| Dataset | DeepCoverMOA Drug Mechanisms of Action |
| Category | proteomics |
| Type | drug perturbation |
| External Link | https://pubchem.ncbi.nlm.nih.gov/compound/216237 |
| Similar Terms | |
| Downloads & Tools |
197 proteins with high or low expression in Tolvaptan relative to other proteins from the DeepCoverMOA Drug Mechanisms of Action dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| GREB1 | growth regulation by estrogen in breast cancer 1 | 0.87 |
| CFAP58 | cilia and flagella associated protein 58 | 0.83 |
| SLC35F6 | solute carrier family 35, member F6 | 0.72 |
| BBS9 | Bardet-Biedl syndrome 9 | 0.55 |
| CYP24A1 | cytochrome P450, family 24, subfamily A, polypeptide 1 | 0.52 |
| ABHD2 | abhydrolase domain containing 2 | 0.46 |
| NOP10 | NOP10 ribonucleoprotein | 0.45 |
| FYN | FYN proto-oncogene, Src family tyrosine kinase | 0.45 |
| VAV1 | vav 1 guanine nucleotide exchange factor | 0.44 |
| HYLS1 | hydrolethalus syndrome 1 | 0.44 |
| TMC4 | transmembrane channel-like 4 | 0.44 |
| CYP51A1 | cytochrome P450, family 51, subfamily A, polypeptide 1 | 0.44 |
| ZNF408 | zinc finger protein 408 | 0.43 |
| GAS2L1 | growth arrest-specific 2 like 1 | 0.42 |
| KIF21B | kinesin family member 21B | 0.41 |
| CEP70 | centrosomal protein 70kDa | 0.41 |
| ACTN3 | actinin, alpha 3 (gene/pseudogene) | 0.41 |
| TPM4 | tropomyosin 4 | 0.39 |
| RBM20 | RNA binding motif protein 20 | 0.37 |
| SUCO | SUN domain containing ossification factor | 0.37 |
| SCMH1 | sex comb on midleg homolog 1 (Drosophila) | 0.36 |
| MKS1 | Meckel syndrome, type 1 | 0.36 |
| PTPN21 | protein tyrosine phosphatase, non-receptor type 21 | 0.36 |
| TFAP2E | transcription factor AP-2 epsilon (activating enhancer binding protein 2 epsilon) | 0.35 |
| MALRD1 | MAM and LDL receptor class A domain containing 1 | 0.35 |
| ADGRV1 | adhesion G protein-coupled receptor V1 | 0.34 |
| KIAA0825 | KIAA0825 | 0.34 |
| MAF1 | MAF1 homolog (S. cerevisiae) | 0.34 |
| ANP32A | acidic (leucine-rich) nuclear phosphoprotein 32 family, member A | 0.34 |
| DVL3 | dishevelled segment polarity protein 3 | 0.33 |
| TNNC2 | troponin C type 2 (fast) | 0.33 |
| RWDD1 | RWD domain containing 1 | 0.33 |
| TMEM68 | transmembrane protein 68 | 0.32 |
| CALU | calumenin | 0.32 |
| TUSC2 | tumor suppressor candidate 2 | 0.32 |
| GTF3C6 | general transcription factor IIIC, polypeptide 6, alpha 35kDa | 0.32 |
| TCTN1 | tectonic family member 1 | 0.32 |
| SET | SET nuclear proto-oncogene | 0.31 |
| CCSAP | centriole, cilia and spindle-associated protein | 0.31 |
| ALG8 | ALG8, alpha-1,3-glucosyltransferase | 0.31 |
| KDM6B | lysine (K)-specific demethylase 6B | 0.31 |
| COX5A | cytochrome c oxidase subunit Va | 0.31 |
| CHRNA5 | cholinergic receptor, nicotinic, alpha 5 (neuronal) | 0.31 |
| DOHH | deoxyhypusine hydroxylase/monooxygenase | 0.3 |
| ADIPOR1 | adiponectin receptor 1 | 0.3 |
| UBE2W | ubiquitin-conjugating enzyme E2W (putative) | 0.3 |
| TRIM37 | tripartite motif containing 37 | 0.29 |
| LATS2 | large tumor suppressor kinase 2 | 0.29 |
| TTPA | tocopherol (alpha) transfer protein | 0.29 |
| TLE5 | TLE family member 5, transcriptional modulator | 0.28 |
| SMC1B | structural maintenance of chromosomes 1B | 0.28 |
| PRSS8 | protease, serine, 8 | 0.28 |
| ELOVL6 | ELOVL fatty acid elongase 6 | 0.28 |
| MTRF1 | mitochondrial translational release factor 1 | 0.28 |
| RAET1G | retinoic acid early transcript 1G | 0.28 |
| UBE2B | ubiquitin-conjugating enzyme E2B | 0.27 |
| BMT2 | base methyltransferase of 25S rRNA 2 homolog | 0.26 |
| PJA2 | praja ring finger 2, E3 ubiquitin protein ligase | 0.26 |
| MCM9 | minichromosome maintenance complex component 9 | 0.26 |
| C2CD4C | C2 calcium-dependent domain containing 4C | 0.26 |
| ODF2L | outer dense fiber of sperm tails 2-like | 0.26 |
| KDELR3 | KDEL (Lys-Asp-Glu-Leu) endoplasmic reticulum protein retention receptor 3 | 0.25 |
| FBXO44 | F-box protein 44 | 0.25 |
| MXRA7 | matrix-remodelling associated 7 | 0.25 |
| EWSR1 | EWS RNA-binding protein 1 | 0.25 |
| ADGRG1 | adhesion G protein-coupled receptor G1 | 0.25 |
| NFU1 | NFU1 iron-sulfur cluster scaffold | 0.25 |
| FZD1 | frizzled class receptor 1 | 0.25 |
| EIF4G1 | eukaryotic translation initiation factor 4 gamma, 1 | 0.25 |
| TRAM2 | translocation associated membrane protein 2 | 0.24 |
| RNASEH2C | ribonuclease H2, subunit C | 0.24 |
| HACD2 | 3-hydroxyacyl-CoA dehydratase 2 | 0.24 |
| SLC4A3 | solute carrier family 4 (anion exchanger), member 3 | 0.24 |
| UBE2Q2 | ubiquitin-conjugating enzyme E2Q family member 2 | 0.24 |
| MPC2 | mitochondrial pyruvate carrier 2 | 0.24 |
| CD81 | CD81 molecule | 0.24 |
| PRELID3B | PRELI domain containing 3B | 0.24 |
| ANKRD13B | ankyrin repeat domain 13B | 0.24 |
| ZNF714 | zinc finger protein 714 | 0.24 |
| RFFL | ring finger and FYVE-like domain containing E3 ubiquitin protein ligase | 0.23 |
| ZSWIM9 | zinc finger SWIM-type containing 9 | 0.23 |
| KLK6 | kallikrein-related peptidase 6 | 0.23 |
| PLPP6 | phospholipid phosphatase 6 | 0.23 |
| CLDN3 | claudin 3 | 0.23 |
| ARL5B | ADP-ribosylation factor-like 5B | 0.23 |
| SORT1 | sortilin 1 | 0.23 |
| LIN7A | lin-7 homolog A (C. elegans) | 0.22 |
| NAP1L1 | nucleosome assembly protein 1-like 1 | 0.22 |
| IFIH1 | interferon induced with helicase C domain 1 | 0.22 |
| CDC34 | cell division cycle 34 | 0.22 |
| TMEM104 | transmembrane protein 104 | 0.22 |
| DIP2C | DIP2 disco-interacting protein 2 homolog C (Drosophila) | 0.22 |
| SPCS1 | signal peptidase complex subunit 1 homolog (S. cerevisiae) | 0.22 |
| SLC25A39 | solute carrier family 25, member 39 | 0.22 |
| MALSU1 | mitochondrial assembly of ribosomal large subunit 1 | 0.22 |
| PPP1R14C | protein phosphatase 1, regulatory (inhibitor) subunit 14C | 0.22 |
| SLC9A1 | solute carrier family 9, subfamily A (NHE1, cation proton antiporter 1), member 1 | 0.22 |
| STC2 | stanniocalcin 2 | 0.22 |
| Symbol | Name | Standardized Value |
|---|---|---|
| DAP | death-associated protein | -0.74 |
| ZNF532 | zinc finger protein 532 | -0.66 |
| MED8 | mediator complex subunit 8 | -0.62 |
| COX19 | COX19 cytochrome c oxidase assembly factor | -0.59 |
| TOR1AIP2 | torsin A interacting protein 2 | -0.59 |
| ATF6B | activating transcription factor 6 beta | -0.56 |
| RNF220 | ring finger protein 220 | -0.54 |
| C4ORF33 | chromosome 4 open reading frame 33 | -0.52 |
| IKBKG | inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase gamma | -0.5 |
| TICAM1 | toll-like receptor adaptor molecule 1 | -0.5 |
| TNFRSF12A | tumor necrosis factor receptor superfamily, member 12A | -0.5 |
| POLR2M | polymerase (RNA) II (DNA directed) polypeptide M | -0.48 |
| ZBTB41 | zinc finger and BTB domain containing 41 | -0.47 |
| SDHAF4 | succinate dehydrogenase complex assembly factor 4 | -0.46 |
| FKBPL | FK506 binding protein like | -0.46 |
| TANK | TRAF family member-associated NFKB activator | -0.44 |
| GALT | galactose-1-phosphate uridylyltransferase | -0.44 |
| RPL26 | ribosomal protein L26 | -0.43 |
| TREX1 | three prime repair exonuclease 1 | -0.43 |
| CCDC102A | coiled-coil domain containing 102A | -0.42 |
| TMEM102 | transmembrane protein 102 | -0.42 |
| BORCS6 | BLOC-1 related complex subunit 6 | -0.42 |
| TIMP3 | TIMP metallopeptidase inhibitor 3 | -0.42 |
| FN1 | fibronectin 1 | -0.42 |
| CDK2AP1 | cyclin-dependent kinase 2 associated protein 1 | -0.42 |
| CMC2 | C-x(9)-C motif containing 2 | -0.41 |
| CRY2 | cryptochrome circadian clock 2 | -0.41 |
| ENTR1 | endosome associated trafficking regulator 1 | -0.41 |
| SLC35A3 | solute carrier family 35 (UDP-N-acetylglucosamine (UDP-GlcNAc) transporter), member A3 | -0.4 |
| TGFB1I1 | transforming growth factor beta 1 induced transcript 1 | -0.4 |
| TINAGL1 | tubulointerstitial nephritis antigen-like 1 | -0.4 |
| RFX7 | regulatory factor X, 7 | -0.39 |
| NCKAP1L | NCK-associated protein 1-like | -0.39 |
| ZNF672 | zinc finger protein 672 | -0.38 |
| CACNA2D2 | calcium channel, voltage-dependent, alpha 2/delta subunit 2 | -0.38 |
| F13A1 | coagulation factor XIII, A1 polypeptide | -0.36 |
| RAMAC | RNA guanine-7 methyltransferase activating subunit | -0.35 |
| MOCS2 | molybdenum cofactor synthesis 2 | -0.34 |
| SNAPIN | SNAP-associated protein | -0.34 |
| RIN3 | Ras and Rab interactor 3 | -0.33 |
| TNFSF9 | tumor necrosis factor (ligand) superfamily, member 9 | -0.33 |
| FGB | fibrinogen beta chain | -0.33 |
| PFDN6 | prefoldin subunit 6 | -0.33 |
| SLC35A5 | solute carrier family 35, member A5 | -0.32 |
| CUL9 | cullin 9 | -0.32 |
| IER2 | immediate early response 2 | -0.32 |
| TTC17 | tetratricopeptide repeat domain 17 | -0.32 |
| HBA1 | hemoglobin, alpha 1 | -0.31 |
| SLC66A2 | solute carrier family 66 member 2 | -0.31 |
| HERPUD1 | homocysteine-inducible, endoplasmic reticulum stress-inducible, ubiquitin-like domain member 1 | -0.31 |
| CCDC115 | coiled-coil domain containing 115 | -0.31 |
| BAK1 | BCL2-antagonist/killer 1 | -0.31 |
| VPS37B | vacuolar protein sorting 37 homolog B (S. cerevisiae) | -0.31 |
| TLL2 | tolloid-like 2 | -0.31 |
| CLCN3 | chloride channel, voltage-sensitive 3 | -0.31 |
| RASSF7 | Ras association (RalGDS/AF-6) domain family (N-terminal) member 7 | -0.31 |
| RNF5 | ring finger protein 5, E3 ubiquitin protein ligase | -0.3 |
| CREBZF | CREB/ATF bZIP transcription factor | -0.3 |
| SLC25A36 | solute carrier family 25 (pyrimidine nucleotide carrier), member 36 | -0.3 |
| LMOD1 | leiomodin 1 (smooth muscle) | -0.3 |
| RTRAF | RNA transcription, translation and transport factor | -0.3 |
| CARD19 | caspase recruitment domain family member 19 | -0.29 |
| ZDHHC23 | zinc finger, DHHC-type containing 23 | -0.29 |
| OTUD3 | OTU deubiquitinase 3 | -0.29 |
| IGBP1 | immunoglobulin (CD79A) binding protein 1 | -0.29 |
| CCN2 | cellular communication network factor 2 | -0.29 |
| PRPF40B | PRP40 pre-mRNA processing factor 40 homolog B (S. cerevisiae) | -0.28 |
| EPDR1 | ependymin related 1 | -0.28 |
| CDC42EP2 | CDC42 effector protein (Rho GTPase binding) 2 | -0.28 |
| TRMT2B | tRNA methyltransferase 2 homolog B (S. cerevisiae) | -0.28 |
| RNF126 | ring finger protein 126 | -0.28 |
| C19ORF25 | chromosome 19 open reading frame 25 | -0.28 |
| MGMT | O-6-methylguanine-DNA methyltransferase | -0.28 |
| NDFIP1 | Nedd4 family interacting protein 1 | -0.28 |
| NDUFA4 | NDUFA4, mitochondrial complex associated | -0.27 |
| UQCRB | ubiquinol-cytochrome c reductase binding protein | -0.27 |
| ATP5IF1 | ATP synthase inhibitory factor subunit 1 | -0.27 |
| SC5D | sterol-C5-desaturase | -0.27 |
| CERS5 | ceramide synthase 5 | -0.27 |
| TAGLN2 | transgelin 2 | -0.27 |
| GALNT14 | polypeptide N-acetylgalactosaminyltransferase 14 | -0.27 |
| PEX7 | peroxisomal biogenesis factor 7 | -0.27 |
| PTPRU | protein tyrosine phosphatase, receptor type, U | -0.27 |
| GLRX | glutaredoxin (thioltransferase) | -0.27 |
| RNF185 | ring finger protein 185 | -0.27 |
| F2 | coagulation factor II (thrombin) | -0.26 |
| KHSRP | KH-type splicing regulatory protein | -0.26 |
| SLC39A3 | solute carrier family 39 (zinc transporter), member 3 | -0.26 |
| EMB | embigin | -0.26 |
| MAFK | v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog K | -0.26 |
| GSTA1 | glutathione S-transferase alpha 1 | -0.26 |
| CD58 | CD58 molecule | -0.26 |
| ADGRE2 | adhesion G protein-coupled receptor E2 | -0.26 |
| PCBD1 | pterin-4 alpha-carbinolamine dehydratase/dimerization cofactor of hepatocyte nuclear factor 1 alpha | -0.26 |
| COQ4 | coenzyme Q4 | -0.26 |
| ECI1 | enoyl-CoA delta isomerase 1 | -0.26 |
| MTFR1 | mitochondrial fission regulator 1 | -0.26 |
| MT1L | metallothionein 1L (gene/pseudogene) | -0.26 |
| C1QBP | complement component 1, q subcomponent binding protein | -0.25 |
