Tolmetin_SNU-423 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Tolmetin perturbation in SNU-423 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Tolmetin_SNU-423 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
MYH9 myosin, heavy chain 9, non-muscle 0.455124
SOD2 superoxide dismutase 2, mitochondrial 0.141212
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.122401
FN1 fibronectin 1 0.104256
TRIO trio Rho guanine nucleotide exchange factor 0.1033
PGK1 phosphoglycerate kinase 1 0.0978452
SPTBN1 spectrin, beta, non-erythrocytic 1 0.0896288
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) 0.0796026
NAV2 neuron navigator 2 0.0790547
CADM1 cell adhesion molecule 1 0.0785814
COL6A3 collagen, type VI, alpha 3 0.0742802
DST dystonin 0.0706126
PABPC1 poly(A) binding protein, cytoplasmic 1 0.0693948
MSN moesin 0.0690868
NAMPT nicotinamide phosphoribosyltransferase 0.0684985
OGA O-GlcNAcase 0.0673726
ZNF292 zinc finger protein 292 0.0620975
KDM3A lysine (K)-specific demethylase 3A 0.0617844
STAT1 signal transducer and activator of transcription 1, 91kDa 0.0612235
IGFN1 immunoglobulin-like and fibronectin type III domain containing 1 0.0610297
TMSB4X thymosin beta 4, X-linked 0.0600976
FNDC3B fibronectin type III domain containing 3B 0.059728
AHNAK AHNAK nucleoprotein 0.0589927
ADM adrenomedullin 0.0583309
TNIP1 TNFAIP3 interacting protein 1 0.057838
CEP250 centrosomal protein 250kDa 0.0573882
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 0.0570929
AFDN afadin, adherens junction formation factor 0.0541445
HNRNPU heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) 0.0535076
APP amyloid beta (A4) precursor protein 0.0516724
EEF2 eukaryotic translation elongation factor 2 0.0516129
MXI1 MAX interactor 1, dimerization protein 0.0510906
MYOF myoferlin 0.0505192
HNRNPA1 heterogeneous nuclear ribonucleoprotein A1 0.0498511
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin) 0.048675
SFTPA2 surfactant protein A2 0.0477836
EEF1A1 eukaryotic translation elongation factor 1 alpha 1 0.0474543
HUWE1 HECT, UBA and WWE domain containing 1, E3 ubiquitin protein ligase 0.0472798
YWHAZ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta 0.0472638
USP9X ubiquitin specific peptidase 9, X-linked 0.0469774
PLOD2 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 0.0465372
GOLGA4 golgin A4 0.0464917
FLNA filamin A, alpha 0.0458957
ATP13A3 ATPase type 13A3 0.0455592
NAP1L1 nucleosome assembly protein 1-like 1 0.044212
ELL2 elongation factor, RNA polymerase II, 2 0.0440994
OPTN optineurin 0.0440028
IGF2R insulin-like growth factor 2 receptor 0.0439388
ANLN anillin, actin binding protein 0.0428438
ENO1 enolase 1, (alpha) 0.0411298
ARRDC3 arrestin domain containing 3 0.0400415
ABCA1 ATP-binding cassette, sub-family A (ABC1), member 1 0.0399401
HSPD1 heat shock 60kDa protein 1 (chaperonin) 0.039777
HNRNPH1 heterogeneous nuclear ribonucleoprotein H1 (H) 0.0392543
PPP1R15A protein phosphatase 1, regulatory subunit 15A 0.0391286
FRMD4A FERM domain containing 4A 0.039065
PJA2 praja ring finger 2, E3 ubiquitin protein ligase 0.0387863
PTMA prothymosin, alpha 0.0382134
DYNC1H1 dynein, cytoplasmic 1, heavy chain 1 0.0372302
SERINC1 serine incorporator 1 0.0369537
YWHAE tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon 0.0368974
MATR3 matrin 3 0.0356937
EIF1 eukaryotic translation initiation factor 1 0.0356353
PRELID2 PRELI domain containing 2 0.0354141
PTPRJ protein tyrosine phosphatase, receptor type, J 0.0351545
RPL3 ribosomal protein L3 0.0351525
RB1CC1 RB1-inducible coiled-coil 1 0.0348666
TPM3 tropomyosin 3 0.032893
SMG1 SMG1 phosphatidylinositol 3-kinase-related kinase 0.0325484
XPO1 exportin 1 0.0325065
HIF1A hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) 0.032224
SDC4 syndecan 4 0.0321308
VCAN versican 0.0320559
BNIP3 BCL2/adenovirus E1B 19kDa interacting protein 3 0.03197
PRKDC protein kinase, DNA-activated, catalytic polypeptide 0.0316418
ESYT2 extended synaptotagmin-like protein 2 0.0315401
TSC22D2 TSC22 domain family, member 2 0.0314907
SRRM2 serine/arginine repetitive matrix 2 0.0313895
ANKRD11 ankyrin repeat domain 11 0.0309893
HELZ helicase with zinc finger 0.0306511
NONO non-POU domain containing, octamer-binding 0.0306239
BBX bobby sox homolog (Drosophila) 0.0305169
FMNL2 formin-like 2 0.030314
MYL6 myosin, light chain 6, alkali, smooth muscle and non-muscle 0.0301904
STAG2 stromal antigen 2 0.0301368
YME1L1 YME1-like 1 ATPase 0.0299762
ANO6 anoctamin 6 0.0299154
ERRFI1 ERBB receptor feedback inhibitor 1 0.029844
DDX3X DEAD (Asp-Glu-Ala-Asp) box helicase 3, X-linked 0.0297892
LCORL ligand dependent nuclear receptor corepressor-like 0.0297435
PCBP2 poly(rC) binding protein 2 0.0296181
RPS2 ribosomal protein S2 0.0293506
SET SET nuclear proto-oncogene 0.0293345
PRRC2C proline-rich coiled-coil 2C 0.0292956
EZR ezrin 0.0289666
HSPA8 heat shock 70kDa protein 8 0.0287546
H1-4 H1.4 linker histone, cluster member 0.0287094
RTN4 reticulon 4 0.0286549
EIF2AK2 eukaryotic translation initiation factor 2-alpha kinase 2 0.0285233
EIF4A1 eukaryotic translation initiation factor 4A1 0.0283312

decreased expression

Symbol Name Standardized Value
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.135723
FTH1 ferritin, heavy polypeptide 1 -0.0962088
IGFBP3 insulin-like growth factor binding protein 3 -0.0951032
VCL vinculin -0.0905308
GLIS3 GLIS family zinc finger 3 -0.0883384
VIM vimentin -0.0789888
BICC1 BicC family RNA binding protein 1 -0.0732567
ZSWIM6 zinc finger, SWIM-type containing 6 -0.0687546
HMGA2 high mobility group AT-hook 2 -0.066327
HLA-B major histocompatibility complex, class I, B -0.0661734
EGR1 early growth response 1 -0.0626479
KYNU kynureninase -0.0590468
IQCJ-SCHIP1 IQCJ-SCHIP1 readthrough -0.0587452
CD44 CD44 molecule (Indian blood group) -0.058104
NABP1 nucleic acid binding protein 1 -0.0463262
PALLD palladin, cytoskeletal associated protein -0.0457197
CTSD cathepsin D -0.0429985
VEGFA vascular endothelial growth factor A -0.0419559
LOX lysyl oxidase -0.041483
HDAC9 histone deacetylase 9 -0.0409388
RAB7A RAB7A, member RAS oncogene family -0.0395209
INTS6 integrator complex subunit 6 -0.038876
PHLDA1 pleckstrin homology-like domain, family A, member 1 -0.0385885
AKAP12 A kinase (PRKA) anchor protein 12 -0.038516
HLA-A major histocompatibility complex, class I, A -0.0362915
VMP1 vacuole membrane protein 1 -0.0338334
BTG1 B-cell translocation gene 1, anti-proliferative -0.0333772
ZBTB38 zinc finger and BTB domain containing 38 -0.0331474
FTL ferritin, light polypeptide -0.0329565
TFPI tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor) -0.0325232
EXT1 exostosin glycosyltransferase 1 -0.0321781
TAPBP TAP binding protein (tapasin) -0.0315206
LGALS3BP lectin, galactoside-binding, soluble, 3 binding protein -0.0314961
SMAD2 SMAD family member 2 -0.028295
NHS Nance-Horan syndrome (congenital cataracts and dental anomalies) -0.0276981
NDRG1 N-myc downstream regulated 1 -0.0275682
EPAS1 endothelial PAS domain protein 1 -0.027232
NR3C1 nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor) -0.0272279
PDLIM5 PDZ and LIM domain 5 -0.0271654
ADAM12 ADAM metallopeptidase domain 12 -0.0268364
MAGI2 membrane associated guanylate kinase, WW and PDZ domain containing 2 -0.0268262
TIMP2 TIMP metallopeptidase inhibitor 2 -0.0267372
ITGA3 integrin, alpha 3 (antigen CD49C, alpha 3 subunit of VLA-3 receptor) -0.0266585
PAPPA pregnancy-associated plasma protein A, pappalysin 1 -0.0262366
PPARD peroxisome proliferator-activated receptor delta -0.0259596
CITED2 Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 2 -0.0256687
PTPN12 protein tyrosine phosphatase, non-receptor type 12 -0.0243296
PHLDB2 pleckstrin homology-like domain, family B, member 2 -0.0242495
ZBTB20 zinc finger and BTB domain containing 20 -0.0238189
MARCKS myristoylated alanine-rich protein kinase C substrate -0.0237859
ATXN1 ataxin 1 -0.0237552
CLMP CXADR-like membrane protein -0.0231456
CASK calcium/calmodulin-dependent serine protein kinase (MAGUK family) -0.0229836
NRP1 neuropilin 1 -0.0224989
SAMD3 sterile alpha motif domain containing 3 -0.0223161
NTN4 netrin 4 -0.0220473
TUT7 terminal uridylyl transferase 7 -0.0218333
IFITM3 interferon induced transmembrane protein 3 -0.0215898
ATRX alpha thalassemia/mental retardation syndrome X-linked -0.0212672
GNB1 guanine nucleotide binding protein (G protein), beta polypeptide 1 -0.0212261
N4BP2L2 NEDD4 binding protein 2-like 2 -0.0210349
TGFBI transforming growth factor, beta-induced, 68kDa -0.0208994
PITPNC1 phosphatidylinositol transfer protein, cytoplasmic 1 -0.0208943
MYADM myeloid-associated differentiation marker -0.0202707
DCBLD1 discoidin, CUB and LCCL domain containing 1 -0.0199084
DHFR dihydrofolate reductase -0.0199078
TRIM55 tripartite motif containing 55 -0.0198358
MT2A metallothionein 2A -0.0193933
RPL9 ribosomal protein L9 -0.019229
ETS1 v-ets avian erythroblastosis virus E26 oncogene homolog 1 -0.0191997
ZCCHC7 zinc finger, CCHC domain containing 7 -0.0191681
TGM2 transglutaminase 2 -0.0191413
EGFR epidermal growth factor receptor -0.0189044
ZFP36L1 ZFP36 ring finger protein-like 1 -0.018802
SLC38A2 solute carrier family 38, member 2 -0.0186574
EHBP1 EH domain binding protein 1 -0.0184575
INHBA inhibin, beta A -0.0181384
PLSCR1 phospholipid scramblase 1 -0.0178935
RAI14 retinoic acid induced 14 -0.0178391
SLC4A7 solute carrier family 4, sodium bicarbonate cotransporter, member 7 -0.0176608
HMGA1 high mobility group AT-hook 1 -0.0176469
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 -0.0176334
CPEB4 cytoplasmic polyadenylation element binding protein 4 -0.0175672
TBCA tubulin folding cofactor A -0.0174835
PALM2AKAP2 PALM2 and AKAP2 fusion -0.0173652
RBCK1 RanBP-type and C3HC4-type zinc finger containing 1 -0.0172004
OSMR oncostatin M receptor -0.0171648
STC1 stanniocalcin 1 -0.0171417
SOX5 SRY (sex determining region Y)-box 5 -0.0171034
HS2ST1 heparan sulfate 2-O-sulfotransferase 1 -0.0170511
GOPC golgi-associated PDZ and coiled-coil motif containing -0.0169598
EDIL3 EGF-like repeats and discoidin I-like domains 3 -0.0167626
COL6A1 collagen, type VI, alpha 1 -0.0166336
SHISA5 shisa family member 5 -0.0166201
SCARB1 scavenger receptor class B, member 1 -0.0157829
MARCHF3 membrane associated ring-CH-type finger 3 -0.0157134
AGRN agrin -0.015684
ATP11C ATPase, class VI, type 11C -0.0156566
CYB5R3 cytochrome b5 reductase 3 -0.0155046
SHOC2 soc-2 suppressor of clear homolog (C. elegans) -0.0154494