| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | Tomivosertib perturbation in A-427 cell line (Tahoe Therapeutics) |
| Similar Terms | |
| Downloads & Tools |
200 genes differentially expressed following the Tomivosertib_A-427 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| HSP90AA1 | heat shock protein 90kDa alpha (cytosolic), class A member 1 | 0.129004 |
| HSP90AB1 | heat shock protein 90kDa alpha (cytosolic), class B member 1 | 0.100894 |
| VIM | vimentin | 0.0879528 |
| SCD | stearoyl-CoA desaturase (delta-9-desaturase) | 0.0632295 |
| AREG | amphiregulin | 0.0501684 |
| RPS12 | ribosomal protein S12 | 0.0468565 |
| RPS6 | ribosomal protein S6 | 0.0396627 |
| RPS8 | ribosomal protein S8 | 0.0353323 |
| FTL | ferritin, light polypeptide | 0.0349358 |
| HSPD1 | heat shock 60kDa protein 1 (chaperonin) | 0.0308488 |
| RPL37A | ribosomal protein L37a | 0.0293233 |
| RPS2 | ribosomal protein S2 | 0.0293129 |
| HMGA2 | high mobility group AT-hook 2 | 0.0286656 |
| VMP1 | vacuole membrane protein 1 | 0.0264771 |
| POTEF | POTE ankyrin domain family, member F | 0.0264392 |
| EIF1 | eukaryotic translation initiation factor 1 | 0.0256753 |
| RAB7A | RAB7A, member RAS oncogene family | 0.0256724 |
| RPS3 | ribosomal protein S3 | 0.0241699 |
| NAP1L1 | nucleosome assembly protein 1-like 1 | 0.0241324 |
| TPI1 | triosephosphate isomerase 1 | 0.0227202 |
| AKAP12 | A kinase (PRKA) anchor protein 12 | 0.0221646 |
| LOC102724023 | ES1 protein homolog, mitochondrial | 0.0205936 |
| SERPINB2 | serpin peptidase inhibitor, clade B (ovalbumin), member 2 | 0.0204652 |
| BRD2 | bromodomain containing 2 | 0.0202312 |
| SLC38A1 | solute carrier family 38, member 1 | 0.0202076 |
| ANXA1 | annexin A1 | 0.0200007 |
| JMJD1C | jumonji domain containing 1C | 0.0198188 |
| RACK1 | receptor for activated C kinase 1 | 0.0192783 |
| LDHB | lactate dehydrogenase B | 0.0164317 |
| HSPB1 | heat shock 27kDa protein 1 | 0.0163786 |
| GPBP1 | GC-rich promoter binding protein 1 | 0.0159142 |
| ZSWIM6 | zinc finger, SWIM-type containing 6 | 0.0158326 |
| SQSTM1 | sequestosome 1 | 0.0157202 |
| HSPA9 | heat shock 70kDa protein 9 (mortalin) | 0.0154541 |
| EIF3A | eukaryotic translation initiation factor 3, subunit A | 0.0148752 |
| ADIPOR2 | adiponectin receptor 2 | 0.0146338 |
| NR2F1 | nuclear receptor subfamily 2, group F, member 1 | 0.0146077 |
| INTS6 | integrator complex subunit 6 | 0.0143318 |
| GARS1 | glycyl-tRNA synthetase 1 | 0.0143064 |
| SRRM1 | serine/arginine repetitive matrix 1 | 0.0142612 |
| EEF1G | eukaryotic translation elongation factor 1 gamma | 0.0138611 |
| RPL31 | ribosomal protein L31 | 0.0137037 |
| OSBPL8 | oxysterol binding protein-like 8 | 0.0136975 |
| EIF4G1 | eukaryotic translation initiation factor 4 gamma, 1 | 0.0136406 |
| TUBA1B | tubulin, alpha 1b | 0.0131738 |
| TTC3 | tetratricopeptide repeat domain 3 | 0.0130381 |
| RPL12 | ribosomal protein L12 | 0.0128616 |
| DNAJA1 | DnaJ (Hsp40) homolog, subfamily A, member 1 | 0.0125252 |
| TMBIM6 | transmembrane BAX inhibitor motif containing 6 | 0.0125144 |
| ERC1 | ELKS/RAB6-interacting/CAST family member 1 | 0.0123528 |
| P4HA1 | prolyl 4-hydroxylase, alpha polypeptide I | 0.0122711 |
| RPS26 | ribosomal protein S26 | 0.0121701 |
| TOMM20 | translocase of outer mitochondrial membrane 20 homolog (yeast) | 0.0120754 |
| HERC4 | HECT and RLD domain containing E3 ubiquitin protein ligase 4 | 0.0120405 |
| EIF2S2 | eukaryotic translation initiation factor 2, subunit 2 beta, 38kDa | 0.0120233 |
| GOLGB1 | golgin B1 | 0.0119368 |
| SLC2A3 | solute carrier family 2 (facilitated glucose transporter), member 3 | 0.0118042 |
| RPS17 | ribosomal protein S17 | 0.011773 |
| BPTF | bromodomain PHD finger transcription factor | 0.011573 |
| APLP2 | amyloid beta (A4) precursor-like protein 2 | 0.0114621 |
| PCDH9 | protocadherin 9 | 0.0114601 |
| SPDYA | speedy/RINGO cell cycle regulator family member A | 0.0114268 |
| PITPNC1 | phosphatidylinositol transfer protein, cytoplasmic 1 | 0.0112373 |
| HSPH1 | heat shock 105kDa/110kDa protein 1 | 0.0110818 |
| SYNE2 | spectrin repeat containing, nuclear envelope 2 | 0.0109682 |
| EEF2 | eukaryotic translation elongation factor 2 | 0.0109671 |
| RPL37 | ribosomal protein L37 | 0.0109007 |
| JUN | jun proto-oncogene | 0.0108979 |
| CSNK1A1 | casein kinase 1, alpha 1 | 0.0108004 |
| KMT2E | lysine (K)-specific methyltransferase 2E | 0.0105794 |
| SLC7A11 | solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11 | 0.0104702 |
| UBXN4 | UBX domain protein 4 | 0.010369 |
| TPM4 | tropomyosin 4 | 0.0102849 |
| HDGF | hepatoma-derived growth factor | 0.0102707 |
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | 0.0101892 |
| KTN1 | kinectin 1 (kinesin receptor) | 0.00991018 |
| ANK2 | ankyrin 2, neuronal | 0.00986119 |
| PRDX1 | peroxiredoxin 1 | 0.00984759 |
| CUX1 | cut-like homeobox 1 | 0.00984044 |
| EHBP1 | EH domain binding protein 1 | 0.00980124 |
| S100A11 | S100 calcium binding protein A11 | 0.00970447 |
| RPS13 | ribosomal protein S13 | 0.00967126 |
| YWHAB | tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta | 0.00952957 |
| EIF2AK1 | eukaryotic translation initiation factor 2-alpha kinase 1 | 0.00951261 |
| RPL9 | ribosomal protein L9 | 0.00949654 |
| RPS27 | ribosomal protein S27 | 0.00945419 |
| DENND5A | DENN/MADD domain containing 5A | 0.00938826 |
| YWHAG | tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, gamma | 0.00932323 |
| CDC42BPA | CDC42 binding protein kinase alpha (DMPK-like) | 0.00928029 |
| ZNF146 | zinc finger protein 146 | 0.00926958 |
| PRRC2C | proline-rich coiled-coil 2C | 0.00925744 |
| RSRC2 | arginine/serine-rich coiled-coil 2 | 0.00924379 |
| FGFR1 | fibroblast growth factor receptor 1 | 0.00899051 |
| CCT5 | chaperonin containing TCP1, subunit 5 (epsilon) | 0.0089797 |
| ASXL1 | additional sex combs like transcriptional regulator 1 | 0.00894575 |
| MCFD2 | multiple coagulation factor deficiency 2 | 0.00894021 |
| EIF5B | eukaryotic translation initiation factor 5B | 0.00892425 |
| SET | SET nuclear proto-oncogene | 0.00891737 |
| EZR | ezrin | 0.00873939 |
| TAF7 | TAF7 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 55kDa | 0.00867975 |
| Symbol | Name | Standardized Value |
|---|---|---|
| NLGN1 | neuroligin 1 | -0.0644222 |
| PDE4D | phosphodiesterase 4D, cAMP-specific | -0.061335 |
| CELF2 | CUGBP, Elav-like family member 2 | -0.0421804 |
| PCDH7 | protocadherin 7 | -0.0388634 |
| ALDH1A1 | aldehyde dehydrogenase 1 family, member A1 | -0.0383424 |
| MGAT4C | MGAT4 family, member C | -0.0354577 |
| ROBO2 | roundabout, axon guidance receptor, homolog 2 (Drosophila) | -0.0306868 |
| AHNAK | AHNAK nucleoprotein | -0.0303805 |
| ADGRG6 | adhesion G protein-coupled receptor G6 | -0.0301579 |
| MYL12B | myosin, light chain 12B, regulatory | -0.0285425 |
| ERBB4 | erb-b2 receptor tyrosine kinase 4 | -0.0280677 |
| ZNF217 | zinc finger protein 217 | -0.0255582 |
| LMO7 | LIM domain 7 | -0.0255051 |
| PDGFC | platelet derived growth factor C | -0.0243184 |
| TMSB10 | thymosin beta 10 | -0.0237915 |
| MARCHF6 | membrane associated ring-CH-type finger 6 | -0.0233763 |
| HNRNPA2B1 | heterogeneous nuclear ribonucleoprotein A2/B1 | -0.0218792 |
| NR5A2 | nuclear receptor subfamily 5, group A, member 2 | -0.0215599 |
| NEK7 | NIMA-related kinase 7 | -0.0214848 |
| ITGB1 | integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) | -0.0213307 |
| NHSL1 | NHS-like 1 | -0.0211782 |
| ERRFI1 | ERBB receptor feedback inhibitor 1 | -0.0210582 |
| TMEM123 | transmembrane protein 123 | -0.0204935 |
| MDM2 | MDM2 proto-oncogene, E3 ubiquitin protein ligase | -0.0204534 |
| YBX3 | Y box binding protein 3 | -0.0202437 |
| DDX5 | DEAD (Asp-Glu-Ala-Asp) box helicase 5 | -0.019372 |
| NCAPD2 | non-SMC condensin I complex, subunit D2 | -0.0193482 |
| EGLN1 | egl-9 family hypoxia-inducible factor 1 | -0.0192838 |
| DPYD | dihydropyrimidine dehydrogenase | -0.0191212 |
| CXADR | coxsackie virus and adenovirus receptor | -0.0185807 |
| CCN2 | cellular communication network factor 2 | -0.0184209 |
| CUBN | cubilin (intrinsic factor-cobalamin receptor) | -0.0180798 |
| SLC38A2 | solute carrier family 38, member 2 | -0.0176223 |
| RERE | arginine-glutamic acid dipeptide (RE) repeats | -0.0171707 |
| KDM3A | lysine (K)-specific demethylase 3A | -0.0171564 |
| MED13L | mediator complex subunit 13-like | -0.0169963 |
| PGK1 | phosphoglycerate kinase 1 | -0.0169354 |
| AXIN2 | axin 2 | -0.0169029 |
| GASK1B | golgi associated kinase 1B | -0.0166875 |
| DCBLD2 | discoidin, CUB and LCCL domain containing 2 | -0.0164201 |
| SMYD3 | SET and MYND domain containing 3 | -0.0161385 |
| ZBTB20 | zinc finger and BTB domain containing 20 | -0.0156612 |
| PUM2 | pumilio RNA-binding family member 2 | -0.0152986 |
| FUS | FUS RNA binding protein | -0.0149102 |
| DKK1 | dickkopf WNT signaling pathway inhibitor 1 | -0.0145799 |
| TENT4A | terminal nucleotidyltransferase 4A | -0.014294 |
| DLC1 | DLC1 Rho GTPase activating protein | -0.0142894 |
| YES1 | YES proto-oncogene 1, Src family tyrosine kinase | -0.0142425 |
| CNOT2 | CCR4-NOT transcription complex, subunit 2 | -0.0142284 |
| PDE4B | phosphodiesterase 4B, cAMP-specific | -0.0141007 |
| VCL | vinculin | -0.0140723 |
| TENM3 | teneurin transmembrane protein 3 | -0.0140379 |
| DST | dystonin | -0.0131753 |
| ANKRD28 | ankyrin repeat domain 28 | -0.0131349 |
| CLTC | clathrin, heavy chain (Hc) | -0.012871 |
| ZFAND6 | zinc finger, AN1-type domain 6 | -0.01283 |
| NCOR1 | nuclear receptor corepressor 1 | -0.0127972 |
| OXR1 | oxidation resistance 1 | -0.0125433 |
| ATP11A | ATPase, class VI, type 11A | -0.0124302 |
| TNFRSF10B | tumor necrosis factor receptor superfamily, member 10b | -0.0124266 |
| ECT2 | epithelial cell transforming 2 | -0.0122565 |
| IL6ST | interleukin 6 signal transducer | -0.0121447 |
| MIS18BP1 | MIS18 binding protein 1 | -0.011998 |
| TEAD1 | TEA domain family member 1 (SV40 transcriptional enhancer factor) | -0.0119436 |
| BIRC2 | baculoviral IAP repeat containing 2 | -0.0118583 |
| NF1 | neurofibromin 1 | -0.0117709 |
| CEP192 | centrosomal protein 192kDa | -0.0115718 |
| BIRC3 | baculoviral IAP repeat containing 3 | -0.0115144 |
| ZDHHC2 | zinc finger, DHHC-type containing 2 | -0.0112301 |
| TGIF1 | TGFB-induced factor homeobox 1 | -0.0112243 |
| PJA2 | praja ring finger 2, E3 ubiquitin protein ligase | -0.0111946 |
| RABGAP1L | RAB GTPase activating protein 1-like | -0.0111673 |
| LOC112694756 | uncharaterized LOC112694756 | -0.011096 |
| PPP6R3 | protein phosphatase 6, regulatory subunit 3 | -0.0110646 |
| XPO1 | exportin 1 | -0.011022 |
| CMIP | c-Maf inducing protein | -0.0109625 |
| PRKDC | protein kinase, DNA-activated, catalytic polypeptide | -0.0109032 |
| RPS24 | ribosomal protein S24 | -0.0108341 |
| TIGAR | TP53 induced glycolysis regulatory phosphatase | -0.010714 |
| TM4SF1 | transmembrane 4 L six family member 1 | -0.0106617 |
| ARL6IP1 | ADP-ribosylation factor-like 6 interacting protein 1 | -0.0105988 |
| AKT3 | v-akt murine thymoma viral oncogene homolog 3 | -0.0105747 |
| EIF4B | eukaryotic translation initiation factor 4B | -0.0105495 |
| CMSS1 | cms1 ribosomal small subunit homolog (yeast) | -0.0105449 |
| TMEM131 | transmembrane protein 131 | -0.0105151 |
| POLR2A | polymerase (RNA) II (DNA directed) polypeptide A, 220kDa | -0.0104202 |
| EIF4A2 | eukaryotic translation initiation factor 4A2 | -0.0104087 |
| AFG3L2 | AFG3-like AAA ATPase 2 | -0.010344 |
| CDK17 | cyclin-dependent kinase 17 | -0.0101994 |
| CSE1L | CSE1 chromosome segregation 1-like (yeast) | -0.0101291 |
| MTAP | methylthioadenosine phosphorylase | -0.0100921 |
| NCEH1 | neutral cholesterol ester hydrolase 1 | -0.010076 |
| CEP95 | centrosomal protein 95kDa | -0.0100386 |
| FANCL | Fanconi anemia, complementation group L | -0.00998094 |
| PPP2CA | protein phosphatase 2, catalytic subunit, alpha isozyme | -0.00992622 |
| KHDRBS1 | KH domain containing, RNA binding, signal transduction associated 1 | -0.00986602 |
| DYNC1H1 | dynein, cytoplasmic 1, heavy chain 1 | -0.00986189 |
| PCNP | PEST proteolytic signal containing nuclear protein | -0.00983585 |
| YAP1 | Yes-associated protein 1 | -0.00980163 |
| PABPC1 | poly(A) binding protein, cytoplasmic 1 | -0.00979763 |
