| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | Tomivosertib perturbation in CHP-212 cell line (Tahoe Therapeutics) |
| Similar Terms | |
| Downloads & Tools |
200 genes differentially expressed following the Tomivosertib_CHP-212 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| TLE4 | transducin-like enhancer of split 4 | 0.145404 |
| VCL | vinculin | 0.134452 |
| EIF1 | eukaryotic translation initiation factor 1 | 0.0751052 |
| ZSWIM6 | zinc finger, SWIM-type containing 6 | 0.0750845 |
| AKAP12 | A kinase (PRKA) anchor protein 12 | 0.0736699 |
| VMP1 | vacuole membrane protein 1 | 0.0728086 |
| FERMT2 | fermitin family member 2 | 0.0673558 |
| PTPRD | protein tyrosine phosphatase, receptor type, D | 0.0636111 |
| LIMA1 | LIM domain and actin binding 1 | 0.0607339 |
| LGR5 | leucine-rich repeat containing G protein-coupled receptor 5 | 0.0583909 |
| GLCCI1 | glucocorticoid induced 1 | 0.0535259 |
| SCN9A | sodium channel, voltage gated, type IX alpha subunit | 0.0518025 |
| MBD5 | methyl-CpG binding domain protein 5 | 0.0510678 |
| RPS6 | ribosomal protein S6 | 0.0475159 |
| NFAT5 | nuclear factor of activated T-cells 5, tonicity-responsive | 0.0458563 |
| FNDC3A | fibronectin type III domain containing 3A | 0.0431305 |
| PLPP1 | phospholipid phosphatase 1 | 0.0419306 |
| GBE1 | glucan (1,4-alpha-), branching enzyme 1 | 0.0405055 |
| BPTF | bromodomain PHD finger transcription factor | 0.0401221 |
| SYNPO2 | synaptopodin 2 | 0.0378473 |
| PLCB1 | phospholipase C, beta 1 (phosphoinositide-specific) | 0.0374055 |
| RPS12 | ribosomal protein S12 | 0.0364756 |
| ASCC3 | activating signal cointegrator 1 complex subunit 3 | 0.0358679 |
| DPH6 | diphthamine biosynthesis 6 | 0.0353909 |
| GATA3 | GATA binding protein 3 | 0.0350073 |
| TPST1 | tyrosylprotein sulfotransferase 1 | 0.0343138 |
| TIMP2 | TIMP metallopeptidase inhibitor 2 | 0.0338829 |
| MEIS2 | Meis homeobox 2 | 0.0336598 |
| HSP90AA1 | heat shock protein 90kDa alpha (cytosolic), class A member 1 | 0.0333056 |
| TCF7L2 | transcription factor 7-like 2 (T-cell specific, HMG-box) | 0.0329335 |
| ZBTB20 | zinc finger and BTB domain containing 20 | 0.0318406 |
| REV3L | REV3-like, polymerase (DNA directed), zeta, catalytic subunit | 0.0318404 |
| STXBP4 | syntaxin binding protein 4 | 0.0306774 |
| ARID5B | AT rich interactive domain 5B (MRF1-like) | 0.0303655 |
| SYT1 | synaptotagmin I | 0.0303102 |
| MAN1A1 | mannosidase, alpha, class 1A, member 1 | 0.0286274 |
| HILPDA | hypoxia inducible lipid droplet-associated | 0.0285108 |
| SLIT2 | slit homolog 2 (Drosophila) | 0.0267253 |
| TMTC2 | transmembrane and tetratricopeptide repeat containing 2 | 0.0261785 |
| GREM2 | gremlin 2, DAN family BMP antagonist | 0.026115 |
| RASSF8 | Ras association (RalGDS/AF-6) domain family (N-terminal) member 8 | 0.0260508 |
| EGR1 | early growth response 1 | 0.0252653 |
| HOMER1 | homer scaffolding protein 1 | 0.0247205 |
| SIK2 | salt-inducible kinase 2 | 0.024067 |
| ARIH1 | ariadne RBR E3 ubiquitin protein ligase 1 | 0.0239602 |
| NR4A3 | nuclear receptor subfamily 4, group A, member 3 | 0.0238592 |
| CALD1 | caldesmon 1 | 0.0235896 |
| RPLP0 | ribosomal protein, large, P0 | 0.0234119 |
| CHD9 | chromodomain helicase DNA binding protein 9 | 0.0233199 |
| NFKB1 | nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 | 0.0231783 |
| STK38L | serine/threonine kinase 38 like | 0.0229465 |
| MDM2 | MDM2 proto-oncogene, E3 ubiquitin protein ligase | 0.0229146 |
| FMN1 | formin 1 | 0.0228324 |
| RGS4 | regulator of G-protein signaling 4 | 0.0228085 |
| STAT3 | signal transducer and activator of transcription 3 (acute-phase response factor) | 0.0227957 |
| HDX | highly divergent homeobox | 0.0226013 |
| NPAS2 | neuronal PAS domain protein 2 | 0.0225753 |
| CADM2 | cell adhesion molecule 2 | 0.0225385 |
| PCNX4 | pecanex 4 | 0.0214832 |
| LOC102724023 | ES1 protein homolog, mitochondrial | 0.0206877 |
| RAP1B | RAP1B, member of RAS oncogene family | 0.0206334 |
| PDLIM5 | PDZ and LIM domain 5 | 0.0203773 |
| MPG | N-methylpurine-DNA glycosylase | 0.0199523 |
| MYO1E | myosin IE | 0.0199318 |
| DUSP10 | dual specificity phosphatase 10 | 0.0196658 |
| MACROD2 | MACRO domain containing 2 | 0.019467 |
| UBAP2 | ubiquitin associated protein 2 | 0.01946 |
| TTC17 | tetratricopeptide repeat domain 17 | 0.0194454 |
| PCDH17 | protocadherin 17 | 0.0194043 |
| NFKBIZ | nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, zeta | 0.019212 |
| CDH10 | cadherin 10, type 2 (T2-cadherin) | 0.0188552 |
| BAZ2B | bromodomain adjacent to zinc finger domain, 2B | 0.0187376 |
| ATM | ATM serine/threonine kinase | 0.0186978 |
| MBTD1 | mbt domain containing 1 | 0.0183663 |
| ATP10D | ATPase, class V, type 10D | 0.0183436 |
| HSP90AB1 | heat shock protein 90kDa alpha (cytosolic), class B member 1 | 0.0183354 |
| RPL31 | ribosomal protein L31 | 0.0180625 |
| FOSB | FBJ murine osteosarcoma viral oncogene homolog B | 0.0180398 |
| DDX18 | DEAD (Asp-Glu-Ala-Asp) box polypeptide 18 | 0.0178345 |
| NRIP1 | nuclear receptor interacting protein 1 | 0.0177411 |
| CTNND1 | catenin (cadherin-associated protein), delta 1 | 0.0175925 |
| INTS6 | integrator complex subunit 6 | 0.0175769 |
| ITGA1 | integrin, alpha 1 | 0.0175452 |
| KCNT2 | potassium channel, sodium activated subfamily T, member 2 | 0.0175381 |
| TMEM87A | transmembrane protein 87A | 0.0174875 |
| ADAMTS1 | ADAM metallopeptidase with thrombospondin type 1 motif, 1 | 0.0174291 |
| RPS6KA3 | ribosomal protein S6 kinase, 90kDa, polypeptide 3 | 0.0173488 |
| FAM13A | family with sequence similarity 13, member A | 0.0173026 |
| PALLD | palladin, cytoskeletal associated protein | 0.0171683 |
| DGKH | diacylglycerol kinase, eta | 0.0170051 |
| SETBP1 | SET binding protein 1 | 0.0169424 |
| PPP4R3B | protein phosphatase 4 regulatory subunit 3B | 0.0167765 |
| REST | RE1-silencing transcription factor | 0.0167475 |
| FER | fer (fps/fes related) tyrosine kinase | 0.0166199 |
| ZMAT3 | zinc finger, matrin-type 3 | 0.0165978 |
| PCDH7 | protocadherin 7 | 0.0165083 |
| SCFD1 | sec1 family domain containing 1 | 0.0165045 |
| LRRFIP1 | leucine rich repeat (in FLII) interacting protein 1 | 0.0164194 |
| PRRC2C | proline-rich coiled-coil 2C | 0.016401 |
| ATF4 | activating transcription factor 4 | 0.0161491 |
| Symbol | Name | Standardized Value |
|---|---|---|
| IGF2 | insulin-like growth factor 2 | -0.206538 |
| DDX1 | DEAD (Asp-Glu-Ala-Asp) box helicase 1 | -0.100154 |
| PTMA | prothymosin, alpha | -0.0925319 |
| NRG1 | neuregulin 1 | -0.0798384 |
| COL3A1 | collagen, type III, alpha 1 | -0.0777226 |
| COL1A1 | collagen, type I, alpha 1 | -0.0736266 |
| NALF1 | NALCN channel auxiliary factor 1 | -0.0660622 |
| LPIN1 | lipin 1 | -0.0617825 |
| THSD4 | thrombospondin, type I, domain containing 4 | -0.0558853 |
| DDX5 | DEAD (Asp-Glu-Ala-Asp) box helicase 5 | -0.0527719 |
| AHNAK | AHNAK nucleoprotein | -0.0526621 |
| SMURF2 | SMAD specific E3 ubiquitin protein ligase 2 | -0.0484851 |
| RBMS3 | RNA binding motif, single stranded interacting protein 3 | -0.0447938 |
| DNAJC5 | DnaJ (Hsp40) homolog, subfamily C, member 5 | -0.0413825 |
| LRFN5 | leucine rich repeat and fibronectin type III domain containing 5 | -0.0403103 |
| GULP1 | GULP, engulfment adaptor PTB domain containing 1 | -0.0394443 |
| ACSL3 | acyl-CoA synthetase long-chain family member 3 | -0.0383998 |
| TMSB10 | thymosin beta 10 | -0.0382708 |
| GPC5 | glypican 5 | -0.0376725 |
| NAMPT | nicotinamide phosphoribosyltransferase | -0.0375835 |
| HMGB2 | high mobility group box 2 | -0.0366856 |
| HIF1A | hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) | -0.0359571 |
| RPS24 | ribosomal protein S24 | -0.0356124 |
| AUTS2 | autism susceptibility candidate 2 | -0.033692 |
| UBR5 | ubiquitin protein ligase E3 component n-recognin 5 | -0.0324531 |
| UBC | ubiquitin C | -0.0323547 |
| LIMCH1 | LIM and calponin homology domains 1 | -0.0316253 |
| DIAPH2 | diaphanous-related formin 2 | -0.0312422 |
| RPS27A | ribosomal protein S27a | -0.0307136 |
| PGK1 | phosphoglycerate kinase 1 | -0.0306096 |
| NUCKS1 | nuclear casein kinase and cyclin-dependent kinase substrate 1 | -0.0300303 |
| GNAQ | guanine nucleotide binding protein (G protein), q polypeptide | -0.0292959 |
| WDR45B | WD repeat domain 45B | -0.0289053 |
| RPL19 | ribosomal protein L19 | -0.0288904 |
| CRH | corticotropin releasing hormone | -0.0287217 |
| CDH13 | cadherin 13 | -0.0285949 |
| PLAT | plasminogen activator, tissue | -0.0284704 |
| CANX | calnexin | -0.0283778 |
| RPL35A | ribosomal protein L35a | -0.0281318 |
| SSBP2 | single-stranded DNA binding protein 2 | -0.0279532 |
| COL6A1 | collagen, type VI, alpha 1 | -0.0277387 |
| NPM1 | nucleophosmin (nucleolar phosphoprotein B23, numatrin) | -0.027637 |
| PABPC1 | poly(A) binding protein, cytoplasmic 1 | -0.0274548 |
| MACF1 | microtubule-actin crosslinking factor 1 | -0.0273897 |
| ARID4B | AT rich interactive domain 4B (RBP1-like) | -0.0271627 |
| RAD21 | RAD21 homolog (S. pombe) | -0.0270773 |
| RHOA | ras homolog family member A | -0.027076 |
| KDM3A | lysine (K)-specific demethylase 3A | -0.0270397 |
| SPAG9 | sperm associated antigen 9 | -0.026871 |
| BMPR2 | bone morphogenetic protein receptor, type II (serine/threonine kinase) | -0.0268169 |
| PRKCA | protein kinase C, alpha | -0.0262767 |
| EIF4A1 | eukaryotic translation initiation factor 4A1 | -0.0258808 |
| SREBF2 | sterol regulatory element binding transcription factor 2 | -0.0257126 |
| KCNQ5 | potassium channel, voltage gated KQT-like subfamily Q, member 5 | -0.0256714 |
| CTNNA1 | catenin (cadherin-associated protein), alpha 1, 102kDa | -0.0253454 |
| NF1 | neurofibromin 1 | -0.0251261 |
| COL18A1 | collagen, type XVIII, alpha 1 | -0.0250907 |
| PSD3 | pleckstrin and Sec7 domain containing 3 | -0.0247969 |
| ZC3H11A | zinc finger CCCH-type containing 11A | -0.0246102 |
| PTPRG | protein tyrosine phosphatase, receptor type, G | -0.0245287 |
| CTNNB1 | catenin (cadherin-associated protein), beta 1, 88kDa | -0.0242866 |
| PACS1 | phosphofurin acidic cluster sorting protein 1 | -0.0241411 |
| MAP3K2 | mitogen-activated protein kinase kinase kinase 2 | -0.0240777 |
| DYNC1H1 | dynein, cytoplasmic 1, heavy chain 1 | -0.0240139 |
| ATXN10 | ataxin 10 | -0.0238349 |
| SRPK2 | SRSF protein kinase 2 | -0.0237792 |
| SRSF1 | serine/arginine-rich splicing factor 1 | -0.0237753 |
| DTNA | dystrobrevin, alpha | -0.0236284 |
| MYH9 | myosin, heavy chain 9, non-muscle | -0.0233359 |
| PRKAR1A | protein kinase, cAMP-dependent, regulatory, type I, alpha | -0.0232177 |
| APP | amyloid beta (A4) precursor protein | -0.023156 |
| HIP1 | huntingtin interacting protein 1 | -0.0230762 |
| MED13L | mediator complex subunit 13-like | -0.023045 |
| IGF2BP2 | insulin-like growth factor 2 mRNA binding protein 2 | -0.0229928 |
| HNRNPU | heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) | -0.0229766 |
| BICD1 | bicaudal D homolog 1 (Drosophila) | -0.0229125 |
| LCORL | ligand dependent nuclear receptor corepressor-like | -0.0227579 |
| FN1 | fibronectin 1 | -0.0226673 |
| SETD5 | SET domain containing 5 | -0.0223882 |
| RPL7A | ribosomal protein L7a | -0.0223731 |
| ROBO2 | roundabout, axon guidance receptor, homolog 2 (Drosophila) | -0.0222379 |
| SLC39A11 | solute carrier family 39, member 11 | -0.0217782 |
| AOPEP | aminopeptidase O (putative) | -0.0216427 |
| ACACA | acetyl-CoA carboxylase alpha | -0.0214308 |
| WAC | WW domain containing adaptor with coiled-coil | -0.0212172 |
| CADM1 | cell adhesion molecule 1 | -0.0212163 |
| RHEB | Ras homolog enriched in brain | -0.0210094 |
| TFG | TRK-fused gene | -0.0209468 |
| ACTN4 | actinin, alpha 4 | -0.0207561 |
| CBFB | core-binding factor, beta subunit | -0.0207495 |
| MAP4 | microtubule-associated protein 4 | -0.0207449 |
| RBM39 | RNA binding motif protein 39 | -0.020635 |
| ZMYM2 | zinc finger, MYM-type 2 | -0.02054 |
| RPS16 | ribosomal protein S16 | -0.020473 |
| CEP95 | centrosomal protein 95kDa | -0.0203815 |
| ZFAND3 | zinc finger, AN1-type domain 3 | -0.0203037 |
| MSI2 | musashi RNA-binding protein 2 | -0.0202572 |
| SET | SET nuclear proto-oncogene | -0.0202548 |
| YWHAZ | tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta | -0.0201785 |
| HELZ | helicase with zinc finger | -0.0201593 |
