4 | golgin A4 | 0.0185434 |
| ANXA1 | annexin A1 | 0.0184477 |
| MYL6 | myosin, light chain 6, alkali, smooth muscle and non-muscle | 0.0183281 |
| ATAD2B | ATPase family, AAA domain containing 2B | 0.0181032 |
| BMS1 | BMS1 ribosome biogenesis factor | 0.017917 |
| HNRNPH1 | heterogeneous nuclear ribonucleoprotein H1 (H) | 0.0178743 |
| RPL18 | ribosomal protein L18 | 0.0177252 |
| SMURF2 | SMAD specific E3 ubiquitin protein ligase 2 | 0.0175829 |
| TBC1D12 | TBC1 domain family, member 12 | 0.0174961 |
| VARS1 | valyl-tRNA synthetase 1 | 0.0173547 |
| SNU13 | small nuclear ribonucleoprotein 13 | 0.0173216 |
| SNX2 | sorting nexin 2 | 0.0172384 |
| CWF19L2 | CWF19-like 2, cell cycle control (S. pombe) | 0.0169709 |
| EIF3H | eukaryotic translation initiation factor 3, subunit H | 0.0169555 |
| RPS3 | ribosomal protein S3 | 0.016939 |
| PRSS23 | protease, serine, 23 | 0.0168489 |
| PPP3CA | protein phosphatase 3, catalytic subunit, alpha isozyme | 0.0165234 |
| CCNT2 | cyclin T2 | 0.0164827 |
| RPL26 | ribosomal protein L26 | 0.0162693 |
| RPL41 | ribosomal protein L41 | 0.016254 |
| CEP250 | centrosomal protein 250kDa | 0.016231 |
| EZR | ezrin | 0.0161211 |
| CCNK | cyclin K | 0.0160173 |
| CNBP | CCHC-type zinc finger, nucleic acid binding protein | 0.0159421 |
| FBL | fibrillarin | 0.0159328 |
| KIF11 | kinesin family member 11 | 0.0159328 |
| RRAS2 | related RAS viral (r-ras) oncogene homolog 2 | 0.0159104 |
| RAD23B | RAD23 homolog B (S. cerevisiae) | 0.0158711 |
| CALM1 | calmodulin 1 (phosphorylase kinase, delta) | 0.0158659 |
| ARGLU1 | arginine and glutamate rich 1 | 0.0158391 |
| WDR43 | WD repeat domain 43 | 0.0157568 |
| ADM | adrenomedullin | 0.0156729 |
| SFRP4 | secreted frizzled-related protein 4 | 0.0156483 |
| SEPTIN9 | septin 9 | 0.0156423 |
| JMJD1C | jumonji domain containing 1C | 0.0155556 |
| ATP5MK | ATP synthase membrane subunit k | 0.0154835 |
| SLC38A2 | solute carrier family 38, member 2 | 0.0152606 |
| HERC4 | HECT and RLD domain containing E3 ubiquitin protein ligase 4 | 0.0152244 |
| CCN2 | cellular communication network factor 2 | 0.0152135 |
| Symbol | Name | Standardized Value |
|---|---|---|
| IMMP2L | IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) | -0.236322 |
| HSPA5 | heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) | -0.209744 |
| VIM | vimentin | -0.172755 |
| GPC3 | glypican 3 | -0.141437 |
| COL11A1 | collagen, type XI, alpha 1 | -0.128412 |
| CADM2 | cell adhesion molecule 2 | -0.127832 |
| PCLO | piccolo presynaptic cytomatrix protein | -0.126132 |
| ADGRL2 | adhesion G protein-coupled receptor L2 | -0.11969 |
| ERBB4 | erb-b2 receptor tyrosine kinase 4 | -0.106601 |
| RALGAPA1 | Ral GTPase activating protein, alpha subunit 1 (catalytic) | -0.106373 |
| PCDH9 | protocadherin 9 | -0.106147 |
| CTNNA2 | catenin (cadherin-associated protein), alpha 2 | -0.101915 |
| CDH10 | cadherin 10, type 2 (T2-cadherin) | -0.100375 |
| COL3A1 | collagen, type III, alpha 1 | -0.0964275 |
| CDH6 | cadherin 6, type 2, K-cadherin (fetal kidney) | -0.0853654 |
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | -0.081859 |
| CTNNA3 | catenin (cadherin-associated protein), alpha 3 | -0.080067 |
| ITGAV | integrin, alpha V | -0.0792436 |
| UBC | ubiquitin C | -0.0769803 |
| ROBO1 | roundabout, axon guidance receptor, homolog 1 (Drosophila) | -0.0726406 |
| TOP2A | topoisomerase (DNA) II alpha 170kDa | -0.0715489 |
| ADGRV1 | adhesion G protein-coupled receptor V1 | -0.066468 |
| HCN1 | hyperpolarization activated cyclic nucleotide gated potassium channel 1 | -0.0664275 |
| LRRC4C | leucine rich repeat containing 4C | -0.0658924 |
| HS3ST5 | heparan sulfate (glucosamine) 3-O-sulfotransferase 5 | -0.0638278 |
| AHNAK | AHNAK nucleoprotein | -0.0631773 |
| RPS16 | ribosomal protein S16 | -0.0624382 |
| EMP1 | epithelial membrane protein 1 | -0.0609644 |
| NTM | neurotrimin | -0.0606088 |
| APP | amyloid beta (A4) precursor protein | -0.0594831 |
| COL1A2 | collagen, type I, alpha 2 | -0.0582892 |
| BACH2 | BTB and CNC homology 1, basic leucine zipper transcription factor 2 | -0.0571312 |
| CALU | calumenin | -0.0565146 |
| THBS1 | thrombospondin 1 | -0.0559946 |
| SMYD3 | SET and MYND domain containing 3 | -0.0550317 |
| FOXP2 | forkhead box P2 | -0.0527601 |
| ZFAND3 | zinc finger, AN1-type domain 3 | -0.0525632 |
| BMPR2 | bone morphogenetic protein receptor, type II (serine/threonine kinase) | -0.0521433 |
| NEBL | nebulette | -0.0495544 |
| GALNTL6 | polypeptide N-acetylgalactosaminyltransferase-like 6 | -0.0494162 |
| RAD51B | RAD51 paralog B | -0.0492805 |
| NPAS3 | neuronal PAS domain protein 3 | -0.0490123 |
| PHIP | pleckstrin homology domain interacting protein | -0.0481082 |
| RBMS3 | RNA binding motif, single stranded interacting protein 3 | -0.0475459 |
| COL5A2 | collagen, type V, alpha 2 | -0.0467927 |
| TENM3 | teneurin transmembrane protein 3 | -0.0467672 |
| ARL6IP1 | ADP-ribosylation factor-like 6 interacting protein 1 | -0.0460482 |
| ENO1 | enolase 1, (alpha) | -0.0456048 |
| S100A10 | S100 calcium binding protein A10 | -0.0424509 |
| PRELID2 | PRELI domain containing 2 | -0.0424382 |
| MAP4 | microtubule-associated protein 4 | -0.0422875 |
| PDIA4 | protein disulfide isomerase family A, member 4 | -0.0418088 |
| HECTD1 | HECT domain containing E3 ubiquitin protein ligase 1 | -0.0407368 |
| CSMD3 | CUB and Sushi multiple domains 3 | -0.0407057 |
| TAS2R14 | taste receptor, type 2, member 14 | -0.0406325 |
| PRTG | protogenin | -0.0404275 |
| RPS27A | ribosomal protein S27a | -0.0401023 |
| MACF1 | microtubule-actin crosslinking factor 1 | -0.0386842 |
| CHD1 | chromodomain helicase DNA binding protein 1 | -0.0385781 |
| BAZ1A | bromodomain adjacent to zinc finger domain, 1A | -0.0385759 |
| KHDRBS1 | KH domain containing, RNA binding, signal transduction associated 1 | -0.0383691 |
| TPT1 | tumor protein, translationally-controlled 1 | -0.0374833 |
| SRP54 | signal recognition particle 54kDa | -0.0374524 |
| LIN28B | lin-28 homolog B (C. elegans) | -0.036854 |
| PROS1 | protein S (alpha) | -0.0364902 |
| NPM1 | nucleophosmin (nucleolar phosphoprotein B23, numatrin) | -0.036486 |
| ANKRD33B | ankyrin repeat domain 33B | -0.0358228 |
| PLPP1 | phospholipid phosphatase 1 | -0.0357781 |
| RHEB | Ras homolog enriched in brain | -0.0349005 |
| STRN3 | striatin, calmodulin binding protein 3 | -0.0347889 |
| ATP5F1B | ATP synthase F1 subunit beta | -0.0347365 |
| ZFPM2 | zinc finger protein, FOG family member 2 | -0.0345124 |
| ANKRD12 | ankyrin repeat domain 12 | -0.0344587 |
| TMTC2 | transmembrane and tetratricopeptide repeat containing 2 | -0.0343476 |
| CDK12 | cyclin-dependent kinase 12 | -0.0343054 |
| ATRX | alpha thalassemia/mental retardation syndrome X-linked | -0.0341922 |
| RTN4 | reticulon 4 | -0.0341896 |
| PHF21A | PHD finger protein 21A | -0.0338565 |
| ZNF385D | zinc finger protein 385D | -0.0338354 |
| MARCKS | myristoylated alanine-rich protein kinase C substrate | -0.0338157 |
| GULP1 | GULP, engulfment adaptor PTB domain containing 1 | -0.0336905 |
| CDH19 | cadherin 19, type 2 | -0.0335183 |
| THOC2 | THO complex 2 | -0.0334476 |
| SEC31A | SEC31 homolog A (S. cerevisiae) | -0.0333068 |
| PARD3B | par-3 family cell polarity regulator beta | -0.0331047 |
| PTK2 | protein tyrosine kinase 2 | -0.0330437 |
| PTGES3 | prostaglandin E synthase 3 (cytosolic) | -0.0322444 |
| ANK2 | ankyrin 2, neuronal | -0.0322183 |
| ACTG1 | actin gamma 1 | -0.0320424 |
| DOCK5 | dedicator of cytokinesis 5 | -0.031149 |
| DMD | dystrophin | -0.0310146 |
| PRKDC | protein kinase, DNA-activated, catalytic polypeptide | -0.0308625 |
| PRKAG2 | protein kinase, AMP-activated, gamma 2 non-catalytic subunit | -0.0301513 |
| CAMTA1 | calmodulin binding transcription activator 1 | -0.0300581 |
| WSB1 | WD repeat and SOCS box containing 1 | -0.0297729 |
| FAF1 | Fas (TNFRSF6) associated factor 1 | -0.0295605 |
| POTEF | POTE ankyrin domain family, member F | -0.0295493 |
| PCDH7 | protocadherin 7 | -0.0295274 |
| MEIS2 | Meis homeobox 2 | -0.0294936 |
| SYT1 | synaptotagmin I | -0.0293521 |
