Tomivosertib_A-172 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Tomivosertib perturbation in A-172 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Tomivosertib_A-172 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.0810335
TRIO trio Rho guanine nucleotide exchange factor 0.0801295
AKAP12 A kinase (PRKA) anchor protein 12 0.0780663
KCNMA1 potassium channel, calcium activated large conductance subfamily M alpha, member 1 0.0550219
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 0.0489782
RHOBTB3 Rho-related BTB domain containing 3 0.0424564
DST dystonin 0.0419347
SQSTM1 sequestosome 1 0.0412013
HDAC9 histone deacetylase 9 0.040751
PALM2AKAP2 PALM2 and AKAP2 fusion 0.0395585
DCBLD2 discoidin, CUB and LCCL domain containing 2 0.0378433
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) 0.0370233
CD44 CD44 molecule (Indian blood group) 0.0359343
GBE1 glucan (1,4-alpha-), branching enzyme 1 0.0332572
STAT1 signal transducer and activator of transcription 1, 91kDa 0.029879
MDM2 MDM2 proto-oncogene, E3 ubiquitin protein ligase 0.0288145
CANX calnexin 0.0285671
RUNX1 runt-related transcription factor 1 0.0282688
PRRC2C proline-rich coiled-coil 2C 0.0278972
SP100 SP100 nuclear antigen 0.0274389
ANKRD11 ankyrin repeat domain 11 0.0266588
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 0.0265849
LDHA lactate dehydrogenase A 0.0248831
CALM2 calmodulin 2 (phosphorylase kinase, delta) 0.0246677
BHLHE40 basic helix-loop-helix family, member e40 0.0246104
YWHAG tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, gamma 0.024478
CENPF centromere protein F, 350/400kDa 0.0237706
TMSB4X thymosin beta 4, X-linked 0.0236258
SAMD9 sterile alpha motif domain containing 9 0.0234454
PARP14 poly (ADP-ribose) polymerase family, member 14 0.023124
CAVIN1 caveolae associated protein 1 0.0226415
NAV2 neuron navigator 2 0.0222473
NAP1L1 nucleosome assembly protein 1-like 1 0.0219078
YWHAE tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon 0.02113
FNDC3B fibronectin type III domain containing 3B 0.0209547
PLOD2 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 0.0203521
BZW1 basic leucine zipper and W2 domains 1 0.019775
TPM4 tropomyosin 4 0.0197673
TLE4 transducin-like enhancer of split 4 0.0195467
GOLGA4 golgin A4 0.0193018
ZBTB20 zinc finger and BTB domain containing 20 0.0191634
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 0.0189453
SPTBN1 spectrin, beta, non-erythrocytic 1 0.0186942
MB21D2 Mab-21 domain containing 2 0.0185492
AHNAK2 AHNAK nucleoprotein 2 0.0182718
MBNL2 muscleblind-like splicing regulator 2 0.0182276
EIF2AK2 eukaryotic translation initiation factor 2-alpha kinase 2 0.0180055
EGFR epidermal growth factor receptor 0.0179455
CDK6 cyclin-dependent kinase 6 0.017787
GOLGB1 golgin B1 0.0177438
IRF2BP2 interferon regulatory factor 2 binding protein 2 0.0174319
RPS6 ribosomal protein S6 0.0174159
ATP13A3 ATPase type 13A3 0.0174085
ZNF292 zinc finger protein 292 0.0171639
EIF3A eukaryotic translation initiation factor 3, subunit A 0.0169123
SEPTIN7 septin 7 0.0168459
HNRNPU heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) 0.0167051
KLF6 Kruppel-like factor 6 0.0166821
IFI16 interferon, gamma-inducible protein 16 0.0166641
HSPD1 heat shock 60kDa protein 1 (chaperonin) 0.0165993
PRPF40A PRP40 pre-mRNA processing factor 40 homolog A (S. cerevisiae) 0.0161785
EEF2 eukaryotic translation elongation factor 2 0.01609
CAPN2 calpain 2, (m/II) large subunit 0.0160244
RPS3 ribosomal protein S3 0.015968
GPBP1 GC-rich promoter binding protein 1 0.0156248
HS3ST3A1 heparan sulfate (glucosamine) 3-O-sulfotransferase 3A1 0.015588
LNPEP leucyl/cystinyl aminopeptidase 0.0152758
LIMA1 LIM domain and actin binding 1 0.0151788
HNRNPH1 heterogeneous nuclear ribonucleoprotein H1 (H) 0.0151144
MYOF myoferlin 0.0150855
CEP350 centrosomal protein 350kDa 0.0149793
ABL2 ABL proto-oncogene 2, non-receptor tyrosine kinase 0.0149496
BNIP3L BCL2/adenovirus E1B 19kDa interacting protein 3-like 0.0148559
RACK1 receptor for activated C kinase 1 0.0147268
VOPP1 vesicular, overexpressed in cancer, prosurvival protein 1 0.0144514
MSANTD3 Myb/SANT-like DNA-binding domain containing 3 0.0143448
SEMA3C sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C 0.014342
NFE2L1 nuclear factor, erythroid 2-like 1 0.0143281
EGLN1 egl-9 family hypoxia-inducible factor 1 0.0141984
LOC102724023 ES1 protein homolog, mitochondrial 0.0141696
FBXL7 F-box and leucine-rich repeat protein 7 0.0141502
CALM1 calmodulin 1 (phosphorylase kinase, delta) 0.0140459
TPR translocated promoter region, nuclear basket protein 0.013985
ROCK1 Rho-associated, coiled-coil containing protein kinase 1 0.0138977
ERBIN erbb2 interacting protein 0.0138539
TNFAIP3 tumor necrosis factor, alpha-induced protein 3 0.013765
CTNNA1 catenin (cadherin-associated protein), alpha 1, 102kDa 0.0137125
YWHAZ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta 0.0135339
STC1 stanniocalcin 1 0.0134687
MCFD2 multiple coagulation factor deficiency 2 0.0134661
ITGA2 integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) 0.0134385
ANO6 anoctamin 6 0.0133096
ENO1 enolase 1, (alpha) 0.0132039
ANKRD12 ankyrin repeat domain 12 0.013107
ERC2 ELKS/RAB6-interacting/CAST family member 2 0.0130324
KIF5B kinesin family member 5B 0.0127194
EIF1 eukaryotic translation initiation factor 1 0.0126003
RND3 Rho family GTPase 3 0.0125475
CDC42BPA CDC42 binding protein kinase alpha (DMPK-like) 0.0125346
RPS2 ribosomal protein S2 0.0124896

decreased expression

Symbol Name Standardized Value
IGFBP3 insulin-like growth factor binding protein 3 -0.159209
SPARC secreted protein, acidic, cysteine-rich (osteonectin) -0.127074
TMSB10 thymosin beta 10 -0.104704
PLAT plasminogen activator, tissue -0.0644763
ADAMTS6 ADAM metallopeptidase with thrombospondin type 1 motif, 6 -0.0632331
FN1 fibronectin 1 -0.0566405
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 -0.0527276
VIM vimentin -0.0489498
COL5A1 collagen, type V, alpha 1 -0.0479455
LOX lysyl oxidase -0.0456417
ABI3BP ABI family, member 3 (NESH) binding protein -0.0444577
DIRAS3 DIRAS family, GTP-binding RAS-like 3 -0.0413606
SUCNR1 succinate receptor 1 -0.0385983
ZC3HAV1 zinc finger CCCH-type, antiviral 1 -0.0323487
KCNQ5 potassium channel, voltage gated KQT-like subfamily Q, member 5 -0.0305602
HLA-B major histocompatibility complex, class I, B -0.0297779
TAGLN2 transgelin 2 -0.0284063
NAV1 neuron navigator 1 -0.028247
PRSS23 protease, serine, 23 -0.0273002
COL8A1 collagen, type VIII, alpha 1 -0.0252632
S100A6 S100 calcium binding protein A6 -0.0243784
SEMA5A sema domain, seven thrombospondin repeats (type 1 and type 1-like), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 5A -0.0225334
MT1X metallothionein 1X -0.0224439
DKK1 dickkopf WNT signaling pathway inhibitor 1 -0.0220591
PODXL podocalyxin-like -0.0204602
KRT81 keratin 81, type II -0.019777
CYTH3 cytohesin 3 -0.0195898
SORBS2 sorbin and SH3 domain containing 2 -0.0191503
SLC38A1 solute carrier family 38, member 1 -0.0172508
CALR calreticulin -0.017111
MT2A metallothionein 2A -0.0168266
LOXL2 lysyl oxidase-like 2 -0.016537
MRPS6 mitochondrial ribosomal protein S6 -0.0162032
FBN1 fibrillin 1 -0.0157117
COL1A2 collagen, type I, alpha 2 -0.0157039
HLA-C major histocompatibility complex, class I, C -0.0155099
CD59 CD59 molecule, complement regulatory protein -0.0148396
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.0147954
MCL1 myeloid cell leukemia 1 -0.0146667
S100A4 S100 calcium binding protein A4 -0.0142942
THBS2 thrombospondin 2 -0.0142533
CD99 CD99 molecule -0.0141176
OASL 2'-5'-oligoadenylate synthetase-like -0.014019
RSAD2 radical S-adenosyl methionine domain containing 2 -0.0136626
COL6A1 collagen, type VI, alpha 1 -0.0136173
PHLDA1 pleckstrin homology-like domain, family A, member 1 -0.0135209
DKK3 dickkopf WNT signaling pathway inhibitor 3 -0.0130978
COL1A1 collagen, type I, alpha 1 -0.0128818
SP3 Sp3 transcription factor -0.012593
FLT1 fms-related tyrosine kinase 1 -0.0125681
IGFBP6 insulin-like growth factor binding protein 6 -0.0124214
LY6E lymphocyte antigen 6 complex, locus E -0.0118437
PLAUR plasminogen activator, urokinase receptor -0.011485
WARS1 tryptophanyl-tRNA synthetase 1 -0.0114345
NDRG1 N-myc downstream regulated 1 -0.0113187
CTSB cathepsin B -0.0110827
RABGEF1 RAB guanine nucleotide exchange factor (GEF) 1 -0.0109793
TPM1 tropomyosin 1 (alpha) -0.0108657
S100A10 S100 calcium binding protein A10 -0.0105685
UBC ubiquitin C -0.0104818
IFITM1 interferon induced transmembrane protein 1 -0.0103033
CTSD cathepsin D -0.0101941
MAP1B microtubule-associated protein 1B -0.0101667
SLC39A11 solute carrier family 39, member 11 -0.0101578
MAP4K4 mitogen-activated protein kinase kinase kinase kinase 4 -0.00996929
TNS3 tensin 3 -0.00992834
FNDC3A fibronectin type III domain containing 3A -0.00990682
TIMP2 TIMP metallopeptidase inhibitor 2 -0.00987418
FLNA filamin A, alpha -0.00986191
S100A9 S100 calcium binding protein A9 -0.00975979
IL7R interleukin 7 receptor -0.00956671
CKAP4 cytoskeleton-associated protein 4 -0.00948391
RPS6KA2 ribosomal protein S6 kinase, 90kDa, polypeptide 2 -0.00942323
ENO2 enolase 2 (gamma, neuronal) -0.00933217
ITGA5 integrin, alpha 5 (fibronectin receptor, alpha polypeptide) -0.00930642
ZNF207 zinc finger protein 207 -0.00930031
PGK1 phosphoglycerate kinase 1 -0.00920321
UAP1 UDP-N-acetylglucosamine pyrophosphorylase 1 -0.00915959
GFPT1 glutamine--fructose-6-phosphate transaminase 1 -0.00905914
ISG15 ISG15 ubiquitin-like modifier -0.00899781
AUTS2 autism susceptibility candidate 2 -0.00899273
TUBB4B tubulin, beta 4B class IVb -0.00894374
MX2 MX dynamin-like GTPase 2 -0.00892811
TMEM165 transmembrane protein 165 -0.00887307
DLG1 discs, large homolog 1 (Drosophila) -0.00879211
SH3RF1 SH3 domain containing ring finger 1 -0.00875232
P4HA2 prolyl 4-hydroxylase, alpha polypeptide II -0.00853959
TUBA1C tubulin, alpha 1c -0.00849775
GOLGA2 golgin A2 -0.00847538
SRPK2 SRSF protein kinase 2 -0.00838988
SLC5A3 solute carrier family 5 (sodium/myo-inositol cotransporter), member 3 -0.00836136
DGKG diacylglycerol kinase, gamma 90kDa -0.00833949
MED13L mediator complex subunit 13-like -0.0082851
PPDPF pancreatic progenitor cell differentiation and proliferation factor -0.0081761
IFI27 interferon, alpha-inducible protein 27 -0.00815291
SPAG9 sperm associated antigen 9 -0.00799244
RNF187 ring finger protein 187 -0.00797377
RNF144A ring finger protein 144A -0.00784863
TUBB6 tubulin, beta 6 class V -0.00777307
L1CAM L1 cell adhesion molecule -0.007759