| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | Tomivosertib perturbation in COLO 205 cell line (Tahoe Therapeutics) |
| Similar Terms | |
| Downloads & Tools |
200 genes differentially expressed following the Tomivosertib_COLO 205 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| LMO7 | LIM domain 7 | 0.172572 |
| GCLC | glutamate-cysteine ligase, catalytic subunit | 0.0729708 |
| HSP90AA1 | heat shock protein 90kDa alpha (cytosolic), class A member 1 | 0.0690336 |
| ZSWIM6 | zinc finger, SWIM-type containing 6 | 0.0667265 |
| INTS6 | integrator complex subunit 6 | 0.0652662 |
| VMP1 | vacuole membrane protein 1 | 0.0600094 |
| CYP3A5 | cytochrome P450, family 3, subfamily A, polypeptide 5 | 0.0588153 |
| CTNNA1 | catenin (cadherin-associated protein), alpha 1, 102kDa | 0.0548526 |
| SMAD3 | SMAD family member 3 | 0.0512092 |
| AKAP13 | A kinase (PRKA) anchor protein 13 | 0.0494757 |
| EXT1 | exostosin glycosyltransferase 1 | 0.0481805 |
| RAB7A | RAB7A, member RAS oncogene family | 0.0441316 |
| ARIH1 | ariadne RBR E3 ubiquitin protein ligase 1 | 0.0429049 |
| RIGI | RNA sensor RIG-I | 0.0412374 |
| HSPH1 | heat shock 105kDa/110kDa protein 1 | 0.0406271 |
| DIAPH1 | diaphanous-related formin 1 | 0.0399544 |
| HKDC1 | hexokinase domain containing 1 | 0.0386243 |
| SIK3 | SIK family kinase 3 | 0.0380745 |
| TJP1 | tight junction protein 1 | 0.0376807 |
| SQSTM1 | sequestosome 1 | 0.0373889 |
| STS | steroid sulfatase (microsomal), isozyme S | 0.0367025 |
| KYNU | kynureninase | 0.0351605 |
| PLSCR2 | phospholipid scramblase 2 | 0.0348816 |
| ERN1 | endoplasmic reticulum to nucleus signaling 1 | 0.0342734 |
| TOP1 | topoisomerase (DNA) I | 0.034214 |
| TMC5 | transmembrane channel-like 5 | 0.0338644 |
| ELOF1 | elongation factor 1 homolog (S. cerevisiae) | 0.0324959 |
| PARP14 | poly (ADP-ribose) polymerase family, member 14 | 0.0323083 |
| NFAT5 | nuclear factor of activated T-cells 5, tonicity-responsive | 0.0321414 |
| ITGA2 | integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) | 0.0320261 |
| PLIN2 | perilipin 2 | 0.0319418 |
| SAMD9 | sterile alpha motif domain containing 9 | 0.0317205 |
| LPP | LIM domain containing preferred translocation partner in lipoma | 0.0299047 |
| EIF3A | eukaryotic translation initiation factor 3, subunit A | 0.0293378 |
| BAZ1A | bromodomain adjacent to zinc finger domain, 1A | 0.0289934 |
| PHF3 | PHD finger protein 3 | 0.0289899 |
| SIPA1L2 | signal-induced proliferation-associated 1 like 2 | 0.0283933 |
| MX2 | MX dynamin-like GTPase 2 | 0.0282621 |
| TM4SF19 | transmembrane 4 L six family member 19 | 0.0276912 |
| LIMA1 | LIM domain and actin binding 1 | 0.0276212 |
| HSP90AB1 | heat shock protein 90kDa alpha (cytosolic), class B member 1 | 0.027369 |
| GK | glycerol kinase | 0.0269975 |
| RASAL2 | RAS protein activator like 2 | 0.026703 |
| RPS6KA3 | ribosomal protein S6 kinase, 90kDa, polypeptide 3 | 0.026556 |
| SP100 | SP100 nuclear antigen | 0.0263128 |
| POF1B | premature ovarian failure, 1B | 0.0262659 |
| CATSPERB | catsper channel auxiliary subunit beta | 0.0260941 |
| UBAP2 | ubiquitin associated protein 2 | 0.0255958 |
| GULP1 | GULP, engulfment adaptor PTB domain containing 1 | 0.0250956 |
| SLK | STE20-like kinase | 0.0248074 |
| JUN | jun proto-oncogene | 0.0240613 |
| MCTP1 | multiple C2 domains, transmembrane 1 | 0.0238945 |
| MAP7 | microtubule-associated protein 7 | 0.0237967 |
| FHIT | fragile histidine triad | 0.0237207 |
| RFFL | ring finger and FYVE-like domain containing E3 ubiquitin protein ligase | 0.0235513 |
| SPATA13 | spermatogenesis associated 13 | 0.0234245 |
| MX1 | MX dynamin-like GTPase 1 | 0.0233555 |
| CEMIP | cell migration inducing protein, hyaluronan binding | 0.0229123 |
| MGAT5 | mannosyl (alpha-1,6-)-glycoprotein beta-1,6-N-acetyl-glucosaminyltransferase | 0.0228097 |
| FNIP2 | folliculin interacting protein 2 | 0.0222712 |
| RAPGEF2 | Rap guanine nucleotide exchange factor (GEF) 2 | 0.0221009 |
| EIF4G3 | eukaryotic translation initiation factor 4 gamma, 3 | 0.0219265 |
| ZC3H13 | zinc finger CCCH-type containing 13 | 0.021841 |
| PITPNC1 | phosphatidylinositol transfer protein, cytoplasmic 1 | 0.0217819 |
| SLC7A1 | solute carrier family 7 (cationic amino acid transporter, y+ system), member 1 | 0.0216689 |
| CYSTM1 | cysteine-rich transmembrane module containing 1 | 0.0214443 |
| RNF213 | ring finger protein 213 | 0.0213491 |
| IMMP2L | IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) | 0.0212175 |
| PDZD8 | PDZ domain containing 8 | 0.0211649 |
| PCCA | propionyl CoA carboxylase, alpha polypeptide | 0.0209679 |
| DUSP10 | dual specificity phosphatase 10 | 0.0208553 |
| PDLIM5 | PDZ and LIM domain 5 | 0.0207901 |
| DIP2B | DIP2 disco-interacting protein 2 homolog B (Drosophila) | 0.0207703 |
| HCN1 | hyperpolarization activated cyclic nucleotide gated potassium channel 1 | 0.0204447 |
| POU2F2 | POU class 2 homeobox 2 | 0.0203648 |
| IFIT3 | interferon-induced protein with tetratricopeptide repeats 3 | 0.020356 |
| MAP3K5 | mitogen-activated protein kinase kinase kinase 5 | 0.0202868 |
| ALCAM | activated leukocyte cell adhesion molecule | 0.0202276 |
| RPL7L1 | ribosomal protein L7-like 1 | 0.0199485 |
| MCU | mitochondrial calcium uniporter | 0.0199175 |
| GMDS | GDP-mannose 4,6-dehydratase | 0.0194006 |
| AREG | amphiregulin | 0.0192819 |
| BAIAP2L1 | BAI1-associated protein 2-like 1 | 0.0192063 |
| HOMER1 | homer scaffolding protein 1 | 0.0188332 |
| SHB | Src homology 2 domain containing adaptor protein B | 0.0188124 |
| PPP1R15A | protein phosphatase 1, regulatory subunit 15A | 0.0187299 |
| SET | SET nuclear proto-oncogene | 0.0186799 |
| SIPA1L1 | signal-induced proliferation-associated 1 like 1 | 0.0186759 |
| THOC2 | THO complex 2 | 0.0185126 |
| CXCL8 | chemokine (C-X-C motif) ligand 8 | 0.0179994 |
| CRY1 | cryptochrome circadian clock 1 | 0.0178717 |
| FOXO1 | forkhead box O1 | 0.0176943 |
| APLP2 | amyloid beta (A4) precursor-like protein 2 | 0.0176521 |
| MYO5B | myosin VB | 0.0176476 |
| FOSB | FBJ murine osteosarcoma viral oncogene homolog B | 0.0175936 |
| LAMA4 | laminin, alpha 4 | 0.0175577 |
| TTC19 | tetratricopeptide repeat domain 19 | 0.0175448 |
| MYO1E | myosin IE | 0.0174523 |
| DST | dystonin | 0.0172995 |
| PSME4 | proteasome (prosome, macropain) activator subunit 4 | 0.0172274 |
| Symbol | Name | Standardized Value |
|---|---|---|
| HSP90B1 | heat shock protein 90kDa beta (Grp94), member 1 | -0.271361 |
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | -0.121222 |
| ZMYND8 | zinc finger, MYND-type containing 8 | -0.106005 |
| PDIA3 | protein disulfide isomerase family A, member 3 | -0.100385 |
| TXNIP | thioredoxin interacting protein | -0.100369 |
| P4HB | prolyl 4-hydroxylase, beta polypeptide | -0.0925044 |
| NDRG1 | N-myc downstream regulated 1 | -0.0924605 |
| TPT1 | tumor protein, translationally-controlled 1 | -0.0860009 |
| PTMA | prothymosin, alpha | -0.0857348 |
| HSPA5 | heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) | -0.0787617 |
| RHOBTB3 | Rho-related BTB domain containing 3 | -0.0779381 |
| P4HA1 | prolyl 4-hydroxylase, alpha polypeptide I | -0.0767457 |
| HLA-B | major histocompatibility complex, class I, B | -0.0766999 |
| PABPC1 | poly(A) binding protein, cytoplasmic 1 | -0.0699358 |
| RNF149 | ring finger protein 149 | -0.0683846 |
| MBNL2 | muscleblind-like splicing regulator 2 | -0.064806 |
| PTBP3 | polypyrimidine tract binding protein 3 | -0.0646637 |
| ZKSCAN1 | zinc finger with KRAB and SCAN domains 1 | -0.0640493 |
| TOP2A | topoisomerase (DNA) II alpha 170kDa | -0.0636575 |
| B2M | beta-2-microglobulin | -0.0629066 |
| ERO1A | endoplasmic reticulum oxidoreductase 1 alpha | -0.0626355 |
| RUNX1 | runt-related transcription factor 1 | -0.0625509 |
| RBM39 | RNA binding motif protein 39 | -0.0578474 |
| CALR | calreticulin | -0.0575984 |
| SREBF2 | sterol regulatory element binding transcription factor 2 | -0.0573773 |
| ERRFI1 | ERBB receptor feedback inhibitor 1 | -0.0531379 |
| NCKAP5 | NCK-associated protein 5 | -0.0517867 |
| PGK1 | phosphoglycerate kinase 1 | -0.0478678 |
| ELF3 | E74-like factor 3 (ets domain transcription factor, epithelial-specific ) | -0.0478562 |
| H1-0 | H1.0 linker histone | -0.045834 |
| RNF43 | ring finger protein 43 | -0.0456927 |
| GPRC5A | G protein-coupled receptor, class C, group 5, member A | -0.0453914 |
| FNIP1 | folliculin interacting protein 1 | -0.0451887 |
| GFPT1 | glutamine--fructose-6-phosphate transaminase 1 | -0.045179 |
| FNDC3A | fibronectin type III domain containing 3A | -0.0451762 |
| N4BP2L2 | NEDD4 binding protein 2-like 2 | -0.0449278 |
| AP3B1 | adaptor-related protein complex 3, beta 1 subunit | -0.0440804 |
| PTEN | phosphatase and tensin homolog | -0.044014 |
| TMPRSS4 | transmembrane protease, serine 4 | -0.0434225 |
| EHF | ets homologous factor | -0.0428761 |
| IRF1 | interferon regulatory factor 1 | -0.0427676 |
| CD46 | CD46 molecule, complement regulatory protein | -0.0427423 |
| PKM | pyruvate kinase, muscle | -0.0421626 |
| ACBD3 | acyl-CoA binding domain containing 3 | -0.0418924 |
| WDR45B | WD repeat domain 45B | -0.0415341 |
| AHI1 | Abelson helper integration site 1 | -0.041029 |
| CHST11 | carbohydrate (chondroitin 4) sulfotransferase 11 | -0.0404659 |
| AHNAK | AHNAK nucleoprotein | -0.0400704 |
| ABHD2 | abhydrolase domain containing 2 | -0.0397615 |
| NUCB2 | nucleobindin 2 | -0.0396257 |
| POLR2A | polymerase (RNA) II (DNA directed) polypeptide A, 220kDa | -0.0395905 |
| TSC22D2 | TSC22 domain family, member 2 | -0.0392631 |
| S100A10 | S100 calcium binding protein A10 | -0.0391388 |
| UBC | ubiquitin C | -0.039042 |
| DIAPH3 | diaphanous-related formin 3 | -0.0383096 |
| CANX | calnexin | -0.0382295 |
| TFG | TRK-fused gene | -0.038033 |
| GNAS | GNAS complex locus | -0.0378521 |
| EZR | ezrin | -0.0376799 |
| AGR2 | anterior gradient 2 | -0.0374684 |
| TMSB10 | thymosin beta 10 | -0.0373833 |
| NCOR1 | nuclear receptor corepressor 1 | -0.0373575 |
| YWHAZ | tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta | -0.0373569 |
| PERP | PERP, TP53 apoptosis effector | -0.0372039 |
| ATP2C2 | ATPase, Ca++ transporting, type 2C, member 2 | -0.0369481 |
| HLA-C | major histocompatibility complex, class I, C | -0.036311 |
| GRAMD2B | GRAM domain containing 2B | -0.0360698 |
| SNTB1 | syntrophin, beta 1 (dystrophin-associated protein A1, 59kDa, basic component 1) | -0.0359787 |
| MBOAT2 | membrane bound O-acyltransferase domain containing 2 | -0.0357919 |
| UFM1 | ubiquitin-fold modifier 1 | -0.0356254 |
| PDIA4 | protein disulfide isomerase family A, member 4 | -0.0355128 |
| PRELID2 | PRELI domain containing 2 | -0.0353892 |
| TM9SF2 | transmembrane 9 superfamily member 2 | -0.0350636 |
| ZMYM2 | zinc finger, MYM-type 2 | -0.0345586 |
| FNDC3B | fibronectin type III domain containing 3B | -0.0340482 |
| COG6 | component of oligomeric golgi complex 6 | -0.0337661 |
| MKI67 | marker of proliferation Ki-67 | -0.0335657 |
| GOLGA2 | golgin A2 | -0.0333553 |
| WSB1 | WD repeat and SOCS box containing 1 | -0.0332126 |
| HELZ | helicase with zinc finger | -0.0329904 |
| MEIS2 | Meis homeobox 2 | -0.032918 |
| HDLBP | high density lipoprotein binding protein | -0.0327623 |
| CCNL1 | cyclin L1 | -0.0327581 |
| PDIA6 | protein disulfide isomerase family A, member 6 | -0.0323392 |
| SMC4 | structural maintenance of chromosomes 4 | -0.0323162 |
| SEC24D | SEC24 family member D | -0.0318451 |
| NPEPPS | aminopeptidase puromycin sensitive | -0.0317869 |
| BCLAF1 | BCL2-associated transcription factor 1 | -0.0311504 |
| TPM4 | tropomyosin 4 | -0.0310291 |
| EPB41 | erythrocyte membrane protein band 4.1 | -0.031012 |
| UBAC2 | UBA domain containing 2 | -0.0309647 |
| ANKHD1 | ankyrin repeat and KH domain containing 1 | -0.0307668 |
| RAB11FIP1 | RAB11 family interacting protein 1 (class I) | -0.0303884 |
| CENPF | centromere protein F, 350/400kDa | -0.0303762 |
| OGA | O-GlcNAcase | -0.0301819 |
| DNAJC3 | DnaJ (Hsp40) homolog, subfamily C, member 3 | -0.0298902 |
| PDK3 | pyruvate dehydrogenase kinase, isozyme 3 | -0.0298604 |
| GBE1 | glucan (1,4-alpha-), branching enzyme 1 | -0.0297773 |
| UBR2 | ubiquitin protein ligase E3 component n-recognin 2 | -0.029724 |
| ZDHHC20 | zinc finger, DHHC-type containing 20 | -0.0296557 |
